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Scientist for Preclinical Mouse Models & Client Solutions \n \n Locations - (Must be currently located without the need for relocation or sponsorship) in Philadelphia or San Diego US, and able to travel locally 25% \n \n We are partnering with a rapidly growing global preclinical research organisation supporting advanced in vivo pharmacology and mouse model platforms that accelerate therapeutic development from early discovery through translational validation. \n \n This is an exciting opportunity for a scientifically driven PhD-level researcher who is looking to transition from the bench into a more commercial, client-facing role within scientific business development and strategic partnerships. \n \n No prior business development experience is required, we are specifically looking for individuals with strong scientific credibility, excellent communication skills, and a genuine interest in building a career in the commercial side of life sciences. \n \n Responsibilities \n\n • Act as a scientific partner to academic and biotech clients, supporting discussions around preclinical study design and mouse model solutions.\n, • Engage with researchers and scientific teams to understand scientific objectives and propose appropriate in vivo strategies.\n, • Support business development activities through scientific presentations, client meetings, conference attendance, and relationship building.\n, • Collaborate closely with internal scientific teams to align client needs with available capabilities and study approaches.\n, • Build long term relationships with clients across academia, biotech, and pharma.\n, • Travel locally within Europe (~25%) for client meetings, conferences, and scientific networking events.\n\n \n Requirements \n\n • PhD in Immunology, Pharmacology, Cancer Biology, or another relevant biomedical/life science discipline.\n, • Hands on experience working with in vivo mouse models in a research setting.\n, • Strong scientific understanding of preclinical research and translational biology.\n, • Passion and motivation to move into a client facing/business development career path.\n, • Excellent communication and interpersonal skills with the ability to explain complex science clearly.\n, • Commercial curiosity and business acumen.\n, • Fluent English communication skills.\n, • Currently based in Philadelphia or San Diego\n, • Willingness to travel regionally up to 25%.\n, • Mandarin Fluency Preferred\n\n \n Why This Role? \n\n • Opportunity to transition into business development without prior commercial experience\n, • Highly scientific and consultative client interactions\n, • Exposure to innovative therapeutics and cutting-edge preclinical platforms\n, • International environment with strong career growth potential\n, • Ability to combine scientific expertise with relationship-building and strategic thinking\n\n

We are looking for a Clinical Research Staff Scientist, Real World Evidence to play a key role in generating the evidence that connects Oura's validated health signals to outcomes, healthcare utilization, and cost savings.

Job Description About the Company: BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies. Bria-IMTTM, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMTTM is a targeted cell-based immunotherapy. Bria-OTSTM, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers. Learn more at: BriaCell | Advancing Cancer Immunotherapy Treatment About the Position: We are seeking a motivated Scientist, Translational Biomarkers & Immunomonitoring to support biomarker strategy and immune monitoring across our clinical immunotherapy programs. This role will focus on characterization of treatment-induced immune responses, pharmacodynamic biomarkers, and translational correlates of clinical activity. The successful candidate will contribute to biomarker assay execution, data analysis, CRO oversight, and cross-functional translational efforts supporting clinical development. Responsibilities: • Support immunomonitoring strategies across oncology clinical trials, • Coordinate biomarker sample collection, processing, tracking, and vendor execution for PBMCs, blood, serum/plasma, and tumor tissue, • Execute and oversee biomarker assays, including:, • multiparameter flow cytometry, • ELISpot / FluoroSpot, • intracellular cytokine staining, • T-cell functional assays, • multiplex cytokine profiling, • humoral immune response assays, • tumor immune profiling (preferred), • Analyze immunologic and biomarker datasets to assess treatment-related immune responses and pharmacodynamic activity, • Support external CRO/vendor management, assay troubleshooting, and data review, • Collaborate with Clinical Development, Clinical Operations, Research, Regulatory, etc, • Prepare presentations, reports, and scientific summaries for internal review Qualifications: Required: • PhD in Immunology, Cancer Biology, Molecular Biology, or related field OR • MS with 3–6 years of relevant biotech experience, • Strong background in immunology and immune monitoring, • Hands-on experience with flow cytometry, PBMC handling, ELISpot, and functional immune assays, • Experience analyzing human translational or clinical biomarker data, • Strong organizational and analytical skills, • Comfortable working