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Prostate Cancer Research is seeking a dynamic Head of Research to oversee a comprehensive research portfolio and manage approximately £2 million in annual funding. The candidate will work closely with the Senior Leadership Team, ensuring effective processes and partnerships between different resear

At Cancer Research UK, we exist to beat cancer. The Cancer Research UK Centre for Drug Development (CDD) is the world's only charity-funded drug development organisation. Cancer Research UK can consider visa sponsorship for this vacancy.

We are looking for a dynamic, motivated and thoughtful individual to take on the newly created role of Head of Research. Oversee the monitoring and evaluation of our research portfolio of both grant-funded and in-house projects, including supporting and mentoring other team members. You will also he

A leading cancer research organization based in the UK is seeking a dynamic Head of Research to oversee their innovative portfolio. The ideal candidate should possess a PhD and have experience in academic research and managing research grants.

Head of Biometrics and Medical Writing. Provide oversight of statistical expertise to support robust trial design, high‑quality datasets and successful onward development. Experience of early phase trials.

A leading health charity in London is seeking a Head of Biometrics and Medical Writing. You will lead the Biometrics & Medical Writing team and ensure the effective delivery of clinical trials while maintaining high regulatory standards.

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. The Executive Director, Head of Discovery Chemistry is accountable for the scientific leadership, strategic direction, and operational excellence of small‑molecule drug discovery from target validation through candidate nomination and transition into Early Development. The role ensures the delivery of high‑quality, differentiated molecules across Neuroscience and Oncology programs, integrating medicinal, computational, and AI/ML‑enabled drug design approaches to maximize probability of technical and clinical success. Essential Functions / Responsibilities Serve as global head of Discovery Chemistry with end‑to‑end accountability for small‑molecule discovery programs from hit identification through candidate nomination (Decision Point 0), including discovery formulation and synthesis enablement of transfer to Pharmaceutical Development partners Define and execute a Discovery Chemistry strategy aligned with portfolio priorities in Neuroscience and Oncology, emphasizing molecule quality, translation, and long‑term value. Ensure rigorous molecular design standards addressing potency, selectivity, CNS exposure where applicable, safety margins, and developability. Lead and integrate medicinal chemistry, computational chemistry, and structure‑based design capabilities across internal teams and external partners. Oversee state of the art and future-facing disciplined use of AI/ML‑enabled drug design platforms to accelerate design cycles, improve decision quality, and reduce technical risk. Ensure quality of due diligence activities within chemistry and discovery domain of corporate development evaluations Drive timely and high‑confidence candidate nominations, ensuring transfer and chemistry readiness for IND‑enabling activities. Represent Discovery Chemistry at the level of Research and Non-Clinical Leadership Team, Scientific Review meetings, and Early Development Portfolio Review Committee governance forums, and development transition reviews. Partner with Neuroscience and Oncology Research, Translational Science, DMPK, Toxicology, CMC, Regulatory, Pharmaceutical Development, and Clinical Development to ensure seamless progression into development. Provide executive scientific chemistry leadership in support of external collaborations and M&A Develop, mentor, and retain senior chemistry leaders, fostering a culture of scientific excellence, accountability, and continuous innovation. Manage chemistry contributions to Oncology, Neuroscience new target prioritization working teams and process, ensuring med chem, structural information, tractability tools appropriately integrated into target matrix assessments. Ensure Chemistry functional and capacity discipline and continuous improvement Governance & Portfolio Accountability Serve as the Discovery Chemistry representative and accountable leader at Early Development Project Review Committee (EDPRC), Development Project Review Committee (DPRC), and other portfolio governance forums as appropriate. Prepare, present, and defend Discovery Chemistry strategies, molecular design rationale, candidate quality attributes, and risk assessments at stage‑gate, portfolio, and governance reviews. Ensure the timely escalation of scientific, technical, and resourcing risks related to molecule quality, developability, or program execution to EDPRC, DPRC, and senior R&D leadership. Partner with senior R&D leadership to enable portfolio decision making across Neuroscience and Oncology programs. Required Knowledge, Skills, and Abilities Executive‑level Discovery Chemistry leader with extensive progressive experience in medicinal chemistry and small‑molecule drug discovery within pharmaceutical and/or biotechnology organizations. Demonstrated track record of pipeline impact, including: Multiple high‑quality clinical candidate nominations, and Documented contributions to late‑stage development assets and/or approved medicines. Deep scientific expertise in medicinal chemistry, lead identification and optimization, and structure‑activity relationships across complex target classes relevant to Neuroscience and Oncology, including CNS‑penetrant small molecules. Proven experience establishing and enforcing molecule quality standards, including potency, selectivity, pharmacokinetics, CNS exposure where applicable, safety margins, chemical developability, and differentiation versus standard of care. Extensive experience leading and integrating computational chemistry, structure‑based drug design, and AI/ML‑enabled drug discovery approaches, with clear understanding of: Model validation and limitations Data integrity and provenance Appropriate application to decision‑making rather