Les 1000+ meilleures offres d'emploi : , Aucune expérience, à La Llagosta (juillet 2026) - page 12

PostDoctoral researcher position associated with MINECO research grant

il y a 3 jours

Cerdanyola del Vallès

ph3Institution /h3 pALBA is the Spanish synchrotron light source, a large research infrastructure operating ten beamlines, complementary facilities, and an Electron Microscopy Center in partnership with other institutions. It is currently constructing additional beamlines, expanding the Electron Microscopy Center, and integrating advanced data analytics, thereby covering a wide range of infrastructures aimed at solving societal challenges. /p pLocated in Cerdanyola del Vallès (Barcelona, Catalonia, Spain), it is funded by the Spanish Government (Ministerio de Ciencia e Innovación) and the Catalan Government (Generalitat de Catalunya, Departament de Recerca i Universitats). The synchrotron light produced by 3 GeV electrons is used by thousands of researchers to analyze and understand the properties and functionality of matter across fields such as catalytic research, health, energy production/storage, environmental research, communication technologies, and cultural heritage. /p pOur staff works in a multidisciplinary environment that values diversity, inclusion and respect. The gender equality plan aims to reach parity within the consortium’s divisions and offices, with actions to encourage applications from women in scientific, engineering and technical positions. /p pLocated close to Barcelona in a natural park, it is well connected by car and public transportation, offering excellent connectivity and a life‑work balance that supports career growth during the upgrade to ALBA II, a 4th‑generation facility that will dramatically increase brightness and coherent flux. /p h3Tasks /h3 pALBA Synchrotron has been awarded a MINECO Research Grant, co‑financed by FEDER, entitled “Structural Mechanism Of Regulation Of Transcription And Exchange Of Genetic Material In Gram Positive Bacteria And Land Plants” (PID2024‑ NB‑I00). The grant proposes to study transcription regulation in plants and conjugation in bacteria. /p pAbstract excerpt: Our lab studies structural mechanisms of regulation of gene transcription and DNA exchange in different organisms. These processes are tightly linked to developmental processes and to response to environmental triggers. When gene regulation goes wrong, many problems can occur, causing cell death or uncontrolled growth of cellular tissues. Our objective is to gain knowledge about aspects of natural processes of DNA transcription and exchange that play a central role in biology and that are crucial to human wellbeing and sustainability. One such process is conjugation, which is the main horizontal gene transfer route responsible for spreading antibiotic resistance genes. The design of strategies to impede conjugation‑mediated spread of AR genes requires a better understanding of different aspects of the conjugation process. So far, little is known about conjugation occurring in Gram‑positive bacteria. Moreover, conjugation is a natural method to genetically modify bacteria and can therefore be exploited to modify industrial and clinical important bacteria that are reluctant to modification by other methods. We also study plant development in the context of Auxin Response Factor (ARF)‑mediated auxin response. A key, yet largely unanswered question in the understanding of auxin signaling and its role in growth and development is what structural mechanisms underlie the generation of distinct, specific responses. Secondly, it is not well understood what evolutionary trajectories have led to the structural diversity of ARFs and their diverse response to auxin. /p h3The Tasks That The Successful Candidate Will Perform /h3 ul liEngage in the ongoing research program, national and European projects and collaborations. /li liOverexpress proteins and interaction partners relevant to the project in expression hosts such as E.coli and the baculovirus/insect system. /li liStudy the interactions at the molecular level in vitro and determine the structures of the partners and their complexes using techniques such as Size Exclusion Chromatography, Surface Plasmon Resonance, Mass Spectrometry, and Structural Biology methods. /li liPerform structural characterization of the complexes of different regulatory proteins with different DNA sequences, where relevant, using Small Angle X‑ray Scattering, X‑ray Microscopy, X‑ray crystallography, and electron microscopy. /li liCharacterize transcription regulation in plant tissues and conjugation efficiency in bacteria. /li /ul h3Requirements /h3 pThe requirements for participation must be met on the date of the application deadline. The CV and supporting documentation will be reviewed by the selection body. Applications lacking the required documentation will not be accepted. /p pThe successful candidate must hold a PhD in Biology or Biochemistry. /p pThis position is reserved for candidates with a legal status of person with disabilities, with an assessed degree of disability equal to or greater than 33 %. If one or more candidates with this status are admitted, they will be evaluated first. Should no candidate with such a status be finally selected, the selection will continue with the other applicants. /p h3Selection Process /h3 pThe selection will be carried out through the competition‑opposition system. /p pIn the first phase an analysis of the curriculum will be conducted, assessing prior experience, degrees, training and other professional information. Career breaks or variations in CV chronology will be considered as a natural evolution of a career and therefore a contribution to professional development. /p pThe CV will be scored up to 40 points: /pul liExperience with wet‑lab molecular biology (15 points) /li liExperience with structural biology (10 points) /li liExperience in biophysical analysis (5 points) /li liSignificant scientific publication record (10 points) /li /ul The best‑rated candidates, at least two if possible, will be invited to an interview where technical competence, knowledge, skills and professional experience will be assessed, with a total score of 60 points. A minimum of 30 points is required to be eligible. pProvided they meet the minimum requirements and rank among the top five, at least one person from the underrepresented gender in the division/office will be interviewed. /p h3Interview /h3 pThe interview will include assessment of the following: /p ul liKnowledge in molecular biology methods and protein production (15 points) /li liSound practice of commonly used macromolecular crystallography, bioinformatics and computational biology techniques (10 points) /li liHands‑on experience with cryo‑electron microscopy data (5 points) /li liAbility to work in a multidisciplinary team (10 points) /li liGood organizational and planning skills (10 points) /li liSelf‑motivation (5 points) /li liMinimum level of English at CEFR standard C1 (5 points) /li /ul h3Other Information /h3 pTwo‑year contract for technical‑scientific activities linked to the funded project TRANSCRITOR. /p pThe Selection Board is composed of: Isidro Crespo, Barbara Calisto, Roeland Boer. /p /p #J-18808-Ljbffr

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