Method Development Lead
2 days ago
Chester
We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role combines technical expertise and team leadership. • Key duties include:, • Leading method development and validation as a subject matter expert., • Optimising analytical extraction techniques, chromatography methods, and LC columns., • Managing and mentoring the Method Development & Validation team., • Ensuring compliance with GLP, SOPs, and international guidelines., • Troubleshooting analytical methods and recommending improvements., • Overseeing cost-effective laboratory operations and consumable spend., • Writing and approving Methods of Analysis and transferring validated methods to analytical teams., • Supporting regulatory submissions and resolving regulatory queries., • Conducting investigations, implementing CAPAs, and driving continuous improvement., • Preparing, reviewing, and ensuring adherence to GLP SOPs., • Leading team meetings and staff development sessions., • Degree in Biochemistry, Biomedical Science, or related field., • 4+ years in a GxP laboratory (2+ years in management)., • Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems., • Proficiency in method development, optimisation, and validation., • Strong problem-solving and troubleshooting capabilities., • Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques., • Understanding of regulatory and GLP requirements., • Strong communication, organisational, and leadership skills., • Experience with Design of Experiments (DOE) for method optimisation., • Proficiency in Minitab/statistical software., • Experience with Empower and Mass Lynx data systems., • GC experience and familiarity with regulatory inspections., • Competitive salary up to £60,000., • Leadership opportunity in a cutting-edge lab environment., • Professional development and training opportunities., • Supportive, collaborative work culture., • Chance to contribute to innovative bioanalytical projects. #J-18808-Ljbffr