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Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law. As Principal Scientist, Analytical Development, you will set and influence analytical strategies across Immunocore's therapeutic project portfolio. You will provide ICH-compliant assay validation expertise and lead the development and qualification of advanced biophysical analytical methods to support drug substance and product testing. You will act as a strategic partner within cross-functional teams and deliver high-quality analytical data and regulatory documentation that drive the success of Immunocore's therapeutic pipeline. KEY RESPONSIBILITIES • Set and influence analytical program strategies across our therapeutic project portfolio, • Represent analytical development within cross-functional project teams, providing strategic support and technical consultancy, • Provide ICH compliant assay validation expertise to the department, • Oversee development and qualification of biophysical analytical methods including electrophoretic and chromatographic (eg. CE-SDS, SE-HPLC, IEX-HPLC, icIEF, excipient quantitation, titre assessment) methods to support drug substance and drug product release and stability testing for the Immunocore therapeutic drug portfolio., • Oversee technical transfer and validation of assays at GMP contract manufacturers and develop phase appropriate specifications, and maintain oversight of method performance within Immunocore and at CDMOs to identify issues and lead method improvements, • Support digital transformation program in defining key analytical outputs and identify methods to streamline data handling, • Write/review CMC analytical sections of regulatory submissions (eg. IMPD, IND, BLA, MAA) and responses to any agency questions., • Prepare reports and presentations of high quality suitable for internal and external audiences., • Represent the function within cross-functional project teams, providing analytical strategic support and technical consultancy., • Develop and mentor staff, to help them succeed and grow., • Keep abreast of developments in area of expertise to advance company activities where deemed appropriate; providing in- depth analysis of new techniques and theories to advance the way the company works, raising and championing these with leaders and colleagues across the company, • Review competing priorities for projects and provide clear and thorough recommendations, considering the overall goals of the project, department and company., • Implement safe working practices in laboratories for the team according to Immunocore EHS policies. Experience & knowledge Essential • Significant experience of all analytical aspects of biopharmaceutical CMC development., • Recognised as an expert in one or more biophysical analytical areas including electrophoretic and chromatographic methods., • Experience with late stage/commercial biopharmaceutical drug programs, including experience of assay and process validation., • Experience with biopharmaceutical regulatory submissions (e.g. IMPD, IND, BLA, MAA), knowledge of relevant regulatory guidelines, • Experience with managing analytical activities at Contract Manufacturing and Development Organisations (CDMO)., • Strong track record of directing projects in a team focussed approach., • Ability to communicate clearly and engage with stakeholders of various levels of seniority effectively., • Presented detailed scientific findings to internal and external audiences., • Mentored and coached less experienced colleagues in scientific practices and theory. Desirable • Built a network of external scientific contacts as both a contributor and recipient., • Bioinformatics and data management experience in a CMC setting., • Contributed to and influenced the strategic scientific direction within the CMC department and company on the whole Education & qualifications • Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline, • Desirable: PhD in related discipline

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law. As Associate Scientist Analytical Development, you will contribute to developing analytical methods to support Immunocore's expanding pipeline of biopharmaceuticals. The core focus will be development and transfer of chromatography and electrophoresis-based methods for lot release and stability testing of protein products. Working closely with experienced scientists and cross-functional teams, you'll contribute to study reports and operating procedures, drive continuous improvement, and expand your technical expertise in a dynamic, collaborative environment. KEY RESPONSIBILITIES • Running pre-established experimental investigations, with guidance from line managers, a mentor or colleagues., • Developing and qualifying (ultra) high performance liquid chromatography (UHPLC), gel / capillary electrophoresis that support stability, lot release and characterisation testing as part of biopharmaceutical product development., • Supporting process development by testing process intermediates and performing investigations., • Contributing to the writing of operating procedures and study reports., • Priorities: working to agreed experimental priorities and deadlines; raising issues or concerns with managers or colleagues so that these can be addressed., • Technical knowledge: actively developing own knowledge, drawing on the experience of others and self-learning., • Laboratory records: Ensuring that all records and data are up to date, on time and recorded to the correct standard, checking with a mentor or colleagues if unsure., • Laboratory equipment: attending training on the use of technical instruments, using equipment appropriately, correctly and tidily., • Health & Safety: compliance with all H&S requirements, attending appropriate training programmes PERSON SPECIFICATION Experience & knowledge Essential • A background in recombinant protein or antibody/biopharmaceutical analytical development or QC, with one or more years' experience gained in industry., • Hands on expertise of HPLC/UHPLC (e.g. size exclusion, ion exchange, reverse phase, hydrophobic interaction) for analysis of proteins., • Hands on expertise of electrophoretic (e.g. CE-SDS) methods for analysis of proteins., • Recorded results and information in a concise, accurate and timely way, • Learned about new practices through observation, self-learning and an enquiring mind, • Worked and contributed actively in a diverse team environment. Desirable • Experience of imaging capillary IEF (icIEF), Western blotting, • Knowledge of GMP, • Experience of lab organisation/maintenance, • Proactive in ensuring high quality of their work and seeking additional responsibilities to help meeting the goals of the team, • Familiar with principles of assay qualification/ validation i.e. robustness and suitability Education & qualifications • BSc. Or MSc. in biochemistry, biotechnology or related discipline

