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Scientist / Senior Scientist – 3D Genome & NGS Assay Development // Oxford You are a creative, hands-on assay developer who loves to tinker with protocols, optimise them, and build NGS-based methods that genuinely move science forward. You think deeply about why assays work, when to deviate from a protocol, and how to adapt methods to new cell types and biological questions. You want to be in a small, high-impact biotech environment where your work directly unblocks an R&D pipeline, rather than adding another incremental dataset to a queue of papers. You’re motivated by impact, pace, and the opportunity to shape how a platform evolves. We’re partnering with an incredibly exciting, Oxford-based biotech operating at the forefront of 3D genome and non-coding genomics, they are operating assays at the forefront of Biotechnology at scale, a true innovator in this space. Their discovery engine integrates novel assays, deep genomics and high-resolution chromatin biology to uncover gene-regulatory mechanisms that conventional approaches miss. You will join a core 3D genome assay team. Your work will directly increase throughput, accelerate assay optimisation, and enable expansion into new disease areas and primary cell systems. THE ROLE You will: • Develop, refine and optimise 3D genome and NGS-based assays (e.g. ATAC‑seq, ChIP‑seq, RNA‑seq and conceptually related methods), • Design and execute experiments to expand assays into new primary cell types and disease-relevant systems, • Work closely with a Principal Scientist to prioritise work, expanding the platform’s capabilities, • Collaborate with bioinformatics and biology colleagues to ensure that assay design and data output align with downstream analysis and decision-making ABOUT YOU • Background in gene regulation, chromatin biology, epigenetics or closely related field, • Strong, hands-on experience in NGS assay development (e.g. ATAC‑seq, ChIP‑seq, RNA‑seq or similar)s), • Bonus: experience with any 3D genome assay (e.g. Hi‑C, Capture‑C or related technologies), • Enjoy working in an experimental, innovation-driven environment and taking ownership of your work LOGISTICS • Title: Scientist or Senior Scientist (flexible, depending on experience), • Location: Oxford, lab-based If you’re excited by the idea of building and refining assays at the heart of a 3D genome discovery platform, Apply Now!

Scientist, Biochemical Assay Development, COR7501 My client, a pioneering start-up organisation within the AgriTech industry are in urgent need of a Scientist, with a background in biochemical assay development, to join their team! Joining the company in their Oxford office, the Scientist will be responsible for designing and developing biochemical and Biophysical assays. The Company This pioneering start-up have developed a range of powerful platforms, that when used in conjunction with artificial intelligence, enable the discovery of new herbicides. This Oxford University spin-out company are already making waves in the AgriTech industry and with an enormous amount of financial backing are set to expand rapidly! Benefits • 25 days holiday, • Pension scheme, • Experience developing biochemical assays for compound screening, • Ideally experience with Kinetics, Fluorescence including Fluorescence Polarization and FRET, • Any experience developing biochemical assays for plant science, would really set your application apart! What Next? If you have any questions or would simply welcome a chat about this Senior Scientist position and company, just call me or drop me an email, as I'd love t...

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law. To characterise the companies biotherapeutic recombinant T-cell receptor based and related molecules using a wide variety of protein characterisation and mass spectrometry methods. To contribute to the development of characterisation methods for the company's biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass spectrometry analysis. KEY RESPONSIBILITIES • Supporting drug substance and drug product impurity characterisation and identification, • Performing protein sequence and post translational modification identification, including glycosylation analysis., • Supporting drug substance and drug product process development by performing characterisation of process intermediates, • Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis, • Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products., • Contribute to writing study protocols and reports., • Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others., • Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance., • Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge. Providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the department., • Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this., • Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively., • Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners., • Adhere to safe working practices in laboratories according to Immunocore EHS policies. PERSON SPECIFICATION Experience & knowledge Essential • Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies., • Experience of glycosylation analysis of recombinant proteins or antibodies., • Independently coordinated extensive testing of protein biomolecules., • Experienced in the characterisation of proteins expressed in both microbial and mammalian systems., • Understanding of expected post-translational modifications in biological systems., • Worked in a bench-based biopharmaceutical laboratory environment., • Experienced in assay development, • Familiar with biopharmaceutical stability study principles and interpretation thereof, • Worked and contributed actively in a diverse team environment, • Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change, • Presented detailed scientific findings and papers to internal and external audiences Desirable • Experience of glycosylation analysis of recombinant proteins or antibodies, • Experience with late stage/commercial biopharmaceutical assay development and characterisation, • Familiar with the principles of Good Manufacturing Practise (GMP), • Presented at external conferences, • Led a small project team, formally or informally, through a change in practice including project management, • Understanding of analytical requirements to support materials for use in clinical trials Education & qualifications • Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline, • Desirable: PhD in related discipline

