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By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s ___ and ___. I further attest that all information I submit in my employment application is true to the best of my knowledge. Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Vice President , Global Clinical Lead - Solid Tumor in our Cambridge office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission. OBJECTIVES: Responsible for leading as the Global Clinical Lead a large solid tumor oncology franchise that encompass multiple late stage and early phase programs . Ensures ongoing review and agreement of the Therapy Area Strategy and associated documents formulated by the OTAU leader prior to their review and approval by appropriate governance committees. Oversees the development and execution of the Integrated Disease Area Strategy (IDAS) and overall Integrated Global Development Plan (IGDP). Responsible for review of synopses, other relevant clinical study documents and critical Study Results. Provide leadership and oversight of specific OTAU related programs and if applicable other indication specific clinical leads. Responsible for providing guidance to TA leaders on regional specificities within Therapeutic Area. ACCOUNTABILITIES: • Clinical Development team participation and leadership, • Accountable to Oncology Clinical Science Head to provide strategic clinical input on assigned clinical studies., • Consistent with the Takeda R&D Oncology Therapeutic Area Unit strategy, goals and objectives, this leader will partner with the other key functions and leaders and members of Oncology Precision and Translational Medicine, Oncology Portfolio Strategy Group, Global Regulatory Affairs, Quantitative and Clinical Pharmacology, other R&D Functional Line Oncology Therapeutic Area Leads, Global Product Launch Strategy Oncology Franchise Leads, Regional Oncology Franchise Leads, Oncology Drug Development Unit (DDU) and other Oncology extended leadership, to drive the alignment on global clinical research and development strategy as related to internal and external pipeline and non-pipeline initiatives for the Takeda R&D Oncology Community across all regions, • Part of the Oncology Clinical Sciences Leadership Team providing key input in strategic planning and connectivity for the overall Oncology Clinical Sciences group, • Leads the Global Development Team (US, EU, and others) managing both the US/EU Development Team and the Japan/ China Development team for assigned compounds. In some cases may lead the US/EU Development Team but more likely will oversee the study physician and/or clinical scientist leads responsible for leading the team. Emphasis will be on insuring that the development teams are proactively identifying contingencies, potential risks and strategies to address future obstacles., • Directs Development Team strategy and deliverables overseeing the Development Strategy, Clinical Development Plan and Clinical Protocols. Recommends scope, complexity and size, which influence the budget of all aspects of a program. Provides continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them., • Responsible for high impact global decisions: interpreting data from ongoing internal and external studies, assessing the medical and scientific implications and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. Plans clinical development strategies in context of medical/clinical significance considering how a given product will fit in with current treatments, standard of care, and unmet medical need., • Accountable for ensuring regional strategies and trade-offs in regional requirements are well articulated in the global strategy documentation and that stakeholders are appropriately briefed., • Providing strategic input into global development strategies and plans for all compounds in OTAU., • Providing clinical and strategic support to evaluation of external compounds (alliances and in-licensing opportunities), • Primary interface with Medical Affairs team for strategy and to support of product commercial efforts, • Contributing to the creation and maintenance of regional KOL network, • Providing recommendations for GDT leader nominations and reviewers of external compounds as part of business development efforts, • Liaison with Clinical Operations and Project Management for co-ordination of logistics study planning and implementation, • Synopsis / Protocol Development, Study Execution, & Study Interpretation, • Consistent with membership of the Clinical Review Board Committee, responsible for critical review of synopses, protocols, IBs and relevant clinical documents relating to studies in assigned compounds., • Trial Medical Monitoring, • Reviews and assesses overall safety information in conjunction with Pharmacovigilance and Medical Monitor of record for assigned compounds., • External Interactions, • Oversees and leads all clinical science activities involved in interactions with FDA, other regulatory agencies and key opinion leaders relevant to assigned compounds., • Responsible for evaluation of external interactions in the context of overall development strategies using complex problem solving in the region but in context of a global environment., • Proactive identification of challenges and development of contingency plans as appropriate., • Due Diligence, Business Development and Alliance Projects, • Responsible for evaluation of potential business development opportunities in the region but with the context of a global environment., • Conducts due diligence evaluations, of clinical development plans for potential alliances and or in-licensing opportunities., • Serves as clinical contact point for ongoing alliance projects and interface with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner., • Assigns and manages clinical science staff who are involved in many of these activities., • Leadership, Task Force Participation, Upper Management Accountability, • Interacts directly with research division based on pertinent clinical and development expertise and in all aspects relating to assigned compound in regional area. Leads TGRD internal teams and global cross-functional teams. Works with functional leadership to prioritize projects within the therapeutic area., • Hires, manages, mentors, motivates, empowers, develops and retains staff to support assigned activities. Conducts performance reviews and drive goal setting and development planning. EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: Experience • MD or combined MD/PhD or internationally recognized equivalent with minimum 15 years pharmaceutical research experience, including minimum 10 years late phase clinical development experience with a focus on medical oncology, • Clinical Training and Clinical Experience in Hematology/Oncology and/or Medical Oncology especially in solid tumor malignancies, • Strong depth of scientific and clinical understanding and experience in cancer biology especially in immune based therapies., • Experience in conducting and/ or leading multiple clinical trials involving immune based therapies, • Proven experience in successfully leading and supervising direct reports including several physicians, physician scientists, scientists within a clinical development team in a global matrix environment., • Demonstrated ability to foster a high-performance culture and build organizational capabilities., • Strong leadership commitment to diversity, equity and inclusion, with experience in creating an inclusive and collaborative team environment that leverages diverse perspectives., • Previous experience in successfully leading several clinical development team/matrix team with responsibility for Global studies in multiple regions. Clinical Development experience beyond US/EU, • Solid and Multiple experience in preparing and interacting with multiple regulatory agencies including FDA, EMA, and others, • Multiple NDA/MAA submission experience, • Proven ability to lead and manage highly trained medical, scientific, and technical professionals., • Superior communication, strategic, interpersonal and negotiating skills, • Enterprise level leadership with the ability to inspire, motivate and drive results, • Excellent communication both verbally and in writing and influencing skills, with the ability to engage, inspire, and influence stakeholders at all levels, including executive management and external partners., • Ability to proactively predict issues and solve problems, • Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams, • Diplomacy and positive influencing abilities across multinational business cultures TRAVEL REQUIREMENTS: • Willingness to travel to various meetings or client sites, including overnight trips. Several international travels may be required., • Requires approximately 25-35 % travel. Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy. #LI-JT1 Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $321,000.00 - $504,460.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Boston, MA Employee Regular Full time Job Exempt Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Job Description The Psychiatry Department at our organization is on the lookout for a passionate and mission-oriented Addiction Psychiatrist to become a part of our rapidly expanding academic team located at our main teaching hospital in downtown Boston. This role presents an exciting chance to join a collaborative and growing Psychiatry Department that is dedicated to establishing a regional model of integrated behavioral health care throughout our organization, which includes our flagship academic medical center and a network of community hospitals across Eastern Massachusetts. Our aim is to provide outstanding, evidence-based addiction treatment while fostering education, research, and innovative practices across the system. Why Join Us * Become a member of a thriving academic department with robust institutional backing and strategic investments in behavioral health. * Play a key role in a comprehensive addiction care model that merges inpatient, outpatient, and community services. * Experience a collaborative work environment alongside Primary Care and specialized medical services. * Participate in impactful teaching and mentorship for medical students, psychiatry residents, and learners from various specialties. * Engage in and contribute to clinical, translational, and health services research in the field of addiction psychiatry. * Help develop innovative programs that meet the changing needs of patients dealing with substance use disorders across various care environments. Primary Responsibilities * Deliver Ambulatory Addiction treatment. * Support the ongoing growth of our Ambulatory Addiction Psychiatry Services. * Provide consultation and ongoing care for patients facing complex substance use and co-occurring psychiatric conditions. * Work closely with other specialties in outpatient settings, including transplant services. * Engage in teaching, supervision, and curriculum development across various training programs. * Have the opportunity to participate in research and scholarly activities, particularly in addiction psychiatry, health systems innovation, and integrated care models. Academic Appointment The faculty position at our organization will be aligned with your experience, academic achievements, and career path. Required Qualifications * MD or DO degree from an accredited medical institution. * Completion of an ACGME- or AOA-accredited Adult Psychiatry Residency. * Board Certified or Board Eligible in Adult Psychiatry. * Eligibility for medical licensure in the Commonwealth of Massachusetts. * Fellowship training and/or Board Certification in Addiction Psychiatry or Addiction Medicine is highly preferred. Apply: Interested candidates are encouraged to submit their application or CV through this job posting.

Job DescriptionPosition Overview Our organization is on the lookout for an academic medical dermatologist who is passionate about patient care and education. With a team of 17 dermatologists, we offer exceptional opportunities for medical dermatologists to engage in practice and teaching at our facility located in the Longwood Medical Area, as well as at our advanced practices in Chestnut Hill and/or Needham. About the Department Our Department of Dermatology not only provides extensive care through General Dermatology clinics but also features 16 specialized clinics and programs. These include areas such as: • Atopic dermatitis, • Patch testing, • Hidradenitis suppurativa, • High-risk assessments Appointments as an Instructor, Assistant, or Associate Professor at the affiliated medical school will be based on experience, training, and accomplishments, alongside teaching responsibilities. Suitable applicants will hold an MD or MD-PhD and have Board Certification in Dermatology. The compensation package includes a competitive base salary, an incentive program, and generous benefits. Employment and benefits are managed by the physician organization associated with our medical center, which operates within the broader health system. About Our Organization Our physicians and staff are recognized nationally for their contributions to clinical research and innovation. We have been acknowledged as one of the top hospitals in Massachusetts by a leading publication. Our robust faculty development program supports career growth and fosters an inclusive environment that attracts diverse talent and promotes retention. As part of the teaching faculty, numerous resources are available to assist with promotion and tenure. Diversity, Inclusion & Advocacy We take pride in the efforts of our Diversity, Inclusion & Advocacy Committees. The core values that guide our initiatives in diversity and inclusion are equity, justice, respect, and dignity for all individuals. While diversity and inclusion focus on our identity and collaboration in the workplace, advocacy reflects our commitment to addressing policy issues that impact our patients and the profession. Application Process We invite interested candidates to apply online, submitting a cover letter and curriculum vitae. We are an equal opportunity employer, and all qualified applicants will be considered for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Living and Working in the Boston Area The Greater Boston area presents a unique combination of history, culture, education, and innovation, making it an appealing place to live and work. Known as one of the oldest cities in the United States, Boston serves as a vibrant hub for education, research, and healthcare. It is home to prestigious institutions such as Harvard and MIT, fostering a lively intellectual atmosphere. The city is also highly walkable, featuring culturally diverse neighborhoods, numerous museums, theaters, art galleries, and beautiful green spaces. Despite its urban vibrancy, Boston is conveniently located near natural attractions, including the beaches of Cape Cod and the scenic mountains and lakes of New Hampshire, Vermont, and Maine.

Job Description The Department of Pathology and Laboratory Medicine at our organization is on the lookout for a board-certified or board-eligible Anatomic Pathologist specializing in surgical pathology to become a part of our academic faculty. This role focuses on delivering exceptional diagnostic surgical pathology services, which includes subspecialty sign-out, intraoperative consultations, and working closely with multidisciplinary clinical teams. The ideal candidate will thrive in a collaborative academic setting, with ample opportunities for teaching and engaging in scholarly activities. Qualifications * Possession of an MD or DO degree * Board certification or eligibility in Anatomic Pathology (AP) or AP/CP * Fellowship training in one or more of the following areas is highly preferred: * Gastrointestinal (GI) Pathology * Gynecologic (GYN) Pathology * Genitourinary (GU) Pathology * Additional knowledge or interest in cytopathology is advantageous * Must be eligible for medical licensure in Massachusetts * We welcome candidates at all stages of their careers. Recent fellowship graduates are encouraged to apply, although prior practice experience is preferred. Key Responsibilities * Deliver diagnostic surgical pathology services, including subspecialty sign-out in line with training * Conduct and interpret intraoperative consultations (frozen sections) * Engage in multidisciplinary conferences and tumor boards * Collaborate with clinical colleagues across surgical and oncology departments * Contribute to the education of residents and medical students * Participate in quality improvement initiatives, focusing on optimizing turnaround times and enhancing service efficiency Academic Opportunities * Faculty appointment at a prestigious medical school, commensurate with experience * Engagement in clinical, translational, or collaborative research projects * Involvement in departmental and institutional educational programs About the Department Our Department of Pathology and Laboratory Medicine offers comprehensive diagnostic services within a leading academic medical center. We are dedicated to excellence in patient care, education, and innovation, fostering strong collaborations throughout our healthcare system. Why Join Us? * A collegial and collaborative academic atmosphere * Robust multidisciplinary clinical partnerships * Opportunities for subspecialty development and academic growth * Located in Boston, a premier hub for healthcare, research, and education Compensation The salary range for this position is between $296,958 and $314,189 for Associate Professor roles, and $353,590 to $386,408 for Professor positions annually. Actual compensation will be determined during the selection process and will take into account various factors such as relevant experience, education, internal equity, and academic rank. We view this investment not just as compensation, but as a recognition of the significant contributions you will make in advancing our mission and shaping the future of patient care, research, and education. About Our Organization Our organization is a respected 400-bed tertiary care academic medical center located in downtown Boston, adjacent to a prominent medical school. We are known for our research in basic, translational, and clinical sciences, as well as our expertise in health policy. Our institution ranks among the top 10 percent of independent entities receiving federal research funding. Our mission is to advance knowledge and train the next generation of investigators, enabling us to swiftly translate innovative research into groundbreaking care.

Job Description The Department of Pathology and Laboratory Medicine within our organization is on the lookout for a full-time Director of Transfusion Medicine. This role encompasses oversight of the blood bank, immunohematology testing, stem cell collection laboratory operations, and the apheresis unit. We encourage candidates with a strong background and interest in additional laboratory medicine areas, such as HLA/histocompatibility, hematology/hematopathology, special coagulation, or molecular pathology, to apply. Your Impact on Patient Care: * You will provide medical leadership and supervision for transfusion medicine services, which include the Blood Bank, apheresis unit, and stem cell processing laboratory. * Your role will involve leading a team to enhance blood product utilization, uphold appropriate transfusion practices, and ensure compliance with local, state, federal, and accrediting agency standards. * You will cover both in-patient and out-patient transfusion and apheresis services, offering medical consultations on transfusion-related matters for patient care. * Your responsibilities will include the collection, cryopreservation, and distribution of hematopoietic stem cell products. * Depending on your interests and qualifications, you may also provide coverage for HLA, special coagulation, hematology/hematopathology, or other clinical laboratory areas. * There will be numerous opportunities and support for engaging in clinical, translational, and basic science research. * You will be eligible for an academic appointment at the affiliated university's School of Medicine, at a rank that reflects your experience. Who You Are: * You hold an MD or DO degree. * You are board certified in Clinical Pathology, Anatomic and Clinical Pathology, or Internal Medicine, with additional board certification or eligibility in Transfusion Medicine. * The ideal candidate will have a minimum of 5 years of experience in transfusion medicine and familiarity with regulatory requirements related to blood banking and cellular therapy (e.g., AABB/CAP, FDA, FACT). * You are dedicated to teaching and providing clinical service. * You are licensed or eligible to practice medicine in Massachusetts. * You qualify for a faculty position at the affiliated university's School of Medicine and are willing to participate in teaching residents and medical students. * A background in clinical research activities and/or funded or transferable research is advantageous. Why Join Our Team: Our Department of Pathology and Laboratory Medicine is accredited by the College of American Pathologists (CAP), the Association for the Advancement of Blood and Biotherapies (AABB), and the American Society for Histocompatibility and Immunogenetics (ASHI). Our Clinical Laboratories conduct approximately two million tests annually, with the Blood Bank facilitating nearly 15,000 blood transfusions each year. The Transfusion Medicine service supports extensive organ transplant programs (cardiac, kidney, and liver), a level 1 trauma center, and a wide range of surgical, oncologic, and high-risk obstetric patients. The Anatomic Pathology service processes around 20,000 specimens each year, including various biopsies and large surgical samples. The salary range for this position is between $279,877 and $310,250 per year. Actual compensation will be determined during the selection process and will take into account various factors, including relevant experience, education, internal equity, and academic rank. At our organization, we view this investment not just as compensation, but as recognition of the significant role you will play in advancing our mission and shaping the future of patient care, research, and education. Why Choose Us: Our organization is a proud member of a healthcare system that unites providers and institutions with a shared commitment to delivering high-quality care in the most suitable settings for our patients. This opportunity is fully academic, yet our department includes both academic and community-based locations. Our medical center is a respected 400-bed tertiary care academic facility located in the heart of downtown, adjacent to a prominent university's School of Medicine. Known for its excellence in basic, translational, and clinical science research, as well as health policy expertise, our center ranks in the top 10 percent of independent institutions receiving federal research funding. Our mission focuses on advancing knowledge and training future investigators, enabling us to swiftly translate innovative research into groundbreaking care. Location: Our principal teaching hospital is situated in the vibrant downtown area.

Job Description Join our organization to make a meaningful impact while advancing your career, all within a supportive community of dedicated and compassionate colleagues. Every individual here plays a vital role in creating a comprehensive healthcare experience that is accessible, empowering, and fundamentally human. We are currently seeking a full-time Academic Rheumatologist to take on the role of Chief of the Division of Rheumatology. In this leadership position, you will provide innovative academic guidance, promote clinical excellence, enhance the division's reputation, strengthen research initiatives, and contribute to the national recognition of our scholarly work and service commitments within the expanding Department of Medicine. About the Division of Rheumatology: • Established over 50 years ago, the Division is renowned for its excellence in research, education, and clinical care., • Our research has led to significant discoveries, including interleukin-1, the first identified cytokine, and the introduction of the term "immunosuppression" through the pioneering efforts of Drs. Sheldon Wolff and Charles Dinarello., • Nearly three decades later, we continued this legacy with the first clinical trials of rituximab and belimumab for Lupus treatment., • Key clinical programs include The Center for Arthritis and Rheumatic Diseases, Musculoskeletal Ultrasound Program, Pediatric/Adult Transitional Clinic, and Lyme Disease Specialty Clinic., • Our research initiatives encompass industry-sponsored trials, complementary and integrated health, and patient-reported outcomes in Systemic Lupus Erythematosus, with collaborations extending to oncology, pulmonary medicine, nephrology, and support from the Department and the Tufts Clinical and Translational Science Institute (CTSI).Why Join Our Team:, • Our Department of Medicine prioritizes compassion, innovation, collegiality, diversity, ethics, and mutual care for each other and our patients., • You will be part of a vibrant faculty environment focused on quality, medical education, and research., • We promote a flexible work atmosphere that respects the need for a balanced life outside of work., • The Division of Rheumatology is expanding across various programs, collaborating with infectious disease, pulmonary (scleroderma and ILD), nephrology (SLE and vasculitis), dermatology (psoriatic arthritis), and orthopedics, while also working closely with the Division of Pediatric Rheumatology for smooth transitions from pediatric to adult care., • As the principal teaching hospital for a prominent medical school, the Division Chief will hold an Endowed Chair, specifically the Natalie V. Zucker and Milton O. Zucker Chair in Rheumatology. This role provides access to resources that enhance education and research, aligning with the School's missions of diversity, community impact, and health equity., • As part of our broader healthcare ecosystem, the successful candidate will help shape the future of integrated community and academic care in Rheumatology, collaborating with various hospitals and a network of over 2,300 employed and independent physicians.Your Role in Transforming Patient Care:, • Recruit, mentor, and lead a growing team of Rheumatology specialists., • Collaborate with other Divisions and Departments to develop new clinical care initiatives., • Act as an attending physician on a consultation service supported by Rheumatology fellows and residents., • Supervise advanced care practitioners, fellows, residents, and medical students in clinical settings., • Enhance and participate in quality improvement programs for both the Division and the Department of Medicine.Your Impact on the Academic Mission:, • Recruit and lead a team dedicated to clinical investigation and medical education., • Develop a vision for interdisciplinary and translational research within the Division., • Oversee a dynamic Rheumatology Fellowship Training Program in collaboration with the Program Director., • Influence the future of our Internal Medicine residency program, with a strong emphasis on teaching., • Enhance the educational experience for medical students at the affiliated medical school, focusing on clinical excellence, professionalism, and scholarship.Who You Are:, • A collaborative team player eager to work with diverse stakeholders to ensure exceptional patient satisfaction., • You have experience in an academic environment, showcasing leadership capabilities in managing a busy Division., • Your background includes personnel oversight, complemented by strong interpersonal skills to inspire a growth-oriented team., • You support the academic mission while integrating our care into community-based settings and partnerships., • A champion for Diversity, Equity, and Inclusion initiatives as outlined by the department and organization., • You are passionate about fostering collaborative and interdisciplinary work, building strong relationships with multidisciplinary teams.