than exploratory novelty. Demonstrated ability to balance innovation, speed, and scientific rigor in early discovery environments characterized by uncertainty and evolving targets. Successful leadership in global, matrixed discovery organizations, with proven ability to influence outcomes and align diverse functional teams toward common objectives. Strong strategic and portfolio‑level thinking, with experience shaping discovery strategy to maximize probability of technical success and long‑term patient and business value. Established external scientific credibility, with the ability to engage effectively with academic leaders, industry peers, alliance partners, and key opinion leaders. Exceptional communication and influencing skills, capable of translating complex scientific data and trade‑offs into clear, actionable recommendations for senior governance bodies and executive leadership. Proven commitment to talent development, succession planning, and inclusive leadership, with a track record of building high‑performing, diverse Discovery Chemistry organizations Extensive experience with internal discovery as well as externalized operating models through CROs and biotech partnerships. Required Experience and Qualifications Experience Extensive progressive experience in medicinal chemistry and small‑molecule drug discovery within pharmaceutical and/or biotechnology organizations. Demonstrated success in senior scientific leadership roles (Director, Senior Director, Executive Director, or equivalent), with accountability for strategy, delivery, and organizational performance. Proven track record of pipeline impact, including: Multiple clinical candidate nominations, and Clear ownership of molecule quality and developability through discovery and early development transition. Significant experience leading discovery programs in Neuroscience and/or Oncology, including complex target classes and, where applicable, CNS‑penetrant small‑molecule design. Extensive experience directing and integrating medicinal chemistry, computational chemistry, and structure‑based drug design capabilities within a matrixed R&D environment. Demonstrated ability to lead and govern the validated use of computational chemistry and AI/ML‑enabled drug design tools, with clear understanding of their appropriate application, limitations, and impact on decision‑making. Experience representing discovery functions in portfolio governance and decision‑making forums (e.g., research review committees, early development or portfolio review committees). Proven ability to lead global, cross‑functional organizations, including mentoring senior leaders, setting performance expectations, and building high‑performing teams. Education PhD in Chemistry (Medicinal Chemistry, Organic Chemistry, or closely related discipline) or equivalent scientific degree required. Preferred Experience and Qualifications Experience Direct contribution to late‑stage clinical development programs and/or approved medicines. Experience leading discovery organizations across multiple therapeutic areas, with depth in both Neuroscience and Oncology portfolios. Hands‑on or leadership experience establishing molecule quality bars, including CNS exposure, safety margins, physicochemical optimization, and chemistry readiness for IND‑enabling studies. Experience serving as a senior scientific leader in Early Development governance bodies (e.g., EDPRC / DPRC equivalents), including preparation and presentation of stage‑gate and portfolio materials. Experience with external collaborations and alliances, including joint governance, CRO strategy, and scientific oversight of external partners. Participation in or leadership of scientific due diligence activities for in‑licensing, acquisitions, or strategic partnerships. Recognized external scientific credibility, demonstrated through publications, patents, invited presentations, or leadership within the broader discovery chemistry community. Education and Training Postdoctoral training in medicinal chemistry, chemical biology, computational chemistry, or a related discipline. Formal or experiential training in computational chemistry, data science, or AI/ML applications in drug discovery. #LI-JC1 #LI-Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. Essential Functions • Support the development and implementation of AI/ML/GenAI solutions to optimize clinical trial operations, including such areas as patient recruitment, patient retention, real-time data monitoring and automated data collection system build. • Support the development and implementation GenAI applications for automated clinical trial documentation generation including such areas medical reports, clinical study reports, protocols and patient narratives. • Support the development and implementation of Digital Healthcare applications for medical and scientific tools, RWE new ways of generating real data, patients’ engagement. • Support the design and develop predictive models and generative AI solutions using diverse healthcare data sources, including clinical trials data, electronic health records, wearable devices, patient-reported outcomes, HEOR data, phase IV studies. • Ensuring compliance with regulatory requirements and data privacy standards. Required Knowledge, Skills and Abilities • Strong programming skills in Python, R, or similar languages, with experience in modern ML frameworks (PyTorch, TensorFlow). • Demonstrated experience with generative AI technologies, including LLM architectures and frameworks. • Knowledge/experience with digital healthcare tools design and development • Experience with natural language processing and generative AI for medical text analysis, generation, and interpretation. • Demonstrated ability to build relationships with stakeholders and subject matter experts. -Familiarity with high compute cloud-based platforms and services, in particular AWS. •Familiarity with code version control and MLOps deployment approaches. Required/Preferred Education and Licenses •Advanced degree (MS or PhD) in Data Science, Computer Science, Biostatistics, or related field •3 – 5 years of related professional experience, with 1+ years of experience applying AI/ML techniques to healthcare or clinical research data. •Experience in healthcare/AI