Principal scientist jobs in San Diego, CaliforniaCreate job alerts

Description Are you a motivated Research Scientist specializing in Computational Design and Manufacturing with a technical vision and hands-on knowledge of mission-focused systems? The Leidos Innovations Center’s newly established Information and Data Science Division is seeking a Principal Autonomy and Resilient Systems Scientist to help lead strategic solution developments and projects. The ideal candidate will have a proven track record in developing technology-based approaches that yield novel, innovative capabilities while advancing the state of the art. We are looking for a proven researcher who can develop and lead a groundbreaking research portfolio using both internal and customer funding. Primary Responsibilities • Develop innovative solutions to challenging problems of interest to the Defense Applied Research Projects Agency (DARPA), the U.S. Department of Defense (DoD), and Intelligence Community (IC)., • Engage R&D customers and transition partners to understand technical gaps and needs for computational design and crisis manufacturing for mission critical systems., • Lead teams that execute advanced research in areas of autonomy, optimization, and generative design., • Develop and deliver complex AI/ML model pipelines and software products., • Collaborate in cross-discipline teams to deliver innovations that provide measurable mission impact., • Track technology trends in the customer and broader R&D communities. Basic Qualifications • Proven track record developing and delivering complex AI/ML model pipelines and software products., • Bachelor’s degree in Computer Science, Applied Mathematics, Industrial Engineering or a related field and 12+ years prior relevant experience, M.S degree with 10+ years of prior relevant experience, or Ph.D. with 8+ years of experience (Ph.D. preferred), • Industry and/or academic experience in generative design, constrained optimization, automated planning, or AI-enabled CAD integration., • Past experience optimizing manufacturing processes through systems engineering and operations research., • At least 4 years of experience with programming languages such as Python, C/C++, Rust, or MATLAB., • Strong verbal and written communication skills, with experience engaging with senior leadership and technical teams as well as ability to present complex technical solutions in a clear, understandable manner., • Ability and willingness to obtain and maintain a DoD Secret clearance. U.S. citizenship is required. Preferred Qualifications • Proven track record in proposing, winning, and executing contract R&D with customers such as DARPA, IARPA, or similar agencies within the last 5 years., • Ph.D. in Computer Science, Applied Mathematics, Industrial Engineering or a related degree., • Strong publication track record demonstrating experience advancing the state of the art in generative design, constrained optimization, automated planning, or AI-enabled CAD integration., • Domain experience in design and manufacturing of naval, air, or surface platforms and autonomous systems., • Experience with simulation, manufacturing automation systems, and digital twin frameworks., • Experience with automation and industrial control languages for integrating legacy equipment., • Strong and proven customer relationship skills including the ability to discover the true technical challenges and requirements associated with opportunities, recommend alternative technical approaches, and shape future opportunities., • Proven experience forming strong teams composed of members from academia and industry for competitive research and development opportunities., • Active DoD Secret clearance., • Ability and willingness to work a hybrid schedule onsite in either San Diego California or Arlington Virginia. If you're looking for comfort, keep scrolling. At Leidos, we outthink, outbuild, and outpace the status quo — because the mission demands it. We're not hiring followers. We're recruiting the ones who disrupt, provoke, and refuse to fail. Step 10 is ancient history. We're already at step 30 — and moving faster than anyone else dares. December 1, 2025 For U.S. Positions: While subject to change based on business needs, Leidos reasonably anticipates that this job requisition will remain open for at least 3 days with an anticipated close date of no earlier than 3 days after the original posting date as listed above. Pay Range $126,100.00 - $227,950.00 The Leidos pay range for this job level is a general guideline only and not a guarantee of compensation or salary. Additional factors considered in extending an offer include (but are not limited to) responsibilities of the job, education, experience, knowledge, skills, and abilities, as well as internal equity, alignment with market data, applicable bargaining agreement (if any), or other law. About Leidos Leidos is an industry and technology leader serving government and commercial customers with smarter, more efficient digital and mission innovations. Headquartered in Reston, Virginia, with 47,000 global employees, Leidos reported annual revenues of approximately $16.7 billion for the fiscal year ended January 3, 2025. For more information, visit ___. Pay and Benefits Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available at ___. Securing Your Data Beware of fake employment opportunities using Leidos’ name. Leidos will never ask you to provide payment-related information during any part of the employment application process (i.e., ask you for money), nor will Leidos ever advance money as part of the hiring process (i.e., send you a check or money order before doing any work). Further, Leidos will only communicate with you through emails that are generated by the Leidos.com automated system – never from free commercial services (e.g., Gmail, Yahoo, Hotmail) or via WhatsApp, Telegram, etc. If you received an email purporting to be from Leidos that asks for payment-related information or any other personal information (e.g., about you or your previous employer), and you are concerned about its legitimacy, please make us aware immediately by emailing us at ___. If you believe you are the victim of a scam, contact your local law enforcement and report the incident to the ___. Commitment to Non-Discrimination All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws. #Remote