Job Description Our organization, located in Boston, Massachusetts, is on the lookout for a medical oncologist with specialized expertise in early-phase (Phase I) clinical trials. This position is perfect for an early to mid-career physician-scientist eager to take on greater leadership responsibilities in the development of early-phase trials while also enhancing an independent clinical and translational research portfolio. The selected candidate will be instrumental in overseeing our current clinical trial framework, as well as in the design, initiation, and execution of Phase I and first-in-human studies. Additionally, they will contribute to the strategic expansion of the Phase I program and deliver exceptional clinical care within a collaborative, mission-oriented academic medical environment. The clinical focus may center on thoracic or breast cancers, depending on expertise and program needs. Key ResponsibilitiesClinical Research Leadership & Phase I Program Development * Act as Principal Investigator for Phase I and early-phase clinical trials, which may include both investigator-initiated and industry-sponsored studies. * Provide scientific and operational guidance for the early-phase research infrastructure, including trial development, initiation, and execution. * Contribute to the strategic growth and visibility of the Phase I clinical trials program. * Develop and enhance a competitive, externally recognized clinical and translational research program with institutional backing. * Work closely with translational scientists and multidisciplinary teams to advance first-in-human and biomarker-driven studies. * Establish and maintain productive relationships with industry sponsors, cooperative groups, and internal stakeholders. * Collaborate with the Neely Center for Clinical Cancer Research to support cooperative group, commercial, and investigator-initiated studies. Clinical Care & Multidisciplinary Leadership * Deliver high-quality clinical care to patients within the candidate’s area of expertise. * Mentor trainees, junior faculty, and research staff involved in early-phase research. * Share responsibilities for inpatient oncology and consult service coverage with faculty, including participation in night and weekend coverage, with fellows providing primary support. * Contribute to the academic mission of the affiliated medical school through teaching and scholarly activities. Qualifications * MD or MD/PhD with board certification or eligibility in Medical Oncology. * Preferred subspecialty focus in thoracic or breast cancers. * Proven experience as a Principal Investigator on Phase I or early-phase clinical trials. * Demonstrated record of academic productivity, including peer-reviewed publications and leadership in clinical trials. * Experience or a strong interest in leading collaborations with pharmaceutical and biotech companies. * Dedication to an academic career with a focus on early-phase clinical research and program leadership. * Eligibility for medical licensure in Massachusetts. What We Offer * A collegial and collaborative academic environment within a growing healthcare system that prioritizes patient care. * The chance to take on a leadership role within an expanding Phase I clinical trials program. * Robust institutional infrastructure and support for early-phase trials, translational research, and partnerships with industry. * Mentorship and resources aimed at facilitating career advancement toward senior leadership positions. * Practice in Boston, a global center for biomedical research and innovation. * Competitive salary and comprehensive benefits package. * A supportive atmosphere for academic growth and leadership development. How to Apply: Interested candidates are encouraged to submit their application through this job posting. The salary range for this position is between $255,670 and $331,507 annually. Actual compensation will be determined during the selection process and will take into account various factors, including academic rank, relevant experience, education, and internal equity. There is also incentive compensation based on clinical productivity. At our organization, we view this investment not just as compensation, but as recognition of the significant contributions you will make in advancing our mission and shaping the future of patient care, research, and education.

Role: Chief Medical Officer (CMO) Job location: HQ in Bangalore, India. Open to U.S.-based remote / hybrid leadership talent. Overview The Head of Clinical Development will lead the overall clinical strategy and execution for oncology programs, from early clinical trials to late-stage development. The role will play a critical part in advancing Aurigene’s pipeline of innovative cancer therapies and enabling global regulatory approvals. Aurigene is a clinical-stage biotech with multiple oncology assets in global clinical development and strong partnerships with global pharma companies. This role is central to translating scientific innovation into successful clinical outcomes. Key Responsibilities Clinical Strategy & Leadership • Define and drive the global clinical development strategy across oncology programs, • Lead clinical development from IND to late-stage trials (Phase I–III), • Oversee design and execution of clinical trials globally (US, India, other regions), • Ensure high-quality protocol design, patient safety, data integrity, and timelines, • Lead interactions with global regulatory agencies (US FDA, DCGI, etc.), • Oversee IND/NDA submissions and approvals, • Collaborate with discovery, translational research, pharmacology, PK, and toxicology teams, • Integrate clinical insights into overall drug development strategy, • Build relationships with key opinion leaders (KOLs), investigators, and partners globally, • Lead and build a high-performing clinical development team, • Strengthen capabilities in clinical operations, medical monitoring, and data review, • Drive a culture of innovation, speed, and scientific excellence. Key Expectations / Success Metrics • Progress multiple oncology assets through clinical milestones (IND, Phase I–III), • Successful regulatory approvals and global trial execution, • Strong clinical data generation to support licensing and partnerships, • Build a scalable and globally competitive clinical development organization. Qualifications & Experience • MD with specialization in Oncology / Haematology (preferred), • 18–25+ years of experience in clinical development in pharma/biotech, • Proven track record of:, • Leading IND filings and global clinical trials, • Supporting NDA/BLA submissions, • Working in both large pharma and biotech environments, • Experience in oncology drug development is essential Key Skills • Strong understanding of oncology clinical development and regulatory pathways, • Expertise in clinical trial design, data interpretation, and safety oversight, • Ability to work across the full drug development lifecycle, • Strong leadership and stakeholder management skills, • Experience in global collaborations and licensing deals Why this role is critical • Aurigene has a robust oncology pipeline with multiple clinical-stage assets, • The role directly impacts value creation through clinical success and partnerships, • Key to transitioning from clinical stage to commercial biotech

Research Assistant/Technician Position in Life Science Lab Employer Brigham and Women’s Hospital Lab/Dept Yakoub lab, Dept of Medicine, BWH Location 75 Francis St, Boston, MA 02115 Salary Commensurate with education and experience Discipline Neuroscience, Stem Cells, Life Sciences, Biochemistry, Molecular Biology Job Type Research Assistant/Technician A Research Assistant/Technician position is available in the Yakoub Lab, Department of Medicine, at Brigham and Women’s Hospital. We are seeking a highly motivated and qualified candidate to join our research team. Our laboratory is dedicated to advancing the understanding and treatment of major human neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. The successful candidate will contribute to addressing critical scientific questions in the field via cutting-edge technologies and innovative experimental approaches, including stem cell derived human neurons, human brain organoids, genetically engineered mouse models, gene therapy, synthetic biology and protein engineering. Candidates must meet the following requirements: • A minimum of 2-3 years of experience in relevant biomedical laboratory research., • A strong background in biomedicine; candidates with hands-on experience in cell culture, differentiation of stem cells into neurons and organoids and molecular biology (protein expression, plasmid/vector design and construction, ELISA, WB, qPCR, etc) will be given priority. Additional experience with mouse work and behavior is a plus., • Demonstrated ability to work effectively in a collaborative research environment, with strong teamwork and communication skills. We are particularly interested in candidates who are intellectually curious, self-driven, and passionate about scientific discovery and translational research aimed at developing novel therapies for neurological disorders. To inquire about this position, please send your CV to Dr. Abraam M. Yakoub, PharmD, PhD (), cc’ing Dr. You Zhou, PhD (), thanks.

We are seeking a highly driven oncologist with a balance of clinical excellence and research ambition. A Clinical Investigator who specialises in any of the following areas: • Gastrointestinal Oncology, • Breast Oncology, • Genitourinary Oncology Boston, Massachusetts | On-Site This is a rare opportunity to step into a high-impact, academically driven oncology role within a world-class, rapidly expanding gastrointestinal, genitourinary and breast oncology program in Boston. Designed for ambitious physician-scientists, this position offers the chance to shape the future of cancer care through cutting-edge clinical practice, translational research, and academic leadership. The Opportunity You will join an elite, multidisciplinary team at the forefront of gastrointestinal, genitourinary and breast cancer innovation, operating in an environment where clinical excellence meets groundbreaking research. You will: • Deliver exceptional, patient-centered care in gastrointestinal oncology, • Lead and contribute to clinical and translational research programs, • Participate in and drive early- and late-phase clinical trials, • Collaborate with top-tier research partners and investigators, • Play an active role in teaching and mentoring future clinicians, • Help shape the direction of a high-growth, high-visibility oncology program Compensation & Benefits • Salary: $255,670 – $534,220 (commensurate with experience and academic rank), • Sign-on bonus: Negotiable, • Relocation package: Partial support available Comprehensive Benefits Package Includes: • Medical, Dental, and Vision Insurance, • Life Insurance, • Retirement Plan, • Generous Paid Time Off, • Additional institutional benefits designed to support wellbeing, career growth, and long-term success What Sets This Role Apart • A premium academic platform with strong national recognition, • Access to state-of-the-art research infrastructure, • Opportunity to build a distinguished academic and clinical profile, • A culture that promotes innovation, diversity, and ambitious thinking, • The chance to make a meaningful impact in a highly specialized oncology field Essential Requirements: • MD, MD/PhD, or DO, • Board Eligible / Board Certified in Medical Oncology, • Eligible for medical licensure in Massachusetts Ideal Experience: • Expertise or strong interest in gastrointestinal, genitourinary or breast malignancies, • Background in clinical and/or translational research, • Evidence of academic contribution or leadership potential, • Passion for education and mentorship

Job Description The Cardiology Division and the CardioVascular Center (CVC) at our organization in Boston are seeking to fill an early-career faculty role that emphasizes general clinical cardiology and echocardiography. If you are a driven physician who thrives in a collaborative team environment and possesses expertise in managing complex clinical cases, we invite you to explore this opportunity further. Why Join Our Team The CVC is composed of a vibrant group of physicians engaged in expanding clinical programs across various specialties, including Cardiology, Cardiothoracic Surgery, and Vascular Surgery, alongside innovative research initiatives. Our environment fosters collaboration and mentorship, focusing on career development and delivering patient-centered care through multidisciplinary teams. Our organization is a globally recognized academic medical center situated in downtown Boston, adjacent to a prominent medical school and part of a larger healthcare system. We are renowned for our research in basic, translational, and clinical sciences, as well as our expertise in health policy. Ranking in the top 10 percent of independent institutions for federal research funding, we are dedicated to advancing knowledge and training the next generation of investigators, swiftly translating innovative research into groundbreaking patient care. We are committed to academic excellence, with 453 residents and fellows across 48 training programs. Our mission is to cultivate knowledge and prepare students to become future leaders in research and patient care. As part of our healthcare system, we unite providers and organizations with a common goal of delivering high-quality care in the most suitable settings for our patients. Together, we blend the strengths of academic medicine with community healthcare. About the Cardiology Division and Our Organization * The Division is integrated within the CardioVascular Center, which aligns financially and strategically across Cardiology, Cardiac Surgery, and Vascular Surgery. * We have robust and expanding interdisciplinary programs focusing on cardiac arrhythmias, structural heart diseases, valvular diseases, and ischemic heart diseases. * Our team conducts approximately 1,000 cardiac surgeries annually. * We host one of the largest heart transplant programs in the nation; in 2024, our Advanced Heart Failure program achieved a record of 70 heart transplants, the highest in New England. * We are dedicated to training the next generation of cardiologists through an ACGME-accredited fellowship program. Your Role in Transforming Patient Care * You will collaborate with an exceptional team of cardiologists and imaging specialists, managing complex inpatient cases and a diverse range of outpatient services. * Your responsibilities will include providing care for both outpatient and inpatient clinical services. Who You Are * Board Certified/Board Eligible in Cardiovascular Disease. * A strong interest in general clinical cardiology and delivering high-quality outpatient care. * Level II or III training in echocardiography, with current or anticipated Board Certification in Echocardiography. * Significant experience with transthoracic and transesophageal echocardiography, stress echocardiography, and advanced techniques such as strain and 3D echocardiography. * A keen interest in academic pursuits is highly desirable, with ample opportunities for teaching and research. Compensation The salary range for this position is between $331,997.00 and $401,935.00 per year. The final compensation will be determined during the selection process and will take into account various factors, including relevant experience, education, internal equity, and academic rank. At our organization, we view this compensation as an investment in your potential to significantly impact our mission and the future of patient care, research, and education. Location This position is based at our medical center, the primary teaching hospital for a well-known medical school, located in downtown Boston. Application Process Interested candidates are encouraged to submit their application or CV through this job posting.

Job Description The Cardiology Division and the CardioVascular Center (CVC) at our organization in Boston are on the lookout for a board-certified or board-eligible Cardiac Electrophysiologist to become part of our growing electrophysiology (EP) program. This full-time faculty role is open at the Assistant or Associate Professor level, depending on the candidate's experience. Applicants should ideally have 3 to 5 years (or more) of experience following their clinical cardiac EP training and should exhibit a strong dedication to delivering high-quality, patient-focused EP care. Position Highlights: * Become a member of a collaborative team of 5 Cardiac Electrophysiologists within a busy academic setting. * Engage actively in an ACGME-accredited Clinical Cardiac EP Program that currently has 3 fellows, with plans to expand to 4. * Work in state-of-the-art EP laboratories performing a wide range of modern electrophysiology procedures, including: * Complex ablation for atrial and ventricular arrhythmias. * Pulsed field ablation and advanced electroanatomic mapping techniques. * Implantation of cardiac electronic devices, including conduction system pacing, leadless technologies, and extravascular devices. * Lead extraction (depending on experience and interest). * As our procedural presence expands in community hospitals, the ability to perform procedures in those settings will be a key aspect of this role. Clinical and Academic Responsibilities: * Provide comprehensive electrophysiology care in both inpatient and outpatient environments. * Conduct a variety of EP procedures, including complex ablation and device implantation. * Play a vital role in the growth and development of the comprehensive ventricular arrhythmia program. The selected candidate will collaborate to enhance referral networks, improve procedural capabilities, and advance multidisciplinary care for patients with complex ventricular arrhythmias. * Participate in the education and mentorship of internal medicine residents, as well as cardiology and EP fellows. * Engage in scholarly activities, quality improvement initiatives, and/or clinical research. * Contribute to the ongoing development and innovation of EP services throughout our healthcare system, including outreach at affiliated community sites. Qualifications * MD or DO with board certification/eligibility in Cardiovascular Disease and Clinical Cardiac EP. * Eligible for medical licensure in Massachusetts. * A minimum of 3 to 5 years of post-fellowship experience is preferred. * Proven excellence in clinical, procedural, and communication skills. * A strong commitment to patient-centered care and teamwork. * Interest in and experience with academic roles is highly desirable, with ample opportunities for teaching. Why Join Our Team: The CVC consists of a vibrant group of physicians engaged in dynamic clinical programs across various specialties, including Cardiology, Cardiothoracic Surgery, Vascular Surgery, and Interventional Radiology, along with innovative research initiatives. We foster a collaborative and collegial atmosphere that emphasizes mentorship and career development, with multidisciplinary teams dedicated to providing exceptional patient-centered care. Our organization is a globally recognized academic medical center located in downtown Boston, adjacent to a prestigious medical school and a proud member of a comprehensive healthcare system. Known for its research in basic, translational, and clinical sciences, as well as health policy expertise, we rank among the top 10 percent of independent institutions receiving federal research funding. Our mission focuses on advancing knowledge and training future investigators, enabling us to swiftly translate innovative research into groundbreaking care. We are dedicated to academic excellence, with 453 residents and fellows training across 48 programs. Our commitment to advancing knowledge and nurturing future investigators drives us to transform innovative research into pioneering care. As part of our healthcare system, we unite providers and organizations with a shared vision of delivering high-quality care in the most suitable settings for our patients. Together, we combine the strengths of academic medicine and community care. Join our organization in our mission to heal, comfort, teach, learn, and seek knowledge to promote health and prevent disease. Compensation: The salary range for this position is $XXX to $XXX annually. Actual compensation will be determined during the selection process and will take into account various factors, including relevant experience, education, internal equity, and academic rank. We view this investment not just as compensation, but as recognition of the significant impact you will have in advancing our mission and shaping the future of patient care, research, and education. Location: This position is based at our medical center, the primary teaching hospital for a renowned medical school, located in downtown Boston. Application Process: Interested candidates can submit their applications using the apply button located at the bottom of the listing. For any inquiries regarding the position or if you encounter any issues while applying, please feel free to reach out to our team. Why Choose Us: We are a leading integrated health system that combines the best of academic and community healthcare to provide exceptional, connected, and accessible care experiences to individuals across Massachusetts. Our system includes a major medical center, several community hospitals, an extensive home care network, and a large integrated physician network. With over 15,000 dedicated team members, we deliver more than 1.5 million patient experiences annually. Our health system serves as the principal teaching affiliate for a prestigious medical school and was established to leverage the strengths of its member organizations to transform how consumers engage with and experience their care.