implementation in healthcare field is a plus. •Knowledge of digital healthcare tools design and development #LI-Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. The Associate Director, Medical Safety (Scientist) is a key member of the Medical Safety team. This role is responsible for ensuring up to date processes / procedures for safety governance, signal management, clinical surveillance, periodic safety reporting, and risk management and/or driving innovation initiatives within Medical Safety organization. In close collaboration with Medical Safety Physician and/or Medical Safety Scientist line manager, this role is also responsible for contributing to regulatory submission safety strategy. Other responsibilities include but are not limited to: signal management activities, production of aggregate safety reports (e.g., DSURs, PADERs, PBRERs), provision of high-level scientific expertise in the safety evaluation and risk management strategies of assigned products (e.g, signal evaluation reports, health hazard evaluations, and RMPs), global leadership / representation of Medical Safety within the company (e.g., leading Safety Management Teams, presenting at Executive Safety Board meetings), and SME support for HA inspections. Essential Functions • Leads cross-functional safety management teams (SMTs) and drives safety strategy for responsible product/program., • Ensures that processes and procedures are up to date to meet regulatory requirements and inspection readiness, • Drives signal management process using available methodologies, including making recommendations for the assessment and prioritization of safety concerns., • Effectively communicates with members of the interdisciplinary team regarding ongoing signal evaluation., • Ensures that available safety information is evaluated in order to meet both internal and external requirements, including identifying the need for labeling updates. Produces accurate and fit for purpose evaluation documents with clear conclusions, as required., • Leads the coordination of aggregate safety reports (PBRERs, DSURs, PADERs) and authors relevant sections, as appropriate., • Authors or provides guidance for the production of risk management plans (RMPs)., • Provides strategic input into regulatory requests / responses., • Delivers clinical safety input into clinical development program., • Leads the medical safety contributions of global regulatory submissions for new products, formulations or indications., • Participates in and/or leads internal safety surveillance meetings as well as joint safety meetings with licensing partners, as needed., • Provides medical safety input into creation / review of Safety Data Exchange Agreements and/or other PV agreements., • Escalates issues / concerns to senior management in a timely and appropriate manner., • Mentors and trains junior members of the Medical Safety team. Required Knowledge, Skills, and Abilities Minimum Requirements • At least 6 years of experience in drug safety, including at least 4 years of experience in surveillance / risk management., • Ability to independently search clinical safety and literature databases for relevant information., • Expert knowledge of pharmacovigilance regulations regarding aggregate safety reports, risk management plans, and signal management., • Excellent medical writing skills, as well as proven ability to effectively lead interdisciplinary teams., • In-depth knowledge of medical and drug terminology, as well as the clinical development process., • Familiarity with MedDRA and safety databases; Proficient with Windows applications, and ability to learn new programs / databases. Required/Preferred Education and Licenses Requires a degree (e.g., BS, BA, MSc or PhD) or professional qualification in a life science field (e.g., nursing or pharmacy) or a relevant scientific/technical discipline and experience. #LI - Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. FOR US BASED CANDIDATES ONLY Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $(phone number removed) - $(phone number removed) Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis. At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. Reporting into the Senior Director, DS development, this role will provide scientific and technical leadership for drug substance development projects at various stages of the development life-cycle. Success requires application of scientific and/or engineering principles and creativity to process design and development studies, and translation into commercially feasible, reliable and robust processes. Experience of the critical interface attributes between drug substance and drug product will be especially relevant. Activities will be performed primarily with external contract development and manufacturing organisations (CDMOs). Other responsibilities will include cross-functional team leadership and/or membership, authoring technical reports and CMC sections of regulatory dossiers, and participation in department or functional initiatives. The role will involve significant cross functional collaboration with other functions including Quality, CMC Regulatory, Manufacturing, and New Product & Technology Integration working towards agile new product introduction and ensuring all processes are understood, robust, efficient and in control. The role is both project and operations orientated. It shall require an ability to drive and deliver multiple projects concurrently. Essential Functions Lead the process development and cGMP manufacture of small molecule drug substances at CDMOs Ensure adequate supply of drug substance for clinical studies and other needs Oversee the development of robust and reliable manufacturing processes utilizing Quality by Design (QbD) principles. Oversee the synthesis of chemical entities to support clinical and non-clinical studies Ensure that all DS processes are in line with all applicable regulations, policies, guidelines and procedures Represent the drug substance team on cross functional project teams as needed Work closely with other cross-functional CMC project team members to deliver on agreed project goals Actively contribute to functional area continuous improvement initiatives Author and/or review drug substance sections of regulatory dossiers