Cex jobs in United Kingdom

ANALYTICAL DEVELOPMENT GROUP LEADER Biosimilar mAb Characterisation Strategy London | On-site | Monday - Friday Visa Support Available: International Applicants Encouraged to Apply ──────────────────────────────────── BioTalent are partnered with a growing biopharma organisation strengthening its analytical development capability within a global biosimilars portfolio. This is not routine analytical testing. This is about building and defending a robust biosimilarity and analytical similarity strategy across monoclonal antibody programmes. The focus is deep molecule-level understanding, structural characterisation and regulatory-defensible data packages. The Role You will lead analytical development strategy for biosimilar mAbs, with responsibility across: • Analytical similarity and biosimilarity assessment frameworks, • Comprehensive physiochemical characterisation of monoclonal antibodies, • Establishment and optimisation of HPLC methods including: Glycan profiling, CEX, SEC, Protein A, HIC, • Capillary electrophoresis techniques including cIEF and CESDS, • LCMS data interpretation for PTM identification and structural analysis, • Impurity profiling and degradation pathway assessment, • Method development, qualification and lifecycle management, • Statistical analysis and use of DoE in analytical method optimisation, • Support of Module 3 analytical content for IND, IMPD, BLA and MAA, • Interaction with Regulatory Affairs on EMA, MHRA and FDA queries You will act as the analytical SME in cross-functional stage gate reviews, challenging interpretations and ensuring analytical conclusions are scientifically defensible. This role is technical leadership rather than daily wet-lab execution. You may not run assays yourself every day, but you will design the strategy, review the data and direct the technical path. Essential Experience • Direct biosimilars analytical development experience, • Demonstrated experience in analytical similarity and biosimilarity assessment, • Strong understanding of mAb structure, PTMs and higher-order structure, • Deep expertise across HPLC and CE platforms, • Ability to interpret LCMS data for structural differences, • Experience supporting regulatory submissions with analytical content, • Experience leading or mentoring analytical scientists This is not suitable for: • QC analysts focused on release testing, • Small molecule analytical chemists, • Scientists without biosimilars exposure, • Pure people managers lacking technical depth Why Move In biosimilars, analytical similarity is the battleground. This role owns how molecules are characterised, compared and defended. It is a high-visibility position within a growing technical site backed by global experience.

DeFi Rust Engineer – London - Salary negotiable Working with a high-calibre DeFi team building serious onchain trading infrastructure. Looking for a quant-minded engineer with a strong academic background (maths, physics, CS, engineering or similar) and a genuine obsession with onchain market mechanics. You should understand: • How liquidity behaves in concentrated AMMs (Uniswap v3-style), • Tick-range management and LP optimisation, • DEX–CEX arbitrage dynamics, • MEV structures and incentive design, • Emerging ecosystems like Hyperliquid What you’ll be doing: • Building and improving connectivity across AMMs, orderbooks and major CEXs, • Optimising pricing and execution engines across L1/L2 environments, • Designing intelligent liquidity strategies (JIT liquidity, dynamic range management), • Working on low-latency data ingestion, mempool flows and cross-rollup execution Requirements: • Advanced degree in a quantitative field, • 2+ years strong Rust and Solidity, • Experience building low-latency, high-throughput trading or onchain systems, • Strong distributed systems knowledge, • Comfortable across Linux, AWS, Docker, Git High ownership. Close collaboration with founders. Real impact on live DeFi infrastructure. London-based preferred but may look at remote candidates. Contact for a confidential discussion