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• GondolaBio Service Co, Inc.

  

  Director, Antibody Development & Engineering

  20 days ago

  Palo Alto

  Job DescriptionDescription: Company Background GondolaBio is a biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally carved out of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. To learn more about our company and current pipeline of drug candidates, visit us at Who You Are We are looking for a highly motivated and innovative scientist to lead the antibody discovery for a newly-formed GondolaBio program. The selected candidate will work within a fast-paced, interactive, and innovative research team to lead discovery campaigns for novel antibodies. This role will lead the development of immunological functional assays, CRO management, oversight of antibody discovery campaign, contribute to future regulatory submissions, and participate in cross-functional meetings. This job requires excellent communication and interpersonal skills as well as technical and scientific abilities. We hope to hear from you. Requirements: Responsibilities • Design, develop and lead multiple antibody discovery campaign efforts with CROs, including biochemical and functional assay screening, • Lead antibody engineering efforts for affinity maturation campaigns, developability, and immunological enhancement, • Lead the development of preclinical animal models with CROs to assess lead candidates, • Engage in scientific discussion with collaborators and management to evaluate ongoing projects, • Develop and optimize the SOPs, validation protocols, provide technical assistance and train research associates as needed, • Oversee wet lab activities including tissue culture, PBMC isolation, protein expression and purification, functional assays, and flow cytometry, • Maintain strong understanding of state-of-the-art protein engineering, • Collaborate with cross-functional teams, including DMPK, toxicology, clinical development, regulatory to advance our therapeutic candidates from preclinical stages toward clinical development in a fast-paced, dynamic environment, • Represent the program scientifically to internal and external audiences, • Contribute to the drafting of translation- and pharmacology-related sections of regulatory documents including INDs, • Contribute to due diligence and gap analysis on potential new GondolaBio assets as needed Education, Experience & Skills Requirements • PhD degree in biochemistry, immunology or related life science field and 8+ years of experience, • Experience with antibody discovery, including antibody engineering, antibody affinity maturation, and developability, • Hands-on experience with immunology skills including PBMC isolation and macrophage differentiation, ADCP/ADCC/CDC assays, multicolor flow cytometry, • Hands-on experience with protein and antibody engineering skills including protein expression and purification, size exclusion chromatography, antibody campaigns and screening, BLI/SPR kinetics and epitope binning,, • Passion for getting lifesaving medicines into the hands of patients as quickly and efficiently as is humanly possible, • Ability to handle multiple projects simultaneously, • Ability to work independently and as part of a team, • Must be comfortable with ambiguity, • Fast (extremely fast) learner, • Strong communication skills, • Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals, • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts, • A culture inspired by our values: put patients first; think independently; be radically transparent; every minute counts; and let the science speak, • Collaborative business environment, • Excellent compensation package (Base, Performance Bonus, Equity), • Excellent benefits package, • Flexible PTO, • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities, • Work with the most productive groups of R&D operators in the industry

• DELFI Diagnostics, Inc.

  

  Senior Research Associate (Assay Development and Manufacturing Associate) - Contract