collaboratively in a team-oriented environment, with the ability to communicate effectively and contribute positively across functions. Preferred: • Experience in immuno-oncology or oncology clinical development, • Familiarity with cancer vaccines, cell-based immunotherapies, or checkpoint inhibitor combinations, • Experience with CRO oversight and clinical biomarker workflows, • Knowledge of FlowJo, GraphPad Prism, and basic biomarker data analysis tools To apply, please visit briacell.com and click on “About Us” and submit your application through the Careers section. Equal Employment Opportunity Statement BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law. Third-Party Agency Statement BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired. \nCompany Description BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies. BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Job Description About the Company: BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies. Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy. Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers. Learn more at: BriaCell | www.briacell.com |Advancing Cancer Immunotherapy Treatment About the Position BriaCell Therapeutics is seeking a Scientist or Senior Scientist – Quality Control to support analytical and quality control activities within the R&D organization. This role will contribute to the development, qualification, and execution of analytical assays used to characterize cell-based immunotherapies and support research, development, and manufacturing programs. The successful candidate will work closely with scientists across the organization to ensure assay rigor, data integrity, and adherence to quality standards, while supporting analytical methods used for product characterization and release testing. Key Responsibilities Quality Control & Analytical Assays • Perform and support QC testing including flow cytometry, ELISA, cell-based assays, and other analytical methods., • Assist in the development, optimization, and qualification of analytical assays used to characterize cell therapy products., • Ensure QC assays are executed according to established protocols and quality standards. Assay Qualification & Data Analysis • Support assay qualification activities including evaluation of precision, accuracy, linearity, and robustness., • Apply appropriate statistical approaches to assess assay performance and reproducibility., • Participate in defining assay acceptance criteria and qualification plans., • Maintain complete and accurate experimental documentation and data records. Quality Systems & Documentation • Contribute to the preparation and maintenance of standard operating procedures (SOPs), protocols, and technical reports., • Ensure proper documentation of QC testing and experimental records in accordance with internal quality standards., • Assist in maintaining an organized and audit-ready laboratory environment. Cross-Functional Collaboration • Work collaboratively with research scientists, manufacturing partners, and external testing laboratories., • Support analytical characterization activities related to cell banks, drug product, and research programs., • Assist in compiling analytical data for internal reports and regulatory documentation. Qualifications • PhD in Immunology, Cell Biology, Biochemistry, or related field, with relevant experience, • Experience with analytical assays commonly used in immunology or cell therapy, such as flow cytometry, ELISA, and cell-based functional assays., • Experience supporting assay development or qualification is preferred., • Experience working in a biotechnology or pharmaceutical research environment., • Expertise in statistical approaches used in assay development and qualification in a regulatory environment, including assessment of assay precision, variability, linearity, and reproducibility., • Experience with flow cytometry and immunological assays is highly desirable., • Strong laboratory documentation practices and attention to data integrity., • Strong attention to detail and commitment to high-quality experimental work., • Ability to work effectively in a collaborative, cross-functional research environment., • Strong organizational and communication skills. To apply, please visit briacell.com and click on “About Us” and submit your application through the Careers section. Equal Employment Opportunity Statement BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law. Third-Party Agency Statement BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired. \nCompany Description BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies. BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Job Description We are seeking a Healthcare Data Scientist (Real-World Evidence) to answer complex healthcare and biopharma questions using large-scale real-world data and help shape the next generation of AI-powered clinical research. This is a hands-on role that combines rigorous real-world evidence analysis with deep collaboration across product, AI, and customer teams. Internally, you will partner closely with Medeloop's AI research and product teams to design and execute real-world evidence analyses, evaluate the performance of our clinical research agents, and apply your scientific expertise to improve