and technical reports Support other Technical Operations functions to ensure a smooth transfer of technologies and products to manufacturing sites Clearly and effectively communicate ideas and results, written and verbal, to technical and non-technical audiences Plan, budget, execute and report on assigned projects Develop knowledge of new pharmaceutical manufacturing processes and technologies as required in line with Jazz business objectives and share best practices within teams Required Knowledge, Skills, and Abilities Strong record of achievement in drug substance development and manufacturing. Substantial experience required with a broad experience across drug development and manufacturing technologies but with specific experience related to drug substance chemical process development. Demonstrated technical expertise in chemical process development and new product introduction Demonstrated technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design to support process development objectives Demonstrated troubleshooting and problem solving skills. Experience of CMC regulatory requirements for pharmaceutical products Demonstrated track record of training and coaching colleagues to improve overall team process knowledge. Demonstrated track record of delivering positive results on a consistent basis. Proven project management skills for technical programs Experience in managing and maintaining budgets desirable Experience in defending processes, procedures and investigation during FDA/EMA (and other competent authorities) inspections desirable. Capability of grasping complex technical issues and make sound decisions based on data and information from various sources Knowledge of formulation development and/or large molecule technologies would be advantageous Excellent written and verbal communication skills. Required/Preferred Education and Licenses Bachelor’s degree and PhD in Chemistry Description of Physical Demands Occasional mobility within office environment. Routinely sitting for extended periods of time. Constantly operating a computer, printer, telephone and other similar office machinery Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. Jazz Pharmaceuticals is looking to hire an experienced External Manufacturing Lead (EML) to join our External Manufacturing organisation. The EML will have overall responsibility for the performance of an external Contract Manufacturing Organisation (CMO) portfolio for Drug Substance commercial products. The EML will be required to build and manage strong business relationships with the CMO and will act as the primary point of contact for all performance, contractual compliance, and supply‑related issues. The EML will lead cross‑functional, high‑performing teams who share accountability for the performance of the CMO. The EML will develop and agree manufacture and supply plans with the CMO in alignment with Technical Operations strategy, oversee the execution of CMO operations, and ensure the delivery of robust, high‑quality, cost‑effective supply, on time and on budget. The EML will be responsible for the periodic assessment and improvement of CMO performance through monitoring and reporting of best‑in‑class metrics and KPIs, risk identification and mitigation, and continuous improvement initiatives to drive operational efficiency and effectiveness while supporting Jazz’s Technical Operations strategy and sustainability goals. In addition, we are seeking someone who is comfortable leading and managing change both externally and internally. The role requires the ability to influence across functions, shape new ways of working, and guide teams through organizational evolution. Experience in establishing or scaling an external manufacturing organisation, building the structures, processes, and governance needed for a high‑performing external manufacturing function is highly desirable. Essential Functions/Responsibilities Contract Manufacturing Organisation (CMO) Relationship and Performance Management Build strong, strategic partnerships with CMOs to enable long‑term value creation, collaboration, and a culture of continuous improvement and innovation. Oversee all aspects of the business relationship, ensuring CMOs meet contractual obligations and performance standards across quality, cost, delivery, compliance, and service, aligned with Jazz’s Technical Operations strategy. Lead External Governance meetings, ensuring outputs, actions, and decisions are documented in accordance with Jazz procedures. Proactively monitor, manage, and communicate CMO performance, ensuring timely issue resolution and alignment with business objectives. Partner with CMOs to define and implement multiyear performance‑improvement initiatives that strengthen capability, reliability, and efficiency. Leadership and Cross-functional Collaboration Build and lead high‑performing cross‑functional team with shared accountability for CMO performance, ensuring supply plans, assignments, and projects are delivered to agreed standards. Drive the onboarding of CMOs in alignment with Technical Operations strategy. Serve as the primary point of contact and escalation lead for all CMO‑related business, performance, and supply issues, ensuring timely mitigation of risks and supply disruptions. Set objectives and multiyear plans for assigned CMOs, ensuring alignment with broader organizational goals and priorities. Influence internal stakeholders and lead internal change to strengthen ways of working, governance, and cross‑functional alignment. Planning and Execution Develop and oversee manufacturing and supply plans for Drug Substance, bulk Drug Product, and Finished Product, ensuring delivery against agreed timelines and budgets. Lead internal and external meetings, driving agendas, prioritizing issues, and enabling effective decision‑making and execution. Develop cost plans for all required activities, ensuring budgets are approved, tracked, and managed effectively. Ensure cross‑functional resources are aligned and leveraged to achieve program objectives in line with corporate priorities. Maintain a flexible, adaptive planning mindset to respond quickly to shifting priorities and unforeseen supply‑chain challenges. Collaborate with stakeholders to ensure seamless transition from development