  19 hours ago

  Palo Alto

  Job DescriptionAbout Us DELFI Diagnostics, Inc. (DELFI Diagnostics) is developing next-generation, blood-based tests that are reliable, accessible and deliver a new way to help detect cancer. Employing advanced machine-learning methods to whole-genome sequencing data, the DELFI ("DNA EvaLuation of Fragments for early Interception") platform is built to address the highest-burden health challenges. DELFI Diagnostics prioritizes solutions that have the potential to save lives on a global scale, including for historically underserved populations. DELFI Diagnostics’ platform relies on fragmentomics – the discovery that cancer cells are more chaotic than normal cells and, when they die, leave behind tell-tale patterns and characteristics of cell-free DNA (cfDNA) fragments. FirstLook Lung, for individuals eligible for lung cancer screening, is DELFI Diagnostics’ first laboratory-developed screening test and can be part of routine blood work. FirstLook Lung uses millions of data points to reliably identify individuals who may have cancer detected through low-dose CT, including early stage disease with a negative predictive value of 99.8 percent. This test has not been cleared or approved by the FDA. In our passionate pursuit to radically improve health outcomes, we serve humanity when we: Lead with Science, Anchor in Pragmatism: We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. We explore thoughtfully, experiment smartly, and deliver impact with conviction. Build With & For All: We embrace diverse backgrounds to innovate and achieve together. We are not just building a product - we aim to disrupt the path of cancer for all - no matter geography or socioeconomic class Put We over I: We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us--win. We show up with empathy, humility, and integrity at every step of the journey. About the Role Join our innovative team dedicated to reducing cancer deaths through cutting-edge liquid biopsy diagnostics. As Sr. Research Associate, you will be responsible for performing functional quality control testing of incoming GMP-grade reagents, preparing manufacturing controls, and supporting our CLIA-certified laboratory operations. You will work with molecular and biochemical assays, utilizing automated liquid handling systems to ensure our manufacturing processes meet stringent quality standards. Additionally, you will support research and development activities as needed, contributing to method optimization and validation studies. This contract position requires strong attention to detail and the ability to work in a regulated GMP/CLIA environment where precision and documentation are critical.What you'll do • Manufacturing & Quality Control, • Perform functional and other quality control testing on incoming reagents for molecular and biochemical assays with meticulous attention to detail and adherence to high-quality standards., • Execute reagent qualification protocols following established SOPs and manufacturing procedures, • Prepare manufacturing controls and reference standards, • Operate automated liquid handling systems (Hamilton or similar platforms) for high-throughput reagent testing, • Maintain comprehensive documentation in compliance with FDA 21 CFR 820, GMP requirements, and CLIA regulations, • Track reagent lot numbers, expiration dates, and qualification results in inventory management systemsResearch & Development Support:, • Design, execute, and troubleshoot moderate to complex laboratory experiments utilizing molecular biology techniques for Next-Generation Sequencing (NGS)., • Assist with method optimization and validation studies for assay and QC method development, • Perform guard banding, stability and other studies, and analytical characterization experiments, • Execute experimental workflows to support product development activities, • Contribute to troubleshooting and resolving technical challenges in assay performanceCross-Functional Collaboration:, • Communicate effectively with Quality Assurance, Manufacturing, and R&D teams regarding reagent performance and study results, • Participate in manufacturing operations while maintaining strict environmental controls for laboratory work, • Support multidisciplinary project teams as neededWhat You'll Have Accomplished 6 Months From Now, • Become proficient in executing all reagent qualification protocols for multiple assay types, • Successfully qualified multiple reagent lots using automated liquid handlers with consistent, high-quality results, • Supported manufacturing laboratory infrastructure setup and process establishment, including development of equipment maintenance schedules and calibration plans, • Developed GMP-compliant documentation including SOPs, work instructions, and quality control policies for manufacturing operationsWhat you'll bring to DELFI, • Required qualifications:, • BS with 3-4 years of experience, or MS with 2-3 years in relevant field (e.g., biomedical engineering, molecular biology, genetics, or genomics), • Hands-on experience with automated liquid handling systems (Hamilton, Tecan, or similar platforms), • Direct experience in a regulated environment (CLIA, CAP, FDA, GXP, etc.), • Proficiency in high-throughput manual and automated laboratory techniques for molecular biology and biochemical assays, • Strong analytical skills with ability to independently design experiments, troubleshoot technical challenges, and interpret results using sound scientific reasoning, • Excellent technical writing capabilities for developing protocols, SOPs, and development reports, • Superior organizational and project management skills with meticulous documentation practices, strategic planning abilities, and keen attention to detail, • Demonstrated ability to work independently while communicating effectively with cross-functional teamsPreferred qualifications:, • Direct experience working in a CLIA-certified laboratory or GMP manufacturing environment and familiarity with FDA 21 CFR 820 and ISO 13485 quality system requirements, • Experience with method development, optimization, and validation studies with NGS assays, • Experience with inventory management and lot tracking systems (NetSuite or similar ERP systems), • Understanding of contamination control requirements for laboratory environments

• xAI

  

