Synthetic Chemist – Peptide Synthesis Specialist
hace 4 días
Madrid
Role Overview: We are seeking a talented and detail-oriented Synthetic Chemist with demonstrated hands-on experience and expertise in peptide synthesis o support our expanding drug discovery programs. The successful candidate will contribute to the design, synthesis, purification, and characterization of peptides and peptidomimetics, working closely with multidisciplinary teams in a dynamic and collaborative environment. Key Responsibilities: • Design and execute solid-phase peptide synthesis (SPPS) using automated synthesizers and manual techniques. - Develop and optimize synthetic routes for linear and cyclic peptides, including complex modifications and conjugations. - Perform purification using preparative HPLC, SFC, MPLC chromatography, and other relevant techniques. - Characterize compounds using HRMS, NMR, and other analytical tools. - Collaborate with medicinal chemists and biologists to support SAR studies and lead optimization. - Document experimental procedures and results in electronic lab notebooks (ELNs) and contribute to internal reports and publications. - Ensure compliance with Eurofins’ quality standards and safety protocols. Qualifications: • Ph.D. or M.Sc. in Organic Chemistry, Medicinal Chemistry, or related discipline. - Minimum 2–5 years of hands-on experience in peptide synthesis, preferably in a CRO or pharmaceutical setting. - Proficiency with automated peptide synthesizers (e.g., Biotage, CEM Liberty Blue). - Strong understanding of protecting group strategies, coupling reagents, and resin selection. - Experience with peptidomimetics, macrocyclization, or conjugation chemistry is highly desirable. - Experience in parallelization using automated platforms is also highly desirable - Excellent problem-solving skills and attention to detail. - Strong communication skills and ability to work effectively in a team-oriented environment. Why Join Us: • Work in a cutting-edge research environment with access to state-of-the-art facilities. - Be part of a global scientific network with opportunities for growth and collaboration. - Contribute to impactful drug discovery projects that advance human health.