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. For t

Collaborate with cross-functional partners (medicinal chemistry, computational genomics, molecular and cellular biology, pharmacology, protein sciences) to support integrated drug discovery programs from target validation through lead optimization. Apply innovative approaches and stay current with a

A leading biotech company is seeking a Senior / Principal Machine Learning Scientist in San Diego, CA.You will contribute to developing advanced AI and ML models for biological applications, playing a crucial role in transforming medical science.The ideal candidate has 6+ years of relevant experienc

Apply innovative approaches and stay current with advances in receptor biology, ligand discovery, and nucleic acid therapeutics to strengthen pipeline opportunities. Strong expertise in receptor biology, ligand-receptor interactions and signaling mechanisms. Master's degree (or equivalent) in biolog

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. Neurocrine Biosciences is an EEO/Disability/Vets employer. At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and pos

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. Neurocrine Biosciences is an EEO/Disability/Vets employer. At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and pos

Job Description Principal Scientist, Toxicology - Simply Biotech OVERVIEW Are you looking for a new career opportunity with an exciting biotech company?! Then we have got the right team for you! In this role, you are responsible for the duties listed below. Immediate opening for a Principal Scientist, Toxicology in San Diego, CA who possess: • Ph.D. in Toxicology, Pharmacology, or a related scientific discipline., • Minimum of 5–7 years of experience designing, directing, and interpreting GLP toxicology studies, preferably within a CRO environment. Demonstrated record of serving as Study Director for multiple GLP studies, with completed studies that contributed to successful FDA submissions., • Experience preparing or contributing to IND/NDA/BLA nonclinical packages, with familiarity interacting with FDA, • DABT Certification is strongly preferred Email resumes to and call 858.427.3668. FULL DESCRIPTION: The Principal Toxicologist serves as the primary scientific expert and client-facing lead within our preclinical research group. You will design, oversee, and interpret a broad range of GLP-compliant toxicology studies for pharmaceutical and biotechnology partners. You will also be responsible for leading multiple GLP studies as Study Director, ensuring data integrity, study execution, and scientific interpretation that support regulatory submissions including IND, NDA, and BLA. The right candidate will have demonstrated success in navigating FDA expectations, preparing high-quality nonclinical packages, and contributing directly to regulatory approvals. The selected candidate will be responsible for: • Scientific Strategy and Client Partnership, • Serve as the principal scientific contact for clients, building long-term partnerships grounded in trust, transparency, and technical excellence., • Collaborate with clients to understand program objectives, ensuring study designs reflect both regulatory expectations and drug development goals rather than generic service deliverables., • Develop scientifically rigorous and customized toxicology study designs that align with FDA guidance, ICH expectations, and clinical-stage needs., • Study Oversight and Execution, • Function as Study Director for GLP toxicology studies, with responsibility for scientific conduct, data accuracy, final reporting, and regulatory readiness., • Maintain a strong portfolio of completed studies, demonstrating consistent success from protocol development through final reporting and client delivery., • Lead cross-functional coordination across in vivo and in vitro operations to ensure efficiency, consistency, and GLP compliance., • Monitor study performance proactively to identify risks, troubleshoot issues, and maintain timelines., • Data Analysis and Reporting, • Integrate toxicology, pathology, and clinical pathology data to generate meaningful, defensible conclusions for regulatory and scientific purposes., • Prepare, review, and sign off on high-quality study reports that accurately reflect study outcomes and support regulatory submissions., • Communicate study findings clearly and confidently in client meetings, regulatory interactions, and technical presentations., • Regulatory and Quality Assurance, • Ensure all studies are performed in full compliance with FDA GLP regulations and applicable international guidelines (e.g., ICH, OECD, ISO 10993)., • Support clients by authoring or contributing to nonclinical sections of IND, NDA, and BLA submissions, leveraging direct experience with FDA expectations., • Represent our Research during audits and health authority inspections, providing scientific and regulatory justification for study decisions and data integrity. The selected candidate will also possess: • Ph.D. in Toxicology, Pharmacology, or a related scientific discipline., • Minimum of 5–7 years of experience designing, directing, and interpreting GLP toxicology studies, preferably within a CRO environment., • Demonstrated record of serving as Study Director for multiple GLP studies, with completed studies that contributed to successful FDA submissions., • Experience preparing or contributing to IND/NDA/BLA nonclinical packages, with familiarity interacting with FDA or supporting sponsor regulatory strategy., • Proven ability to distinguish between CRO service execution and the strategic, milestone-driven requirements of drug development., • D.A.B.T. certification strongly preferred (or active pursuit/eligibility). Salary Range: $160-210k/year For immediate and confidential consideration, please email your resume to and call 858.427.3668. More information can be found at Company DescriptionSimply Biotech was founded in 2008 and has been repeatedly recognized as one of San Diego County's fastest growing businesses. In 2025, we were named Business Journal's 'Best Places to Work'. Even as our competitors are scaling back and laying off staff, Simply Biotech is expanding to new markets and hiring additional staff in existing offices.Simply Biotech was founded in 2008 and has been repeatedly recognized as one of San Diego County's fastest growing businesses. In 2025, we were named Business Journal's 'Best Places to Work'. Even as our competitors are scaling back and laying off staff, Simply Biotech is expanding to new markets and hiring additional staff in existing offices.