  Lead Network Engineer - Core

  2 days ago

  Palo Alto

  Job DescriptionAbout xAI xAI's mission is to create AI systems that can accurately understand the universe and aid humanity in its pursuit of knowledge. Our team is small, highly motivated, and focused on engineering excellence. This organization is for individuals who appreciate challenging themselves and thrive on curiosity. We operate with a flat organizational structure. All employees are expected to be hands-on and to contribute directly to the company's mission. Leadership is given to those who show initiative and consistently deliver excellence. Work ethic and strong prioritization skills are important. All engineers are expected to have strong communication skills. They should be able to concisely and accurately share knowledge with their teammates. About the Role Data Center Fabrics are the foundational building blocks of the complex architecture that enables Grok to be trained and serve customer queries as they learn to understand the universe. To enable us to move faster we are looking for a Core Network Engineering Team Lead in our Palo Alto Office. You will develop and execute the team's roadmap in collaboration with partner teams. You will guide your team and directly contribute to its network's development, while hiring and developing the world class talent xAI needs to achieve AGI. Responsibilities • Develop and execute the team's roadmap for data center network fabrics in collaboration with partner teams., • Lead and mentor a team of engineers, providing technical guidance and feedback to ensure high performance and growth., • Directly contribute to the design, development, and optimization of network infrastructure to maximize availability and performance., • Write Python scripts to automate processes, optimize compute resources, and reduce repetitive engineering tasks., • Partner with cross-functional teams to align on roadmaps and resolve break/fix issues efficiently., • Hire and develop top-tier talent to support xAI's mission of achieving AGI., • Ruthlessly prioritize team efforts to maximize weekly impact for customers.Required Qualifications, • 3+ years as a technical lead in AI networking, with at least 8 years of experience in hyperscale network environments., • Proficiency in Python scripting to optimize compute resources and automate engineering tasks., • 3+ years of experience with RoCEv2 and/or InfiniBand technologies., • Proven ability to deliver highly available and performant data center network fabrics through individual and team contributions., • Demonstrated experience mentoring engineers and providing constructive feedback.Preferred Qualifications, • Ability to navigate ambiguity and drive progress without being hindered by over-analysis., • Strong collaboration skills to align multiple teams on cohesive roadmaps and solutions., • A proactive, hands-on approach to tackling challenges, with no task considered too small., • Experience in high-stakes environments requiring rapid prioritization and decision-making. xAI is an equal opportunity employer. California Consumer Privacy Act (CCPA) Notice

• Ronald McDonald House Charities Bay Area

  

  Family Support Services Program Coordinator (Supervising Psychologist)