Valo Health is a human-centric, AI-enabled biotechnology company working to make new drugs for patients faster. The company’s Opal Computational Platform transforms drug discovery and development through a unique combination of real-world data, AI, human translational models and predictive chemistry. Our talented team of biologists, chemists and engineers, armed with advanced AI/ML tools, work together to break down traditional R&D silos and accelerate the speed and scale of drug discovery and development. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We embrace new ways of learning, solve complex problems and welcome diverse perspectives that can help us advance patient-centric innovation. Valo is headquartered in Lexington, MA, with additional offices in New York, NY and Tel Aviv, Israel. To learn more, visit ___. Staff Data Scientist, Graph ML About Us Valo Health is a technology company applying human and machine intelligence to accelerate the creation of life-changing medical treatments. At the core of this vision is Valo’s computational platform: an end-to-end, integrated drug discovery and development engine built from the ground up. Valo hires the best and gives them first-class training and support. We approach our work fearlessly, learn quickly, improve constantly, and celebrate our wins. A centerpiece of our culture is our commitment to inclusion across race, gender, age, religion, identity, and experience. Diversity fuels the Valo experience and drives us every day. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. As Staff Data Scientist, Graph ML, you will develop and deploy graph ML solutions to synthesize and extract novel insights from Valo data in the context of a vast corpus of knowledge in medicine, molecular biology, human genetics, and drugs, to drive compute-enabled biological hypothesis generation. Our innovative platform leverages advanced computational techniques, starting with patient data, to bring better medicines to patients, faster. You will be responsible for developing and delivering graph ML and network biology-based analyses that generate and support drug target hypotheses on the path to discovery of new medicines. You will collaborate closely with a diverse group of data scientists and biologists to enable the contextualization of predicted drug targets within relevant patient subpopulations. You will also be accountable for communicating methodological approaches and key results to internal and external cross-functional stakeholders. Additionally, you will work with other data scientists, software engineers, and data engineers to continue building and improving Valo’s integrated graph platform to accelerate insights across multiple projects and applications. A successful candidate brings deep technical expertise in graph machine learning, network analytics, and modern data science best practices, along with experience in biology research in the context of drug discovery, and curiosity and excitement to learn. What You’ll Do… • Lead the design, implementation and application of graph ML and network biology approaches to target discovery from RWD and multi-omic datasets., • Prototype new approaches aimed at enhancing and improving Valo’s graph platform, seeking out new scientific opportunities to increase the team’s impact., • Work with world-class engineers to ensure that graph methodologies, graph construction, and underlying data are robustly integrated, to develop generalizable solutions to core scientific problems., • Apply your technical knowledge and intuition to break down large problems into solvable pieces. Time is limited; you’ll need to prioritize which problems are critical-path today from those that can wait., • Be an agile and pro-active Data Science team member, providing regular updates on your work, and input into the work of your colleagues; championing data science best practices; participating in code, design, and analysis review. What You Bring… • MS or PhD in a quantitative field with extensive experience at the intersection of machine learning and graph analytics, • Experience in healthcare, medicine, molecular biology, computational biology, or life sciences., • Advanced knowledge of and experience with graph ML techniques such as Graph Neural Network (GNN) models applied to link prediction, node classification, and other biomedical-relevant computational tasks, as well as related explainability methods, • Experience or general knowledge of knowledge-graph building and graph databases, • Familiarity with general graph algorithms and relevant Python libraries, • Strong experience in Python and machine learning and/or deep-learning frameworks (e.g., pytorch), • Experience with data science best practices (data provenance, code versioning, reproducibility, git, etc), large-scale data analytics engines (e.g., Spark or Dask), and working in cloud environments (e.g., AWS), • Strong data visualization, analytical, problem-solving, and communication skills, with demonstrated ability to condense, summarize, and synthesize results into informative and actionable presentations to experts from different fields. Nice to have… • Experience with traditional drug discovery and development processes and approaches, • Domain expertise in neuroscience, immunology, and/or cardio-metabolic biology, • Knowledge of related data science domains, including statistical genetics, multi-omics & real-world evidence Remote Salary Range $200,600 - $236,000 USD MA Salary Range $170,000 - $200,000 USD Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Valo Health currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Valo Health's good faith estimate as of the date of publication and may be modified in the future. Please note: At this time, we are only able to consider candidates who currently have permanent US work authorization without the need for immediate or future sponsorship.

Senior Director, Biostatistics Location: Boston, MA Role Purpose This organization is driven by a commitment to improving patient outcomes through scientific excellence and innovation. Data, analytics, and quantitative rigor are central to how research and development decisions are made, enabling faster progress, stronger evidence, and more predictable delivery of new medicines. Within the R&D organization, a global quantitative sciences function provides strategic leadership across areas such as biostatistics, quantitative pharmacology, programming, real-world evidence, patient safety, and operational strategy. This group integrates advanced analytics, statistical methodology, machine learning, and modern data platforms to guide development decisions across the discovery, preclinical, translational, and clinical continuum. Position Overview The Senior Director, Biostatistics provides enterprise-level leadership for statistical strategy, execution, and delivery within a therapeutic area, business unit, or specialized quantitative function. This role carries accountability for influencing R&D outcomes, shaping delivery models, and ensuring high-quality, timely, and efficient program execution. The position serves as a key decision-maker and cross-functional leader with direct impact on development strategy and operational success. Key Responsibilities Strategic Leadership & Delivery • Provide executive-level leadership for statistical delivery across development programs and portfolios, • Act as a primary decision authority for execution and delivery matters impacting R&D outcomes, • Define and implement strategies that enable consistent, predictable, and high-quality development execution, • Build, scale, and sustain statistical delivery capabilities through effective processes, systems, and governance, • Drive continuous improvement and innovation in delivery models, tools, and methodologies, • Lead and influence multidisciplinary teams across research, development, and operations, • Represent the biostatistics function in senior-level internal forums and with external partners and vendors, • Advanced degree in statistics, biostatistics, or a related scientific discipline, • PhD with approximately 12+ years of relevant experience, or, • Master’s degree with approximately 15+ years of relevant experience, • Demonstrated leadership in regulatory submissions (e.g., NDA, CTD, or equivalent), • Experience representing statistical perspectives in discussions with health authorities, • Deep expertise in clinical trial design, analysis methodologies, and interpretation of results, • Strong understanding of the pharmaceutical development lifecycle and cross-functional interfaces, • Comprehensive knowledge of global regulatory standards and guidelines governing clinical research, • Advanced statistical programming proficiency, • Exceptional written, verbal, and executive-level communication skills, • Broad statistical experience across multiple therapeutic areas or development phases, • Strong people leadership, talent development, and organizational management capabilities Successful candidates will demonstrate the ability to: • Inspire, motivate, and develop high-performing teams, • Lead with confidence while fostering collaboration and inclusion, • Balance strategic vision with operational execution, • Drive alignment and accountability across diverse stakeholder groups Compensation & Benefits Estimated Base Salary Range (Boston, MA): $208,200 – $327,140 Final compensation will be determined based on experience, education, role scope, geographic location, and other relevant factors, in accordance with applicable laws. In addition to base pay, this role may be eligible for short- and long-term incentive programs. Please note: This job posting is just a preview of the full scope of the position. A comprehensive job description is shared by a member of our team

COMPANY OVERVIEW AIRNA is a biotechnology company with a mission to be the leading RNA editing company delivering precision therapies to patients with rare and common diseases. AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of Tübingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health. AIRNA has raised $245 million in financing from a world-class syndicate of investors including Arch Venture Partners, Forbion, Venrock Healthcare Capital Partners, RTW Investments, Nextech Invest, and ND Capital. We value teamwork, resilience, excellence, human, and health, and have a diverse team at both our headquarters in Cambridge, MA and our research operations in Tübingen, Germany. POSITION SUMMARY: We are seeking a highly motivated Analytical Biomarker Scientist to support biomarker discovery and translational research using advanced mass spectrometry platforms. The successful candidate will develop, validate, and apply LC-MS–based assays for proteomics, metabolomics, and lipidomics to enable biomarker identification, pharmacodynamic assessment, and disease mechanism studies in preclinical and clinical samples. This role requires strong expertise in sample preparation, LC-MS method development, data analysis, and biomarker interpretation within a multidisciplinary research environment. Assay Development & Analytical Work • Develop and optimize LC-MS/MS assays for proteomics, metabolomics, and lipidomics., • Design and execute quantitative and qualitative biomarker assays in biological matrices (plasma, serum, tissue, CSF, etc.)., • Perform sample preparation workflows including protein digestion, metabolite extraction, and lipid isolation., • Operate and maintain high-resolution and triple-quadrupole LC-MS systems., • Identify and validate protein, metabolite, and lipid biomarkers relevant to disease biology and drug response., • Support preclinical and clinical biomarker studies including pharmacodynamic and mechanistic endpoints., • Process and analyze LC-MS data using appropriate bioinformatics and statistical tools., • Perform quantitative analysis and biomarker data interpretation., • Maintain data quality and ensure reproducibility of assays., • Work closely with cross-functional teams including biologists, clinicians, and computational scientists., • Contribute to study design and experimental strategy for biomarker discovery projects., • Present results at internal meetings and external scientific conferences., • Support manuscript preparation and regulatory documentation when applicable. QUALIFICATIONS Education • PhD in Analytical Chemistry, Biochemistry, Proteomics, Metabolomics, or related field, • Hands-on experience with LC-MS/MS instrumentation., • Expertise in proteomics workflows (protein extraction, digestion, peptide analysis)., • Experience with metabolomics and/or lipidomics assays., • Experience analyzing complex biological samples., • Experience with high-resolution MS platforms (e.g., Orbitrap, Q-TOF)., • Knowledge of biomarker discovery pipelines in translational research., • Experience with quantitative MS methods such as MRM/PRM., • Familiarity with bioinformatics tools for omics data analysis., • LC-MS method development, • Proteomics / metabolomics / lipidomics, • Biomarker discovery and validation, • Sample preparation and assay optimization, • Data analysis and statistical interpretation, • Cross-functional collaboration LOCATION: AIRNA has a hybrid work model, and the role will be based in AIRNA’s corporate headquarters in Cambridge, MA ~3 days per week. COMPENSATION: $120,000 - $155,000

Postdoctoral Research Fellow Position in Macrophage Biology/Immunology The Center for Interdisciplinary Cardiovascular Sciences (CICS), directed by Masanori Aikawa, MD, PhD, at Brigham and Women’s Hospital and Harvard Medical School is seeking a postdoctoral research fellow to join our translational research program in macrophage biology/immunology. Our team takes a systems approach—integrating multi-omics, network science, machine learning, and comprehensive in vitro and in vivo studies—to identify novel therapeutic targets for inflammatory vascular diseases. Established in 2009, CICS is dedicated to accelerating the translation of basic cardiovascular research into clinical application. We foster multidisciplinary, team-based research by bringing together scientists from academia and industry in a shared space designed to encourage collaboration and innovation. We are committed to building a diverse, dynamic, and intellectually stimulating environment. We are therefore seeking a highly motivated and enthusiastic candidate with a strong scientific track record and excellent interpersonal skills. CICS occupies a fully-equipped, 24,000-square-foot facility on the 17th floor of the state-of-the-art Center for Life Sciences, located in Boston’s Longwood Medical Area—the heart of one of the world’s leading medical and research communities. Application: Please send your CV and an outline of your current research interests to Masanori Aikawa () and Yennie Lee (). For further information about CICS, please visit our website at .

Erdogan Lab at Boston University Medical Campus is seeking a highly motivated Postdoctoral Associate to join an NIH-funded interdisciplinary research program investigating how neuro-immune responses and interactions shape pain, infection, and tissue repair in barrier tissues in the oral cavity. Erdogan Lab, in the Department of Translational Dental Medicine at Boston University Henry M. Goldman School of Dental Medicine, operates at the interface of neurobiology, immunology, and microbiology, combining in vivo disease models, genetic and chemogenetic manipulations, systems-level profiling, advanced imaging, and translational approaches. Our overarching goal is to define how sensory neurons respond to and interact with immune and microbial signals in dental and oral tissues and to translate these insights into pain management strategies and minimally invasive therapies. Erdogan Lab is highly collaborative, with active partnerships across Boston’s leading academic and research institutions. Key Responsibilities • Design, execute, and lead independent and collaborative, hypothesis-driven research at the intersection of neuroimmunology and oral biology, • Utilize in vivo models of dental injury, infection, and chemogentic approaches, • Integrate molecular, cellular, and systems-level approaches (e.g., flow cytometry, imaging, transcriptomics), • Analyze complex datasets, including transcriptomic and microbiome data, • Lead projects from experimental design through publication, • Mentor trainees and contribute to a dynamic, team-oriented lab environment Required Qualifications • PhD, MD/DDS/PhD or equivalent doctoral degree in immunology, neuroscience, microbiology, oral biology, or a related discipline, • Ability to work both independently and as part of a collaborative team, • A creative and rigorous scientist with a strong track record of research productivity, • Excited to tackle mechanistic, translational, cross-disciplinary questions, • Comfortable with (or eager to learn) in vivo biology and complex experimental systems, • Preferred: Experience in neuroimmunology, pain biology, host–microbe interactions, imaging, or transcriptomics Candidates with clinical training in dentistry (DDS/DMD) with substantial research experience are encouraged to apply. Please submit CV, cover letter, and contact information for three references to: Alecha Pantaleon For inquiries: PI Dr. Ozge Erdogan () Boston University is an equal opportunity employer and is committed to building a diverse and inclusive academic community.

Location: Zurich - remote, hybrid or relocation. Have you ever wanted to take full ownership of a drug discovery programme, from initial idea through to first in human? This is an opportunity to join a venture-backed, AI native biotech at the earliest stage and play a central role in shaping how programmes are built, prioritised and advanced. You will not be inheriting a function. You will be helping define it. About the company Our client is building a new type of biotech. A small, high agency team focused on developing novel therapies for diseases with limited treatment options, using a combination of modern AI-enabled biology and a highly leveraged external model. Rather than scaling large internal teams, they partner with best-in-class computational and wet lab CROs, allowing them to run multiple programmes in parallel while staying lean and focused. The founding team brings deep expertise in AI-driven biology and early discovery, with an ambition to build a new generation of virtual biotech capable of moving quickly from idea to clinical validation. The role This is a founding-level hire, intentionally broad in scope and high in impact. You will operate across the full lifecycle of drug discovery and early development, with real ownership of programmes rather than a narrow functional remit. Key responsibilities include: • Defining and prioritising therapeutic programmes, including target selection and disease focus, • Shaping translational strategy, including biomarker plans and disease models, • Identifying programme risks and designing mitigation strategies, • Driving preclinical development from concept through to IND enabling studies, • Working closely with CRO partners across both computational and experimental workflows, • Helping build the scientific and operational foundations of the company You will also play a role in company building, from engaging external experts to selecting tools and shaping how work gets done. What they are looking for There is no single background that defines the right profile. This could suit: • A senior scientist in translational biology or early development who wants greater ownership, • Someone from a biotech or academic environment who has worked across multiple stages of the discovery process, • A future founder looking to gain hands on experience at the earliest stage of company building, • An individual with strong biological depth and a clear track record of learning quickly across disciplines Core attributes include: • Deep biological understanding in any relevant discipline, • High agency and comfort operating in ambiguity, • Strong intellectual curiosity and ability to self direct learning, • Comfort operating in a tech enabled biology environment, including hands on familiarity with computational tools and basic Python or similar coding for practical use, • Genuine engagement with modern AI driven approaches to biology, beyond conceptual interest, with evidence of applying or experimenting with these tools in practice, • A practical mindset around translating science into viable programmes What sets you apart • Experience identifying and validating therapeutic targets or pathways, • Exposure to both discovery and preclinical development, • Evidence of building something meaningful, whether research, tools or programmes, • Interest or experience in immunology, neurodegeneration or related areas Why this role This is not a typical hire into an established structure. It is an opportunity to shape both the science and the way the company operates, working closely with a founding team that is already thinking differently about how biotech should be built. Process The process will involve an initial discussion, followed by deeper technical and strategic conversations with the founders. Timing is flexible, but the intention is to move with the right individual rather than a fixed deadline. About Aspire Life Sciences Aspire Life Sciences partners with founder-led biotech and technology-driven life science companies from early stage through to growth. We support across key leadership and technical hires, as well as advising on team build, structure and hiring strategy at critical inflection points. If this role is of interest, or you would like to explore whether it aligns with your background, feel free to get in touch directly.

COMPANY OVERVIEW AIRNA is a biotechnology company with a mission to be the leading RNA editing company delivering precision therapies to patients with rare and common diseases. AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of Tübingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health. AIRNA has raised $245 million in financing from a world-class syndicate of investors including Arch Venture Partners, Forbion, Venrock Healthcare Capital Partners, RTW Investments, Nextech Invest, and ND Capital. We value teamwork, resilience, excellence, human, and health, and have a diverse team at both our headquarters in Cambridge, MA and our research operations in Tübingen, Germany. POSITION SUMMARY: The Head of Bioinformatics will lead the strategic vision, build and manage a high-performing computational biology team, and drive data science innovation across discovery, preclinical, and clinical development programs. This leader will play a critical role in advancing our RNA editing platform by developing robust computational frameworks for guide design, off-target prediction, transcriptome-wide analyses, biomarker development, and clinical data integration. The ideal candidate combines deep expertise in genomics and RNA biology with demonstrated leadership experience in biotech or pharmaceutical environments, ranging from early discovery to clinical-stage activities. RESPONSIBILTIES Scientific & Technical Leadership • Define and execute the bioinformatics strategy aligned with company objectives and clinical milestones., • Mine large public domain databases to build innovative analysis strategies to generate focused hypotheses for the identification of new therapeutic targets., • Apply advanced analytics to large-scale Genome-Wide Association Studies (GWAS) and mutation datasets and interpret genomic information for a variety of Cardiovascular, Thrombotic and Metabolic or Rare genetic diseases., • Combine molecular biology and epidemiology expertise with data analysis strategies to identify novel gain of function variants., • Establish machine learning approaches to improve editing efficiency prediction and specificity modeling., • Build AI based data analysis strategies to identify chemical modification patterns required for efficient endogenous ADAR based RNA editing., • Lead development of computational tools and pipelines for:, • RNA editing guide design and optimization, • Transcriptome-wide off-target assessment, • RNA-seq, single-cell RNA-seq, long-read sequencing analysis, • Variant detection and editing quantification, • Biomarker discovery and patient stratification, • Oversee analysis of preclinical and clinical sequencing datasets (GLP/GCP compliant environments)., • Integrate multi-omics datasets to support translational and clinical strategy., • Partner with Clinical Development to support trial design, endpoint strategy, and regulatory submissions., • Lead bioinformatics contributions to IND/CTA filings and interactions with regulatory agencies., • Build, mentor, and scale a high-performing bioinformatics and computational biology team., • Collaborate cross-functionally with Discovery, Preclinical, Translational Medicine, CMC, Regulatory, and Clinical Operations., • Drive a culture of rigor, reproducibility, and data integrity., • Publish and present findings in peer-reviewed journals and scientific conferences., • Prepare written and oral reports on a regular basis., • Collaborate with head of IT for scalable cloud-based data infrastructure and secure data governance frameworks to support bioinformatics., • Oversee implementation of workflow management systems and version-controlled analysis pipelines., • Ensure bioinformatics group compliance with data privacy and regulatory standards in collaboration with IT and other stakeholders (e.g., HIPAA, GDPR as applicable). REQUIREMENTS • Ph.D. in Bioinformatics, Computational Biology, Genomics, Systems Biology, or related field., • 10+ years of experience in biotech or pharma, with increasing leadership responsibility., • Demonstrated expertise in RNA biology, transcriptomics, and NGS data analysis., • Experience supporting clinical-stage programs and regulatory submissions., • Strong programming skills (Python, R) and experience with workflow tools (Nextflow, Snakemake, WDL/Cromwell)., • Background in machine learning applied to genomics., • Experience with cloud platforms (AWS, GCP, or Azure)., • Proven track record of building and leading high-performing teams., • Familiarity with models & AI products applied to a broad range of business use cases related to research and development., • Innovative and critical thinking, problem solving, cross-disciplinary communications Preferred • Experience in RNA therapeutics, gene editing, or nucleic acid drug development., • Familiarity with ADAR-mediated RNA editing mechanisms., • Experience with long-read sequencing technologies (PacBio, Oxford Nanopore). Key Competencies • Strategic thinking with hands-on scientific depth, • Strong executive communication skills, • Regulatory and compliance awareness, • Collaborative leadership style, • Results-oriented with high scientific rigor What We Offer • Opportunity to shape the future of RNA editing therapeutics, • Competitive compensation, equity participation, and benefits, • Salary Range: $220,000 - $260,000, • Collaborative and mission-driven culture LOCATION: AIRNA has a hybrid work model, and the role will be based in AIRNA’s corporate headquarters in Cambridge, MA ~3 days per week.

