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Company Overview: Founded in 1999, Asymchem is a globally integrated Contract Development and Manufacturing Organization (CDMO) providing drug R&D and manufacturing for leading pharmaceutical and biotech companies. Our mission is to drive smarter, greener,and more cost-effective manufacturing to support clinical research and commercialization. Asymchem currently operates eight manufacturing facilities offering solutions ranging from early clinical stage to commercial stage, including R&D, cGMP production of advanced intermediates, APIs, formulations, and clinical research services. Asymchem Group, headquartered in Tianjin, P. R. China. The Asymchem Sandwich site focuses on drug substance development and transfer of these early-stage processes into manufacturing within the Product Development Facility (PDF) in support of clinical and small scale commercial manufacturing. Job Overview: The Senior Process Engineer is a role in the manufacturing team in Sandwich. This position manages the delivery of new equipment/technology via continuous improvement as part of the site capital projects program. It provides process safety support to ensure the facilities manufacturing processes are capable of meeting the processing demands of the latest generation of Drug Substance Targets and their intermediates. Duties & Responsibilities: • Provides process engineering support to the PDF to ensure it meets operational requirements and all applicable legislative and corporate standards. Complies with all aspects of current Good Manufacturing Practices., • Supports the ongoing capital development of operations and process facilities by defining and clearly specifying requirements, and then collaborating with external vendors, facilities, and engineering groups to deliver and implement the appropriate design solution., • Project manage and provide technical expertise to capital projects from initial conceptual design, through detailed design, installation, and commissioning/validation. Ensure that projects are completed on schedule and to budget following all applicable corporate and regulatory guidance/requirements., • Leads the definition of validation requirements and standards including writing, review and technical assessment of validation protocols, commissioning and start up., • Leads specialist safety reviews and Process Hazard Assessments (PHA) including What-If evaluations, HAZOP, LOPA, and Failure Mode & Effects Assessments, when required., • Provides process safety engineering support to the PDF to meet Operational requirements & applicable Legislative and Corporate standards., • Reviews changes for technical accuracy and applicability to ensure the proposed change meets operational requirements while adhering to Good Engineering Practice and EHS/Quality requirements as required., • Provide expertise to the Pilot Plant or Laboratories by bringing knowledge of chemical engineering concepts and techniques to solve practical development and plant operational problems., • Leads or participates in Quality and Safety investigations., • All other duties as assigned. Essential Experience Requirements - Knowledge, Skills, & Abilities (KSAs): • Degree in Chemical Engineering, Pharmaceutical Engineering, or related engineering discipline. (BEng, MEng, BSc), • Minimum of 5 Years relevant experience within a manufacturing environment., • Competent in equipment specification, purchase, and related tasks., • Experience in HAZOP, LOPA, and process safety analysis., • Capable of writing and reviewing commissioning or validation protocols and technical documents., • Strong communication, teamwork, and adaptability skills. Desirable Experience Requirements • Experience in the delivery of capital projects within a pharmaceutical environment or similar industry such as Chemical or FMCG., • Knowledge of chemical engineering principles applied to drug substance manufacturing., • Experienced in leading Process Safety technical discussions., • An understanding of engineering controls required to manage high potency compounds.

Company Overview: Founded in 1999, Asymchem is a global integrated Contract Development and Manufacturing Organization (CDMO) providing drug R&D and manufacturing for leading pharmaceutical and biotech companies. Our mission is to drive smarter, greener, and more cost-effective manufacturing to support clinical research and commercialization. Asymchem currently operates eight manufacturing facilities offering solutions ranging from early clinical stage to commercial stage, including R&D, cGMP production of advanced intermediates, APIs, formulations, and clinical research services. Asymchem Group, headquartered in Tianjin, P. R. China. Our research laboratories and small molecule API pilot plant at Discovery Park, Sandwich, UK, is our flagship site for European R&D and we are looking to recruit into key roles. This is a fantastic opportunity to join an innovative, collaborative, dynamic team of scientists and engineers and help shape our operations and the future growth of our organization What we offer We offer competitive compensation, flexible benefits package including health insurance, retirement plans, opportunities to buy or sell holidays, as well as a good work-life balance. Enjoy a fun and rewarding career with daily opportunities to collaborate with highly talented colleagues. Additionally, there will be myriad opportunities to learn new technical and interpersonal skills, develop existing strengths, coach and mentor others, while pursuing our company's mission. Position Summary: The EHS Manager works as part of the site EHS team to deliver the Environmental Health and Safety (EHS) programme for both the Development Laboratories and Drug Substance Manufacturing area. At Asymchem you will have the opportunity to • Act as a subject matter expert ensuring site compliance with health and safety legislation as it applies to both laboratory and Manufacturing teams., • Manage and Analyze EHS data to identify trends and inform decision making to identify improvements, ensuring that systems meet internal and external auditor expectations., • Lead and support EHS based investigations and associated action outcomes, ensuring root cause and human factors analysis, working proactively to deliver high quality completed records, investigations, and associated actions on time., • Lead and develop sustainability programmes to support both laboratory and manufacturing teams and manage the collection of Scope,1,2 and 3 data to support the site environmental programme., • Support assessment of EHS implications of changes, ensuring risks are identified and controls and implemented