About Coding Bio Coding Bio is a startup focused on building modular therapies engineered for immune activation through the blending of computation, synthetic biology, and immunotherapy. We are a tight-knit, passionate team dedicated to advancing science and developing innovative therapies. At Coding Bio, we use an ML-first approach to design new immunotherapies, combined with our high-throughput screening platform to discover new life changing therapies for patients. Our mission is to radically accelerate the design of next-generation immunotherapies using machine learning and high-throughput biology. We’re building the tools to unlock life-changing treatments faster, with greater precision, and at scale. Want to become part of the team? We are looking for an Associate Scientist, or Scientist (dependent upon experience) to join our ResearchTeam. In this role you will be involved at the critical point of candidate screening and assay development. Identifying best-in-class immunotherapies. If you are a highly motivated individual, thrive in collaborative environments, and are keen to grow, we would love to hear from you. This role offers hands-on involvement across our discovery pipeline, with close collaboration across our platform, development, and machine learning teams. You’ll thrive here if you’re experimental by nature, driven by data, and excited to grow with a startup shaping the future of immunotherapy. The Role • Independently design and execute T cell activation and killing assays using primary cells and cell lines., • Maintain adherent and suspension mammalian cell cultures for use across the team in cell-based assays., • Collaborate closely with team members, contributing to our research goals and discovery of new therapeutic candidates., • Work closely with other teams within the company, • Maintain meticulous records of experimental procedures and outcomes, ensuring transparent communication within the team., • Follow established procedures, protocols to support the progress of ongoing projects., • Work closely with teams across the company to contribute to broader company goals., • Adapt to evolving responsibilities and goals to meet the changing needs of an early stage company. Required Skills and Qualifications: Required skills and qualifications for the advertised position. • MSc/PhD degree in a relevant discipline (cell biology, immunology, biochemistry, pharmacology, etc)., • Mammalian cell culture experience for suspension and adherent cell line maintenance., • Strong interpersonal skills, showcasing the ability to collaborate effectively with team members., • Move fast make it last, • Cells, not just organelles, • Furiously curious Desirable Skills and Qualifications: Nice to have skills and qualifications that may be advantageous but should not deter you from applying. Please apply as we want diverse candidates. • Experience using cell-based assays for immunotherapy/antibody discovery., • Flow cytometry experience., • Experience designing and executing primary cell assays, ideally T cell killing/cytotoxicity assays., • Molecular biology experience (PCR, Golden Gate Assembly, etc.)., • Knowledge of antibody and T cell engager structure and function. Not sure you meet all the requirements? Don’t let that hold you back. We’re looking for people with passion and potential, not just a perfect checklist match.

Overview: We are seeking an exceptional Scientist with a passion for immuno-oncology and hands-on expertise in CAR-T and TCR cell therapy discovery and development. This is a dynamic, lab-based role based at our Oxford site, where you will lead experimental design, execute in vitro functional assays, and collaborate cross-functionally to advance innovative cell therapies toward the clinic. This position offers an exciting opportunity to contribute directly to the design and optimisation of novel CAR-T constructs within a fast-paced, collaborative biotech environment. Key Responsibilities: • Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity, including cytotoxicity, cytokine release, and target engagement., • Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering., • Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data., • Develop and validate ELISA and Western blot assays to support functional and mechanistic studies., • Generate actionable insights from experimental data to guide CAR/TCR construct selection and refinement., • Collaborate closely with bioinformatics, translational, and cell engineering teams to integrate data and align project goals., • Prepare scientific presentations, technical reports, and contribute to regulatory documentation as needed., • Stay abreast of emerging trends in CAR-T/TCR research and immuno-oncology; implement innovative approaches in R&D., • PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required for Scientist level, • Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy., • Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture., • Proven ability to analyse complex datasets and extract meaningful biological insights., • Excellent scientific communication skills, both written and verbal., • Ability to work independently and collaboratively in a fast-paced, team-oriented environment., • Contribute to groundbreaking advances in next-generation cell therapy innovation., • Work within a mission-driven, supportive, and collaborative scientific team.