About the Job The Sr Computational Biologist position sits within the Computational Discovery team and is responsible for building advanced algorithms and technical features that will drive R&D’s innovation roadmap. This role leverages multi-modal data, including large scale genomics, real-world clinical outcomes, and imaging datasets, to identify and establish feasibility of novel biomarkers and therapeutic targets. The Sr Computational Biologist contributes as a subject matter expert in cross-functional initiatives to identify opportunities for growth and innovation that can advance FMI’s assay and data product capabilities. This position requires a deep understanding of cancer biology and bioinformatics, as well as the ability to communicate complex findings to internal and external stakeholders. Key Responsibilities • Utilize statistical expertise to explore multimodal data and lead scientific investigations into mechanisms of oncogenesis, prognostic and predictive biomarkers, drug resistance, and disease monitoring., • Manage and/or support code bases/repositories and dataset versioning and quality control., • Represent Computational Discovery to cross-functional departments and leadership teams to refine product strategy., • Collaborate with clinical partners in translational research projects that result in abstracts and publications., • Communicate results to both technical and non-technical stakeholders., • Other duties as assigned. Qualifications: Basic Qualifications: • PhD in a life science or mathematical field with a clinical focus and 4+ years of industry or post-doctorate experience within Cancer Biology, Bioinformatics, Biochemistry, or another related life science; OR Master’s degree in a life science or mathematical field with clinical focus and 6+ years of industry experience within Cancer Biology, Bioinformatics, Biochemistry, or another related field, • Proficiency with one or more of the following scientific computing languages: Python, R, Matlab, or Java Preferred Qualifications:, • Practical graduate and post-doctoral experience exhibited by first-author publications, • Subject matter expertise in one of the following areas: cancer genomics, bioinformatics, biostatistics, or machine learning, • Working knowledge of NGS technology, biomarker development, and real-world clinical outcomes, • Working knowledge of clinical nomenclature including line of therapy, stage, ECOG, and the patient journey in oncology, • Experience with computational technologies such as databases (SQL), cloud computing (AWS), and deep learning (AI), • Experience managing collaborations with multiple stakeholders, • Experience mentoring and developing junior scientists, • Translational research experience and ability to analyze and critically interpret scientific literature, • Understanding of HIPAA and the importance of patient data privacy, • Commitment to reflect FMI’s values: Integrity, Courage, and Passion The expected salary range for this position based on the primary location of Boston, MA is $145,000 - $180,000 per year. The salary range is commensurate with FMI’s compensation practice and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for FMI benefits. #LI-Onsite

About the Job Senior Scientist, Clinical Development is a scientist with translational expertise leading key scientific studies from concept through to publication, focused on value of FMI’s products in clinical practice and oncology drug development. This role executes on strategic scientific collaborations involving a range of functions and external collaborators, driving studies that establish the clinical validity and utility of products and biomarkers aligned to Clinical Development Plans and FMI enterprise strategy. Working with Clinical Development leadership, this position will execute analysis for and lead studies through conceptualization, narrative building, and writing using clinical cohorts or real-world evidence. This position will also contribute to department strategy and will generate and present evidence to inform biomarker and product prioritization and development. Key Responsibilities • Execute analysis and interpret data for multiple projects and publications supporting Clinical Development Plans (CDPs) and establishing clinical validity and clinical utility of our products., • Lead projects through submission including layout key objectives, figures, and narrative for abstracts and manuscripts, and solicit and incorporate input from key stakeholders with minimal guidance from CDP leads., • Conduct translational research to develop insights into predictive and prognostic biomarkers., • Leverage FMI’s clinical and genomic datasets to link genomic findings with clinical outcomes., • Contribute to protocol and SAP design and review for studies led by Clinical Development., • Support collaboration cross-functionally with internal and external stakeholders and thought leaders (academic and biopharma)., • Ensure studies further the strategic evidence needs of FMI products., • Manage and establish beneficial collaborations with key opinion leaders in oncology., • Continually develop deep domain expertise in genomics from a scientific, clinical and technical standpoint and lend insights to cross-functional teams to further the development of our products and strategy., • Maintain availability to the wider FMI business for clinical development expertise, presenting information and evidence to scientific, medical legal, commercial or other stakeholders as appropriate., • Maintain and deepen disease area-specific clinical and data science expertise., • Build awareness of biomarker and product development and department and business strategy and evaluate strategic alignment and priority of new projects., • Other duties as assigned. Qualifications: Basic Qualifications: • Master’s Degree in life sciences and 7+ year(s) of experience in clinical outcomes and/or genomics in an academic or life sciences industry setting, OR, • Doctorate Degree or Ph.D. in a life science and 5+ year(s) of experience in clinical outcomes and/or genomics in an academic or life sciences industry setting Preferred Qualifications:, • Proficiency with one or more script languages (Python, Perl, etc.) and statistical software package (R, SAS), • Demonstrated experience designing and executing analyses in cancer genomics, • Expertise in translational research linking genomic biomarkers with clinical outcomes, • Experience leading biomedical data analysis (genomics data, clinical outcomes, real-world data, liquid biopsy, RNA and protein expression), • Experience with communicating with academic scientists and treating physicians, • Track record of taking projects from concept to completion, • Lead-authored publications, and demonstrated excellence in writing, • Ability to work independently as well as collaborate and communicate effectively with cross-functional teams; drive agendas, lead discussions, and drive results on cross-functional teams, • Knowledge of oncology, next-generation sequencing, clinical trials, and/or companion diagnostics., • Experience with oncology diagnostic development and product development and validation, • Demonstrated ability to successfully manage multiple concurrent projects in a fast-paced, dynamic environment, • Excellent organizational skills and meticulous attention to detail, • Demonstrated ability to think creatively and problem solve, • Extremely high level of integrity and reliability, • Excellent presentation skills, • Willingness to adhere to all applicable FMI Standard Operating Procedures, policies, processes, and compliance guidelines, • Understanding of HIPAA and the importance of patient data privacy, • Commitment to FMIs values: Integrity, Courage, and Passion The expected salary range for this position based on the primary location of Boston, MA is $143,000 - $179,000 per year. The salary range is commensurate with Foundation Medicine's compensation practice and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for Foundation Medicine's benefits. #LI-Hybrid

Job Summary: Natera is seeking an experienced Senior Software Engineer with modern data engineering and AI-enabled development skills with deep scientific R&D background to design and build data products that directly support genomics research and translational science. This role is intended for someone who already understands how research organizations operate, how genomic data flows from experiment to insight, and how to engineer data systems that accelerate discovery without compromising rigor or compliance. The ideal candidate combines strong data engineering skills with a computer science background and hands-on experience in bioinformatics, genomics, or computational biology, and the ability to work independently in an R&D environment. You will also be comfortable moving quickly to prototype novel data products while ensuring solutions evolve into robust, compliant, and scalable platforms. You will bring an internalized sense of what “good” looks like for research data: reproducibility, traceability, performance, and scientific usability. * Design, build, and maintain the data products that support R&D, analytics, Lab and scientific workflows, from initial design through deployment and iterations * Build and maintain data pipelines for large and complex datasets, from raw inputs through derived and analysis-ready datasets. * Apply domain knowledge in genetics and bioinformatics to design data models, schemas, and abstractions that align with real research patterns and downstream analysis needs. * Design and enforce de-identification and privacy-preserving architectures that meet HIPAA and related regulatory requirements while remaining usable for research. * Design scalable data models to power analytics, reporting, and downstream applications. Maintain high standards of data quality, accuracy, lineage, and observability across data pipelines. * Partner closely with R&D scientists, bioinformatics teams, and software engineers to translate research needs into well-structured, reusable data assets. * Optimize storage, retrieval, and lifecycle management for large scientific files (E.g. sequencing data, intermediate artifacts, derived datasets). * Drive rapid prototyping efforts to support exploratory, proof-of-concepts, and early-stage initiatives, while guiding the transition to production-grade systems. * Implement best practices for data quality, validation, lineage, observability, and reproducibility to enable a trusted 360° view. * Collaborate with product managers and domain experts to translate requirements into technical solutions * Establish golden paths (templates, examples, docs) and contribute to shared data product catalogs, patterns, and best practices used by other engineers * Provide technical guidance and mentorship to mid-level engineers * Bachelor’s or Master’s degree in computer science or bioinformatics with healthcare or biotech data domain experience preferred * 8+ years of experience in data engineering, designing and maintaining data pipelines and cloud data architectures (e.g, Snowflake, AWS, etc) * Strong background in bioinformatics, genomics, or computational biology (required). Understands key genomics and bioinformatics data formats, such as BAM, VCF, FASTQ, common compression techniques for these file formats, and their storage, delivery, and management needs. * Demonstrated experience supporting scientific R&D, Lab workflows and research teams with production-grade data systems. * Strong proficiency in Python, SQL, and distributed processing frameworks (Spark or equivalent) * Experience with modern orchestration tools (Airflow, dbt, Dagster) * Experience leveraging AI-assisted development tools (e.g., LLM copilots) to accelerate data solution development * Familiarity with building data products that support analytics, ML, or AI applications * Strong data modeling expertise (dimensional, normalized, healthcare-specific schemas) * Experience implementing CI/CD for data pipelines and IaC (Terraform, CloudFormation); Knowledge of data observability, testing, and data quality frameworks * Demonstrated ownership of production-grade data systems and end-to-end pipeline lifecycle * Ability to evaluate emerging data and AI technologies and recommend scalable solutions * Exposure to vector databases, embeddings, semantic search, or RAG-based architectures is a plus * Proven ability to operate effectively in fast-paced environments, balancing speed, rigor, and compliance * Strong written and verbal communication skills with ability to collaborate across engineering, analytics, and business stakeholders * Experience working with healthcare, life sciences, or other highly regulated data, including hands-on HIPAA compliance. The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA $125,000 - $156,300 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit ___. Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: ___ Please be advised that Natera will reach out to candidates with a @___ email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information:

Manager, Translational Scientist | Cardiology Dallas, Texas, United States (Remote) Hartmann Young are partnering with a fast‑growing, privately held biotech advancing a novel therapeutic platform in cardiovascular disease, with a strong focus on cardiomyopathy and heart failure. This is a high‑impact Manager‑level Translational Scientist role within a lean, agile organization, offering meaningful hands‑on ownership across preclinical and early clinical development. The role is remote across the U.S., with Dallas / Plano–based candidates of particular interest given the company’s growing presence in Texas. This is an urgent hire and an opportunity to join a program at a critical development inflection point. The Role You will contribute scientific leadership across translational cardiovascular research, bridging mechanistic biology, cardiovascular animal models, and early clinical development. The role is ideal for a translational biologist with strong in vivo cardiovascular expertise who can partner cross‑functionally to support progression from preclinical studies into Phase 1/2 clinical trials. Key Responsibilities • Lead and execute translational biology activities supporting cardiovascular programs from preclinical through early clinical stages, • Serve as a subject‑matter expert in cardiovascular animal models, including models of cardiomyopathy and heart failure, • Design, oversee, and interpret nonclinical efficacy, PK/PD, and mechanistic studies, • Translate preclinical findings into clinical hypotheses, biomarker strategies, and dose rationale, • Collaborate closely with Clinical Development, Clinical Operations, Regulatory, and Biometrics to enable efficient bench‑to‑bedside translation, • Contribute to key program documents including nonclinical study reports, Investigator’s Brochures, translational sections of protocols, and regulatory submissions, • Manage and interact with external CROs, academic collaborators, and vendors supporting in vivo and translational studies, • Support interpretation of emerging early clinical data in the context of preclinical and translational evidence Expertise We’re Looking For • PhD (or MD with strong research focus) in cardiovascular biology, physiology, pharmacology, or a related field, • Demonstrated experience in a translational biology or preclinical cardiovascular role within biotech, pharma, or an academic–industry environment, • Strong hands‑on familiarity with cardiovascular animal models, particularly:, • Cardiomyopathy (genetic and acquired models), • Heart failure–relevant models (HFrEF / HFpEF), • Solid understanding of translational biomarkers, PK/PD relationships, and mechanistic data integration, • Experience supporting programs advancing toward or into early clinical development (Phase 1 / 2), • Comfort operating in a fast‑paced, resource‑lean biotech environment, • Strong scientific writing, communication, and cross‑functional collaboration skills Why Join? • Join a mission‑driven biotech focused on high‑unmet‑need cardiovascular diseases, • Hands‑on translational role with real impact on program direction and clinical strategy, • High visibility within a flat organizational structure, • Remote U.S. working model, with added opportunity for local impact if Dallas‑based, • Opportunity to contribute to programs with genuine potential to improve outcomes in heart failure and cardiomyopathy

Company Description Michael Farzan’s laboratory at Boston Children’s Hospital and Harvard Medical School engineers lymphocytes – B cells and T cells – for a range of scientific and translational goals. For example, this technology allows us to use murine germinal centers to select potent and highly bioavailable human antibodies. It also provides us useful animal models to evaluate and improve vaccines, as well as a new way to address unanswered questions in lymphocyte-cell biology and adaptive immunity. Finally, the chimeric antigen receptor (CAR) B cells and CD4-positive CAR T cells so generated can themselves be conceived of as a therapy for many disease states including HIV infection. Because our engineered B cells affinity mature, we apply them to our efforts to predict uniquely human responses to candidate vaccines in mice and non-human primates. This tool is critical for our parallel efforts to develop novel antigens that elicit antibodies in humans that protect from HIV-1 infection. Finally, we seek to develop better genome editing and gene delivery tools that will improve the quality and safety of our engineered lymphocytes. The pay range is Boston Children Hospitals’s reasonable and good-faith expectation for this pay at the time of posting, and depends on skills, experience, education, certifications, and a variety of other job-related factors. BCH offers a comprehensive benefits package that includes flexible schedules, medical/vision/dental coverage, child-care and student-loan subsidies, generous paid time off, a 403(b) retirement plan, commuter and other employee discounts. Boston Children’s Hospital requires influenza vaccination for all employees, unless eligible for a medical or religious exemption. Boston Children’s Hospital is an Equal Opportunity/Affirmative Action Employer; all qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, disability, or other protected status. Role Description This is a full-time on-site position for a Post-doctoral Fellow at Boston Children's Hospital in Boston, MA. The Fellow will engage in advanced research activities, perform laboratory experiments, analyze data, contribute research publications, academic teaching and mentoring, and work closely with other members of the laboratory to advance new science that contributes to human health. Qualifications • A Ph.D. in biological science, bioengineering, or a related field., • Proficiency in cell culture and molecular biology techniques., • An ability to work effectively with others., • A willingness and ability to learn new science and technologies., • A commitment to training students, research assistants, and other fellows., • Previous experience in vivarium studies, bioinformatics and/or immunology would be a plus.

Job Description Senior Scientist 1/Senior Scientist 2- Translational Sciences About Seismic Seismic Therapeutic is making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. We have brought together a stellar team of leading immunology drug developers, machine learning innovators and company builders who are charting new drug discovery territory to open better and faster ways to make medicines for patients with immune-driven diseases. At our core, we are focused on phenomenal science, supportive culture, a superstar team, meritocracy, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that. Role Summary This is a terrific opportunity for a highly motivated senior scientist with expertise in translational immunology, focusing in autoimmunity, to join our translational sciences team. In this role, you will design and execute translational strategies that inform biomarker development, and proof-of-concept for our immunology pipeline. Key Responsibilities • Partner with external CROs and clinical sites to execute translational studies., • Oversee biomarker and bioanalytical assays (PK and ADA) development, transfer and implementation in clinical setting, • Analyze and interpret complex immunological datasets from exploratory clinical samples (PBMC, tissue biopsies, serum/plasma), including flow cytometry, CyTOF, single-cell RNA-seq, cytokine profiling, and multiplex immunoassays., • Contribute to regulatory filings, clinical study reports, and scientific publications., • Serve as the scientific lead for immunology biomarker strategy on one or more programs, representing translational science in cross-functional teams., • Ph.D. Immunology or a closely related field., • 3-5+ years of relevant experience in translational research with autoimmunity in an industry setting, • Fluent in bioanalytical assay development, including transferring of assays to CROs, • Hands-on experience with immunological assays: flow cytometry/mass cytometry, ELISAs/MSD, multiplexed cytokine panels, and transcriptomic methods., • Experience with GCP/GLP environments and regulatory submissions (IND, BLA/NDA)., • Experience with bioinformatics tools and analysis of high-dimensional datasets (scRNA-seq, CyTOF, proteomics)., • Deep working knowledge of human immunology, including innate and adaptive immune pathways, T cell biology, B cell biology, or innate immune signaling., • Demonstrated ability to analyze and communicate complex biological data to cross-functional audiences., • Strong publication record or equivalent evidence of scientific contribution. Competencies: • Scientific rigor with the ability to think critically and independently about complex translational questions., • Excellent written and verbal communication skills; able to distill complex science for diverse audiences., • Collaborative, team-oriented mindset with comfort operating in a fast-paced, matrixed environment. Annual Salary Range: $145,000 - $170,000 (depending on level)

Job DescriptionDescription: The ADA Forsyth Institute was founded in 1910 as the Forsyth Dental Infirmary for Children (later, the Forsyth Institute), to provide dental care to the disadvantaged children of Boston. While continuing to serve children in need, yet recognizing the ultimate goal is to prevent dental disease, the Institute in 1915 began to focus on scientific research and is today the world’s leader in oral health research. In October of 2023, the Institute joined with the American Dental Association to form the ADA Forsyth Institute, a 501(c)(3) entity dedicated to improving people’s oral and overall health and powering the profession of dentistry through cutting-edge basic research, creative translational science, innovative clinical technologies, and global public health outreach. Consistent with the Institute’s founding mission, the ADA ForsythKids mobile dental program continues to serve children in need. ADA Forsyth, an independent not-for-profit research organization, is located in the Brick bottom District of Somerville, in a newly built life-science building. We are in close walking distance to restaurants, the Community Path, and T & bus routes for easy commuting. We are seeking a highly motivated Postdoctoral Fellow to join a dynamic research team for a 5-year project funded by the National Institute of Dental and Craniofacial Research (NIDCR/NIH). This project aims to develop a streamlined platform for creating bioactive dental restoratives with self-healing and dynamic capabilities, tailored to individual patient needs. Using hybrid modeling and simulation approaches, we will refine material formulations and optimize the application of restorative materials for effective caries treatment. The successful candidate will collaborate with materials scientists, microbiologists, AI and Machine Learning experts, and dentists. Additionally, opportunities for participation in NIH training programs and career development initiatives will be available. We welcome self-driven researchers to join our team and contribute to advancing global oral health through innovative biomaterials research. For additional inquiries, please contact Dr. Jirun Sun, Full Professor, ADA Forsyth Institute: . RESPONSIBILITIES • Independently plan, design, optimize and execute experiments., • Design, prepare, and characterize dental adhesives and composites., • Perform experiments to improve performance and robustness., • Carry out dental bonding, bioactive mineralization, mechanical testing and durability experiments., • Analyze and interpret experimental data, as well as maintain accurate and detailed documentation of completed experiments., • Development, verification, validation and technology transfer of dental restoratives and other dental products.Requirements:, • PhD, DDS, or equivalent degree in chemistry, mechanical engineering, polymer science, materials science, chemical engineering, or related fields., • Strong motivation, responsibility, and attention to detail., • Excellent analytical, problem-solving, and experimental skills., • Effective interpersonal and communication skills., • Ability to work collaboratively in a multidisciplinary environment., • Experience in calcium phosphate mineralization, • Experience in antimicrobial evaluation, • Expertise in mechanical testing including three-point bending, fracture toughness and fatigue evaluation., • Experience and knowledge in spectrometers, SEM, DMA, Instron, and nanoindentor, • Familiar with dental bonding procedures and bonding tests.

