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ROLE OVERVIEW An exciting opportunity has arisen for a Computational Chemist to join our client's innovative team, supporting their cutting-edge drug discovery pipeline. Based in the UK, you will be instrumental in applying and developing computational techniques to advance the design and optimization of new therapeutics. This role offers the chance to work within a highly collaborative environment alongside multi-disciplinary teams dedicated to transforming scientific insights into tangible healthcare solutions. Our client is seeking candidates with a strong background in computational chemistry methods, including molecular dynamics, virtual screening, and machine learning applications. Whether you're at Senior Scientist, Associate Principal Scientist, or Principal Scientist level, this is a fantastic opportunity to make a real impact in the field of drug discovery. KEY DUTIES AND RESPONSIBILITIES Your duties as the Computational Chemist will be varied; however, the key responsibilities are as follows: Lead the development and execution of computational strategies across multiple drug discovery projects, from hit identification to lead optimization. Apply advanced molecular dynamics simulations (e.g., using AMBER, GROMACS, OpenMM) to investigate protein-ligand interactions and system behavior. Develop and utilize predictive QSAR models and machine learning techniques to improve molecular properties such as potency, selectivity, and ADMET. Design, implement, and maintain bespoke computational tools and workflows to analyze and visualize complex chemical and biophysical data. As the Computational Chemist, you will mentor and train discovery scientists in computational methods, empowering the wider team to utilize these approaches effectively.ROLE REQUIREMENTS To be successful in your application to this exciting role as the Computational Chemist, we are looking to identify the following on your profile and past history: A Degree or higher level in Chemistry, Biochemistry, or a related scientific field (e.g., Computational Chemistry / Drug Discovery / Machine Learning). Proven expertise applying computational chemistry methods within industrial or post-doctoral settings, with demonstrated coding skills (particularly in Python) and experience using HPC resources (on-premise or cloud platforms like GCP or AWS). Strong knowledge of cheminformatics tools and AI/ML techniques relevant to drug discovery, with the ability to critically evaluate and implement these technologies.WHAT’S IN IT FOR YOU? Joining our client offers a dynamic environment where innovation and scientific excellence are at the forefront. You will contribute to pioneering projects that have the potential to make a significant impact on healthcare, working in a collaborative atmosphere that encourages professional growth and development. Key Words: computational chemistry / drug discovery / molecular dynamics / machine learning / QSAR / protein-ligand interactions / HPC / cheminformatics / biophysical data / AI / Python / workflow development "Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer. We welcome applications from anyone who meets the role requirements. HRS exclusively supports the STEM sectors, combining recruitment expertise with scientific knowledge to help you advance your career

If you are a current Jazz employee please apply via the Internal Career site. Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit for more information. The Associate Director, Medical Safety (Scientist) is a key member of the Medical Safety team. This role is responsible for ensuring up to date processes / procedures for safety governance, signal management, clinical surveillance, periodic safety reporting, and risk management and/or driving innovation initiatives within Medical Safety organization. In close collaboration with Medical Safety Physician and/or Medical Safety Scientist line manager, this role is also responsible for contributing to regulatory submission safety strategy. Other responsibilities include but are not limited to: signal management activities, production of aggregate safety reports (e.g., DSURs, PADERs, PBRERs), provision of high-level scientific expertise in the safety evaluation and risk management strategies of assigned products (e.g, signal evaluation reports, health hazard evaluations, and RMPs), global leadership / representation of Medical Safety within the company (e.g., leading Safety Management Teams, presenting at Executive Safety Board meetings), and SME support for HA inspections. Essential Functions • Leads cross-functional safety management teams (SMTs) and drives safety strategy for responsible product/program., • Ensures that processes and procedures are up to date to meet regulatory requirements and inspection readiness, • Drives signal management process using available methodologies, including making recommendations for the assessment and prioritization of safety concerns., • Effectively communicates with members of the interdisciplinary team regarding ongoing signal evaluation., • Ensures that available safety information is evaluated in order to meet both internal and external requirements, including identifying the need for labeling updates. Produces accurate and fit for purpose evaluation documents with clear conclusions, as required., • Leads the coordination of aggregate safety reports (PBRERs, DSURs, PADERs) and authors relevant sections, as appropriate., • Authors or provides guidance for the production of risk management plans (RMPs)., • Provides strategic input into regulatory requests / responses., • Delivers clinical safety input into clinical development program., • Leads the medical safety contributions of global regulatory submissions for new products, formulations or indications., • Participates in and/or leads internal safety surveillance meetings as well as joint safety meetings with licensing partners, as needed., • Provides medical safety input into creation / review of Safety Data Exchange Agreements and/or other PV agreements., • Escalates issues / concerns to senior management in a timely and appropriate manner., • Mentors and trains junior members of the Medical Safety team. Required Knowledge, Skills, and Abilities Minimum Requirements • At least 6 years of experience in drug safety, including at least 4 years of experience in surveillance / risk management., • Ability to independently search clinical safety and literature databases for relevant information., • Expert knowledge of pharmacovigilance regulations regarding aggregate safety reports, risk management plans, and signal management., • Excellent medical writing skills, as well as proven ability to effectively lead interdisciplinary teams., • In-depth knowledge of medical and drug terminology, as well as the clinical development process., • Familiarity with MedDRA and safety databases; Proficient with Windows applications, and ability to learn new programs / databases. Required/Preferred Education and Licenses Requires a degree (e.g., BS, BA, MSc or PhD) or professional qualification in a life science field (e.g., nursing or pharmacy) or a relevant scientific/technical discipline and experience. #LI - Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. FOR US BASED CANDIDATES ONLY Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $(phone number removed) - $(phone number removed) Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis. At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here