Protein Crystallographer
hace 3 días
Bracknell
We’re partnering with a globally recognised biopharmaceutical organisation to find a Protein Crystallographer to join their innovative Small Molecule Discovery team. This role sits within a newly established Discovery Technology & Platforms function, focused on accelerating drug discovery through cutting-edge structural biology and fragment-based design approaches. About the Role This is a hands-on laboratory role focused on fragment-based ligand design (FBLD), where you’ll contribute to building and advancing internal crystallography capabilities. You’ll work within a highly collaborative, multidisciplinary team to: • Identify novel binding sites, • Generate structural insights, • Support structure-guided drug design Key Responsibilities • Analyse crystallographic datasets from fragment screening campaigns, • Apply refinement tools to model protein–ligand structures, • Coordinate X-ray data collection (in-house and external synchrotrons), • Contribute to the development of FBLD workflows and methodologies, • Collaborate across biology, chemistry, and computational teams, • Support innovation in identifying cryptic binding sites Required Experience Exposure to: • Protein crystallography or structural biology techniques, • Protein purification or biophysics, • Strong willingness to learn and specialise in crystallography, • Motivated, detail-oriented, and eager to develop in a cutting-edge environment Desirable Experience • Experience working with large crystallographic datasets, • Exposure to HPC environments or automation workflows, • Passion for platform development and scientific innovation, • Strong problem-solving and collaboration skills For more information please get in touch - jamie.keith@cpl.com