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Postdoctoral Researcher in Synthetic Light-Gated Actuators for Neuronal Optogenetics

hace 16 días

Castelldefels

ICFO is a research center located in the Mediterranean Technology Park in the metropolitan area of Barcelona, employing approximately 500 people, including researchers, PhD students, and operational staff. In its field of specialization, ICFO is consistently ranked among the highest-quality research institutions worldwide. We are seeking a highly motivated researcher to develop next-generation neuronal actuators based on light-gated ion channels. The ideal candidate will have experience in protein engineering, preferably involving membrane proteins and channelrhodopsins. The project will combine in silico mutagenesis with structure-guided design to identify key residues that enhance light sensitivity and photocurrent amplitude, inspired by naturally occurring photoreceptors in photosynthetic organisms. Engineered variants will be functionally characterized using in vitro reconstitution and automated patch-clamp electrophysiology. The goal of this position is to engineer novel light-gated actuator with unprecedented photon-sensitivity for use in non-invasive, translational neurotherapies. The position is placed at the interface between the Prof. Dr. Michael Krieg and Prof. Dr. Nicoletta Liguori labs at ICFO and the candidate will collaborate with the two teams and thus benefit from a cutting-edge interdisciplinary environment. The candidate will be mentored by the PI and collaborators with the goal of developing the skills required to become an independent researcher. Key Responsibilities The successful candidate will lead a team of bioengineers, protein biochemists, and ultrafast spectroscopists to develop, deploy, and elucidate the mechanisms of novel light-gated ion channels. Working closely with team members and collaborators specializing in rational protein engineering, protein reconstitution, ultrafast spectroscopy, and C. elegans neurobiology, the candidate will: Engineer new channelrhodopsin variants incorporating secondary light-absorbing groups. Design and execute in vitro reconstitution experiments with purified proteins and targeted mutants. Perform electrophysiological measurements using automated patch-clamp systems to characterize photocurrents of engineered channels in heterologous expression systems. Collaborate with cell biologists and electrophysiologists to translate in vitro findings to heterologous cells and C. elegans neurons. The candidate is expected to communicate results in group meetings, conferences, and peer-reviewed publications, and to provide regular updates to the PI and collaborating partners. A proven track record of effective teamwork is essential. Required Qualifications A PhD (or equivalent doctoral degree) in a relevant field, such as: Biophysics, Biochemistry, Bioengineering, Molecular Biology, Physics (with strong focus on biological systems) or related interdisciplinary fields Required Experience All applicants with track record in membrane protein engineering, optogenetics/electrophysiology, or photoreceptor biophysics are encouraged to apply. The ideal candidate will have a strong background in protein engineering, especially structure-guided protein design, ion channel biophysics, and have expertise in molecular cloning and mutagenesis and recombinant protein expression. Experience with channelrhodopsins, or photoreceptor proteins is highly desirable, with electrophysiological characterization of ion channels in heterologous systems considered positively. A proven experience in team work and leadership is required. What We Offer Competitive salary according to the institutional salary scales. Contract for periods of 3 years renewable upon existence of funding or extension of tasks. Additionally, a family allowance is also available on request and after corresponding approval for people with family charges in the terms described in the corresponding policy. A family allowance may be granted to candidates with dependents, upon request and in accordance with ICFO’s policies. ICFO is an equal opportunity employer. We hire based solely on merit and potential, regardless of gender, nationality, or disability. ICFO fully endorses the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers, ensuring a transparent and supportive recruitment process. Application procedure Required application materials (in English): A presentation letter outlining your interest in the position. A curriculum vitae, including full contact information. The contact e-mail addresses of two referees who can provide professional references. The application deadline is July 8, 2026. For formal enquiries regarding the application process, please contact: jobs@icfo.eu For project and technology enquiries, please contact: michael.krieg@icfo.eu #J-18808-Ljbffr

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