Senior Manager, Data Sciences
23 hours ago
Uxbridge
At Bristol Myers Squibb, our employees often ask, "Who are you working for?"-a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. Are you a hands-on data scientist with a passion for turning complex, multi-modal data into actionable insights that shape clinical decisions? Bristol Myers Squibb is seeking a Senior Manager, Data Science to join our Drug Development Data Science & Advanced Analytics (DSAA) team. • Develop and apply novel computational methods for patient segmentation, biomarker discovery, and hypothesis generation from multimodal clinical and omics datasets, in partnership with Translational, Clinical, and Statistical Scientists, • Execute data science analyses on datasets from BMS clinical trials and real-world data cohorts, spanning genomics, proteomics, imaging, flow cytometry, and other high-dimensional biomarker data types, • Develop innovative approaches to integrating, mining, and visualising diverse, high-dimensional, and disparate datasets generated across early-to-late phase drug development, • Formulate, implement, test, and validate predictive models and build efficient, automated processes for delivering modelling results at scale, • Apply modern machine learning capabilities - including AI/ML, deep learning, NLP, causal ML, and explainable AI - across multiple data modalities and clinical development contexts, • Apply statistically rigorous approaches to clinical trial data, including survival analysis, longitudinal/mixed-effects modelling, and appropriate handling of missing data and censoring, • Contribute to the scientific and statistical strategy of drug development programs, including the development of predictive biomarkers, novel trial designs, and precision medicine approaches, • Build and maintain well-structured, reproducible, version-controlled analytical pipelines and codebases using Python, R, SQL, and cloud platforms, • Develop and apply data quality frameworks to assess and ensure fitness-for-purpose of diverse data sources for specific analytical questions, • Implement strong model evaluation practices including cross-validation strategies, calibration assessment, and transparent reporting of model performance and limitations, • Build scalable, automated processes for delivering analytical results across multiple programs and data types, • Partner with lead and protocol statisticians in contributing to statistical analysis plans (SAPs) for exploratory data science analyses supporting drug development programs, • Collaborate with cross-functional teams including clinicians, translational medicine scientists, biostatisticians, data engineers, and IT/engineering professionals, • Contribute to team excellence through code reviews, technical mentorship, and raising the overall engineering and methodological standards of the team, • Communicate analytical strategies and results clearly and effectively to both technical and non-technical stakeholders, with strong data presentation and visualisation skills, • Manage and coordinate deliverables across concurrent, fast-paced projects within tight timelines, • PhD in a relevant quantitative field (e.g., Computational Biology, Biostatistics, Statistics, Biomedical Engineering, or Computer Science) with 1+ years of academic/industry experience; or a Master's Degree in a relevant quantitative field with 3+ years of industry experience, • Strong experience in data science and statistical analysis using clinical trial or electronic health records data, particularly in a pharma R&D context, • Experience developing and validating statistical and machine learning models on high-dimensional data for time-to-event, longitudinal, and multivariate outcomes, • Experience in the application of AI/ML and proficiency in Python, R, SQL , and cloud platforms (e.g., AWS, Azure, Databricks), • Familiarity with clinical trial design, drug development processes, and the role of biomarkers in regulatory and clinical decision-making, • A perspective on leveraging innovati #J-18808-Ljbffr