Job DescriptionDescription: Founded in 2010, Terraphase Engineering is a dynamic, privately owned environmental consulting firm seeking a Principal Environmental Compliance Consultant (Scientist, Geologist, or Engineer) with 16+ years of professional experience to help grow and support our Compliance Services Division, one of Terraphase’s four core Service Areas—alongside Environmental, Site Engineering, and Water Resources. The Compliance Division offers significant career growth as one of our fastest growing service areas and is central to Terraphase’s long-term growth strategy, with dedicated resources and leadership focused on expanding our reach and capabilities. This is a senior leadership opportunity for a proven seller–doer—a consultant who combines deep technical expertise with a strong record of cultivating and sustaining client relationships while delivering practical compliance solutions. At Terraphase, you’ll enjoy the personal attention and entrepreneurial culture of a small-to-mid-sized firm (fewer than 200 people), backed by the technical depth, multidisciplinary resources, and geographic reach of a company with offices across the U.S. You’ll have the platform to shape strategy, mentor emerging talent, and deliver tailored, high-value service to clients in a variety of industries—all while contributing to the continued growth of our compliance practice through your network and technical expertise. Our compliance professionals help clients meet critical environmental and safety standards, contributing to healthier communities and sustainable operations. The Role • Maintain comprehensive knowledge of federal, state, and local environmental regulations (CWA, RCRA, CAA, EPCRA, etc.)., • Lead large-scale and multi-state compliance programs., • Serve as a trusted advisor to clients, guiding regulatory negotiations and agency interactions., • Manage diverse projects—compliance audits, gap analyses, discharge monitoring, tank programs, litigation support, and permitting efforts., • Develop proposals, scopes, budgets, and schedules while ensuring client satisfaction and profitability., • Lead teams for responses to small and large RFPs/SOQs, • Oversee and mentor a team of consultants, scientists, and engineers, while managing subcontractors and vendors., • Provide quality assurance and technical reviews of deliverables, including reports, plans, and specifications., • Support project bidding, contract solicitation, and business development opportunities., • Collaborate across disciplines to deliver innovative, cost-effective compliance solutions., • 16+ years of consulting experience with a focus on environmental compliance., • Bachelor’s degree in Engineering, Geology, Environmental Science, or related discipline., • Demonstrated ability to lead compliance programs and manage client portfolios., • Recognized expertise in federal and multi-state regulatory frameworks., • Strong record of client development and relationship management., • Professional licensure such as CHMM or proven leadership in subject matter areas (Hazardous Waste, Stormwater, Air), • Experience using many government platforms such as US EPA CDX, CERS, RCRAInfo / myRCRAid, TRI-MEweb, ECHO, E-Plan, and similar compliance systems. Terraphase offers an extensive benefits package including; Medical, Dental, Vision, Employer Paid Life Insurance, Long-Term Disability, a generous 401(k) match, Commuter Benefits, TerraLunches, TerraTalks, Tuition/Licensing/Professional Development Reimbursement, Flexible Work Schedule, ongoing company-sponsored events. Terraphase is a privately-owned S-Corp with a path to ownership. EOE Statement Terraphase is an Equal Opportunity Employer, committed to an inclusive & diverse work environment where individual strengths and diverse viewpoints are respected and complement each other to achieve common goals. (EOE M/V/F/D) Salary Compensation for this position is based on years of experience, technical expertise, technical education, and geographic location with a range of $135,000-$200,000. Requirements:

Job DescriptionSr. Principal Scientist / Associate Director – Antibody Engineering Location: San Diego, CA Employment Type: Full-time Hiring Company: BioPhase (on behalf of our client) Pay: $170,000–$190,000 base + bonus; stock options Hours: Monday–Friday, full-time (no overtime) Job Description: We’re seeking a hands-on scientific leader to head Protein/Antibody Engineering. You’ll guide strategy and execution from hit discovery through optimization to development candidate, manage a small team, and partner closely with cross-functional groups to advance novel biologics. Essential Duties and Responsibilities: • Serve as subject-matter expert for protein/antibody engineering, formatting, and structure–function hypotheses., • Lead, mentor, and develop protein engineering scientists; provide technical oversight., • Act as project lead to deliver milestones across discovery programs., • Collaborate with biology, computational, and development teams to progress hits into developable candidates., • Design/build antibody & protein combinatorial libraries; plan and run engineering campaigns., • Drive continuous improvement of lab workflows and data practices., • Oversee curation/aggregation of experimental & in-silico data to inform predictive models., • MS/PhD in Biochemistry, Chemistry, or related field with 7+ years biopharma experience., • Deep knowledge of protein structure, interactions, and physicochemical properties., • Proven people leadership and experience managing scientists., • Track record leading cross-functional programs from target validation through optimization to candidate nomination., • Advanced understanding of multiple antibody formats (mAbs, bi/multispecifics, scFv, sdAbs, etc.)., • Extensive hands-on experience in antibody/protein engineering (humanization, liability removal, optimization)., • Familiarity with developability assessments (solubility, stability, manufacturability) and using them to guide design., • Experience with plate-based assay development & high-throughput workflows., • Engineering of small proteins/enzymes.

