Medicinal Chemist
hace 15 días
Cambridge
Job Summary/Experience: Genome Therapeutics Ltd (GTx) is seeking a medicinal chemist with experience in pre-clinical drug discovery to drive the development of novel therapeutics that target G-quadruplex structures. The ideal candidate will manage outsourced drug discovery activities and play a key role in the design and synthesis of lead compounds, applying a comprehensive understanding of medicinal chemistry principles across internal programmes from hit-to-lead through to candidate nomination. GTx is a fast paced multidisciplinary company, offering training and experience in genomics, computational biology, drug discovery and clinical studies. Location: This is an on-site position based at the GTx labs in Cambridge UK. Key Responsibilities • Leverage expertise in organic and medicinal chemistry to design and synthesise novel small molecules across multiple programmes and chemotypes, • Monitor and interpret biological, ADME/PK, and physicochemical property data to propose and execute innovative strategies for improving key drug attributes, • Manage multiple CRO relationships, providing synthetic and medicinal chemistry expertise and guidance, and driving productivity and deliverables, • Provide regular updates on project results both internally and externally, • Effective written communication, including responsibility for drafting and maintaining patent applications and scientific publications, • Meticulous record-keeping and strong data organisation using commercial data management systems and electronic notebooks Essential Skills/Experience: • PhD in synthetic organic chemistry with >5 years industry experience within pharma/biotech, • Exposure to medicinal chemistry programmes from hit identification through to candidate nomination, • Understanding of the multi-parameter optimisation process and ability to integrate disease biology, ADME/PK and toxicology data to solve complex drug discovery problems., • Management of outsourced drug discovery projects Desirable Skills/Experience: • Prior experience of drug discovery programmes in the field of oncology, • Knowledge of in silico tools to aid drug design