how our platform reasons about healthcare data. Externally, you will serve as an embedded data scientist for our partner institutions, working directly with clinicians, researchers, and life sciences organizations to scope research questions, deliver high-quality evidence, drive adoption of the platform, and expand each customer's use of Medeloop over time. This is a highly technical role centered on analytical reasoning, statistical rigor, and scientific problem-solving. Your work will directly influence both the intelligence of our AI systems and the real-world impact they create for healthcare and life sciences organizations. Role & Responsibilities • Build and execute real-world evidence analyses to answer complex healthcare and biopharma questions using large-scale claims and EHR data., • Write high-quality, scalable code (SQL and Python; R also welcome) to define cohorts, model patient journeys, and generate rigorous, reproducible research outputs., • Apply clinical and statistical judgment to evaluate treatment patterns, utilization, and outcomes in observational data, reasoning carefully about bias and limitations., • Work directly with Medeloop's AI research agents, reviewing and challenging their analytical outputs, and partner with AI and product teams to improve how agents translate research questions into high-quality analyses., • Partner with customer institutions: scope their research questions, deliver evidence, drive adoption, and help expand how each institution uses Medeloop., • Communicate analyses, assumptions, and limitations clearly to internal teams, scientific stakeholders, and customers, translating technical findings into plain-language insight., • Help shape the analytical foundations and evaluation frameworks behind the next generation of AI-driven clinical research tools.Requirements, • PhD, or a Master's degree minimum plus 5+ years of industry experience, in a quantitative-health field (biostatistics, epidemiology, clinical trials, public health, health informatics, or health economics). PhD preferred; strong industry experience can substitute for the doctorate., • Strong grounding in real-world data/evidence (RWD/RWE) methodology, with domain experience in biostatistics, epidemiology, clinical trials, or public health., • Proven ability to answer complex clinical or biopharma questions using SQL and Python, plus statistical software (R and/or SAS)., • Experience with large healthcare datasets, such as claims or EHR data (clinical coding systems, ICD/CPT/RxNorm), assumed to come with an RWE background., • Track record of producing rigorous, research-grade analyses, reports, or publications; comfort working with messy, high-dimensional data., • AI/ML experience required, with clear evidence of hands-on use; comfortable reviewing code and reasoning about model outputs., • Strong communicator; customer-facing experience preferred (trainable for the right analytical candidate).Nice to Have, • Experience working directly with customers and in a sales capacity., • Industry background strongly preferred over consulting (industry candidates preferred over consultants).

The Medical Laboratory Scientist is responsible for obtaining or receiving specimens, performing clinical laboratory tests by standardized procedures, understanding method principles, performing quality control, performing preventive maintenance, and interpreting results accurately, acceptably and within critical limits. The MLS works independently, organizing work to meet established deadlines and validates all data obtained. Education Bachelor's Degree Medical Technology, Biological Sciences, Chemistry, or Life Sciences with 26 science credits with appropriate experience in a CLIA laboratory Required Experience 1 year experience in relevant laboratory section Preferred Licenses Amer Soc Clinical Pathology Preferred

The role of Director, US Real-World Evidence & Health Outcomes Research Scientist Hematology-Oncology ensures that each medicine GSK brings to market is supported by scientifically credible, high-quality evidence that drives competitiveness and strong evidence-based product positioning, value propositions, and value-based pricing. The role is accountable for developing and delivering components of the US data generation plan (including RWE and economic value evidence), ensuring strategic alignment across key internal stakeholders (US Medical, Commercial/Market Access, Global RWE & HO, Global Medical Affairs, R&D Epidemiology and Clinical Development), and driving high-quality deliverables that inform internal decision-making during product development, pre-launch readiness, and lifecycle planning. This role promises a fast-paced environment supporting a new-to-market product in a dynamic hematology space. Responsibilities This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: • Evidence strategy and planning: Implementation of RWE/HO research by developing evidence generation plan and designing multiple RWE/HO studies, aligned to US medical, payer, and access needs; translate strategy into actionable workplans, timelines, and resourcing proposals. Translate needs for evidence into study concepts in alignment with strategic objectives and vision for the asset, e.g. development of study protocols and proposing innovative and cost-effective ways