Head of Pipeline Biology
11 hours ago
Oxford
We are seeking an innovative and hands-on scientific leader to serve as Head of Pipeline Biology, responsible for advancing the biological development of our client's pioneering bispecific TCR therapeutics targeting AML and solid tumours. This is a critical leadership role in progressing first-in-class, first-in-human molecules to the clinic. Key Responsibilities Scientific Leadership & Strategy • Lead the preclinical biology group, overseeing in vitro and in vivo testing of bispecific TCR molecules., • Design and implement assays to assess binding specificity, T cell activation, and T cell-mediated killing., • Develop testing strategies to evaluate efficacy, safety, and mechanism of action., • Collaborate with Protein Engineering to optimise candidate molecules. Regulatory & Translational Development • Drive the generation of data packages to support regulatory submissions (MHRA, FDA, EMA)., • Contribute to Clinical Trial Authorisation (CTA) and IND/NDA applications., • Engage with regulatory bodies and external experts to ensure alignment with global standards. Team & Operational Leadership • Manage and mentor a growing team of cell biologists (initially 3–4 scientists)., • Oversee budgets, timelines, and reporting for biological testing activities., • Present findings to the Senior Leadership Team and external stakeholders., • Foster a culture of innovation, collaboration, and scientific excellence. Experience & Qualifications Background • PhD in Immunology, Cell Biology, Molecular Biology, or a closely related discipline., • At least 5 years of R&D experience within biotechnology or pharmaceutical settings, ideally in TCR therapeutics, bispecifics, or immuno-oncology., • Demonstrable hands-on experience in evaluating the safety and efficacy of high-affinity soluble TCR molecules., • Proven track record in non-clinical development and regulatory interactions., • Experience contributing to successful regulatory submissions and clinical trial initiation. Technical Expertise • In-depth understanding of T-cell biology, cellular assays, and molecular techniques, including target binding, T-cell activation, and cytotoxicity assays both in vitro and in vivo., • Proficiency in lentiviral transduction, molecular cloning, and engineering of isogenic cell lines., • Experience in maintaining diverse cell systems, including human organoids, and primary human cells., • Skilled in multi-colour flow cytometry, EliSpot, luminometry, and fluorescence-based assays. Leadership & Communication • Demonstrated leadership in developing and implementing scientific strategies., • Excellent communication and presentation skills, with the ability to convey complex scientific data to senior leadership and external audiences., • Strong record of cross-functional collaboration and evidence-based decision-making., • Experience managing budgets, project timelines, and preparing technical reports., • Ability to represent an organisation’s work through publications and scientific presentations., • Familiarity with the requirements for preparing preclinical data packages for CTA (MHRA) and NDA (FDA/EMA) submissions.