Join Ivy Farm Technologies as Automation Senior Scientist – Help Shape the Future of Sustainable Food! At Ivy Farm our mission is to create the world’s best guilt free and sustainable meat, it’s cultivated meat, just like real meat, only made differently - and we’re super excited by it. Were a fun and humble community of 40+ technical and scientific crew; a team where you can make a true difference to animal well-being and global sustainability, and we’re looking for a driven Automation Senior Science to help us achieve our high throughput ambitions. Are you ready to spearhead our Automation function at the forefront of the cultivated meat revolution? Your Purpose: We are seeking an enthusiastic and hard-working Laboratory Automation Senior Scientist to join the Automation team to collaborate in transforming validated benchtop analytical assays into end-to-end fully automated high-throughput processes. In this role you will collaborate with Cell Sciences, Media Development, Analytics, Digital Biology, and Lab Operations to increase sample testing throughput while reducing time-to-result, hands-on time, repetitive strain, and assay variability. A successful candidate will be versed in the latest automation technologies and be willing to work in fast paced team-oriented environment to support Cell Line and Media Development focus areas in R&D. The primary focus will be automating analytical workflows such as molecular biology, cell-based bioassays, liquid chromatography, mass spectrometry and flow cytometry. Key Responsibilities - to give you a flavour - but of course not limited to: As an R&D Laboratory Automation Senior Scientist, based at our state-of-the-art labs in Oxford, a typical day might include: • Collaborating within a cross-functional team to design, develop, and deploy end-to-end laboratory automation, • Creating, modifying, optimising, continuously improving and troubleshooting robotic methods on liquid handling devices (E.g., Hamilton STAR, etc.), integrated systems (eg: automated lab scheduling software, LIMS/ELN, etc.), and supporting devices, • Conducting validation testing of developed protocols to ensure qualification for release into operation, • Working with instrument vendors and our internal system support team to implement hardware/software upgrades and changes to the existing platforms, • Troubleshooting laboratory automation by liaising with internal subject matter experts and external vendors to perform root cause analysis based on thorough scientific and technical investigations, • Expanding the scope of existing automation by introducing new functionalities, • Sharing knowledge and documenting best practices within the automation team and providing hands-on training to end-users on new equipment, methods, and procedures to independently execute automated workflows, • Partnering with the Digital Biology and Quality teams to automate data flows to ensure data integrity through capture in appropriate electronic systems and high-throughput processing via review by exception, • OPTIONAL: Transferring and revalidating established processes to other Automation core systems, • OPTIONAL: Evaluating novel devices/instruments/technologies for the enhancement of laboratory processes This role might be for you if you…: • Can work independently with some supervision, • Have excellent written and verbal communication skills, • Are capable of multi-tasking and prioritising multiple projects at different development stages, • Enjoy collaborating with cross-functional teams in a dynamic research environment, • Possess exceptional problem-solving skills to troubleshoot technical issues, • Are passionate about laboratory automation technologies and are eager to contribute to the design, development, and deployment of new integration projects The skills that you’ll bring, aka: Qualifications / Requirements: Essential qualifications: • At least a bachelor’s degree in life science, engineering, computer science, physics or related field, • Ph.D. with a minimum of 2 years of experience working with automation systems in a research laboratory environment or M.S./B.S. with a minimum 8 years of laboratory automation experience Must haves: • Wet lab experience and understanding of molecular biology, genomics, or cell-based assays is preferred, • Experience migrating biological or biochemical assays/methods onto automated systems, • Experience in programming and operating liquid handling methods is required. Programming on Hamilton STAR platforms using Hamilton Venus is preferred, • Experience with complex laboratory workcells and orchestration, • Knowledge of Python and C# programming languages is desirable, • Basic understanding of scheduling software, robotic integrations, and databases is desirable., • Experience implementing automated laboratory workflows within the biotechnology or pharmaceutical industries, • Ability to gather, understand, and assign priorities to user requirements for complicated laboratory workflows, and to translate them into robust automated solutions To be an Ivy Farmer, we need you to have/be: • Attention to Detail: Commitment to ensuring high standards are met, • Analytical Skills: Strong ability to analyse data and spot trends, • Problem-Solving: Skilled in identifying and resolving issues quickly – innovative and lateral thinking, • Confident communicator, both written and verbal, happy to work with a team in a matrix structure or alone to achieve deadlines, • Excellent time-management & organisational skills Why Ivy Farm? At Ivy Farm, you won’t just be part of a company - you’ll be part of a movement. We’re driving innovation that will change the future of food, and we need visionaries like you to help us get there. We offer competitive compensation, opportunities for career growth, and the chance to work on something truly groundbreaking. We’re an innovative bunch, with a can-do attitude and one that’s unafraid to think differently. We also have project targets, compliance expectations and – as in any fast-growing business – sometimes competing priorities. That’ll be something you have not just experienced previously but somewhere you thrive. We’ll be looking to you to share your expertise and experience with the team. We also realise this may well be your first venture into cultivated meat – and that’s absolutely fine – we have a great team that will be excited to help you get to grips with that. So, if you’re ready to join an emerging groundbreaking industry, that’s both able to think differently and actively looking to do so, and one where you can make a difference to animal well-being and sustainability then we’re waiting to hear from you! And just to confirm, here at Ivy Farm, we're an employer that believes in creating a workplace where everyone feels included and valued, no matter who they are. Total Package: At Ivy Farm, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role. You will also be eligible for: • 25 days annual leave + bank holidays, • Company pension contribution 5%, • Private health care from day one, • Shares, • Company Bonus, eligible from day one, • Oodles of amazing fresh ground coffee, tea and snacks, • Company events, • Fabulous super cool office environment, we’re biased, but let’s face it – it’s cool (no agencies, thank you)

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