Job Description Vice President, Head of Clinical R&D (HoC) – Solid Biosciences Charlestown HQ preferred Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a Vice President, Head of Clinical R&D to work as a strategic partner with the CMO, and other members of the Executive team to provide strategic direction and technical leadership to the clinical R&D and clinical scientist groups and is responsible for the overall management, direction and performance of Phase I-IV for drug products, including: overseeing clinical development and pharmacovigilance according to agreed-upon deadlines and budgets, clinical trial design, implementation and execution, clinical research, data analysis and management. The HoC also provide strategic direction and technical leadership to the clinical R&D and clinical scientist groups in their role to guide translational development and clinical guidance and planning for Lead and IND Candidate programs as well as for evaluation, input and direction on potential partnering/business development opportunities. The HoC works in partnership with the CMO to establish the clinical research vision and regulatory roadmap for the company including standards and policies designed to ensure the quality and outcomes of compounds under development. The HoC in collaboration with the CMO and the rest of the Executive team will have over-arching responsibility for the successful clinical development of Solid’s pipeline programs including development of a clinical roadmap for all compounds. This role will report to the Chief Medical Officer and can be based in Solid’s Corporate Headquarters located in Hood Park in Charlestown, MA or work remotely from the East Coast. Key Position Responsibilities • Provide oversight and leadership of the various functional areas: Clinical R&D (medical directors and therapeutic area heads), clinical science, medical monitoring, pharmacovigilance, • Work collaboratively with the Research function, providing input into design of preclinical trials to support drug products from Lead through candidate phase as they enter in the clinic and including but not limited to CDP development, TPP development and IND/CTA clearance along with associated activities., • Close collaboration with Patient Advocacy to ensure patient centricity from product conception, through clinical trial conduct into and through commercial launch and to work collaboratively to ensure the voice of the patient is represented in all decisions and actions and to ensure the voice of the physician is appropriately presented., • Experience managing multiple programs across multiple geographies, • Input into the development of key marketing materials., • Research and identify new opportunities and novel therapeutic opportunities that augment the company’s mission, vision, values, and goals, • Establish and maintain relationships with principal investigators and KOL’s to ensure that the Company has a clear understanding of clinician needs and requirements., • Represent and manage communication of Solid’s clinical and regulatory programs to diverse audiences including: the executive team, regulatory agencies including the FDA and EMA, investors, Board of Directors, and other key stakeholders., • To assist in communications with other pharmaceutical companies and partners to identify and implement collaborative studies, regulatory activities, and other programs that align with the company’s strategy and goals., • Attract, motivate, retain and lead a highly skilled clinical development and regulatory team., • Maintain current understanding of competitors and clinical developments in relevant therapeutic areas by attending scientific presentations and reviewing relevant literature., • Other related ad hoc duties and projects as required., • Dedicated to maintaining and or adapting our clinical R&D structure and cross functional matrix relationships that empower colleagues, leverage and optimally harness their talents and maximizes their opportunities for promotion and advancement, • Dedicated to providing a dynamic working environment for mentorship and professional growth of clinical R&D colleagues. Experience Requirements • Board Certified MD with medical research and drug development experience., • MD with regenerative medicine (such as AAV) preferred, • MD with experience in neuromuscular and or cardiovascular rare disease space preferred., • Proven leader of high potential high performing teams., • Prior experience in clinical development leadership roles (preferably global experience) across all phases of clinical studies. Demonstrated capabilities leading clinical programs to successful filing and approval in both US and globally., • Experience interacting with the FDA/EMA and knowledge of GCP clinical requirements, general regulatory requirements, and relevant regulatory guidance documents pertinent to the Company., • Excellent interpersonal and communication skills with ability to relate to both internal and external stakeholders. Ability to develop strong relationships with Executive team and Board of Directors., • Able to foster and nurture a company culture grounded in science and ethics. Key Position Attributes This role should have an expectation of 20% travel and may require significant travel on an ad hoc basis. Compensation The base compensation range for this role is: $290,000 - $400,000. Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits and Solid Advantages At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices. • Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs, • 401(k) program participation with competitive company matched contributions, • Eligibility to participate in Solid’s Employee Stock Purchase Plan, • Mobile phone subsidy for eligible employees, • Tuition Reimbursement, • Vision Coverage, • Life Insurance, • Voluntary Pet Insurance, • Employee Discount Program on Travel, Entertainment, and Services, • Employee Assistance Programs, • Daily Subsidized Lunch Delivery (onsite @ Hood Park), • Free Onsite Full-Service Gym (onsite @ Hood Park), • Employee Parking (onsite @ Hood Park), • 12 Observed Holidays and a winter shut down, • 15-day PTO Policy and a 40-hour rollover YoY, • 40-hour Sick Policy, • 8 Hour Floating Holiday

Job DescriptionAbout InduProInduPro, Inc. is bringing life-changing therapies to patients through novel cell-surface platform technologies. We are defining and manipulating protein interactions beyond natural signaling paradigms. InduPro platforms integrate inherent protein proximity at the cell surface with the ability to manipulate protein pairings via induced protein proximity to create novel signaling pathways and logic gates. Our culture fosters innovation at every level. The OpportunityWe are seeking a highly-motivated and collaborative Executive Director with strong leadership and technical skills to oversee CMC activities for our ADC programs including: cell line, drug substance, drug product, process development, analytical development, cGMP manufacturing and stability studies, and clinical packaging labeling and distribution. This role will serve as the main point of contact with CDMOs and work within a cross-functional team, including representatives from research, translational, operations, clinical, and finance departments to successful advance programs through the clinic. This is an exciting, high visibility role for a seasoned individual looking to make an impact in a startup company.Key Responsibilities: • Establish, manage and lead CMC strategy and execution for assigned programs for drug substances and drug products from pre-clinical through commercial development with close attention to timelines and budget., • Select third-party vendors, negotiate effective supply/technical agreements. Identify contract analytical laboratory sites required to guide and support third party manufacturing relationships., • Direct/oversee contract manufacturing, testing, packaging and labeling operations for the company’s drug substances and drug products. Act as primary liaison with contractor(s) on assigned projects. Guide external operations through tech transfer, process and method development, optimization, qualification and validation of the activities related to all manufacturing operations in compliance with GMP., • Participate in product development project teams as CMC functional area representative., • Support the creation of SOPs and guidelines related to the production, planning, disposition and management, materials, etc. in compliance with GMP., • Work with consultants for Regulatory and QA, alongside Senior Management to ensure that all company policies are adhered to and all external manufacturing activities comply with relevant regulations., • Maintain knowledge of current best practices of biological manufacturing. Identify emerging trends and technologies and lead implementation/feasibility assessment, as appropriate., • Design and execute the CMC development plan to support global submissions., • Prepare CMC regulatory filing sections (domestic and international) including Module 3 and review of supporting documentation., • Review and approve master and executed batch records from all manufacturing activities; analytical release testing, stability studies and investigations, as required., • Develop production plans to support preclinical, clinical, and commercial development and adjust plans as appropriate to meet corporate objectives., • Provide comprehensive project analysis to senior management as required in the form of reports or presentations as needed.Education & Experience:, • BS/MS or PhD in a relevant discipline., • A minimum of 10 years of experience in CMC project management, development, scale-up and clinical/commercial development and manufacturing of biologic products in the biotechnology or pharmaceutical industry. At least 5 years of experience in a leadership role., • Experience in leading and direct management of research, process development, and manufacturing., • Extensive experience in leading biological process and analytical development., • Previous experience leading cross-functional project teams, and familiarity with the drug development process, including transitions from pre-clinical to clinical development., • Experience managing contract development and manufacturing (CDMO) partnerships strongly preferred., • ADC experience strongly preferred., • Hands on experience in more than one of the following CMC functions; drug substance, drug product, analytical development, process development, and stability, or program management., • Experience developing and manufacturing aseptic biologic products., • Experience authoring successful IND and IMPD CMC regulatory submissions., • Familiarity with small start-up environments is strongly preferred., • Team player that is able to think creatively and integrate perspectives from different functional areas., • Strong leadership skills with demonstrated track record of success., • Excellent oral and written communication skills., • Able to effectively balance technical program requirements with business needs.Physical Work Requirements: Physical presence at the InduPro worksite, or in the field, is required for this role. At InduPro we believe that physical presence helps enhance collaboration, innovation, productivity, employee well-being, employee engagement, and Company culture. BenefitsAt InduPro we believe that being face to face helps enhance collaboration, innovation, productivity, employee well-being, employee engagement, and Company culture. Every member of the InduPro team plays a role in shaping our science and our culture in a dynamic startup environment. We offer a competitive total compensation package, including stock options, participation in an annual performance bonus incentive program, a comprehensive benefits package, paid time off, and exciting opportunities for professional development. Benefits include medical, dental, and vision coverage; company-paid life and disability insurance; supplemental life and disability insurance; voluntary accident, critical illness, and hospital indemnity insurance; a 401(k) plan with employer matching contributions; flexible spending accounts; an employee assistance program; flexible paid time off; 10 paid company holidays; and employee access to voluntary auto, home, legal, and pet insurance. InduPro, Inc. is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability, or any other status protected by federal, state, or local law. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Job Description The Animal Medical Center's world-renowned Cancer Institute is seeking a board-certified or board-eligible Medical Oncologist (ACVIM or ECVIM) with PHD and research experience to join our dedicated oncology team, which includes medical, radiation, and surgical oncology. The position will be a clinical oncology role with protected research time and flexibility to expand research responsibilities over time. In this role, the incumbent will lead our academic research efforts, by developing clinical trials, fostering translational collaborations, and advancing evidence-based oncology initiatives. In parallel, the incumbent will provide compassionate, high-quality clinical oncology care, including diagnosis, staging, chemotherapy, immunotherapy, and palliative care. This individual will also drive the adoption of innovative medical practices and serve as a key advisor to the team on emerging and novel therapies, both currently in practice and those on the horizon of becoming the standard of care. AMC is a leading animal hospital with a 115-year legacy, AMC offers specialty, emergency, and primary care to over 55,000 patient visits annually. As a mission driven non-profit, we provide animals with the gold standard in patient care while emphasizing lifelong learning, postgraduate intern and resident training, and scholarship. AMC is dedicated to supporting excellence in clinical practice and post-graduate teaching, ensuring rewarding careers, and assuring the health and safety of all hospital employees and clients. The Cancer Institute at the Animal Medical Center is modeled after progressive, patient-centered human cancer hospitals. The Animal Medical Center's Cancer Institute is a revolutionary medical center created to provide integrative and comprehensive care for pets diagnosed with cancer. This innovative design enables our staff to deliver on the Institute's core mission – to care for more animals, focus on early detection, maximize the amount of time pet parents can spend with their beloved pets while maintaining a good quality of life, and work toward a cure through advanced research. The Cancer Institute consists of three ACVIM board-certified oncologists, two ACVR board certified radiation oncologists, and one ACVS board-certified Fellow in Surgical Oncology, three residents in medical oncology, two residents in radiation oncology, one specialty intern in medical oncology, and 32 rotating general interns. Supporting services to the Cancer Institute include high-field MRI, 64-slice CT with advanced reconstruction capabilities, and Interventional Radiology. Additionally, the AMC has an on-site IDEXX laboratory including on-site clinical and anatomical pathologists with stat cytology capabilities. The AMC is equipped with a new Elekta Infinity Linac system with electron and 6- MV photon capability equipped with a 6-degree HexaPOD couch and a cone-beam CT for IMRT, VMAT and SRS and for 4DCT respiratory gating. We are also equipped with the most updated version of the Monaco computer treatment planning system licensed for all 3D IMRT, VMAT and SRS planning as well as for Electron Monte Carlo planning. Our CT couch is equipped with an iBEAM evo CT overlay table for proper CT simulation imaging to match the Linac couch. The Radiation Oncology department is also equipped with a Strontium probe for the treatment of small surface lesions (ex: feline nasal planum SCC, feline cutaneous MCT and avian uropygial SCC). The AMC offers a unique hybrid of academia and clinical practice, that creates a collegial environment within the hospital and promotes inter-departmental consultations and cohesive patient care. In addition to our Cancer Institute, the Animal Medical Center is home to boarded specialists in over 20 services and specialties including avian and exotic pet medicine, cardiology, dermatology, emergency and critical care, internal medicine, interventional radiology and endoscopy, neurology, ophthalmology, pathology, primary care, radiology, rehabilitation and sports medicine, and surgery. Job Responsiblities • Establishing and leading the oncology research program including clinical trials and translational initiatives., • Providing comprehensive oncology care including diagnosis, staging, treatment planning, and longitudinal case management., • Mentoring, training, and evaluating residents and interns., • Active participation in rounds, teaching, and service activities., • Communicating clearly and compassionately with clients regarding diagnosis, prognosis, quality of life, and end-of-life decisions. Our Benefits:, • Competitive salary, • Generous sign-on bonus, • Four-day work week, • Comprehensive benefits including health insurance with medical, dental, and vision benefits, very generous paid time off, paid continuing education time-off and stipend, and 403-b retirement plan with employer contribution, • School loan debt forgiveness opportunity as a non-profit hospital, • Non-corporate practice without pressure for percentage pay A Commitment to Lifelong Learning: Founded in 1910, the Schwarzman Animal Medical Center is the world's largest veterinary teaching hospital, offering compassionate, collaborative, and cutting-edge veterinary care. Our commitment to innovation has led to the creation of one of the most advanced veterinary facilities in the world. State-of-the-Art Facilities: AMC just completed a major expansion and renovation. This project transformed the hospital's entire 83,000-square-foot space into a state-of-the-art facility unlike any other. Highlights include: A brand-new full floor surgical center, 1.5 Tesla Philips MRI (the exclusive high field MRI for small animals in NYC), 64-slice spiral CT scanner, Electroencephalography (EEG), Elekta Versa HD Linear Accelerator, In-house Laboratory, Ultrasound, Echocardiogram, and Mobile Cone Beam CT A multidisciplinary team of 140+ veterinarians across 20+ specialties: With over 20 specialties and services under one roof, our departments frequently work together to deliver the highest quality of patient care in the veterinary field. Our dynamic array of specialists means that we are the go-to place for complex cases. A Hospital in the heart of NYC: AMC is located in Manhattan, surrounded by leading research and teaching institutions such as Cornell University College of Veterinary Medicine, Weill Cornell Medical School, and NYU. Collaborative research opportunities abound, and our strong focus on education ensures a rewarding career for those passionate about mentoring and advancing veterinary medicine.

Job DescriptionCompany Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube. Job Description Purpose: As a translational scientist in Precision Medicine Neuroscience bridges basic brain and nervous system research and clinical applications, focusing on developing biological and disease insights for neurological and psychiatric disorders. Responsibilities: Uncover neurobiological mechanisms of disease that elucidate patient subtypes; mechanisms of action, response, or resistance, and advance the development of novel interventions. • Develop testable hypotheses related to neurobiological pathways, neuronal circuitry, cognitive or behavioral domains, or functional markers of disease or patient subtypes that will advance pipeline and disease area goals. Collaborate with PMed DAS leads and other functional leads, develop and execute operationally-sound approach and generate actionable outcomes., • Shape and enhance efforts in human neuroscience, including promoting research synergies with other areas of R&D, aligned to disease area strategic goals., • Drive scientific strategy for translational biomarker development and discovery target validation / MOA projects., • Lead the design of clinically translational experiments in collaboration with PMED, clinical leads, or discovery research translational teams that achieve disease area strategic goals., • Establish external collaborations to augment internal translational efforts and expand experimental design options., • Ensure quality and effectiveness of major project plans within precision medicine through sound design and early risk assessment., • Advance clinical translational efforts through alignment with relevant stakeholders and leadership, and navigation of current and emerging business challenges to goal achievement., • Communicate scientific expertise and learnings by proactively advising and knowledge-sharing with subordinates, peers, and senior management., • Source and leverage relevant emerging scientific trends from inside and outside the organization to keep pace with and advance standards in the field of translational neuroscience.Qualifications, • Bachelor’s Degree in Science related field with 16 years of related work; Master’s Degree Science with 10 years of related work; PhD or equivalent professional terminal degrees (or PharmD/MD) in Science or related field with 6 years of related work experience., • Relevant biology, target validation, and biomarker research experience in the areas of neural circuits, functional domains in clinical sciences using clinical science approaches (e.g., cognitive, emotional, behavioral), liquid-based methods, or structural and functional imaging. Expert in one/at least one., • Knowledge of the drug development process and how clinical translation fits within this., • Proven leadership ability to direct, lead, and learn from cross-functional teams., • Strong presentation skills required, with the ability to present data successfully to scientists and nonscientists., • Tests new innovations and manages to reality. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: * The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. * We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. * This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 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Job Description About the ALS Therapy Development Institute The ALS Therapy Development Institute (ALS TDI) is the world's leading nonprofit biotech focused exclusively on discovering and developing effective treatments for amyotrophic lateral sclerosis (ALS). Our multidisciplinary team integrates in vivo pharmacology, molecular biology, and clinical insights to accelerate ALS therapy development from bench to bedside. Position Summary We are seeking a highly motivated scientist to join our preclinical pharmacology team. The successful candidate will bring a broad and robust technical skill set largely focused on in vivo techniques. This position is responsible for developing new animal models of ALS and performing preclinical pharmacology studies to evaluate the safety, efficacy, and mechanism of action of experimental drugs. Key Responsibilities • Design, execute, and interpret pharmacology studies including tolerability, PK/PD, and efficacy to evaluate therapeutic candidates., • Perform aseptic surgical procedures in rodents such as stereotaxic ICV and intrathecal injections and osmotic pump implantations., • Develop and conduct phenotypic, behavioral, and functional assays to assess drug efficacy and characterize disease progression., • Generate and characterize novel ALS models using transgenic approaches, viral vectors, and CRISPR-based genome editing, • Design and manage transgenic mouse breeding strategies to investigate genetic interactions., • Write grant proposals, manuscripts, presentations, and reports to communicate experimental findings., • Prepare and maintain standard operating procedures (SOPs) and ensure all studies comply with IACUC, animal welfare, and biosafety requirements., • Mentor and train junior staff in experimental techniques, data analysis, and scientific problem solving. Required • PhD in neuroscience, pharmacology, molecular biology, or related field, • Strong publication record with at least two first-author papers, • Hands on experience with rodent models, behavioral assays, and stereotaxic surgery, • Background in mouse model development, transgenic strategies, or genetic engineering, • Strong foundation in experimental design and statistical analysis, • Postdoctoral or industry experience in drug discovery or translational research, • Work in ALS or related neurodegenerative diseases, • Experience with transgenic colony management, genotyping, and breeding strategies, • Experience with histology, immunohistochemistry, or imaging-based analyses, • Work with non-rodent models (zebrafish, Drosophila, C. elegans), • Exposure to gene therapy, antisense oligonucleotides, or biologics, • Familiarity with pharmacology studies and drug discovery workflows, • Proficiency with coding and AI based tools, • A mission-driven environment focused on accelerating therapies for ALS patients., • A collaborative, cross-functional research setting with access to advanced technology platforms., • A competitive salary and benefits package commensurate with experience and level., • Opportunities for scientific growth and contribution to high-impact research. Job Posted by ApplicantPro