Job Description Job Title: Veterinary Research Scientist Primary Responsibilities: This position requires a broad knowledge of the anatomy and physiology of small and large animals to help develop and support in vivo models to screen therapeutics and devices being developed for various disorders. Experience with surgical, dosing and sampling techniques is required. In addition, the Veterinary Scientist is responsible for assisting in the clinical care of animals on surgical studies including post-operative monitoring and evaluations. Principal Duties and Responsibilities * Perform surgical support and provide anesthesia, surgical, and analgesic technical expertise/advice to facilitate protocol development. * Provide clinical and technical support to internal and external customers, regarding surgical models and services. * Serve as the Research Lead or Study Director responsible for preclinical studies in various species. * Assist in the preparation and review of study protocols and reports. * Provide support for activities of the Institutional Animal Care and Use Committee (IACUC), including protocol review, program review, and facility inspections. * Assist in activities to ensure the facility is in compliance with all applicable regulations, guidelines, and standards that relate to animal care and use. (USDA, FDA, and AALAC) * Train staff on in-vivo procedures * Make recommendations and assist in establishing and enhancing veterinary and animal care standards * Will administer controlled substances and be responsible for maintaining appropriate records. * May develop new or innovative surgical techniques or other procedural improvements appropriate to research studies. * Perform special projects and assist with administrative efforts as needed. Candidate Requirements: * Background in lab animal (in vivo) research with a focus on surgical techniques is a must. * Ability to perform study duties and responsibilities in multiple species with minimal supervision. * Must be flexible to work various schedules and hours as well as provide comprehensive, after hours, and on-call coverage as needed. * This position requires good communication skills and attention to detail. * Strong work ethic, self-motivation, and the ability to adapt to a dynamic team/work environment are keys to success. Education: * Degree in veterinary medicine (BVM, DVM, or VMD) preferred. * Graduate-level degree (M.S. or Ph.D.) in pharmaceutical science, life sciences, or pharmacology considered. Experience: * Minimum 5-7 years of relevant industry experience depending on education level. * Experience working with both small and large animals preferred. * Working knowledge of imaging modalities (TEE, C-arm) will be a plus * A comprehensive understanding of the requirements for GLP study execution and documentation is required.

A biotechnology company in San Diego is seeking a Principal Scientist/Director in Biology to lead preclinical research.