to commercial manufacturing. Risk Management Lead proactive identification, documentation, and mitigation of supply risks and opportunities across assigned CMOs. Develop and oversee implementation of robust mitigation plans to prevent or minimize supply disruptions. Communicate and escalate supply and performance risks to senior management as appropriate. Support the development and maintenance of business continuity plans for Jazz’s external manufacturing network Innovation and Continuous Improvement Foster a culture of continuous improvement and innovation within Jazz and across CMOs to enhance quality, reduce cost, and improve supply‑chain efficiency and sustainability. Collaborate with CMO partners and internal stakeholders to share best practices, identify improvement opportunities, and drive operational excellence in external manufacturing. Data Analysis and Reporting Support the development and implementation of best practices and best-in-class metrics / KPI’s to enhance CMO performance and Technical Operations performance reporting capability. Utilize data analytics to monitor supplier performance metrics, identify trends, and areas for improvement. Prepare and present reports on CMO performance to senior management and key stakeholders as required. Supplier Compliance and Contract Management Own and oversee Master Services Agreements with CMOs, ensuring alignment with contractual obligations and business needs. Partner with Quality, Legal, Procurement and other stakeholders to ensure supplier relationships are governed by appropriate quality and legal agreements. Lead CMO governance processes, ensuring compliance with company policies, regulatory requirements, and industry best practices. Required Knowledge, Skills, and Abilities 1. External Manufacturing & Supplier Relationship Management Strong background in managing CMOs or External Vendors within the pharmaceutical/biopharmaceutical industry. Experience in overseeing supply agreements, contractual compliance, and CMO performance management. Ability to build and maintain strategic partnerships with external suppliers, ensuring alignment with business objectives. Proven track record of driving supplier performance improvements and resolving supply-related challenges 2. Supply Chain & Operations Management Hands-on experience across end-to-end supply chain management, including demand planning, production scheduling, and inventory management. Knowledge of manufacturing and distribution processes for drug substances, bulk drug products, and finished goods. Experience working with cross-functional teams to develop production plans to ensure delivery of supply while managing risks. 3. Leadership & Cross-Functional Team Management Experience leading and managing cross‑functional teams and key stakeholders. Proven ability to set clear objectives, drive accountability, and foster a high‑performance culture. Strong decision‑making skills in fast‑paced, complex manufacturing environments. Comfortable leading internal and external change, influencing ways of working, and shaping organizational evolution 4. Risk Management & Continuous Improvement Experience in identifying, documenting and developing risk mitigating plans in supply chain and external manufacturing operations. Familiarity with business continuity planning for external vendors, including contingency planning for supply disruptions. Experience driving continuous improvement initiatives, including cost reduction, process optimization, and operational efficiency. 5. Compliance, Quality & Regulatory Knowledge Strong understanding of GMP, regulatory compliance, and industry standards for pharmaceutical manufacturing. Experience working with Quality, Regulatory Affairs, and Legal teams to ensure vendor compliance with company policies and industry regulations. Familiarity with supplier audits, quality agreements, and deviation/change control management. 6. Financial & Contractual Acumen Experience in budget management, cost forecasting, and financial tracking related to external manufacturing. Understanding of contract negotiation, supplier agreements, and procurement processes. Ability to assess financial risks and optimize cost efficiency in external supply partnerships 7. Data Analytics & Performance Management Experience using data analytics to monitor supplier performance, track KPIs, and drive data-driven decision-making processes. Ability to develop and present performance reports to senior management and key stakeholders. Familiar with supply chain and manufacturing software/tools (e.g., SAP, ERP systems, or other planning tools) preferred. Preferred Industry & Functional Experience Industry: Pharmaceutical, Biotech, or Life Sciences (experience in highly regulated environments preferred). Functional Areas: Supply Chain, Manufacturing Operations, Procurement, Quality Assurance, or External Vendor Management. Global Experience: Working with international CMOs, suppliers, or manufacturing networks across multiple regions. Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. Brief Description: The Senior Clinical Data Manager will be responsible for performing Data Management activities that support Jazz Pharmaceuticals’ commercial and development projects worldwide. You will participate as an active member of a multi-disciplinary team to plan, lead and execute the Data Management tasks required for phase 1-4 studies. The Senior Clinical Data Manager has a broad, fundamental knowledge of the data management process and is able to perform most required tasks with minimal guidance. Be able to lead a complex clinical study or a series of related studies with minimal guidance. Essential Functions/Responsibilities Represents Data Management on the study team for assigned studies. Manage and monitor the progress of data management activities and vendors on assigned studies. Manage and monitor CRO progress for outsourced studies. Build effective relationships with CRO / vendor counterparts. Review protocols for appropriate data capture requirements including electronic Case Report Form (eCRF) design and electronic Clinical Outcome Assessments (eCOA) forms. Interact with study team members e.g., CRAs, programmers, CTMs and statisticians in designing eCRFs and CRF completion guidelines. Lead the