Principal Scientist
5 days ago
Bracknell
Job Title: Principal Scientist - Protein Working Location: Bracknell Rate: £23.89 per hour Contract Length: 24 months Start Date: 19th January 2026 We are seeking a Principal Scientist to direct and inform our process development and discovery. The ideal candidate will have a deep understanding of protein expression systems and how to optimise conditions to improve protein quality. They will also require a good knowledge of protein purification methods to leverage the optimisation in expression conditions to maximise final protein quality. This two-year contract offers the opportunity for the successful candidate to join a dynamic team that works across multidisciplinary functions in a leading AgriTech business. Role profile: • Lead upstream process development for recombinant protein production., • Provide scientific leadership and technical guidance to team members and project teams., • Be the technical lead to translate expression optimisation from shake flask to bioreactor., • Design and refine expression methods and protocols to optimize protein quality., • Investigate the relationship between expression conditions and protein quality attributes across key projects., • Collaborate with team members and across functions to enhance overall process improvements., • Drive optimisations in upstream processes with a data led approach., • Work safely and with due care to others ensuring compliance with company HSE policies. Essential experience: • Post Doc or equivalent experience in Biotechnology, Microbiology or other similar disciplines., • 8 + years of hands-on experience in upstream bioprocessing with expertise in:, • Recombinant protein expression (bacterial, insect, yeast or plant systems)., • Knowledge and experience of working with bioreactors., • Experience and knowledge of transferring shake flask processes into bioreactors., • Good knowledge of protein purification methods and techniques., • Strong evidence of troubleshooting and innovative problem solving., • Strong understanding of how upstream decisions impact downstream processing outcomes., • Excellent communication skills with the ability to present complex concepts clearly. Desirable experience: • Knowledge of how construct design can impact protein expression., • Knowledge and application of AI tools and models to inform experimental design., • Knowledge of DoE approaches for method optimisation., • Experience with Ambr250 micro bioreactor systems., • Background in protein characterisation to validate protein quality from a bioprocess., • Experience of working with scalable bioprocess technologies e.g. Tangential flow filtration, • Industry experience in Biopharma, AgriTech or related sectors.