Senior LCMS Scientist
1 day ago
Southampton
Senior Scientist – Subject Matter Expert (SME) in Mass Spectrometry Up to £45,000 + Benefits Full-time, On-site – Southampton We’re partnering with an innovative scientific organisation to find an experienced Senior Scientist with deep expertise in Mass Spectrometry to join a high-performing team based in Southampton. This role offers the chance to lead analytical strategies, contribute to cutting-edge projects, and support the development of high-quality modified nucleic acid in a fast-paced, collaborative environment. About the Role As the subject matter expert in mass spectrometry, you’ll play a central role in driving analytical method development, ensuring high standards in nucleic acid production, and mentoring junior team members. This is a hands-on role in a modern laboratory, where scientific excellence and operational efficiency go hand-in-hand. Key Responsibilities • Lead and manage analytical workflows using LC-MS, UPLC-MS, HPLC, PAGE, and flash chromatography, • Act as the go-to expert for mass spectrometry, including troubleshooting and continuous improvement, • Collaborate with cross-functional teams to support small molecule preparation and oligonucleotide synthesis, • Maintain, calibrate, and optimise analytical instrumentation in line with internal and ISO quality standards, • Support and mentor Associate Scientists and Lab Technicians, providing technical guidance and training, • Ensure high levels of documentation accuracy and data integrity, • Uphold Health, Safety and Environmental (HSE) standards and promote a safety-first culture, • Manage the inventory of analytical reagents and consumables, • Stay informed on emerging techniques in nucleic acid chemistry and analytical science About You We’re looking for a driven and detail-focused scientist who thrives in a collaborative lab environment and is passionate about pushing the boundaries of analytical science. You’ll ideally have: • PhD in Chemistry, Analytical Chemistry, or a closely related field, • Significant hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Waters Connect experience highly desirable), • Proven track record in high-throughput chemistry or oligonucleotide production environments, • Strong grounding in nucleic acid chemistry and experience with purification techniques, • Experience working in ISO or GMP-regulated environments, • Ability to lead projects and mentor junior staff, • Excellent communication, problem-solving and organisational skills, • A proactive mindset, able to adapt and perform under pressure Salary & Benefits • Salary: Up to £45,000 depending on experience, • Location: On-site in Southampton, • Holidays: 25 days annual leave + 8 bank holidays, • Pension: 6% employer contribution, • Work-Life Balance: Flexible working hours, • Life Assurance: 4x salary, • Other Benefits:, • Long service awards, • Reward and recognition scheme, • Employee Assistance Programme with 24/7 remote GP access, • Annual flu vaccinations, • Cycle to work scheme, • Gym discounts, • Discount and savings platform, • Professional membership reimbursement, • Referral incentives If you're ready to make an impact in a dynamic and supportive environment, we’d love to hear from you. Apply today or get in touch to learn more.