Job Description The Sr. Air Quality Engineer / Scientist (Environmental Permitting and Compliance Specialist) performs professional engineering work, leading and executing the compliance and permitting functions in relation to Air Quality Regulations and Compliance. This candidate will be reviewing processes and equipment, analyzing permit-related technical and regulatory issues, and communicating those analyses within Yorke, the client organization, with government agencies and with the public at large. The work is challenging, broad in scope, and variable from project to project. The position involves effective communication, decision-making, and time management. The candidate performs other duties as required or assigned. This is a Senior to Principal level position. Positions at this level are assigned to perform the more complex and sensitive duties in the occupational field. The employee in this position may be assigned to train and mentor other employees and/or monitor work produced by other employees. The candidate qualifications we are seeking include: • 10-20+ years of work experience in the Air Quality and/or Environmental industry in an engineering role (preferably in a consulting environment);, • Experience in the environmental services industry focusing on leading Air Quality services:, • Process and equipment review;, • Air quality permitting under SCAQMD and other Air Districts, including Title V Permitting;, • RECLAIM implementation and reporting;, • Annual Emissions Reporting;, • Air Dispersion Modeling;, • Air Quality Assessments including Data Analysis and Emission Inventories;, • General Air Quality Compliance for facilities in CA., • Ability to manage and lead active team members on project teams towards project completion within project scope, budget and schedule and ensure quality work product and deliverables;, • Ability to manage successful relationships with clients, staff, and regulators through effective communication and expertise by fostering a collaborative environment without losing focus of quality;, • Proven track record or desire to engage in successful regulatory work in dealing with the SCAQMD, EPA, CARB and/or other similar regulatory agencies;, • Experience working on-site at client facilities;, • Prepare reports and submissions in timely manner;, • Experience with handling highly technical data and technical data interpretation;, • Highly motivated to continue working in Air Quality environmental field and expand their knowledge and experience;, • B.S or M.S. degree in Chemical Engineering, Environmental Engineering, or Mechanical Engineering, or other relevant technical degrees from an accredited college (minimum GPA of 3.0);, • Ability to work collaboratively in a team fashion, handle several projects at once, prioritize work, and work efficiently;, • Desire to train and share technical expertise in environmental rules and regulations with clients and team members;, • Excellent oral and written communications skills;, • Experience in conflict resolution and crisis management;, • Track record of successful analysis, interpretation, and application of rules and regulations towards practical solutions;, • Ability to think critically and develop solutions;, • Software Knowledge:, • Strong Microsoft Excel, Word, Outlook, and Powerpoint skills (required);, • Microsoft 365 Applications, including Sharepoint (a plus), • P.E. Certification (a plus);Company DescriptionJoin Yorke Engineering, LLC, an Environmental Consulting leader in California that implements Environmental Engineering and Compliance solutions for our clients throughout California. Our mission is to solve environmental compliance problems for industrial and governmental/infrastructure facilities. We are a growing and dynamic organization of highly respected professionals. Yorke Engineering, LLC has assisted over 2,000 client organizations with their Air Quality and Environmental Compliance, Engineering, and Permitting needs. Our philosophy is to efficiently help government and industrial customers with the complex array of environmental laws and regulations. From simple permits to complex agency negotiations, from small companies to the largest of California’s organizations, Yorke successfully solves our clients’ Air Quality and Environmental challenges. Our team has over 1,000 years of combined environmental experience and consists of engineers and scientists that specialize in Air Quality, Waste, Water, CEQA, Safety, and Industrial Hygiene.Join Yorke Engineering, LLC, an Environmental Consulting leader in California that implements Environmental Engineering and Compliance solutions for our clients throughout California. Our mission is to solve environmental compliance problems for industrial and governmental/infrastructure facilities. We are a growing and dynamic organization of highly respected professionals. Yorke Engineering, LLC has assisted over 2,000 client organizations with their Air Quality and Environmental Compliance, Engineering, and Permitting needs. Our philosophy is to efficiently help government and industrial customers with the complex array of environmental laws and regulations. From simple permits to complex agency negotiations, from small companies to the largest of California’s organizations, Yorke successfully solves our clients’ Air Quality and Environmental challenges. Our team has over 1,000 years of combined environmental experience and consists of engineers and scientists that specialize in Air Quality, Waste, Water, CEQA, Safety, and Industrial Hygiene.