Job DescriptionDescription: The ADA Forsyth Institute was founded in 1910 as the Forsyth Dental Infirmary for Children (later, the Forsyth Institute), to provide dental care to the disadvantaged children of Boston. While continuing to serve children in need, yet recognizing the ultimate goal is to prevent dental disease, the Institute in 1915 began to focus on scientific research and is today the world’s leader in oral health research. In October of 2023, the Institute joined with the American Dental Association to form the ADA Forsyth Institute, a 501(c)(3) entity dedicated to improving people’s oral and overall health and powering the profession of dentistry through cutting-edge basic research, creative translational science, innovative clinical technologies, and global public health outreach. Consistent with the Institute’s founding mission, the ADA ForsythKids mobile dental program continues to serve children in need. The ADA Forsyth Institute is looking for a dedicated and detail-oriented Research Dental Hygienist that will work under the direction of the Director of the Center for Clinical & Translational Research (CCTR) and the Principal Investigator (PI) to support the conduct and management of clinical research studies. This role is responsible for performing clinical procedures, ensuring protocol compliance, and supporting regulatory and data management activities across research projects. The Research Dental Hygienist must demonstrate a strong understanding of clinical trial conduct, Good Clinical Practice (GCP), and applicable federal regulations, including Title 21 of the Code of Federal Regulations. Requirements: Clinical Research & Trial Conduct • Perform clinical periodontal assessments and other protocol-required clinical measurements and procedures., • Conduct dental hygiene treatments in accordance with study protocols and Standard Operating Procedures (SOPs)., • Successfully complete required calibration exercises for all clinical indices and maintain satisfactory calibration status., • Monitor study activities to ensure compliance with approved protocols and regulatory requirements., • Collect and record study data accurately on paper and electronic case report forms (CRFs/eCRFs)., • Support investigational product administration, inventory management, and randomization procedures as assigned., • Maintain required research certifications and complete all mandatory regulatory and ethics training., • Participate in CCTR meetings, annual trainings, and study team discussions., • Report to the Director and Principal Investigator (or designated study coordinator)., • Communicate effectively with study participants, including scheduling visits, providing reminders, and delivering study-related instructions., • Graduate of an accredited Dental Hygiene program with an active and unrestricted Dental Hygiene license., • Current CPR/BLS certification., • Completion of required continuing education credits to maintain licensure., • Knowledge of Good Clinical Practice (GCP) and applicable FDA regulations (21 CFR) governing clinical research., • Experience working under IRB-approved protocols and understanding of informed consent processes preferred., • Prior experience in a clinical trials, academic, or research setting preferred., • Experience with electronic data capture (EDC) systems and case report forms (CRFs) preferred., • Strong documentation, data accuracy, and organizational skills., • Proficiency in Microsoft Office and ability to learn research software systems., • Ability to follow detailed protocols, maintain regulatory compliance, and prepare for audits., • Excellent communication skills and ability to work effectively within a multidisciplinary research team., • Strong attention to detail, professionalism, and ability to maintain confidentiality. ADA Forsyth is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Job Description Why Join Us? Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead candidate, FOG-001, is the first direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in colorectal cancer, desmoid tumors, and a range of other Wnt/β-catenin-driven tumors. Parabilis is also advancing investigational degraders of ERG and ARON for the treatment of prostate cancer, as well as other preclinical programs. What's the opportunity? This role is the primary computational partner for one or more pipeline programs, working across both preclinical and clinical spaces to convert complex biomarker, mechanistic, and RWD/E datasets into clear, actionable insights for target, dose, indication, and combination strategy. Reporting to the Head of Computational Biology, a successful candidate will design and implement robust analysis workflows spanning in vitro and in vivo studies, early‑phase trials, and external data sources to refine patient selection and mechanism‑of‑action understanding. The ideal candidate will couple their prior experience in oncology with a deep understanding of bioinformatics methodologies, a strong computational skill set, and an ability to translate scientific challenges into technical solutions and analysis that informs team decisions. Scope of the role: • Strategic thinker, planner and implementer of computational biomarker and translational analyses for early‑phase oncology studies (e.g., FOG‑001 and ERG/AR degraders), from IND‑enabling work through Phase 1/2, ensuring continuity between preclinical and clinical datasets., • Design and execute analysis plans for diverse biomarker modalities across preclinical models and clinical samples, including bulk and single‑cell RNA‑seq, DNA panels/WES, ctDNA, IHC/IF, multiplex protein assays, and other exploratory readouts., • Analyze preclinical in vitro and in vivo data (e.g., Helicon screens, xenograft/PDX models, pharmacology and PD studies) to characterize target engagement, pathway modulation, and resistance mechanisms, and translate these findings into clinical hypotheses., • Analyze pre and on treatment patient biopsies and blood samples to quantify pathway modulation, signaling changes, and emergent resistance or sensitivity signatures, integrating with preclinical findings where possible., • Develop, validate, and operationalize predictive and pharmacodynamic biomarker signatures for use in preclinical strategy, trial design, and RWD/E anchored analyses, including patient stratification and indication/expansion cohort selection, • PhD in Computational Biology, Bioinformatics, Statistics, Epidemiology, or related field, or MS with significant industry experience in translational, clinical biomarker, and/or RWD/E analysis in oncology., • 7+ years of relevant post graduate experience (biotech/pharma or closely related), including direct work with both preclinical and clinical oncology datasets., • Strong hands on experience analyzing biomarker data such as DNA sequencing, RNA seq (bulk and/or single cell), ctDNA, and tissue based assays (IHC/IF, multiplex platforms), with demonstrated impact on either discovery or development decisions, ideally both., • Proficiency in Python and/or R, including data wrangling, statistical modeling, visualization, and best practices for reproducible research (version control, environments, documentation)., • Comfortable operating at the interface of discovery, translation, clinical development, and external data, with a track record of effective collaboration with non-computational colleagues., • Excellent communication skills, with the ability to translate complex analyses into concise, decision ready narratives for diverse audiences., • Demonstrated use of AI tools in your current role and responsibilities is required. Advanced or innovative use of AI is a strong plus. Parabilis is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit. • Growth-Minded. We're inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable., • In(ter)dependent.We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options., • Patient-focused.We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact. As an equal opportunity employer, Parabilis values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

Job DescriptionHere at Kelonia Therapeutics, we aren’t just a clinical company; we’re trailblazers in viral engineering, pushing the boundaries of in vivo lentiviral gene and cell therapy. We're not just a team; we're dreamers on a mission to bring the promise of cell and gene therapy to every patient in need. We've gathered a group of pioneers in cell and gene therapy to lead our journey, with extraordinary scientific founders at the helm, providing the cutting-edge technology that sets us apart. We're not just building a company; we're cultivating a culture that values both skill and care. What You Will Do: Clinical Trial Execution & Program Ownership • Lead the end-to-end execution of clinical trials from study start-up through close-out, • Translate clinical development strategy into actionable operational plans, timelines, and budgets, • Own study-level delivery, ensuring trials are conducted on time, within budget, and in compliance, • Lead day-to-day oversight of CROs and external vendors, ensuring performance, quality, and accountability, • Define and track KPIs and deliverables, escalating issues as needed, • Partner with VP and cross-functional stakeholders on vendor selection and governance, • Drive alignment across:, • Clinical Development, • Translational & Research, • Regulatory, • CMC / Manufacturing, • Ensure seamless communication of timelines, risks, and decisions across teams, • Build and implement study-level processes, tools, and tracking mechanisms, • Contribute to the development of broader clinical operations infrastructure in partnership with the VP, • Ensure study execution aligns with ICH-GCP, regulatory requirements, and internal SOPs, • Oversee TMF quality and completeness at the study level, ensuring inspection readiness, • Support audits and inspections in collaboration with Quality and VP Clinical Operations, • Provide direction and mentorship to clinical operations staff (e.g., CTAs, CTMs) as applicable, • Foster accountability, prioritization, and strong execution across the study team, • Bachelor’s degree in life sciences or related field; advanced degree preferred with 10+ years (Director) / 12+ years (Senior Director) in clinical operations, • Demonstrated experience leading early-phase oncology clinical trials (Phase I/II), • Experience in hematological malignancies and cell and gene therapy strongly preferred, • Proven success managing CROs and cross-functional clinical programs, • Deep understanding of clinical trial execution, ICH-GCP, and global regulatory requirements, • Experience with clinical systems (e.g., CTMS, eTMF, EDC), • Strong operational planning and risk management capabilities, • Experience managing study budgets and timelines, • Strong execution mindset with end-to-end ownership of deliverables, • Ability to operate effectively in a lean, ambiguous, and fast-moving environment, • Skilled at balancing strategic thinking with hands-on execution, • Excellent communication and cross-functional influence

Job Description Company Overview: Aitia is the leader in development and application of Causal AI and Digital Twins to discover the next generation of breakthrough drugs in neurodegenerative disorders, oncology, and immunology. By leveraging the convergence of multi-omic patient data, high-performance computing, causal learning and AI. Aitia is revealing the hidden biological mechanisms of disease to create Digital Twins. Gemini Digital Twins are being used today to discover novel therapies and accelerate R&D in Alsheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Multiple Myeloma, Prostate Cancer and Pancreatic Cancer with several more in development. Position Summary: The Research Scientist/Sr. Research Scientist will join a dynamic Precision Medicine team to apply Aitia’s powerful Causal AI platform to drug discovery and clinical development. The candidate will work closely with scientists at major biopharma and emerging drug discovery companies to deliver unique scientific insights for decision making. The candidate will be responsible to work with internal and external teams to formulate scientific questions into coherent analytical efforts for causal analysis with a variety of goals including discovering new biology, identifying potential disease targets, developing prognostic and predictive biomarkers, defining target populations for clinical trials patient stratification and predicting patient outcomes to treatment. The candidate will carry out all these projects using Aitia’s proprietary Causal AI modeling and simulation platform and synthesize these results with relevant literature and bioinformatics resources. They will communicate scientific findings to partners and collaborators and contribute to presentations at scientific conferences and publications. The company engages in a variety of disease areas, so the research scientist may work on multiple disease areas including oncology, neurology, immunology, metabolic and cardiovascular. Principal Duties and Responsibilities: • Work as part of internal research teams to collaborate with clients to frame research questions, propose solutions, identify and QC data sources, conduct analyses and prepare reports., • Communicate technical results clearly and concisely to collaborators. Discuss how to incorporate information into their processes and achieve high client satisfaction., • Manage and complete external facing projects of high complexity in a timeline driven manner., • Contribute to cross-team efforts (e.g. business, R&D) to build in silico patient causal AI., • Advanced degree in quantitative life sciences such as Bioinformatics, Computational Biology, Biophysics, Epidemiology or Biostatistics, • Solid understanding of statistical analysis with R/Bioconductor or Python, • Experience with analysis, evaluation of QC of multi-omics data, single cell data, and high-throughput screening data, • Experience working with advanced ML techniques, probability theory, Bayesian analytics, deep learning or causal inference methods preferred, • Preferably, prior experience working with drug discovery or translational work Our philosophy at Aitia is simple: we cannot transform drug discovery and development with anything less than an all-star team. We are seeking smart, driven people who are experts in their field, have a track record of success, and a passion for creating change. We believe that strong teams supercharge the performance of individuals, create a fun and dynamic workplace, and provide first-class results for our clients and the people they serve. We are passionate about our work and believe in the ability of our technology to change the world. Our core values of integrity, collaboration, value, diversity, and game-changing initiatives guide our behaviors with each other and our clients. Aitia offers competitive salaries, stock options, unlimited vacation, health, dental and vision insurance, life insurance, long-term disability, 401(k), parental leave, tuition reimbursement, professional development, tasty food, social gatherings, and more. Equal Employment Opportunity Aitia provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics. In addition to federal law requirements, Aitia complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. Powered by JazzHR b1n3wp0o5R

Job DescriptionCompany Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro is based in Cambridge, Massachusetts. We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.Position Summary:We are seeking an experienced and versatile Senior Scientist, Computational Biology to join our Data Science team and contribute across the breadth of Korro’s research and translational programs. The successful candidate will operate as an analytical generalist — comfortable moving between target validation, NGS/omics analysis, assay analytics, and translational support for our oligonucleotide therapeutics pipeline. This is a hands-on role suited to someone who has already proven themselves in a biotech or pharma environment and who thrives in a small, fast-moving organization where program needs evolve quickly.Key Responsibilities: * Drive computational biology analyses across Korro’s research pipeline, including target validation, mechanism-of-action studies, and characterization of RNA editing activity in preclinical models. * Design, execute, and interpret NGS-based experiments (RNA-seq, variant calling, targeted amplicon sequencing) in support of oligonucleotide design, screening, and pharmacology workstreams. * Partner with platform biology, chemistry, and pharmacology teams to translate experimental questions into rigorous analytical workflows and to communicate results in a form that informs program decisions. * Develop and maintain reproducible analysis pipelines in R and/or Python, leveraging existing Data Science infrastructure (Posit Connect, MLflow, containerized environments, AWS). * Contribute analytical support to the preclinical-to-clinical translational handoff for our GalNAc-conjugated programs, including PK/PD characterization and biomarker analysis as programs mature. * Collaborate with cross-functional stakeholders to scope new analyses, set realistic timelines, and deliver results that are technically sound and decision-ready. * Mentor junior scientists and contractors on best practices in scientific computing, reproducibility, and statistical rigor. * Share findings through internal presentations and contribute to the scientific community through publications or presentations as appropriate. Required Qualifications: * Ph.D. in Computational Biology, Bioinformatics, Genomics, Computational Chemistry, or a related quantitative discipline, with 3+ years of post-PhD experience in a biotech or pharmaceutical industry setting. Academic-only or pure-tech industry experience will not be considered for this role. * Demonstrated track record of shipped, decision-impacting analyses on industry programs — e.g., target validation, biomarker discovery, oligonucleotide or small-molecule pharmacology, or preclinical-to-clinical translation. * Strong scientific programming in R and/or Python, with proficiency in standard biological data analysis libraries (Bioconductor, tidyverse, pandas, numpy, scikit-learn, etc.). * Solid experience analyzing NGS data, including RNA-seq differential expression workflows, variant calling, and quality control of sequencing experiments. * Familiarity with oligonucleotide or RNA-based therapeutics — including chemical modifications, delivery modalities (GalNAc, LNP), and the analytical considerations specific to ASOs, siRNAs, or related modalities. * Working knowledge of statistical modeling appropriate to biological data: linear and generalized linear models, mixed-effects models, multiple testing correction, and basic experimental design. * Comfort working with messy, real-world experimental data and collaborating directly with bench scientists to refine analytical questions. * Excellent written and oral communication skills, including the ability to translate technical results for non-computational stakeholders. Preferred Qualifications: * Experience analyzing clinical or translational data — Phase 1 PK/PD, biomarker time-courses, or exposure-response analyses — is a strong plus. * Familiarity with hepatology, metabolic disease, or other indications relevant to GalNAc-conjugated oligonucleotide therapeutics. * Experience with cloud-based analytical infrastructure (AWS), containerized workflows (Docker), and reproducible reporting tools (Posit Connect, Quarto, R Markdown). * Prior contribution to IND-enabling packages or regulatory submissions. * Peer-reviewed publications in computational biology, genomics, or therapeutic pharmacology. * Hands-on experience using agentic coding assistants (e.g., Claude Code, Cursor, GitHub Copilot) in a production scientific computing context, with a thoughtful perspective on where these tools accelerate work and where human review remains essential. The range provided is based on what we believe is a reasonable estimate for the base the salary pay range for this job at this time. This does not include annual bonus and equity. The actual salary will be based on a number of factors including skills, competencies, experience, and other job related factors permitted by law.Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Job Description Senior Director, Discovery and Translational Development – Solid Biosciences Charlestown, MA Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. The Senior Director, Discovery and Translational Development will be a senior scientific and operational leader within Solid Biosciences’ Discovery & Translational Development (DTD) organization. This individual will play a critical role in building and advancing Solid’s early pipeline, while also providing scientific leadership for a lead development program and supporting the operational execution of the DTD function. This role requires a leader who can seamlessly integrate deep scientific expertise with clear, succinct executive communication, and who thrives in a highly collaborative, cross-functional environment spanning Clinical Development, Regulatory, CMC, Program Management, Business Development, and external partners. The ideal candidate will bring experience in genomic medicines, ideally AAV-based gene therapy, with a strong preference for experience in genetic cardiomyopathies or related rare genetic diseases. Key Position Responsibilities • Leadership & Strategy, • Lead the development and progression of early pipeline programs, from target identification through translational strategy definition and program readiness., • Serve as scientific leader for a designated lead program, ensuring alignment of discovery, translational, and development strategies., • Contribute to portfolio strategy and prioritization, including risk assessment, scenario planning, and definition of key decision points., • Develop and deliver clear, concise, and decision-enabling scientific narratives to the executive team and governance forums., • Cross-Functional Collaboration, • Partner closely with Clinical Development, Regulatory Affairs, CMC, Program & Portfolio Management, Business Development, and Finance to ensure integrated program execution., • Support governance processes by contributing to program reviews, milestone planning, and cross-functional alignment., • Engage with external collaborators, CROs, academic investigators, and key opinion leaders to advance Solid’s scientific and translational objectives., • Assay Development & Validation, • Provide oversight of discovery, translational, and biomarker assay strategy supporting early and advancing programs., • Ensure assays are fit-for-purpose, robust, and scalable, with a clear line of sight to clinical and regulatory needs., • Guide the development and qualification of assays spanning in vitro, in vivo, and translational biofluid and tissue-based endpoints., • Preclinical & Translational Research, • Oversee preclinical and translational studies, including mechanism-of-action, biodistribution, dose-response, and proof-of-concept efforts., • Ensure translational relevance of models and endpoints, particularly as they relate to human disease biology and clinical hypotheses., • Integrate learnings across discovery, nonclinical, and emerging clinical data to continuously refine program strategies, • Regulatory & Documentation, • Contribute to regulatory strategy and scientific documentation, including IND-enabling plans, briefing documents, and regulatory interactions., • Ensure scientific content supporting regulatory submissions is rigorous, coherent, and aligned with agency expectations., • Support preparation of high-quality internal and external documentation, including study reports, executive summaries, and data packages., • Team Building, Operations & Management, • Lead and mentor a small, high-performing team, fostering scientific excellence, accountability, and collaboration., • Play a key role in DTD operational leadership, including resource planning, prioritization, and process improvement., • Required, • PhD, MD, or equivalent advanced degree in a relevant scientific discipline., • 10+ years of industry experience in discovery and/or translational research within biotech or pharmaceutical settings., • Demonstrated experience in genomic medicines, with strong preference for AAV-based gene therapy., • Proven ability to lead programs and teams across early discovery through IND-enabling development., • Strong experience operating in cross-functional, matrixed environments., • Exceptional ability to communicate complex science clearly and succinctly, particularly to senior and executive stakeholders., • Preferred, • Experience in genetic cardiomyopathies, cardiovascular biology, or related rare genetic diseases. Prior involvement in regulatory interactions and IND-supporting activities. Experience contributing to portfolio strategy and executive-level governance discussions. * Comfort working in a fast-paced, evolving organization with multiple priorities. Compensation The base compensation range for this role is: $260,000 - $305,000 Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits and Solid Advantages At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices. • Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs, • 401(k) program participation with competitive company matched contributions, • Eligibility to participate in Solid’s Employee Stock Purchase Plan, • Mobile phone subsidy for eligible employees, • Tuition Reimbursement, • Vision Coverage, • Life Insurance, • Voluntary Pet Insurance, • Employee Discount Program on Travel, Entertainment, and Services, • Employee Assistance Programs, • Daily Subsidized Lunch Delivery (onsite @ Hood Park), • Free Onsite Full-Service Gym (onsite @ Hood Park), • Employee Parking (onsite @ Hood Park), • 12 Observed Holidays and a winter shut down, • 15-day PTO Policy and a 40-hour rollover YoY, • 40-hour Sick Policy, • 8 Hour Floating Holiday