design and testing of Electronic Data Capture (EDC) systems according to company standards. Able to resolve EDC system issues with team members. Support the development of other system set-up e.g., eCOA and Interactive Response Technology (IRT). Lead the development of data edit check specifications and data listings and run data listings as required. Develop or lead the development of the Data Management documents for a clinical study. Able to review and provide feedback to the clinical team on other study documents e.g., Clinical Monitoring plans, Statistical analysis plans and vendor specifications. Provide training on the EDC and/or eCOA system and/or eCRF Completion Guidelines at Investigator Meetings and to internal and external study team members as needed. Lead database upgrades/migrations including performing User Acceptance Testing. Enter data queries into the EDC system to be resolved at investigational sites and manage the resolution of those queries. Perform reconciliation of data from external data sources against the clinical database. Perform Serious Adverse Event reconciliation activities. Perform database freeze and lock activities. Be able to maintain study eTMF. Participate in the generation of study timelines and manage DM activities against the timelines. Provide mentoring and training to junior level Data Management staff assigned to his/her studies. Assist with the onboarding and/or training of new employees and/or contractors. Participate in regular Clinical Data Operations team meetings and provide input when appropriate. Contribute to or lead department process improvement initiatives which could include the development of data management SOPs, Work Instructions, and process documents. Contribute to a professional working environment including the application of Jazz Pharmaceuticals Code of Business Conduct and Ethics Essential Functions/Responsibilities Be able to lead a complex clinical study or a series of related studies with minimal guidance. Represents Data Management on the study team for assigned studies. Manage and monitor the progress of data management activities and vendors on assigned studies. Manage and monitor CRO progress for outsourced studies. Build effective relationships with CRO / vendor counterparts. Review protocols for appropriate data capture requirements including electronic Case Report Form (eCRF) design and electronic Clinical Outcome Assessments (eCOA) forms. Interact with study team members e.g., CRAs, programmers, CTMs and statisticians in designing eCRFs and CRF completion guidelines. Lead the design and testing of Electronic Data Capture (EDC) systems according to company standards. Able to resolve EDC system issues with team members. Support the development of other system set-up e.g., eCOA and Interactive Response Technology (IRT). Lead the development of data edit check specifications and data listings and run data listings as required. Develop or lead the development of the Data Management documents for a clinical study. Able to review and provide feedback to the clinical team on other study documents e.g., Clinical Monitoring plans, Statistical analysis plans and vendor specifications. Provide training on the EDC and/or eCOA system and/or eCRF Completion Guidelines at Investigator Meetings and to internal and external study team members as needed. Lead database upgrades/migrations including performing User Acceptance Testing. Enter data queries into the EDC system to be resolved at investigational sites and manage the resolution of those queries. Perform reconciliation of data from external data sources against the clinical database. Perform Serious Adverse Event reconciliation activities. Perform database freeze and lock activities. Be able to maintain study eTMF. Participate in the generation of study timelines and manage DM activities against the timelines. Provide mentoring and training to junior level Data Management staff assigned to his/her studies. Assist with the onboarding and/or training of new employees and/or contractors. Participate in regular Clinical Data Operations team meetings and provide input when appropriate. Contribute to or lead department process improvement initiatives which could include the development of data management SOPs, Work Instructions, and process documents. Contribute to a professional working environment including the application of Jazz Pharmaceuticals Code of Business Conduct and Ethics Required Knowledge, Skills, and Abilities Experience in Data Management for the pharmaceutical/biotechnology industry, or equivalent experience in an FDA-regulated environment, including study lead experience. Understands the scope and focus of Phase 1-4 clinical studies and has a proven ability to perform most of the core Data Management tasks and interact with vendors. Possesses a comprehensive understanding of regulatory guidelines and industry standards (e.g., ICH/FDA guidance, CDISC standards, GCDMP, 21 CFR 11, MedDRA, WHO Drug Dictionaries, etc.) and their application to Data Management practice. Has good project management skills and a proven ability to prioritize across multiple tasks. Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors. Experience working with a globally distributed team. Good communication/interaction skills and ability to work in a dynamic and growing organization. Experience of Risk Based Monitoring principles and using critical thinking to assess and manage risk on assigned studies. Possesses strong English language written and verbal communication skills. Possesses solid computer system and technical skills with a strong ability to learn multiple computer applications. Prior experience with different Data Management systems and technologies, and Electronic Data Capture systems is desirable. Able to travel to off-site meetings or training seminars as needed. Required/Preferred Education and Licenses BA/BS, preferably in the scientific/healthcare field #LI-SM1 #LI-remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. Brief Description: The Global Safety Physician serves as the safety expert accountable for the global safety strategy and overall safety profile for Jazz Pharmaceuticals product/s (investigational and marketed) throughout their lifecycle. This includes supporting