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This role provides clinical pharmacology and pharmacometrics leadership for assigned development programs and may be based in San Diego, CA or Madison, WI. The position is responsible for contributing to clinical trial design, authoring key protocol and regulatory sections, and performing hands-on PK/PD analyses to guide dose selection and program strategy. It oversees the preparation and authorization of PK analysis reports, CSR content, and clinical pharmacology components of global regulatory submissions Responsibilities • Provide Clinical Pharmacology and pharmacometrics leadership for designated programs, contribute to design of clinical trial protocols and relevant sections in Investigational Brochure (IB), conduct hands-on analysis of clinical or translational PKPD data, support dosing strategies and clinical pharmacology planning. Authorize clinical PK analysis reports and relevant sections in the Clinical Study Report (CSR)., • Provide high quality documentation of clinical pharmacology analysis compatible with global regulatory submission requirements. Authorize clinical pharmacology modules of CTD to support global filings of marketing application., • Provide timely communication of analysis results and interpretation with drug development teams., • PhD or PharmD in the field of pharmacokinetics, pharmacology or pharmaceutical science,, • 3 years of pharmaceutical industry experience in clinical-stage drug development., • Good understanding of FDA/EMA/ICH guidance related to clinical pharmacology, • Established experience in clinical NCA PK analysis and data reporting using Phoenix WinNonlin with familiarity of authorizing PK study report., • PBPK/PD modeling California pay range $120,000—$170,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Job Description Research Scientist/Study Director Ocular Description: We are seeking to find an accomplished Ocular Scientist with requirements of a broad knowledge of Ocular anatomy, physiology, and biochemistry to help develop and support in vivo models to screen small molecule, cell/gene therapy, as well as large molecule therapeutics and devices being developed for various ocular disorders. Experience with ocular surgical, dosing and sampling techniques is necessary. The Ocular Research Scientist will assist in the development of protocols and criteria to effectively and efficiently carry out experiments. The successful candidate will provide investigators with written and oral updates to scientific data generated during the conduct of the studies they oversee. They may also participate in presentations at scientific meetings and/or preparation of manuscripts for presentations. Expertise to guide investigators on the approaches necessary to characterize the pharmacological effects of target molecules based on disease mechanisms is valuable. Principal Duties and Responsibilities: The Scientist will perform the following duties and responsibilities: * Assume the functional role of Principal Investigator or Study Director for preclinical ophthalmic studies. * Participate in study design and the development and generation of study protocols. * Manage the conduct of preclinical studies, evaluated the data, and assist in the writing and review of final reports. * Develop and execute research studies to expand research capabilities. * Develop and execute training programs for research associates and junior team members. * Write or revise Standard Operating Procedures (SOPs) to assure