Job Description The Opportunity Precede Biosciences is seeking an exceptional scientific leader to serve as Vice President, Translational Cancer Epigenomics and External Research Partnerships. This role will define and lead the company’s translational strategy in oncology and other disease areas, translating discoveries in epigenomic biology into clinically impactful blood-based diagnostics. The VP will serve as a key member of the scientific leadership team, responsible for advancing the biological and clinical understanding of Precede’s epigenomic platform and ensuring that insights generated across internal and collaborative research efforts translate into high-value diagnostic products and partnerships. This individual will play a central role in shaping Precede’s scientific direction, building strong collaborations with academic investigators and biopharma partners, and guiding the development of next-generation assays that improve drug development and patient care. About Us Founded in 2021, Precede Biosciences is a diagnostic company pioneering a minimally invasive, comprehensive epigenomics platform. Our technology has the potential to profoundly impact the research and development of new medicines and getting the right therapy to the right patient at the right time. More information on our company and platform can be found on our company website and in our recent publication in Nature Medicine. Our team cares deeply about creating a place where folks can do their best work from the start and have intentionally created an environment that is defined by purpose, teamwork, and excellence. This means nurturing team spirit, facing challenges together, collaboratively solving complex problems, while also ensuring a strong focus on individual initiative, accountability, and delivery. Who You Are • M.D. and/or Ph.D. in cancer biology, molecular biology, genomics, or a related field, • Extensive experience in translational oncology research and biomarker development, • Deep expertise in cancer biology, including signaling pathways, regulatory networks, tumor evolution, and mechanisms of therapeutic resistance, • Experience applying multi-omic approaches—including epigenomics—to translational research or diagnostic development, • Demonstrated success building and leading collaborative research programs with academic and industry partners, • Strong publication record and experience presenting research at major scientific meetings, • Proven ability to translate complex biological insights into clinically relevant hypotheses and applications, • Strategic thinker with strong leadership capabilities and a bias toward action in a fast-moving scientific environmentWhat You'll DoScientific & Translational Strategy, • Partner with the CSO, CEO and scientific leadership to define and execute Precede’s translational science strategy across oncology and other disease areas, • Identify and prioritize key biological questions that unlock new applications for blood-based epigenomic diagnostics, • Develop indication strategies and guide the discovery of novel epigenomic biomarkers for disease detection, monitoring, and therapeutic response, • Translate insights from cancer epigenomic pathways and regulatory networks into clinically actionable hypotheses and diagnostic strategiesAcademic & External Research Leadership, • With Translational Science leads, present Precede’s platform and translational capabilities to academic and biopharma partners, • Lead and oversee Precede’s portfolio of collaborations, ensuring scientific rigor and strategic alignment with company objectives, • Build and maintain strong relationships with leading academic investigators and key opinion leaders in oncology and epigenomics, • Drive the design and execution of collaborative research studies that expand scientific understanding and inform internal assay development, • Develop and execute a publication and scientific communication strategy, including peer-reviewed manuscripts, conference presentations, and scientific abstracts, • Interpret multi-omic datasets generated through collaborative studies and translate findings into actionable biological and clinical insightsSupport Diagnostic Test Development, • Inform the clinical strategy and intended use for new diagnostic tests derived from Precede’s epigenomic platform, • Guide biomarker discovery, validation, and integration into assay development and product pipelines, • Support algorithm development and cutoff determination through the integration of orthogonal biological and clinical datasets, • Ensure translational insights inform assay optimization, clinical validation strategies, and product positioningTranslational Execution & Team Leadership, • Build, lead, and mentor a high-performing translational science organization, • Establish strategic priorities, goals, and operating processes for translational research programs, • Ensure strong alignment across translational science, computational biology, assay development, regulatory, and business development teams, • Foster a collaborative and innovative scientific culture that supports rapid discovery and executionScientific Communication & Publications, • Represent Precede Biosciences at major scientific conferences and industry forums, • Contribute to the scientific visibility of the company through publications and external collaborations, • Maintain deep awareness of emerging discoveries and technologies in epigenomics, cancer biology, and biomarker developmentCross-Functional Collaboration, • Establish strong working relationships across computational biology, assay development, operations, regulatory, and business development

Job Description At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Why Choose Editas? At Editas Medicine, we are a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what is possible in medicine, come join us and become an Editor! Decoding the Role: Editas Medicine is seeking a strong scientific and strategic leader to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) group. This highly visible role will be accountable for the preclinical bioanalytical strategy, biomarker strategy, data quality, and regulatory readiness, ensuring successful EDIT-401 IND submission and Clinical Trial execution. The role serves as a critical bridge between DSTS/RTO, Clinical Development, and CMC working closely with Clinical Operations, Regulatory Affairs, and Biostatistics to ensure timelines and regulatory expectations are met. Characterizing Your Impact: As the Senior Director, Bioanalytical and Biomarker Development, you will: • Lead assay development, qualification, validation, and execution for measuring drug product components, immunogenicity, biomarkers, and other analytes in biological matrices., • Author BioA/BioM strategies and review nonclinical and clinical protocols to ensure alignment with regulatory expectations., • Design and implement BioA/BioM strategies across discovery, translational, and clinical stages including supporting global trials. Align biomarker plans with program objectives, regulatory expectations, and intended clinical use., • Author, review, and/or approve bioanalytical reports and regulatory and clinical documents including pertinent sections of non-clinical and clinical protocols., • Serve as a subject matter expert in resolving complex analytical challenges and integrating cutting-edge technologies., • Ensure bioanalytical/biomarker studies comply with GXP and other relevant regulatory standards. Partner with compliance teams to identify and qualify CROs and other vendors appropriately., • Serve as BioA/BioM subject matter expert on program teams and sub-teams., • Collaborate with CMC to ensure consistent bioanalytical assays between pre-clinical and clinical development., • Communicate complex scientific concepts effectively to non-expert stakeholders., • Deliver high-quality data within tight timelines, meeting >95% of R&D development expectations., • Apply understanding of disease biology and therapeutic mechanisms to guide biomarker strategy in collaboration with discovery team., • Work closely with Clinical Operations to enable seamless central and specialty laboratory sample analysis for clinical BioA/BioM data., • Ensure team members feel supported, held accountable, and have documented professional development plans with quarterly check-ins., • Develop next-level leaders to support current programs and future pipeline targets., • Develop relationships with external thought leaders to ensure alignment with highest clinical standards and emerging science. The Ideal Transcript: To thrive in this role, you will need: • PhD or equivalent advanced degree in biochemistry, medicinal chemistry, biology, or related field with 10+ years of relevant industry experience., • Experience in bioanalytical sciences within a regulated drug development environment. Strong knowledge of regulatory requirements and strategic application of bioanalytical and biomarker methods., • Excellent verbal and written communication skills across all levels both within an organization and with external collaborators/companies with the ability to recognize, articulate, and accept calculated risks to make informed decisions., • Demonstrated experience in the appropriate application of various scientific technologies into translational research strategies., • Proven leadership in cross-functional teams and external collaborations; mentor mid-level and junior level scientists., • Experience working on clinical trials., • Experience with LNP and gene therapy is highly desired. Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy. Salary Range: $270,000 - $300,000 Pay Transparency Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices. Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.

Who is BlueRock? BlueRock Therapeutics LP is a clinical stage cell therapy harnessing the power of cell therapy to create a pipeline of new medicines for people suffering from neurological and ophthalmic diseases. Two of our novel investigational cell therapies, bemdaneprocel (BRT-DA01) for the treatment of Parkinson's disease and OpCT-001 for the treatment of primary photoreceptor diseases are clinical stage programs. BlueRock was founded in 2016 as a joint venture of Versant Ventures and Leaps by Bayer. Our culture is defined by the courage to persist regardless of the challenge, the urgency to transform medicine and deliver hope, integrity guided by mission, and community-mindedness with the understanding that we are all part of something bigger than ourselves. What Are We Doing? Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit. We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options. We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients' lives. It continues to be an exciting time for BlueRock Therapeutics as the company advances cutting edge cellular therapies to positively impact patients' lives across multiple disease areas. The Associate Director, Toxicology Operations will be expected to take on a highly visible role with internal and external stakeholders through the management of nonclinical study plans in support of BlueRock's pipeline. The Program Toxicologist will leverage their expertise in toxicology to advance the company's development pipeline by working closely with program leads and other subject matter experts. The position will be based in Cambridge, Massachusetts with a hybrid expectation (3 Days/Week in Office). • As a critical member of the Translational Medicine and Nonclinical Development team, the Toxicology Operations Expert will leverage their expertise in cell therapy to:, • Support Program Toxicologists in the design of nonclinical studies, • Lead Nonclinical Study Team(s) for multiple studies and assets, • Lead nonclinical study start-up, execution, and timely reporting of results and ensure organizational awareness around study progress, • Partner with CRO to plan and manage study timelines, • Act as the internal lead to ensure smooth transfer of study materials to CRO in support of study plans, • Partner with Research, CMC, Device, and other cross-functional teams to ensure awareness around study timelines, upcoming milestones, and study reporting, • Manage all associated tasks in the planning, initiation, monitoring, and compliance of nonclinical studies, • Develop a relationship with key leaders at CRO, including Study Directors and Business Development, • Travel regularly to CRO to oversee study execution, • Travel to audit CROs/labs as needed, • Ensure raw data and study reports are archived appropriately, • Ensure clinical and nonclinical samples are archived appropriately, • Collaborate within TMND to ensure broad awareness around nonclinical strategy and input into forward looking plans, • BS or MS in relevant field, • Minimum of 6 years toxicology operations experience in industry, • Must have direct experience partnering with CROs to deliver nonclinical studies (e.g., biodistribution, tumorigenicity, local tolerability), • Knowledge of cell therapy space preferred, • Ability to travel

Job Description Summary Internal Title: Director #LI-Hybrid Location: Cambridge, MA or San Diego, CA In this key role you will provide global, end to end nonclinical safety leadership across multiple therapeutic areas and modalities, ensuring scientifically robust, fit for purpose, and regulatory compliant safety strategies that enable successful clinical trial initiation and support registration. You will serve as the primary Preclinical Safety (PCS) authority on cross functional R&D teams and in interactions with global Health Authorities. You will be a critical enabler of portfolio progression, providing authoritative nonclinical safety leadership, regulatory credibility with Health Authorities, and strategic integration across therapeutic areas and modalities. Success is defined by timely clinical entry, robust regulatory outcomes, and strong cross functional trust in PCS scientific leadership. Job Description Key Responsibilities: • Lead PCS Target Teams to design, integrate, interpret, and apply nonclinical safety assessment programs, including impact on development strategy and timelines., • Represent Preclinical Safety on cross functional R&D project teams, ensuring scientifically sound and globally compliant nonclinical safety packages., • Define and implement fit for purpose, modality appropriate nonclinical programs in collaboration with PCS and external line functions., • Lead global Health Authority interactions, including negotiation on safety issues, scientific interpretation, and acceptability of nonclinical packages., • Author nonclinical safety sections of internal and regulatory documents supporting clinical development and market approval (e.g., IND/NDA)., • Drive and coordinate communication strategies between PCS and R&D project teams., • Participate in or lead internal and external cross functional initiatives advancing PCS and/or Translational Medicine objectives and current safety topics., • Support evaluation of in licensing and out licensing opportunities, including collaboration with BD&L and integration activities., • Mentor and coach colleagues on drug development strategy and project related scientific decision making. Essential Requirements: • Advanced scientific degree (PhD, MD, DVM, PharmD, or equivalent) in Toxicology, Pharmacology, or related discipline; or DABT; or equivalent industry experience., • 5 plus years experience as a nonclinical safety Project Team member, preferably across multiple development phases up to registration., • 8 or more years experience in nonclinical drug development (e.g., project toxicologist, pharmacologist, study director)., • Demonstrated expertise across multiple modalities (e.g., small molecules, biotherapeutics, oligonucleotides) and their safety considerations., • Proven track record of direct interaction with global Health Authorities, including shaping regulatory strategy and submission writing., • Recognized scientific and regulatory expertise in nonclinical safety assessment within a global drug development context., • Demonstrated leadership and influence in complex, matrix managed, international project environments., • Strong problem solving capability in multidisciplinary, project driven settings. Desirable Experience: • Prior experience in the pharmaceutical industry., • Leadership or participation in relevant to drug development or safety assessment. The salary for this position is expected to range between $185,500 and $344,500 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click ___. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $185,500.00 - $344,500.00 Skills Desired Animal Models, Bioinformatics, Collaboration, Communication Skills, Data Analysis, Decision Making, Ethics, Laboratory, Leadership, Management, Mentorship, Problem Solving, Regulatory Compliance, Research, Risk Assessment, Toxicology, Training, Waterfall Model

Job Description Summary About the role: #LI:Onsite Are you ready to make a lasting impact by building the future of oncology research? Novartis Biomedical Research (NBR) is searching for a visionary Associate Director to lead Clinical Data Engineering within our Oncology Data Science (OncDS) team. In this pivotal role, you'll be at the forefront of shaping early clinical development by building innovative biomarker data infrastructure, championing translational research, unlocking AI-powered discoveries, and raising the bar for operational excellence in biomarker data and multimodal analytics across Novartis' oncology trials. Job Description Key responsibilities: * Define and implement the clinical data engineering roadmap in alignment with Novartis' data and digital strategy, collaborating with SMEs and OncDS leadership. * Integrate advanced tools and AI/ML-ready infrastructure to support predictive modeling, multimodal analytics, and real-world data applications. * Align clinical and pre-clinical data engineering initiatives with the broader oncology strategy. * Lead, manage, and develop a high-performing clinical data engineering team, fostering collaboration and growth. * Drive strategic initiatives and partnerships across a matrixed organization. * Oversee data ingestion, transformation, and validation processes for clinical trial data, ensuring compliance with GCP/GxP, CDISC, and SOPs. * Collaborate with CROs and internal teams to optimize data flow, versioning, and retention policies. * Build and optimize data pipelines for both structured and unstructured clinical data to enable advanced analytics and informed decision-making. * Deploy scalable solutions for data harmonization, metadata management, and interoperability across platforms such as Foundry, Domino, Snowflake, and POSIT Connect. * Develop and manage applications and visualization tools, contributing to novel data products that support clinical decision-making and enable AI-driven initiatives in oncology trials. Essential Requirements: * This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require 0-3% travel as defined by the business (domestic and/ or international). * Master's degree in computer science, Bioinformatics, Data Engineering, Software Engineering or a closely related discipline; PhD preferred. * Minimum 10 years of hands-on experience architecting and managing clinical data engineering, data management, and bioinformatics solutions in pharmaceutical or biotechnology industry. * Demonstrated expertise in designing, implementing, and scaling data infrastructure to support clinical development-including Artificial Intelligence (AI) / Machine Learning (ML) -driven analytics and multimodal data integration. * Proven ability to define, document, and operationalize end-to-end assay data generation and processing pipelines, with a focus on automation, orchestration, and compliance. * Extensive experience with oncology clinical trials, including regulatory-compliant management of clinical biomarker data and application of data standards (e.g., Clinical Data Interchange Standards Consortium [CDISC], Study Data Tabulation Model [SDTM], Analysis Data Model [ADaM]). * Deep familiarity with FAIR (Findable, Accessible, Interoperable, Reusable) data principles, data harmonization, and enterprise data governance frameworks. * Strong leadership in technical teams, with advanced communication and stakeholder management skills. Desirable requirements: * Extensive experience leading cross-functional data science initiatives in oncology, including translational science, biomarker analysis, real-world data, and exploratory clinical research; proven expertise with NGS technologies, and modern bioinformatics tools. * Advanced proficiency in cloud-native architectures, data lakes, and visualization frameworks (e.g., RShiny, Dash, Spotfire); strong programming and engineering skills (R, Python, Java, shell scripting, Linux, HPC), with a deep understanding of GxP, Agile methodologies, AI/ML operations, and architecting/managing AI agents in large clinical data environments. The salary for this position is expected to range between $176,400 and $327,600 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $176,400.00 - $327,600.00 Skills Desired Apache Spark, Artificial Intelligence (AI), Big Data, Data Governance, Data Literacy, Data Management, Data Quality, Data Science, Data Strategy, Data Visualization, Machine Learning (Ml), Master Data Management, Python (Programming Language), R (Programming Language), Statistical Analysis

Job Description Summary About the role: #LI:Onsite The Oncology Data Science team in Biomedical Research supports the Oncology Disease Area with computational biology, Artificial Intelligence / Machine Learning (AI/ML), and data engineering for novel therapeutics across multiple drug modalities. As integrated scientists and engineers, we apply advanced analytics to pre-clinical and clinical projects, enabling progress in target discovery, drug development, and translational and clinical science. We seek a Director of Data Science to lead our global team of US and Europe-based data scientists specializing in Low Molecular Weight (LMW) drug development who will guide the LMW data science team, collaborate closely with Oncology stakeholders and Biomedical Research, and introduce innovative data-driven solutions to enhance our LMW portfolio and benefit patients. Job Description Key Responsibilities: * Lead and develop a global team of US and Europe-based data scientists, driving high-quality data science that is grounded in deep understanding of biology and applicable data science methodologies and approaches. * Co-develop and execute a data science strategy to enable and enhance innovation in the LMW drug development space. * Closely align with the Oncology Drug Development teams to represent the low molecular weight data science function and ensure effective embedding of data science in drug development teams and alignment on scientific direction. * Regularly interface with Oncology Disease Area leaders to align priorities and to effectively deploy resources. * Collaborate closely with the Oncology Data Science AI team and other teams such as generative chemistry teams on the development and implementation of innovative machine learning algorithms, AI models, and platforms to enable the delivery of predictive and prescriptive insights. * Actively engage with stakeholders within partner functions, such as IT, Chemistry and Technology departments and build strong partnerships and shared projects. * As a member of the Oncology Data Science Leadership team, contribute to Oncology Data Science overall direction and management, represent the low molecular weight portfolio as a function. * Closely collaborate with Oncology Data Science engineering teams to ensure team adherence to data standards, data governance and data strategy and ensure the application of best practices in analytics and high standards of reproducibility in research across the team. * Play a leading role in matrix teams such as Translational Data Science Clusters around disease areas or teams centered around key technologies such as genomics, proteomics, spatial technologies etc. * Present and externalize work of the team in conferences, abstracts and scientific journals. Essential Requirements: * This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require 10% travel as defined by the business (domestic and/ or international). * Ph.D. in data science, computational biology or related fields, strong scientific mindset, with a deep understanding of biology, oncology and low molecular weight drug development process. * 10+ years of experience in a data science role in oncology drug development. * Excellent leadership and management skills, with 5+ years of people management experience in the data science space. * Experience with Quality Control (QC) and data analysis for common assays, such as bulk RNA-seq, scRNA-seq and/or chromatin-based assays (ChIP-seq, ATAC-seq, Hi-C). * Strong expertise in quantitative and computational biology approaches, general AI/machine learning and statistical modeling techniques and a proven track record of delivering data-driven insights and solutions. * Excellent communication skills, with the ability to communicate complex data insights and recommendations to cross-functional teams and stakeholders. * Proven history of contributions to the scientific community in the form of papers and/or conference presentations. Preferred Requirements: * Experience with AI/ML approaches specific to the low molecular weight field including computational chemistry and application of generative AI in chemistry. * Experience with cell line profiling, shRNA or CRISPR perturbation screens, high content cell imaging, proteomics or in vivo efficacy analysis. The salary for this position is expected to range between $194,600 and $361,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $194,600.00 - $361,400.00 Skills Desired Applied Mathematics, Artificial Intelligence (AI), Aws (Amazon Web Services), Big Data, Building Construction, Cloud Computing, Computer Science, Data Governance, Data Literacy, Data Management, Data Quality, Data Science, Data Strategy, Electrical Transformer, Machine Learning (ML), Master Data Management, Professional Services, Python (Programming Language), R (Programming Language), Random Forest Algorithm, Statistical Analysis, Time Series Analysis