major pre- and post-marketing safety deliverables including signal, benefit-risk evaluation and risk management activities for specific products. This individual must effectively interface cross-functionally at all levels in the organization as well as with external Regulatory Authorities. This individual will work together with PV management to ensure the safety assessment of priority product/s, including review of aggregate safety analyses and scientific literature, preparing safety reports and communicating changes in the product risk profile to internal and external stakeholders. The ability to work in a dynamic, changing environment to meet corporate and patient needs is essential. Essential Functions Job Responsibilities and Requirements: Lead the preparation and review of safety-related section(s) for product/s. Documents include review of specific clinical, regulatory, and scientific documents including protocols, informed consent/assent forms, case report forms (CRFs), statistical plans, clinical study reports/synopses, integrated summaries of safety, New Drug or Biologic License Applications (NDA/BLA), Marketing Authorization Applications (MAA), Common Technical Document (CTD) submissions, Regulatory Agency responses, IRB/EC requests, briefing books, manuscripts/journal articles and other documents as needed, ensuring safety profile reflected for assigned product/s. Be a key member, as the safety representative, to a Global Regulatory Team and to a Core Development Team. Interface with Risk Evaluation and Mitigation Strategy (REMS) team to optimize risk management of assigned products from a PV perspective. Where relevant, support creation and maintenance of Company Core Safety Information (CCSI) and ensure implementation of CCSI in all Reference Safety Information (RSI) including Investigator Brochures (IBs), Company Core Data Sheet (CCDS), national labels and other associated product labeling. Support review of medical/scientific literature to identify literature relevant for signal detection activities and aggregate reporting for assigned product/s, as needed. Support signal detection activities to ensure signal identification, evaluation, validation, for assigned product including individual and aggregate data analyses; interpretation of safety signals and trends; documentation and communication of safety assessments (written and verbal) of safety risks in collaboration with CRSO and PV management. Participate in or Lead a Safety Management Team (SMT) for an assigned product. Contribute to the preparation and review of pre- and post- marketing aggregate safety reports IND Annual Reports, and 6-monthly Suspected Unexpected Serious Adverse Reactions (SUSARs) Line Listing Reports and ensure consistent communication of safety profile/topics across various regulatory safety documents for assigned product/s. Contribute to preparation of Risk Management Plans (RMPs) for assigned products ensuring identification of risks, appropriate risk minimization and effectiveness measures in accord with regulatory requirements. Provide guidance with adverse event (MedDRA) and drug (WHO Drug) coding for clinical and postmarketing safety data. Demonstrate or gain knowledge of current and applicable global PV regulations and guidelines (e.g., CIOMS, EMA, FDA, ICH, etc.), SOPs and quality standards. Provide safety expertise to due diligence activities, if/ as needed. Keeps abreast of new PV/safety regulations and guidance from the regulatory authorities. Required Knowledge, Skills, and Abilities Minimum Requirements Minimum 2-5 years of Clinical Development, Medical Affairs or Drug Safety/Pharmacovigilance experience; other relevant medical affairs experience may be considered. Excellent knowledge of drug development process. Requires a high level of initiative and independence. Must have excellent written and oral communication skills, resourcefulness and personal organization skills together with demonstrated cross-functional teamwork. Computer literacy with proficiency in external Regulatory Databases, Microsoft Excel, PowerPoint and Word. Some national/international travel may be required. Leadership Skills Enterprise and Proactive Mindset—demonstrate collaborative spirit, understanding the benefit of working with others cross functionally, in a dynamic environment. Set & Achieve Goals: Understand business objectives and effectively translate them into strategies, while skillfully navigating obstacles and resistance to change. Inspire & Mobilize Others: Serve as a positive role model – create followership and effectively mobilize and influence others, both on your teams and across the organization. Understanding of target product profile; clinical designs and/or global PV regulatory environment with working knowledge of international regulations, initiatives, standards and Good Clinical and Pharmacovigilance practices (GCP, GVP). Exposure to working relationship with the FDA, EMA and other regulatory authorities is preferred. Working knowledge of safety databases (ARISg, ARGUS, or other safety database applications) and electronic data capture systems a plus. MedDRA trained and working knowledge of MedDRA and WHO Drug coding dictionaries a plus. Ability to manage multiple tasks with deadlines in fast-pace environment. Required/Preferred Education and Licenses MD required; medical licensure in at least one region preferred; clinical research and/or fellowship training in internal medicine, oncology, neurology, or other relevant specialty is a plus. #LI-Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. FOR US BASED CANDIDATES ONLY Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $(phone number removed) - $(phone number removed) Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis. At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. 