facility compliance with applicable regulations, client expectations, and current industry standards. * May be asked to serve on the Institutional Animal Care and Use Committee (IACUC) Requirements: * Hands-on in vivo experience with multiple research species, at a minimum, rodent, and rabbit. * Ability to perform ocular injections, such as sub-conjunctival, sub-tendon, retrobulbar, intravitreal, and/or subretinal injections. * Experience with various imaging modalities, such as Optical coherence tomography (OCT), fundus photography, and fluorescein angiography. * Experience with other ocular techniques, such as intraocular pressure measurements, electroretinography (ERG), or optokinetic response (OKR). * Ability to perform duties and responsibilities with minimal supervision * Ability to understand Standard Operating Procedures (SOPs) and study protocols. * Must be flexible to work various schedules and hours as well as provide comprehensive, after-hours, and on-call coverage as needed. Education * Graduate-level degree (M.S./ PhD/ DVM, VMD) required. Post Doctoral candidates are preferred. * Additional training in the GLPs and other applicable regulations required. Experience * Minimum 3-6 years of experience required, based on education.

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values.We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.Neurocr

We collaborate with colleagues in both the discovery and development organizations, including scientists in therapeutic area biology, biomolecule formulation and developability, ADME, Toxicology, PK/PD, Statistics, Computational Biology and clinical development. We are seeking a highly motivated and

Principal Scientist, Data Science/Associate Director, Data Science. Principal Scientist, Data Science: $160,300 and $297,700 per year, and Associate Director, Data Science: $176,400 and $327,600 per year.

Principal Scientist, Protein Sciences. Lead, mentor, train, and manage members of the Protein Sciences group, including Scientists and Research Associates. At iBio, your expertise will shape the future of biologics, with opportunities to drive innovation, collaborate with top scientists, and make a

We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. This particular role may also be suitable for PhD-level scientists with degrees in organ

Senior Principal Scientist, Computational Multiomics, Precision Measures. Experience in leading interdisciplinary teams including scientists, data analysts and clinicians. Demonstrated interpersonal skills with the ability to work effectively with an interdisciplinary team, including laboratory scie

This Senior Principal Scientist position will be a strong scientific and leadership role within the Early Formulation Science and Drug Delivery (EFS-DD) group, supporting early-stage drug and drug product design, materials science characterization and strategy, and biopharmaceutics understanding as

Global Discovery Chemistry at BR is seeking a passionate and innovative Senior Principal Scientist with a Ph. Collaborate closely with cross-functional teams including computational chemists, biologists, protein scientists and pharmacologists. Mentor and coach scientists, fostering their development

Depending on experience, career aspirations, and business needs, candidates may be considered for either the Sr Director or Sr Principal Scientist role. The estimated base salary range for the Sr Director/ Sr Principal Scientist, Protein Engineering role based in the United States of America is: $22