optimally. Manage documentation associated with change requests, across manufacturing, ensuring all documentation is accurately completed, available, and controlled., • Apply data and PDCA to support continuous improvement of systems that will maintain or enhance EHS systems across the site (e.g., EHS management system, documentation life cycle, training practices, SOP improvements, process flows)., • Lead and manage Risk Assessment programme within the development laboratories, ensuring required controls are well defined and implemented., • Support the site Industrial Hygiene programme and work with onsite teams to implement improvements., • Lead internal and external audit programme activities and support the implementation of potential improvements. Required Qualifications, Skills and Experience • Bachelors degree or equivalent experience in Science, Occupational Health and Safety, Environmental Science, Engineering or a related field., • Certification in NEBOSH National Diploma in Occupational Health and Safety, IOSH or equivalent., • Strong Knowledge of UK EHS legislation, risk assessment methodologies and investigation practices., • Extensive experience in a UK based EHS role including experience in laboratory safety practices., • Experience in the management of Industrial Hygiene Programmes, • Proactive and flexible profile, collaborates and communicates effectively with all. Desirable Experience • Experience in the pharmaceutical industry or other similar industries including chemical and FMCG., • Experience of delivering Environmental and Sustainability programs and supporting Ecopharmacovigilance assessment as part of a broader Environmental programme., • Experience in the management of hazards of highly potent compounds.

Company overview Founded in 1999, Asymchem has grown into a leading global integrated Contract Development and Manufacturing Organization (CDMO), renowned for its innovative solutions and commitment to excellence. Our mission is to drive smarter, greener, and more cost-effective manufacturing to support pharmaceutical and biotech research and commercialization. Since 2024 Asymchem have been operating research laboratories and a small molecule API pilot plant at Discovery Park, Sandwich, UK, establishing our first manufacturing facility in Europe and expanding our capabilities to meet the needs of global clients. The Sandwich facility acts as the flagship site for European R&D and we are looking to recruit into key roles. This is a fantastic opportunity to join an innovative, collaborative, dynamic team of scientists and help shape our operations and the future of our organization. What we offer We offer competitive compensation, flexible benefits package including health insurance, retirement plans, opportunities to buy or sell holidays, as well as a good work-life balance. Enjoy a fun and rewarding career with daily opportunities to collaborate with highly talented scientists. Additionally, there will be a myriad of opportunities to learn new technical and interpersonal skills, develop existing strengths, coach and mentor others, while pursuing our company's mission. Position summary The successful candidate will have a passion for synthetic organic chemistry and a desire to join our highly innovative High-Throughput Experimentation (HTE) team within Chemical Research & Development (CRD). As a key member of the team, you will be responsible for designing and developing efficient chemical routes and processes for the large-scale manufacture of small molecules, including complex Active Pharmaceutical Ingredients (APIs), for the pharmaceutical and other industries. Using state-of-the-art technologies, robotics and digitalised workflows, you will contribute to the development of novel synthetic methodologies, from organometallic chemistry to biocatalysis. With your expertise in organic chemistry and a strong understanding of contemporary literature, you will play a crucial role in driving our projects forward and making a meaningful impact on patients' lives. Asymchem will invest in your development so that you can: • Support the design new synthetic routes and processes to new chemical entities, • Develop advanced skills in data-centric process design enabling the development of the most efficient, sustainable, robust and safe manufacturing processes., • Deliver innovative solutions to chemical challenges utilising advanced automated technologies to execute and analyse high-throughput reaction screens from a wide variety of modern chemical transformations, such as homogeneous & heterogeneous catalysis, photochemistry, electrochemistry, biocatalysis., • Utilise statistics, machine learning and data visualisation applications to support the design and analysis of experimental programs., • Become a subject matter expert and industry leader in the art of HTE whilst gaining leadership skills delivering scientific excellence through others., • Engage in departmental science and share your knowledge., • Apply a continuous improvement mindset to identify opportunities for improved work processes to deliver increased productivity, value and quality., • Continue to develop professionally in a range of technical areas and transferable skills, by utilising the experience and support of our highly skilled team. Qualifications, skills and experience • A PhD in Synthetic Organic Chemistry with pharma or CDMO experience is highly desirable, or a Bachelor’s/Master’s in Chemistry with substantial pharma or CDMO experience is essential., • Experience working in High Throughput Experimentation (HTE) is beneficial but not essential., • Extensive knowledge of contemporary literature and organic chemistry covering classic and modern synthetic reagents, asymmetric methodologies, and related reaction mechanisms., • A passion for continuous learning and improvement, with a strong ability to acquire new skills and apply them effectively., • Creative and analytical problem-solving skills, with a proven ability to apply knowledge to new challenges and develop innovative solutions., • Strong interpersonal and communication skills, fostering effective teamwork and collaboration, are essential., • Experience in overseeing scientific projects and providing colleague mentorship is highly desirable. Company values At Asymchem, we are deeply committed to fostering an inclusive and diverse workplace where every individual feels valued and cared for. We believe that diversity drives innovation and success, and we provide career development opportunities to support the professional growth of all employees. Join us in creating a workplace where diversity is celebrated, and inclusivity is at the heart of everything we do.