1 Essential Functions/Responsibilities The Associate Medical Director / Global Safety Physician is responsible for implementing the global safety strategy and monitoring the overall safety profile for Jazz Pharmaceuticals products (investigational and marketed) throughout its lifecycle. This includes generating all major pre- and post-marketing safety deliverables including signal, benefit-risk evaluation and risk management activities. This individual must effectively interface cross-functionally at all levels in the organization as well as with external Regulatory Authorities. This individual, under supervision from the Senior Medical Director in Medical Safety, will work together with PV staff in managing the safety assessment of products, including review of aggregate safety analyses and scientific literature, preparing safety reports and communicating changes in the product risk profile to internal and external stakeholders. The ability to work in a dynamic, changing environment to meet corporate and patient needs is essential. Provide Medical Safety/PV inputs to the assigned products at Jazz Pharmaceuticals, which may include Clinical Development program of all phases, Investigator Sponsored, Compassionate Use, and Disease Monitoring Programs; liaise with Clinical Sciences, Clinical Operations, Medical Affairs, Biometrics, Regulatory Affairs, Contract Research Organizations (CROs), Data Monitoring Committees (DMCs) and other entities to contribute to overall study execution while ensuring safety strategy and operational excellence Provide Medical safety/PV inputs to Jazz Pharmaceuticals Commercial organization to support global launch activities for assigned products Participate in the preparation and review of safety-related section(s) for clinical, regulatory, and scientific documents including protocols, informed consent/assent forms, case report forms (CRFs), statistical plans, clinical study reports/synopses, integrated summaries of safety, New Drug or Biologic License Applications (NDA/BLA), Marketing Authorization Applications (MAA), Common Technical Document (CTD) submissions, Regulatory Agency responses, IRB/EC requests, briefing books, manuscripts, journal articles and other documents as needed, ensuring safety profile reflected for assigned products Collaborate in the creation and maintenance of Company Core Safety Information (CCSI) and with the Jazz Labeling Committee ensure implementation of CCSI in all Reference Safety Information (RSI) including Investigator Brochures (IBs), Company Core Data Sheet (CCDS), national labels and other associated product labeling Perform review of medical/scientific literature to identify literature relevant for signal detection activities and aggregate reporting for assigned products, as needed Conduct signal detection activities to ensure signal identification, evaluation, validation, for assigned products including individual and aggregate data analyses; interpretation of safety signals and trends; documentation and communication of safety assessments (written and verbal) of safety risks in collaboration with key internal/external stakeholders Chair the Safety Management Team (SMT) of products under authority and participate in other executive forums for assigned products Serve as the signatory and overseer of the preparation and review of pre- and postmarketing aggregate safety reports including Periodic Safety Update Reports (PSURs)/Periodic Benefit Risk Evaluation Reports (PBRERs), Periodic Adverse Drug Experience Reports (PADERs), Development Safety Update Reports (DSURs), IND Annual Reports, and 6-month Suspected Unexpected Serious Adverse Reactions (SUSARs) Line Listing Reports and ensure consistent communication of safety profile/topics across various regulatory safety documents for assigned products Contribute to preparation of Risk Management Plans (RMPs) for assigned products ensuring identification of risks, appropriate risk minimization and effectiveness measures in accord with regulatory requirements Provide guidance with adverse event (MedDRA) and drug (WHODrug) coding for clinical and post-marketing safety data Demonstrate knowledge and ensure compliance with current and applicable global PV regulations and guidelines (e.g., CIOMS, EMA, FDA, ICH, etc.), SOPs and quality standards; active involvement in inspection readiness activities, internal audits and external inspections Represent PV in cross-functional forums and committees involving products under responsibility to achieve the Company’s goals Contribute to key performance indicators to ensure PV excellence Maintain knowledge of Jazz Pharmaceuticals indications for investigational and/or marketed products assigned Keeps abreast of new PV/safety regulations and guidance from the regulatory authorities 2 Required Knowledge, Skills, and Abilities Understanding of global PV regulatory environment with working knowledge of international regulations, initiatives, standards and Good Pharmacovigilance practices (GVP) including but not limited to Americas and European Union, territories including an understanding of case processing procedures and other pharmacovigilance processes Working knowledge of safety databases (ARISg, ARGUS, or other safety database applications) and electronic data capture systems MedDRA trained and working knowledge of MedDRA and WHO Drug coding dictionaries Working experience with PV audit process with active participation in Regulatory Authority Inspections is preferred Ability to manage multiple tasks with deadlines in fast-paced working environment Knowledge of drug development process Requires a high level of initiative and independence Must have excellent written and oral communication skills, resourcefulness and personal organization skills together with demonstrated cross-functional teamwork Computer literacy with proficiency in external Regulatory Databases, Microsoft Excel, PowerPoint and Word Some national/international travel may be required 3 Required/Preferred Education and Licenses MD required (or equivalent); medical licensure in at least one state preferred; clinical research and/or fellowship training in internal medicine or neuroscience, hematology/oncology or other relevant specialty is a plus Minimum 3 years of Drug Safety/Pharmacovigilance (PV) experience or 3 or more years clinical development experience. Other relevant experience may be considered #LI-Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. FOR US BASED CANDIDATES ONLY Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $(phone number removed) - $(phone number removed) Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis. At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here

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