This Senior Principal Scientist position will be a strong scientific and leadership role within the Early Formulation Science and Drug Delivery (EFS-DD) group, supporting early-stage drug and drug product design, materials science characterization and strategy, and biopharmaceutics understanding as

Senior Principal Scientist, Computational Multiomics, Precision Measures. Demonstrated interpersonal skills with the ability to work effectively with an interdisciplinary team, including laboratory scientists, bioinformaticians, statisticians, and data analysts. Experience in leading interdisciplina

Principal Scientist, Data Science/Associate Director, Data Science. Principal Scientist, Data Science: $160,300 and $297,700 per year, and Associate Director, Data Science: $176,400 and $327,600 per year.

The Principal Research Scientist will focus on targeted drug delivery including nucleic acid therapies.

Safety Scientist Lead for assigned programs or studies.

In close partnership with principal investigators, dedicated medical professionals, patient advocacy groups, and regulatory authorities, you will drive the evidence needed to optimize patient outcomes.

We collaborate with colleagues in both the discovery and development organizations, including scientists in therapeutic area biology, biomolecule formulation and developability, ADME, Toxicology, PK/PD, Statistics, Computational Biology and clinical development. We are seeking a highly motivated and

A leading medical technology company in California is seeking an experienced professional to lead the development of machine learning solutions for clinical trials.The role involves collaborating across teams to enhance data-driven decision-making and ensure data accuracy.Candidates should have a re

Intuit is hiring a Principal Data Scientist to join our Intuit AI team. Come join our collaborative and creative group of data scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers.

Join the Intuit Customer Success team as a Principal Data Scientist within our Expert Network. Mentor senior data scientists and establish best practices in experimental design, model validation, and responsible AI usage; drive a culture of analytical excellence and scientific rigor.

Principal Scientist / Director, Biology – Respiratory Research. We are seeking a Principal Scientist or Director‑level Biologist with a strong background in respiratory pharmacology and translational medicine to lead preclinical research activities.

A leading financial software company seeks a Principal Data Scientist for their Customer Success team in San Diego, California.

Principal Scientist, Machine Learning: $376,550 - $509,450. Senior / Principal Machine Learning Scientist Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. What You Will Contribu

In close partnership with principal investigators, dedicated medical professionals, patient advocacy groups, and regulatory authorities, you will drive the evidence needed to optimize patient outcomes.

A leading medical technology company in California is seeking an experienced professional to lead the development of machine learning solutions for clinical trials.The role involves collaborating across teams to enhance data-driven decision-making and ensure data accuracy.Candidates should have a re

Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers.

Principal Scientist, Oligonucleotide Chemistry Research.

We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, wit

Principal Scientist, DMPK page is loaded Principal Scientist, DMPKremote typeOn-Site locationsUS CA San Diego time typeFull time posted onPosted Today job requisition idR5444 Who We Are:At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive c

Join the Intuit Customer Success team as a Principal Data Scientist within our Expert Network. Mentor senior data scientists and establish best practices in experimental design, model validation, and responsible AI usage; drive a culture of analytical excellence and scientific rigor.

Sr Director/ Sr Principal Scientist, Protein Engineering page is loaded## Sr Director/ Sr Principal Scientist, Protein Engineeringlocations: US - California - San Diegotime type: Full timeposted on: Posted Todayjob requisition id: 41713-JOB## At Illumina, we are expanding access to genomic t

Join the Intuit Customer Success team as a Principal Data Scientist within our Expert Network. Mentor senior data scientists and establish best practices in experimental design, model validation, and responsible AI usage; drive a culture of analytical excellence and scientific rigor.

Principal Scientist, Preclinical Toxicology. Principal Scientist, Preclinical Toxicology. We are seeking a highly experienced and forward‑thinking Principal Toxicologist to join our scientific leadership team.

Principal Scientist, Data Science/Associate Director, Data Science Position Location:. Principal Scientist, Data Science: $160,300 and $297,700 per year, and Associate Director, Data Science: $176,400 and $327,600 per year.