  3 years ago

  Palo Alto

  Job DescriptionSalary: 40,000-50,000 ABOUT FAMILY SUPPORT SERVICES AT RONALD MCDONALD HOUSE CHARITIES BAY AREA Ronald McDonald House Charities Bay Area (RMHC Bay Area) envisions a world where all children have access to health care and their families are fully supported and actively involved in their care. RMHC Bay Area supports more than 4,000 children and their families annually through three Ronald McDonald Houses, two Ronald McDonald Care Mobiles, a Ronald McDonald House School, as well as regional food insecurity programs, alternative housing support, psycho-social and respite programs and specialized programming delivered on site inside area pediatric hospitals. Family Support Services (FSS) provides emotional support, education, and resources to the families and staff of the Ronald McDonald House Charities. Individuals, couples, and entire families are served in the privacy of the FSSoffices, around the House, in the kitchen, playroom, on Zoom, or wherever a person feels most comfortable. FSSnot only offers support to individual families, but also plans and manages House therapeutic activities such as Fun Clubs, holiday activities, and special events that provide a caring, supportive, and fun environment for all. FSSprovides support and training for the staff at the Ronald McDonald House. This helps staff handle their own stress and feelings, which enables them to provide even better customer service to families. JOB SUMMARY The Family Support Services Program Coordinator is responsible for contributing to the management and program development of FSS supporting the families residing at Ronald McDonald House Charities Bay Area, as well as strengthening the mission through community engagement. The FSS Program Coordinator supports the mission of FSS by supervising a group of masters and doctoral level graduate student trainees, assessing House needs, and developing new innovative programming to support families and trainee professional development. The FSS Program Coordinator is responsible for on-going program improvement and new program development at the Stanford site and online. This role also provides support to other Family Support Services teams and engages our community partners (universities, potential recruits, other organizations, etc.). This role requires strong managerial, relationship building, and strategy implementation skills. The FSS Program Coordinator must be a self-starter, strong leader that is empathetic, highly skilled problem solver, and has previous supervisor experience. Bilingual Spanish speaking strongly preferred, however, not required. This is a part-time, non-exempt position reporting to the Director, Families & Wellness. This position has a flexible schedule to meet the 20 hours a week requirement, with a mandatory of Wednesdays 9-4pm for student training purposes. This role may require working some weekends, and holidays. DUTIES AND RESPONSIBILITIES Management • Oversee Family Support Services Trainees, • Provide 1 hour minimum of primary supervision to each trainee (3-5 trainees), • Lead and facilitate FSS staff meetings, group supervision, and professional development on Wednesdays, • Manage and coordinate all trainees schedules to meet House needs, • Review progress notes and additional documentation, as per APA and CAMFT guidelines, • Provide ongoing verbal and written evaluations for trainees throughout the academic year and per university requirements, • Attends supervisor meetings Operations Families * • Responsible for the support of individuals, couples, and families, • Provide Therapeutic Fun Clubs and host significant House events, • Intervene and the first point of contact during family crises, • Support Operations team by providing support, resources, answering questions, • Support in developing strategies and problem solving in family related issues, • Participate in House Operations meetings, • Participate in RMHC Staff meetings and provide trainings prepared by Director Community Engagement & Development • Have regular communication regarding trainee needs, challenges, and strengths with university liaisons, • Attend all practicum fairs, workshops, and university open houses for the recruitment of new trainees, • Interview prospective students in individual and group formats, • Conduct site tours and program presentations for universities, possible future trainees, and community members SALARY RANGE: $40,000-50,000 QUALIFICATIONS AND PREREQUISITES EDUCATION AND EXPERIENCE EDUCATION: • A doctoral degree from an APA-accredited university (Ph.D. or PsyD), • Must hold an active California Clinical Psychologist License, • Be licensed for at least two years to provide supervision to MFT Trainees as well KNOWLEDGE, SKILLS, AND EXPERIENCE: • Be able to navigate being the sole psychologist on-site and be solely responsible for all trainees/families served, • A strong understating of the APA/AAMFT/CAMFT ethics codes, laws, and legal mandates that apply to mental health professionals, • Excellent interpersonal and communication skills, • Ability to work in a semi-medical environment with children being treated with life-threatening illnesses and their families, • Certified in Adult & Pediatric CPR, First Aid and AED (or ability to get certified), • Must be able to lift 25 pounds Job description is for informational purposes only. Additional duties that are consistent with the responsibility level may be assigned. To apply, please prepare a cover letter and resume and submit to: Martha Hernndez, Ph.D., Director, Families & Wellness at .

• Palantir Technologies

  

  Software Engineer, New Grad - Infrastructure

  6 days ago

  Palo Alto

  Job DescriptionA World-Changing Company Palantir builds the world’s leading software for data-driven decisions and operations. By bringing the right data to the people who need it, our platforms empower our partners to develop lifesaving drugs, forecast supply chain disruptions, locate missing children, and more. The Role Are you passionate about engineering quality, performance, and increasing the impact of engineers around you? Software Engineers at Palantir build software at scale to transform how organizations around the world use data. As an engineer within Palantir’s Foundations organization, you’ll have the opportunity to grow more quickly than you ever imagined, as you build the shared infrastructure that underpins the Palantir Foundry, Palantir Gotham, and Palantir Apollo platforms, and drive investments to improve the velocity and quality of our engineering. Teams within Palantir’s Foundations organization are made up of a small number of engineers, each focused on one of four major categories of our infrastructure: • A variety of languages, including Java and Go for backend and TypeScript for frontend• Open-source technologies like Cassandra, Spark, Elasticsearch, React, and Redux• Industry-standard build tooling, including Gradle, CircleCI, and GitHubWhat We Value • Passion for helping other developers build better applications., • Empathy for the impact your changes will have on the workflows and productivity of developers and end users., • Ability to communicate and collaborate with a variety of individuals, including engineers, users and non-technical team members., • Willingness to learn and make decisions independently, and the ability to ask questions effectively., • Eagerness to delve into the source code of open-source libraries (such as Cassandra or Chromium) to truly understand how they work or to debug an issue., • Staying up-to-date with recent industry practices and advancements in open-source technology., • Active US Security clearance, or eligibility and willingness to obtain a US Security clearance.What We Require, • Engineering background in fields such as Computer Science, Mathematics, Software Engineering, or Physics., • Familiarity with data structures, storage systems, cloud infrastructure, frontend frameworks, and other technical tools., • Experience coding in programming languages, such as Java, C++, Python, TypeScript, JavaScript, or similar languages.To apply, please submit the following:, • An updated resume / CV - please do so in PDF format.