of developing and executing studies, • Study leadership (RWE/HEOR): Own day-to-day leadership for assigned real-world evidence and health outcomes studies (e.g., real-world evidence studies, cost-effectiveness/budget impact analyses, burden of illness, treatment patterns, patient-focused outcomes) including design and execution in partnership with internal functions and external vendors., • Cross-functional stakeholder management: Build strong working relationships with internal stakeholder groups across medical, market access, R&D and commercial to ensure strategic alignment and optimal cross-functional collaboration and communication. Lead cross-functional stakeholder meetings to align on evidence generation gaps and priorities., • Scientific communication and quality: Draft/review project specifications, protocols, statistical analysis plans, study reports, abstracts, posters, and manuscripts; ensure adherence to SOPs and high scientific/operational quality., • Internal decision support: Provide RWE & HO input to internal decision-making during development and commercialization planning (e.g., trial design considerations, data gap assessments, value messages, evidence prioritization and sequencing)., • External insight generation: Maintain strong alignment with Field Based Payer Medical Teams and other field stakeholders to obtain customer insights; incorporate insights into evidence plans and value communication needs., • Vendor and budget management: Manage vendors and contractors for assigned studies, including scope, timelines, budget tracking, and change control; escalate risks/issues proactively., • Governance, compliance, and capability building: Complete required training, adhere to company/department SOPs, and contribute to continuous improvement of processes that enable efficient planning, execution, and dissemination of RWE & HO deliverables. Work arrangement This role is hybrid. Candidates must be located in the United States and able to travel as needed. Basic Qualifications: We are seeking professionals with the following required skills and qualifications to help us achieve our goals: • Master's degree or PhD in health economics and outcomes research, epidemiology, public health, biostatistics, or related discipline., • 3+ years' experience within the pharmaceutical industry or academia related research within US Oncology experience., • Designing a publication plan and having a presence of RWE/HO research studies at major clinical congresses., • Experience managing multiple projects simultaneously., • Expertise in RWE and economic evaluation study designs/methods evidenced by publications and/or contributing to study concept sheets and protocols (including clear research questions, endpoints, data source selection, and bias/confounding mitigation), reviewing/authoring key sections of statistical analysis plans and study reports, and ensuring publication/disclosure readiness in accordance with internal SOPs and external requirements., • Strong communication and presentation skills, demonstrated by developing and presenting clear, decision-oriented materials (e.g., evidence strategy slides, executive readouts) and summarizing outcomes/next steps for senior audiences., • Proven ability to prioritize, pivot, and manage multiple projects simultaneously in a matrix environment. Preferred Qualifications: If you have the following characteristics, it would be a plus: • Demonstrated success developing and executing health outcomes research plans and delivering high-quality data generation outputs., • Oncology experience (US or global), including familiarity with evolving standards of care, evidence requirements, and stakeholder needs across disease areas., • Masters + ~46 years or PhD with 24+ years of experience within the pharmaceutical industry and/or managed care, hospital, academic, or healthcare consulting environment, including experience collaborating with field-facing teams (e.g., Field Based Payer Medical, Field Medical) and/or Market Access partners., • Experience managing real-world data sources and vendors (e.g., claims, EHR, registries) and translating findings into actionable insights and value messages., • Demonstrated ability to influence without authority in a matrix environment, evidenced by aligning cross-functional stakeholders on objectives/trade-offs, documenting decisions, and driving actions to closure., • Strategic execution experience, demonstrated by translating evidence strategy into workplans (milestones, timelines, resourcing) and delivering outputs across 12 concurrent asset workstreams., • Demonstrated project and vendor management experience, including defining scope and success criteria, tracking budgets/timelines, proactively identifying risks/issues, and implementing mitigation plans through change control., • Experience contributing to congress strategy and publication planning (abstracts, posters, manuscripts). What we value in you You explain technical findings clearly and simply. You build trusted relationships and collaborate respectfully. You use evidence and judgement to drive decisions. You are curious, pragmatic, and focused on delivering high-quality results that benefit patients. If this role excites you, please apply and help us build the evidence that improves care for people with cancer.