Analysis of protein‑protein interactions using SPR (BIAcore). Protein expression in bacterial and/or mammalian systems. Protein purification using column chromatography methods and ӒKTA system (such as via affinity tags, ion exchange and size exclusion).

A leading biotechnology firm in Oxford is seeking a Senior Scientist I in Protein Science Pipeline. The ideal candidate will engineer ImmTAX molecules, contributing to pipeline advancements, and possessing expertise in protein biochemistry.

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A biotechnology company in Oxford is seeking a Senior Scientist I for Analytical Development & Validation.

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PhD (or equivalent experience) in Cell Biology, Molecular Biology, Immunology, or related scientific field. Proven experience (typically 5+ years post-PhD) in cell biology or related research within a biotech/biopharma settings. Strong technical background in cell culture, flow cytometry, ELISA, Wes

Recombinant protein expression of affinity enhanced proteins in mammalian systems (Expi293 and ExpiCHO). Protein purification and protein analysis. We are seeking a Senior scientist / Scientist to work within our Protein Engineering team to provide essential hands‑on support to accelerate our pipe

ROLE OVERVIEW Are you a driven and innovative scientist looking to make a significant impact in the field of vaccine development? Our client, a leading company in the pharmaceutical industry, is seeking a Senior Analytical Scientist to join their team based in Oxfordshire. As the Senior Analytical Scientist, you will be at the forefront of generating and implementing novel ideas to resolve complex analytical problems, ensuring high-quality analysis to support a variety of technically challenging projects. KEY DUTIES AND RESPONSIBILITIES: Your duties as the Senior Analytical Scientist will be varied however the key duties and responsibilities are as follows: 1. Research and implement innovative methods to overcome technical challenges in biochemical analysis of solid dose vaccines., 2. Develop and optimise new methods for analysing novel solid dose vaccine formulations, ensuring their suitability through appropriate studies., 3. Perform routine analysis, record data accurately, and peer review analysis records to maintain data integrity and quality standards., 4. Lead and collaborate on projects, ensuring all analytical readiness activities are executed to generate quality data and achieve project goals. ROLE REQUIREMENTS: To be successful in your application to this exciting role as the Senior Analytical Scientist we are looking to identify the following on your profile and past history: 1. Relevant degree in biological sciences or proven industry experience in a laboratory-based analytical position., 2. Proven experience in troubleshooting, optimising, and developing complex methods for biomolecules such as ELISA, HPLC, and transfection., 3. A working knowledge and practical experience with leading and training team members, ensuring high standards in analytical, health and safety, and lab operations. Key Words: Senior Analytical Scientist / Pharmaceutical / Vaccine Development / Biochemical Analysis / Solid Dose Vaccines / ELISA / HPLC / Transfection / Data Integrity / Analytical Methods / Oxfordshire Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer. We welcome applications from anyone who meets the role requirements. HRS exclusively supports the Life Science sectors, combining recruitment expertise with scientific knowledge to help you advance your career

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Overview We are currently supporting an exciting opportunity for a Senior New Product Development Scientist to join a growing and dynamic Analytical Development team. The role also provides scope to mentor junior scientists and share your knowledge, while remaining focused on laboratory work and pro

As a Senior Data Scientist, you'll join the Data Science Team within DWP's Working Age Services (WAS) - the area responsible for the digital services behind Universal Credit and other key benefits. As our Senior Data Scientist, you'll play a central role in shaping how Working Age Services uses data

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Senior Postdoctoral Scientist – Autoantibodies. The Ludwig Institute for Cancer Research at the University of Oxford invites applications for a Senior Postdoctoral Scientist specializing in Autoantibodies.

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