• Ascend

  

  Systems Analyst - Facilities

  21 days ago

  Palo Alto

  Job DescriptionSystem Analyst – Facilities Management Essential Duties and Responsibilities: We are searching for a System Analyst for the Facilities Management team to oversee and manage the various software platforms utilized by the firm as a part of its various facilities operations. This position requires a highly flexible individual that can manage multiple responsibilities. This position would report to the Director of Facilities Operations. • Serve as the key liaison between the Real Estate & Workplace Services (REWS) department, IT, and other internal stakeholder groups, ensuring seamless integration and collaboration on technology projects., • Work with REWS leadership to improve efficiency, scalability and value of the facilities and security function through the deployment of technology solutions., • Role responsibilities for existing applications and platforms in use:, • Function as firm’s representative in communications with vendors including contract management and issue escalation., • Serve as the firm’s product administrator, receiving escalated work tickets from helpdesk and working directly with vendor to resolve issues., • Remain current on all releases and communications from vendors., • Collaborate to keep technical and end-user documentation needed to support and use the application/function up to date., • Provide end-user support for applications/functions when required., • Answer application functionality questions., • Update and maintain settings in each system as a global administrator., • Role responsibilities for new projects:, • Work with internal stakeholders to determine, define and gather requirements for application/functions needed., • Handle collaboration with IT teams, including serving as liaison to the vendor to gather required documentation for IT to complete vetting and implementation of product., • Perform feasibility study/cost benefit analysis for any products under consideration., • Develop and communicate business requirements., • Evaluate and analyze current work-flow processes to determine feasibility of automation/product implementation., • Explore application package functionality to satisfy business requirements., • Act as the Project Lead on behalf of REWS for implementation, including:, • Evaluate, review and test applications/functions., • Collaborate on project plans and related project management documentation., • Collaborate on technical and end-user documentation needed to support and use the application/function. This includes working with the internal technical training team on the development of training materials for various user groups., • Directly develop/write training materials related to procedure that fall outside of the technical training team scope., • Create documentation for admin support on new products, including documenting settings, rules, and conventions specific to the firm’s environment., • Co-manage all testing (e.g., pilot testing), including creating the participant list, creating testing instructions, creating communications., • Lead the development of communications for the project.Education and/or Work Experience Requirements:, • Bachelor's degree, preferably in Computer Science, Information Technology, Computer Engineering, or related IT discipline., • 5+ years' experience working as a Systems Analyst., • 2+ years’ experience in property management or office operations, including experience with facilities management software., • 2+ years’ experience in project management., • Competency with a variety of software including MS Word, MS Excel, MS Outlook, MS PowerPoint., • Strong written and verbal communication skills., • Highly organized and demonstrate strong attention to detail., • Communicate essential information needed for decision making., • Analytical ability to manage multiple projects and prioritize tasks into manageable work products.Compensation - $90k - $120k

• xAI

  