Here at Appian, our values of Intensity and Excellence define who we are. We set high standards and live up to them, ensuring that everything we do is done with care and quality. We approach every challenge with ambition and commitment, holding ourselves and each other accountable to achieve the best results. When you join Appian, you’ll be part of a passionate team dedicated to accomplishing hard things, together.Here at Appian, our values of Intensity and Excellence define who we are. We set high standards and live up to them, ensuring that everything we do is done with care and quality. We approach every challenge with ambition and commitment, holding ourselves and each other accountable to achieve the best results. When you join Appian, you’ll be part of a passionate team dedicated to accomplishing hard things, together.SC 2.0 is the engine powering our vision. Appian’s Solutions Consulting team is in the midst of an exciting transformation—redefining what it means to be a trusted advisor in today’s fast-paced, mission-driven environment. Our SCs don’t just demo features—they tell stories, co-create with customers, and help shape strategy with technical credibility and business insight. Read More About SC 2.0 Here You can listen to our Global SC leader, Gregg Aldana discuss SC 2.0 hereAppian’s Game Changing Solutions Consulting Team - Do you enjoy solutioning with an award winning technology? Do you like working alongside the smartest and most creative people in the tech industry? Ready to take your career to the next level and have a tremendous amount of fun in the process? Come and join one of the most exciting, energetic and emerging areas of Appian that is poised to fuel the next stage of growth of this ambitious company and your career: Solutions Consulting. The Global Solutions Consulting organization at Appian is a team like no other out there. We are self-starters that are passionate about our mission and are redefining what it means to work in the Pre-Sales or Sale Engineering profession. Whether you are a seasoned veteran of Solution Consulting for many years or looking to pursue a new career in this area, this is THE TEAM…..THE COMPANY and THE MOVEMENT you want to be a part of. Appian Solution Consulting starts with the “Why” behind the mission critical solutions that are driving success for our customers. Through a combination of creative persona-based storytelling, technical solutioning, and business consulting, Appian’s Solution Consultants are the driving force behind helping customers understand the business value that Appian’s technology can provide during the sales cycle and beyond. Appian’s Solution Consultants are the trusted advisors for customers, partners, sales, product, marketing and the company’s leadership. Join this exciting team today to begin fueling your career!In this role, you will be a senior Solutions Consultant supporting pharma, biotech, medtech, and CRO clients. While you do not need to be a scientist, you should understand how Life Sciences organizations operate.To be successful in this role, you needDeep and recent expertise in the Life Sciences industry that is demonstrated through knowledge of Life Sciences business processes such as Clinical Development, Quality Management, Regulatory Affairs, Pharmacovigilance, Manufacturing, and/or Medical Affairs. Experience supporting digital transformation initiatives within pharmaceutical, biotechnology, medical device, or contract research organizations.Understanding of GxP environments, FDA regulations, 21 CFR Part 11, and validated system requirements strongly preferred.Experience working in an enterprise software sales position OR a client-facing technology advisory role within a Life Sciences institution or ISV (e.g., in transformation, architecture, or strategy).Technical depth to respond to all functional and technical elements of RFIs/RFPsAbility to strategically problem-solve by thinking outside-the-box to create innovative solutions that address complex Life Sciences’ challenges.Technical expertise to identify how Appian can fit into the wider organizationStrong verbal and written communication skills; experience with customer interaction, requirements analysis, and presentationsAbility to have technical discussions with Appian’s product team.Familiarity with production environments (application servers, web servers, databases)Basic Qualifications:Bachelor's or Master's degree in Information Systems, Engineering, Computer Science, or a related field or equivalent experience5+ years as a successful Pre-Sales Engineer OR 6+ years in a Professional Services/Consulting role, with a significant focus (3+ years) in the Life Sciences IndustryUp to 70% travel to customer locations throughout the assigned regionYou may also have:An advanced degree (MS, MBA, PharmD, MPH, or PhD)The ability to fluently speak a second language, preferably Portuguese#LI-MB1The base salary range per provided represents a good faith and