Company overview Founded in 1999, Asymchem has grown into a leading global integrated Contract Development and Manufacturing Organization (CDMO), renowned for its innovative solutions and commitment to excellence. Our mission is to drive smarter, greener, and more cost-effective manufacturing to support pharmaceutical and biotech research and commercialization. Since 2024 Asymchem have been operating research laboratories and a small molecule API pilot plant at Discovery Park, Sandwich, UK, establishing our first manufacturing facility in Europe and expanding our capabilities to meet the needs of global clients. The Sandwich facility acts as the flagship site for European R&D and we are looking to recruit into key roles. This is a fantastic opportunity to join an innovative, collaborative, dynamic team of scientists and help shape our operations and the future of our organization. What we offer We offer competitive compensation, flexible benefits package including health insurance, retirement plans, opportunities to buy or sell holidays, as well as a good work-life balance. Enjoy a fun and rewarding career with daily opportunities to collaborate with highly talented scientists. Additionally, there will be a myriad of opportunities to learn new technical and interpersonal skills, develop existing strengths, coach and mentor others, while pursuing our company's mission. Position summary Working within our state-of-the-art laboratories at Sandwich, your role will be to design and develop new routes to starting materials, intermediates and APIs (Active Pharmaceuticals Ingredients) through considered, data-driven experimental execution in the laboratory.Within a collaborative team environment, you will create safe, robust, scalable and efficient chemical processes to manufacture pharmaceutical API’s. You will also have the opportunity to transfer these chemical processes to scale up facilities and ultimately manufacturing. Asymchem will invest in your development so that you can: • Deploy your excellent knowledge of contemporary organic chemistry in the design and demonstration of new synthetic routes to small molecule API candidates., • Develop robust processes which ensure safe, reproducible and scalable manufacturing in large scale GMP equipment., • Employ a range of laboratory equipment from mg to multigram scale, in conjunction with a suite of analytical tools, to maximize the generation of knowledge from each experiment., • Contribute directly in technology transfer activities to the Sandwich plant facility and other sites within the Asymchem network., • Collaborate with scientists within and outside their functional area to achieve team goals., • Utilize a systematic methodical approach to solve complex chemistry problems and identify the root cause of any processing issues., • Perform laboratory operations with a critical focus on safety ensuring process safety guidelines are followed when conducting scale-up experiments., • Apply a continuous improvement mindset to identify opportunities for improved work processes to deliver increased productivity, safety and quality., • Take responsibility for the technical delivery of work packages through team leadership., • Utilize the experience of the group to support continued professional development in a range of technical areas to develop a high level of expertise supplemented with transferrable soft skills. Qualifications, skills and experience • A PhD in chemistry with excellent knowledge of organic chemistry is highly desirable or a Bachelor’s or Master’s degree with significant experience in the pharmaceutical or a related industry is essential., • The ability to communicate effectively both in verbal and written forms is essential., • A collaborative approach to work in a team environment is essential., • Proactive planning and organizational skills and the ability of multi-tasking and prioritizing in a highly dynamic environment is essential. Company values At Asymchem, we are deeply committed to fostering an inclusive and diverse workplace where every individual feels valued and cared for. We believe that diversity drives innovation and success, and we provide career development opportunities to support the professional growth of all employees. Join us in creating a workplace where diversity is celebrated, and inclusivity is at the heart of everything we do.

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