  Network Engineer - Backbone

  2 days ago

  Palo Alto

  Job DescriptionAbout xAI xAI's mission is to create AI systems that can accurately understand the universe and aid humanity in its pursuit of knowledge. Our team is small, highly motivated, and focused on engineering excellence. This organization is for individuals who appreciate challenging themselves and thrive on curiosity. We operate with a flat organizational structure. All employees are expected to be hands-on and to contribute directly to the company's mission. Leadership is given to those who show initiative and consistently deliver excellence. Work ethic and strong prioritization skills are important. All engineers are expected to have strong communication skills. They should be able to concisely and accurately share knowledge with their teammates. About the Role Data Center Fabrics are the foundational building blocks of the complex architecture that enables Grok to be trained and serve customer queries as they learn to understand the universe. To enable us to move faster we are looking for a Core Network Engineering Team Lead in our Palo Alto Office. You will develop and execute the team's roadmap in collaboration with partner teams. You will guide your team and directly contribute to its network's development, while hiring and developing the world class talent xAI needs to achieve AGI. Responsibilities • Design, develop, deploy, and operate global backbone infrastructure to ensure high performance and reliability., • Partner with internal teams to gather requirements and leverage xAI systems for insights to meet current and future product needs., • Utilize Python and Ansible to automate customer impact mitigations and eliminate repetitive engineering tasks., • Manage and troubleshoot cloud VPCs and connected network hardware to maintain seamless operations., • Apply deep traffic engineering skills to optimize backbone network performance., • Collaborate with cross-functional teams to enhance infrastructure efficiency and support xAI's AI platforms.Required Qualifications, • 5+ years of experience working on backbone network hardware and protocols (e.g., MPLS, RSVP-TE) in large or hyperscale environments., • 5+ years of routing experience with BGP and IS-IS in backbone, peering, and transit areas, with expertise in traffic engineering., • 3+ years of experience using Python scripting to automate deployments and break/fix tasks., • 3+ years of experience managing and troubleshooting cloud VPCs and connected network hardware.Preferred Qualifications, • Experience with Juniper, Cisco, and Arista hardware., • Familiarity with AWS, GCP, and OCI cloud environments., • Expertise in capacity planning for large networks with minimal customer input., • Proven success in on-call rotations and incident response in high-stakes environments. xAI is an equal opportunity employer. California Consumer Privacy Act (CCPA) Notice

• Lucence

  

  Development Scientist - US (1 Year Contract)

  1 month ago

  Palo Alto

  Job Description About us: Lucence is a pioneering precision oncology company with a bold vision: a world where cancer is defeated through early detection and timely treatment. Our cutting-edge liquid biopsy tests use advanced molecular profiling to guide personalized cancer therapies, transforming how cancer is diagnosed and treated. At Lucence, we are shaping the future of precision medicine by capturing both genetic and cellular data from a single blood draw, bringing us closer to our mission of overcoming cancer. As a Development Scientist at Lucence, you will play a vital role in developing and implementing clinical assays to advance cancer care. [Key Responsibilities] • Design and conduct laboratory experiments to develop new clinical assays., • Plan and lead assay validation studies., • Troubleshoot and resolve technical challenges during assay development., • Drive the automation of novel assays., • Maintain accurate and organized experimental records., • Prepare detailed protocols and validation reports to ensure regulatory compliance., • Train staff and facilitate assay transfer from R&D to clinical operations. To be a good fit for this role, you would have: • A PhD in Molecular Biology, Cancer Biology, Genomics, or related field., • A proven track record of quick learning., • Strong background in molecular biology, including PCR, RT-PCR, genotyping and NGS., • At least 2 years of working experience in the development of clinical assays, with significant hands-on expertise in troubleshooting, optimizing, and validating molecular assays., • Good understanding of the regulatory and quality requirements of clinical diagnostics., • Strong self-motivation, resilience, adaptability, and a keen interest in learning., • Excellent communication and presentation skills. The following would be advantageous, but not required: • A deep understanding and knowledge of oncology and/or genomics., • Proficiency in R or Python., • Fluency in variant annotation and interpretation and use of genome databases such as COSMIC, ClinVar, Varsome, Ensembl, and OncoKB., • Ability to interpret genomic data in patient- and treatment-specific contexts. Specific title and responsibilities may be calibrated to match a given candidate’s experience. This is a one year on-site fixed term contract in our Palo Alto Office.