reasonable estimate of the range at the time of posting. Actual compensation will be dependent on a number of factors including, but not limited to, the candidate’s relevant work experience, qualifications, internal peer equity, and market and business conditions that exist when extending an offer. Sales roles may be eligible to participate in a commission plan subject to the terms of the applicable plans and policies. In addition, Appian provides generous benefits offerings that include a 401(k) plan with company match, flexible time off, paid parental leave, medical, dental, and vision plans, life insurance, disability insurance, wellness programs, flexible spending accounts, health savings account contributions, an employee referral bonus program, and learning and development resources. Certain positions may be eligible for equity awards. Pay and benefits are subject to change at any time, consistent with the terms of any applicable compensation, commission, bonus, or benefit plans.Base Salary Range$125,000—$250,000 USDTools and Resources Training and Development: During onboarding, we focus on equipping new hires with the skills and knowledge for success through department-specific training. Continuous learning is a central focus at Appian, with dedicated mentorship and the First-Friend program being widely utilized resources for new hires. Growth Opportunities: Appian provides a diverse array of growth and development opportunities, including our leadership program tailored for new and aspiring managers, a comprehensive library of specialized department training through Appian University, skills based training, and tuition reimbursement for those aiming to advance their education. This commitment ensures that employees have access to a holistic range of development opportunities.Community: We’ll immerse you into our community rooted in respect starting on day one. Appian fosters inclusivity through our 8 employee-led affinity groups. These groups help employees build stronger internal and external networks by planning social, educational, and outreach activities to connect with Appianites and larger initiatives throughout the company.BenefitsAppian offers a comprehensive benefits package designed to support your health, wellbeing, and financial future. Benefits may include health coverage, Employee Assistance Program (EAP) with free mental health support, life and disability insurance, an Employee Stock Purchase Program (ESPP), a retirement/pension plan, wellness dollars, tuition reimbursement, family-forming benefits and more. Benefits vary by country—please ask your Talent Acquisition contact for details specific to the location you are applying to.About AppianAppian provides AI automation for mission-critical work. We automate complex processes in large enterprises and governments. Our platform is known for its unique reliability and scale. We’ve been automating processes for more than 25 years and understand enterprise operations like no one else. For more information, visit appian.com. [Nasdaq: APPN]Follow Appian: LinkedIn, Youtube, Instagram, FacebookAppian is an equal opportunity employer that strives to attract and retain the best talent. All qualified applicants will receive consideration for employment without regard to any characteristic protected by applicable federal, state, or local law. Appian provides reasonable accommodations to applicants in accordance with all applicable laws. If you need a reasonable accommodation for any part of the employment process, please contact us by email at ReasonableAccommodations@appian.com. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.Appian's Applicant & Candidate Privacy Notice

Philadelphia, PennsylvaniaCategory: Research and Cellular ImmunologyType: Full-timeMin. Experience: Some ExperiencePosition Title: ScientistLocation: On-Site/Philadelphia, PAReports to: Jinmin LeeDepartment: Cellular Immunology PreclinicalCabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit and connect with us on LinkedIn.Uniquely Differentiated. Rapid. Elegant.At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. We’re proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to WorkAbout the Position: Please provide a summary of the Position:We are seeking a highly skilled and motivated Scientist with expertise in cell-based assays for CAR T cell therapy. As a key member of our research and development team, you will play a crucial role in advancing the field of cellular immunotherapy by developing in vitro, ex vivo, and in vivo assays to contribute to enhancing the safety and efficacy of CAR T cells in preclinical settings. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to revolutionize treatment for autoimmune disease patients.Responsibilities:Conduct hands-on laboratory experiments following established protocols to maintain and expand, bank, and manage various cell lines and generate CAR T cells.Perform and validate cytotoxicity and flow cytometry assays. Perform and validate ELISpot, ELISA, Luminex, MSD, or other assays as needed.Perform lab associated tasks in accordance with Cabaletta Bio lab safety policies and SOPs.Oversee in vivo mouse studies and perform related ex vivo assays as needed.Ensure proper maintenance and cleanliness of laboratory equipment and workspaces.Maintain accurate and well-organized records and electronic laboratory notebook.Analyze experimental data using basic statistical methods and software tools.Work collaboratively within a multidisciplinary team, actively participating in team meetings and discussions.Communicate experimental results and findings effectively to colleagues and supervisors through written reports and oral presentations.Required Qualifications:Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field with 0-2 years, or Master's degree with a minimum of 5 years, or Bachelor’s degree with minimum of 10 years of experience.Hands-on experience with cell culture and basic molecular biology techniques. General lab skills, including aseptic techniques and human tissue handling required.Must have prior experience and be highly skilled at mammalian cell culture (aseptic techniques).Experience in primary cell husbandry, cytotoxicity assays, and flow cytometry. Prior involvement in animal studies or hands-on animal handling advantageous.Must be highly organized and able to work independently.A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise. Strong team orientation and passion for continuous self-development.Strong organizational skills, attention to detail, and the ability to follow protocols accurately.Effective written and verbal communication skills to share experimental findings and collaborate with team members.Preferred Qualifications: Extensive hands-on experience with primary immune cell cultures and assays advantageous. Experience working in a research or industry setting related to immunology and/or cell therapy.Experience in industry or in a startup industrial setting.Enthusiasm for learning and contributing to innovative research in the field of CAR T cell therapy.Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.For more information, please visit Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans. Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.#LI-ONSITE

The Director, Clinical Scientist plays a key role in supporting the clinical development of the company’s CAR-T cell therapy programs in autoimmune diseases. Key Responsibilities:Serve as a key clinical science contributor for assigned CAR-T programs, partnering with the Medical Director and other

Philadelphia, PennsylvaniaCategory: Process DevelopmentType: Full-timeMin. Experience: Some ExperiencePosition Title: Associate Scientist, Process DevelopmentLocation: Philadelphia, PA, On-SiteCabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit and connect with us on LinkedIn.Uniquely Differentiated. Rapid. Elegant.At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. We’re proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to WorkAbout the Position: The Associate Scientist, Process Development (PD) will be responsible for refinement, development, and assist in transfer of product candidates through to Cabaletta’s cell therapy CDMOs. This position will work very closely with internal stakeholders (e.g. MSAT, Analytical Development, QA, Regulatory, supply chain), external manufacturing partners, and require up to 10% domestic travel or occasional weekend and overtime work.Responsibilities:Execute process development experimental plans, provide associated protocols and final reports as needed, and present updates and data to teams. Design and execute Design of Experiments (DoE) studies to support process improvement, process characterization, and evaluate their impact on critical quality attributes (CQAs) and process performance.Support phase-appropriate cell therapy production processes using QbD principles.Assist the transfer of process to CDMOs for cGMP clinical manufacturing.Develop and review electronic Batch Records (eBRs) to support clinical manufacturing, ensuring alignment with process requirements, manufacturing procedures, and GMP expectations.Accurately capture data in a timely manner, ensuring data integrity and protocol compliance.Maintain all individual training requirements in a compliant state.Identify and evaluate new technologies to improve manufacturing outcomes such as: reduced costs, increased throughput, and enhanced quality. Coordinate with internal groups and external partners, scheduling and tracking clinical patient material/product shipping and receiving, troubleshooting associated issues.Maintain laboratory material and sample inventory, support the planning of MS&T process development materials needs and coordinate purchasing with lab manager.Required Qualifications:B.S. with 3 + years or M.S. with 1 + years’ experience within process development and manufacturing under cGMP processes.Previous experience and working knowledge of T-cells or immunological cell therapies.Experience with cell therapy manufacturing scale up, technology transfer, and process development and optimization is required.Experience in process automation is a plus.Experience in flow cytometry and cell-based bioassays is a plus. Good working knowledge in cGMP manufacturing of biological process and ICH regulations.Good coordination and communication skills are required. Highly organized and efficient, able to work independently. Strong problem-solving skill is preferred.Ability to coordinate parallel tasks across multiple projects, demonstrating prioritization.Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.For more information, please visit Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans. Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.#LI-ONSITE

Our extraordinary professionals are continuously discovering clinical innovations and enhanced access to the most up-to-date facilities, equipment, technologies and research protocols. Provide methodological leadership for observational studies, registry analyses, comparative effectiveness research,

Philadelphia, PennsylvaniaCategory: ResearchType: Full-timeMin. Experience: Some ExperiencePosition Title: Research Associate/Sr. Research AssociateLocation: On-Site/Philadelphia, PADepartment: PreclinicalCabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit and connect with us on LinkedIn.Uniquely Differentiated. Rapid. Elegant.At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. We’re proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to WorkAbout the Position: Reporting to Senior Scientist, Cellular Immunology, Preclinical Research, we are seeking an experienced, motivated, detail-oriented, and highly skilled Research Associate/Sr. Research Associate to join our preclinical research team. Under scientific and technical supervision, the individual will perform various cell-based assays and other in vitro and ex vivo based assays to contribute to the discovery and development of novel therapeutics at Cabaletta. Additionally, the individual will be responsible for cell line generation and maintenance to assist in the development of novel cell-based assays for the Cellular Immunology team. The position allows for potential impact in additional areas within Cabaletta, including molecular biology, immunology, and cell therapy development. Responsibilities:Maintain and expand, bank, and manage various cell lines, including primary cellsCell line generation using lentivirus technology for suspension cell lines. Perform cytotoxicity and other cell-based assaysPerform IND-enabling assays following SOPs and proper documentationPerform lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies and SOPs.Maintain accurate and well-organized records and electronic laboratory notebook.Actively contribute to process improvements and the implementation of new technologies.Perform flow cytometry assaysRequired Qualifications:MS degree in Biology or Bioengineering (or related field) with 0-3 years of experience, or bachelor’s degree with 2-4+ years of experience in the biotechnology industry required. General lab skills, including aseptic techniques and human tissue handling requiredLab experience and expertise in mammalian cell husbandry required, including maintaining cell cultures with good aseptic technique, media preparation, and generating/managing cell banksA high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise Must be highly organized, have excellent attention to detail, and be able to work independently with trainingMust be able to clearly communicate in writing and have excellent record-keeping skills Preferred Qualifications: Experience in primary cell and iPSC-derived cell culture desiredStrong team orientation and passion for continuous self-developmentExperience in industry or in a startup industrial setting is preferred, including knowledge of good documentation practicesPrevious experience with flow cytometry is not required but would be a plusMust have a desire to be part of a growing organization that uses cutting-edge scienceOur name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.For more information, please visit Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans. Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.#LI-ONSITE

Experience: Senior LevelPosition Title: Associate Principal Scientist, Preclinical ResearchLocation: Hybrid/Philadelphia, PAReports to: Vice President, Preclinical ResearchDepartment: Preclinical ResearchCabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developin

Experience: Some ExperiencePosition Title: Associate Scientist, Computational BiologyLocation: Hybrid/Philadelphia, PAReports to: Scientist, Computational BiologyDepartment: Research – Computational BiologyCabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on devel

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