Job Description Summary Senior Principal Scientist / Associate Director, PK Sciences, Therapeutic Areas (DUAL LEVEL POSTING) #LI_Hybrid Location: Cambridge, MA or San Diego (US) We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement translational or clinical pharmacology strategies to support the pursuit of transformative new medicines through late clinical development. Our unique organizational structure enables colleagues to work seamlessly in the translational and/or clinical space, offering opportunities for development and bench-to-bedside-to-bench translation. Experience in late discovery and/or clinical area is preferred. The scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell therapies across major therapeutic areas in Novartis, including oncology, immunology, cardiovascular renal metabolism, neuroscience, and global health. This position drives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science sub-teams to achieve a holistic and integrative perspective of the ADME/clinical pharmacology properties of candidates and drugs Job Description Key Responsibilities: • Independently represent the PK Sciences function in cross-functional project teams, interactions with stakeholders within the organization and interactions with regulatory agencies, as appropriate, • Lead a PK Science Subteam with interdisciplinary representation of the major functions from within PK Science and beyond, • Ensures implementation of project strategies and monitors timelines, objectives, and budgets for assigned projects, • Present projects at various institutional review and approval boards, • Proactively contributes to developing drug candidates across Research Development and Commercial continuum, providing expert pharmacokinetic / drug metabolism and clinical pharmacology input, • Develop and execute clinical pharmacology strategies, including input into nonclinical and clinical study design, and analyzing PK and PK/PD data, to support compound development from discovery through late development, • Provide PK, dosage, PK/PD and M&S component of study protocols, reports, project summaries and development plans, and author pharmacokinetic/clinical pharmacology/biopharmaceutics sections/radiation dosimetry of IND/IMPDs and NDA/BLAs as well as prepare appropriate responses to global Health Authority questions, • Use of Artificial intelligence (AI) / Machine Learning (ML) approaches to enable model guided molecular design, preclinical and clinical data automation, authoring regulatory documents, and the use of predictive models, • Is a mentor to or manages junior associates in the organization This role reports to Therapeutic Area Head in PK Sciences within Translational Medicine (TM) in Biomedical Research. PKS is a global organization situated within Translational Medicine (TM), the clinical research arm of Biomedical Research within Novartis. PK Sciences plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, bridging drug discovery and clinical application. PK Science is an enterprise-wide organization, working across both Biomedical Research and the Development organizations to advance the scientific knowledge of pharmacokinetics, metabolism and clinical pharmacology. Essential Requirements: • Ph.D. / Pharm.D. with relevant experience, • Preferred candidates will have a minimum of 5+ yrs at the Senior Principal Scientist Level and 8+ years at the Associate Director level) in clinical pharmacology, drug metabolism and pharmacokinetics or a related background in an industry setting., • Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global) as well as sound awareness of recent developments in drug development and regulatory sciences., • Demonstrated success in working in a cross-functional, matrixed, project-team environment., • An influential Team player and talented negotiator with strong oral and written communication skills., • Proven record of mentorship and/or people management Desirable Requirements: • Hands-on project experience with Artificial intelligence (AI) / Machine Learning (ML) approaches is a plus Leadership / Novartis Behaviors in Action • Delivers results through disciplined execution, continuous improvement, and a strong focus on value and outcomes., • Demonstrates an enterprise mindset and strong ownership by prioritizing resources and decisions for maximum Novartis and patient impact., • Role models Novartis leadership behaviors through visible actions, continuous self reflection, and openness to feedback, • Builds trust through transparent communication, clear accountability, and consistent delivery against commitments., • Empowers others to innovate and improve while maintaining high scientific, ethical, and operational standards. AI fluency: • Brings strong AI and digital fluency, using enterprise tools to enhance insight generation, decision making, and team productivity., • Accountable for the ethical, transparent, and compliant use of AI in line with Novartis AI governance and data protection standards. External eminence: • Acts as an external thought leader, advancing Novartis' reputation in translational science and innovation. Operational excellence: • Drives operational excellence through disciplined execution, continuous improvement, and effective use of resources to maximize PKS and enterprise value., • Acts as a responsible steward of people, data, and digital capabilities, leveraging AI and automation to improve efficiency, quality, and decision speed. This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered. The salary for this position is expected to range between: Senior Principal Scientist: $138,600 and $257,400 per year. Associate Director: $145,600 and $270,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $138,600.00 - $257,400.00 Skills Desired Chemistry, Clinical Pharmacology, Clinical Research, Clinical Study Reports, Clinical Trials, Data Entry, Drug Discovery, Due Diligence, Electronic Components, Gene Therapy, Lifesciences, Medical Research, Microsoft Office, Modeling And Simulation, Patient Care, Physics, Translational Medicine, Waterfall Model

Job Description Summary About the role: #LI-Onsite Help us ensure that safe, effective and innovative treatments reach patients as quickly as possible! The Clinical Program Leader (CPL) / Senior Clinical Program Leader (Senior CPL) will play a critical role in overseeing the planning, execution, and interpretation of clinical trials research, data collection activities and clinical operations. Job Description Key Responsibilities: * Provides strategic medical guidance for the development of new oncologyagents that are in preclinical development, typically beginning at thedevelopment candidate (DC) phase. Accountable for Translational Clinical Oncology (TCO) aspects of one or more global drug developmentprograms. Establish and approve scientific methods for design and implementation of clinical protocols, data collection systems and final reports. * Evaluation of external opportunities for potential business development purposes * Responsible for creating a clinical development strategy for new oncologyagents. The development strategy combines the Clinical Program Leader's (CPL) medical knowledge withthe expertise of colleagues in a wide range of other disciplines (e.g. Biomarkers, Clinical Pharmacology, Biostatistics) to optimize the clinicaldevelopment strategy.Although registration studies are not within the responsibility of TCO, the CPL in TCO must provide an early clinical development strategy that foresees andsupports subsequent registration trials * Leads Biomedical Research Program Teams (BPTs), beginning at the time of approval toconduct Good Laboratory Practices (GLP) toxicology studies to enable the start of clinical development, andcontinuing through those clinical trials.May lead multiple global project teams. * Support new and ongoing clinical research and clinical trials and ensure efficient and timely processing of confidentiality agreements and clinical agreements. * Responsible for development of the Integrated Development Plan (IDPA). * Integrates preclinical information (pharmacology, toxicology, pharmacokinetics)and interprets its implications for clinical development, as articulated in theInvestigator's Brochure and first-in-human protocol. * Collaborates with clinical scientists to develop clinical protocols for TCO compounds and to develop the instruments needed to implement, interpret andreport them (e.g., case report forms, report and analysis plans, clinical studyreports). * Applies his or her medical knowledge to guide the safe, ethical and efficientconduct of the trials under his or her responsibility. He or she is knowledgeablein Good Clinical Practice guidelines and Novartis Standard Operating Proceduresand strives to maintain compliance with them. * Liaises with outside experts, investigators, and regulatory authorities in thefield of oncology, and represents his or her projects to those groups andauthorities. Fosters communication with key opinion leaders and collaboratinginvestigators. Acts as the medical monitor for one or more global clinical studies. Writes and reviews abstracts/manuscripts, etc. for presentation/publications atinternal/external meetings.Participates in task forces to support continuous improvement and othermanagement objectives.Mentors and serves as an educational resource across Novartis. Acts as a key resource for less experienced CPLs in TCO. Essential Requirements: * This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require approximately 10% travel as defined by the business (domestic and/ or international). * This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered (Clinical Program Leader / Senior Clinical Program Leader): * Clinical Program Leader: 1-3 years ofexperience leading complexearly phase Oncology clinical programs from the pharma/biotech industry and/or academia; Experience with the interpretation of preclinical data in oncology (molecular biology, pharmacology, pharmacokinetics, and toxicology) * Senior Clinical Program Leader: 3-5+ years ofexperience leading complexearly phase Oncology clinical programs from the pharma/biotech industry and/or academia; Experience with the interpretation of preclinical data in oncology (molecular biology, pharmacology, pharmacokinetics, and toxicology) * MD or DO degree and additional laboratory-based training are required; Board certification (or equivalent expertise) in an Oncology sub-specialty * Working knowledge of the application of pharmacokinetic / pharmacodynamic (PK/PD) and biostatistics to clinical development and clinical trials * Proven ability to analyze and interpret efficacy and safety data relating to oncology; Knowledge of Good Clinical Practices (GCP) and world-wide regulatory requirements relating to clinical trials and oncology * Excellent medical/scientific writing and oral communication / presentation skills * Proven ability to manage and develop a team; Used to working successfully across more than one indication; Excellent teamwork in multidisciplinary settings; Creative and independent leader; Innovative and fearless in designing new approaches to PoC studies and in critical thinking; Looks beyond what is evident and visible * Inspires others and strong passion for translational science; Excellent personal ethical integrity and a commitment to improving the outcomes for patients with malignancies Desirable Requirements: * Pharma / biotech industry preferred * PhD The pay range for this position at commencement of employment is expected to be between: $248,500.00 - $461,500.00; however, while salary ranges are effective from 1/1/26 through 12/31/26, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $248,500.00 - $461,500.00 Skills Desired Clinical Monitoring, Clinical Research, Clinical Trial Protocol, Clinical Trials, Decision Making Skills, Drug Development, Health Sciences, Medical Strategy, Regulatory Compliance

Job Description Summary This role is a key scientific leader and integral part of the Oncology Translational Research global leadership team accountable for overseeing the generation and integration of genomic, transcriptomic, and proteomic data to deepen our understanding of cancer biology and guide the development of multiple therapeutic modalities (i.e. low molecular weight molecules, radioligand therapies, biologics, CAR-T). This role will lead both forward and reverse translational research for preclinical and clinical oncology programs, including exploratory clinical biomarker development of high-plex molecular assays. As a senior leader, this role will interface extensively with drug discovery, oncology data sciences, early clinical development, and late-stage development, including the Clinical Innovation team who oversees regulated biomarker assays for clinical decision-making. Job Description Key Responsibilities: * Directs successful translation of pre-clinical research to human clinical trials, leveraging learnings from genomic, transcriptomic, and proteomic analyses of both preclinical models and patient samples. * Guides exploratory biomarker plan design and strategy for early-stage Translational Clinical Oncology (TCO) and Global Drug Development (GDD) trials, serving as a core member of the Biomarker Review Committee. * Integrates pre-clinical and emerging clinical efficacy and biomarker data to understand cancer biology and mechanisms of response and resistance to therapy in patients. * Leverages quantitative/computational background to collaborate effectively with Oncology Data Science to analyze high-dimensional preclinical and clinical data to guide clinical decisions and inform research strategy. * Explores and onboards innovative technologies to advance translational research and new biomarker development. * Responsible for quality and compliance of exploratory molecular biomarker assays. * Interfaces closely with late-stage clinical development to enable translational research and development of regulated biomarker assays. * Leads a team responsible for driving genomic, transcriptomic, and proteomic preclinical and clinical data creation, enabling Artificial Intelligence / Machine Learning (AI/ML) modeling, and generating actionable insights. * Develops talent by being a mentor, coach, and educational resource. * Member of the Oncology Translational Research global leadership team and responsible for representing leadership at senior levels/disease boards and other internal/external forums. Essential Requirements: * This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require 10% travel as defined by the business (domestic and/or international). * M.D., Ph.D. or comparable doctoral degree in a relevant discipline. * 6+ years of experience in a pharmaceutical or biotech-based company or as a leader in academia ideally with multiple years in a matrixed leadership role. * Outstanding scientific depth and breadth with a demonstrated track record of high-impact publications in the field of oncology and/or molecular pathology. * Strong leadership presence and the ability to develop talent; demonstrated ability to lead and influence. * Experience working with senior leaders (unit heads, board members), while equally comfortable collaborating with junior associates. * Excellent analytical and communication skills. * Must have a strong quantitative/computational background and broad scientific/technical knowledge base in the area of oncology, including a solid track record of innovation. Preferred Requirements: * Demonstrated leadership and a strong track record of accomplishments within the fields of oncology and molecular pathology (typically >6 years). * Completion of a Molecular Genetic Pathology fellowship with board certification from the American Board of Pathology or American Board of Medical Genetics and Genomics. The salary for this position is expected to range between $204,400 and $379,600 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $204,400.00 - $379,600.00 Skills Desired Analytical Thinking, Analytical Thinking, Bioinformatics, Clinical Data Management, Collaboration, Communication Skills, Critical Thinking, Data Analysis, Detail-Oriented, Drug Discovery, Ethics, Genomics, Global Project Management, Laboratory, Leadership, Lifesciences, Management, Medical Research, Molecular Pathology, Omics, Oncology, Organization, Problem Solving Skills, Regulatory Compliance, Reports Writing {+ 6 more}

About the Job: The Sr Director, Clinical Trials, Clinical Development is a senior, highly visible and cross-functional leadership role within the Foundation Medicine (FMI) Clinical Development team, partnering closely with various teams across the company. It is designed for a biopharma drug developer leader with deep experience across first-in-human (FIH) through Phase 3 clinical trials. This position partners with internal and external collaborators to design, execute, and interpret precision medicine-enabled clinical trials that integrate FMI’s genomic profiling into therapeutics development programs. The ideal candidate is an experienced physician (M.D.) with a strong track record in oncology drug development, clinical protocol authorship, and end‑to‑end execution of global interventional studies. This leader will ensure that FMI assays are optimally incorporated into internal evidence programs defined in the Clinical Development Plans (CDPs), and into biopharma or academic (AMC)-sponsored trials in order to generate data that support clinical development, regulatory and reimbursement strategy, and downstream clinical adoption. Key Responsibilities: • Provide strategic and scientific leadership for clinical trial design and execution across FIH, Phase 1, Phase 2, and Phase 3 oncology programs incorporating precision medicine approaches to support CDPs and product strategy., • Lead or co-lead the design, authoring and review of clinical protocols, including biomarker strategies, statistical consideration and operational feasibility., • Serve as a senior clinical development partner to biopharma or AMC collaborators, advising on optimal use of FMI assays within therapeutic development programs., • If appropriate, oversee execution of interventional and observational studies, ensuring high-quality delivery, data integrity, and adherence to GCP and regulatory standards, • Provide expert clinical input into the translational research to develop insights into predictive and prognostic biomarkers, to further the development of our products and strategy., • Partner with Clinical Development Plan Leads and scientists to guide and support the CDP execution, including the planning and delivery of impactful evidence generation activities. • Working closely with Product, R&D, Clinical Commercial, Biopharma, Biostatistics, Clinical Operations, Payers, Medical Affairs, and other functions to ensure alignment and successful product development throughout the life cycle management., • Demonstrate Medical leadership, including on Department initiatives (and/or Evidence Generation Working Groups), Business teams, Working groups and Product strategy. Can conceptualize/identify projects and prioritize in the context of FMI business interests, ensuring studies advance the strategic priorities of FMI portfolio., • Apply extensive theoretical and cross-functional expertise, including outside of own discipline, in the context of company objectives to independently address complex problems with regular use of ingenuity and innovation., • Establish and maintain strong relationships with key opinion leaders, academic investigators, and biopharma partners., • Contribute to scientific publications, abstracts, regulatory and reimbursement documents, and external-facing materials., • Maintain availability to the wider FMI business for clinical development expertise, presenting information to scientific, medical, or nonprofessional stakeholders., • Other duties pertinent to clinical / translational science as assigned. Basic Qualifications: • M.D. with 10+ years of industry experience or equivalent in oncology or hematology field or equivalent combination of training and experience Preferred Qualifications:, • Board-certified or board-eligible medical oncologist., • Extensive experience in:, • Designing and executing Phase 1–3 interventional clinical trials, • Clinical protocol writing and review (including biomarker-driven designs), • Precision medicine and molecularly selected patient populations, • Prior experience working closely with or within biopharmaceutical organizations., • Strong understanding of regulatory and reimbursement expectations for clinical development and diagnostics used in therapeutic trials., • Demonstrated excellence in scientific and medical writing (protocols, publications, regulatory-facing documents)., • Proven ability to lead complex, cross-functional initiatives in a fast-paced environment., • Demonstrated ability to lead cross-functional teams, collaborate effectively and communicate clearly with various stakeholders, • Experience communicating with treating physicians and other external stakeholders, • Ability to work independently as well as collaborate and communicate effectively with cross-functional teams, • Strong interpersonal skills that include excellent skills in written communication, oral communication, collaboration, and problem solving with other departments and colleagues, • Excellent organizational skills and meticulous attention to detail, • Extremely high level of integrity and reliability, • Willingness to adhere to all applicable FMI Standard Operating Procedures, policies, processes, and compliance guidelines, • Agreement to maintain confidentiality regarding sensitive company, employee, and proprietary data and information, • Commitment to reflect FMI’s values: Integrity, Courage, and Passion The expected salary range for this position based on the primary location of Boston, MA is $275,000 - $327,000 per year. The salary range is commensurate with Foundation Medicine's compensation practice and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for Foundation Medicine's benefits. #LI-Hybrid

About the Job The Computational Biologist I contributes to the early innovation of novel bioinformatics methods and genomic signatures in oncology. Leveraging Foundation Medicine’s FoundationCORE dataset of 800,000+ samples and the Flatiron Health-Foundation Medicine joint Clinico-Genomic Database of 100,000+ samples with annotated clinical outcomes, this role explores novel patterns in cancer biology. The position plays a key role in conducting original research, generating insights, and preparing high-impact scientific abstracts, presentations, and peer-reviewed manuscripts. The work drives foundational understanding that supports clinical diagnostics and translational research in oncology. In addition to research, this role develops sub-specialization in the data architecture supporting the team’s efforts, including pipeline workflow development, cloud-based data storage, and maintaining data quality and integrity. Key Responsibilities • Develop and evaluate potential signatures and biomarkers using large-scale datasets; investigate genomic mechanisms underlying oncogenesis., • Apply statistical analyses, analyze genomic data via HPC clusters, and improve assay performance., • Organize, visualize, and interpret data in a high-throughput, data-intensive environment., • Collaborate with internal cross-functional teams — including R&D, Medical, Commercial, Biopharma, and Regulatory — and engage with external collaborators to support enterprise goals., • Work closely with molecular biologists, computational scientists, and regulatory teams to inform the feasibility and planning of translational next-generation sequencing (NGS) assays., • Maintain awareness of current bioinformatics methods and diagnostic oncology literature., • Prepare and present results in internal meetings and contribute to scientific literature., • Design and refine bioinformatics algorithms, workflows, and analysis pipelines; manage cloud-based data infrastructure and ensure data quality., • Build, maintain, and enhance internal data workflows and computational pipelines; implement and uphold best practices in data architecture and cloud-based data systems, • Other duties as assigned. Qualifications: Basic Qualifications: • Bachelor’s degree in related field and 6+ years of research experience preferred in the life sciences industry; OR,, • Master’s and 2+ year of research experience preferred in the life sciences industry; OR,, • PhD and no experience Preferred Qualifications:, • 1+ years of industry or post-doctoral research experience in cancer biology, bioinformatics, or a related field using NGS data, • Proficiency in Unix or Unix-like operating systems; proficiency in one or more programming languages such as Python, R, SQL, or similar scientific computing languages; familiarity with other programming or scripting languages, • Familiarity with cloud computing platforms (e.g. AWS), • Experience using version control tools (e.g. Git), • Experience working with public datasets (e.g., TCGA, cBioPortal, Genomic Data Commons), • Competence in basic statistical methods and applications in bioinformatics, • Fundamental understanding of molecular biology and NGS principles (e.g., DNA-seq, library prep, target enrichment), • Effective collaboration and communication skills, including scientific writing and presenting data to multidisciplinary teams, • Understanding of HIPAA and the importance of patient data privacy, • Commitment to reflect FMI's values of Integrity, Courage, and Passion The expected salary range for this position based on the primary location of Boston, MA is $112,560 - $133,000 per year. The salary range is commensurate with Foundation Medicines compensation practice and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for Foundation Medicine's benefits. #LI-Hybrid