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Company Description Uncommon Schools is a nonprofit network of high-performing public charter schools dedicated to providing an exceptional K-12 education in economically disadvantaged communities. Operating in Boston, Camden, New York City, Newark, and Rochester, we are committed to closing the college completion gap and preparing every student for college and beyond. Our students consistently exceed national benchmarks, reflecting our dedication to their success. We invest deeply in our educators, offering weekly coaching, feedback, and professional development to ensure excellence in teaching and leadership. Join us to work hard, do good, and make a lasting difference! Job Description 1. Instruction • You'll teach a curriculum that prioritizes analysis of World, US History, American Government, and Economics in preparation for Advanced Placement (AP) and collegiate level coursework., • You'll facilitate student-led discourse of historical topics, where students grapple with open-ended guiding questions, engage in peer to peer debate, and synthesize arguments., • You'll guide students to understand the author's claim and the power of sourcing while developing the skills of argumentation, corroboration, inquiry, and historiography through primary and secondary source analysis., • You'll build an inclusive and safe environment where students are empowered to use their voices to express evidence-based opinions and perspectives., • You'll work with the History department to determine academic and engagement goals for students. 2. Data Analysis • You'll meet weekly with your principal and/or instructional coach to analyze and respond to trends in student work samples and assessments., • You'll learn and implement strategies to differentiate instruction for all learners in your classroom. 3. School Culture • You’ll build positive relationships with students to ensure they feel seen, loved, and heard., • You’ll partner with students’ families to ensure appropriate resources are available to support their child's learning needs., • You'll engage in practice-based professional development, mentorship, and coaching sessions., • You'll participate in weekly, school-wide meetings to cultivate community, model our core values, and encourage student achievement., • A demonstrated commitment to supporting students’ social emotional and academic development, • An enthusiasm for collaborating with internal and external partners in the best interest of students, • A self-directed learner who solicits and implements feedback to improve outcomes and achieve objectives, • Required Experience:, • A demonstrated interest in impacting K-12 students in urban schools and communities (1-2 years experience preferred)., • Academic expertise in Education, History, Geography, Political Science, Criminal Justice, Social Sciences, or the Humanities., • Prior to the start of employment, you must have a bachelor's degree from an accredited college or university and have earned a cumulative GPA of 2.5 or higher by the time employment begins. You do not need to be certified to be hired; however, if hired you will need to pass state teacher certification tests to meet the MA state requirements. Our people are what makes us Uncommon. We offer competitive compensation and comprehensive benefits that support the personal health, wellness, and finances of our staff and their families. Our compensation philosophy values equity & fairness and attracting & retaining top talent. Compensation Compensation for this role is between $71,000 to $116,000. Starting pay is determined using various factors including but not limited to relevant full-time teaching experience, education certifications, and tenure with Uncommon Schools. Candidates without full-time Teaching experience will likely have a starting salary of $71,000. • The range above represents our compensation scales for the 2026-2027 school year. If starting prior to June 30th, 2026, compensation will be based on a slightly lower range, reflective of current compensation scales. New hires who fall into this category will see an increase in their compensation starting on July 1st, 2026 for next school year which aligns to the scale above. Benefits • Generous paid time off inclusive of sick time, paid holidays, and 10 weeks of paid breaks (Spring, Winter, and Summer)., • Extensive, best-in-class training and development, • Comprehensive health, dental, and vision insurance plans + pre-tax flexible spending (FSA), dependent care (DCFSA), and health saving accounts (HSA), • Financial Planning, • Pension through Mass. Teachers Retirement System, • 403(b) retirement savings program, • Paid leave of absence options (parental, medical, disability, etc.) At Uncommon, we believe that a supportive and welcoming environment helps our students, staff, and community thrive. We are dedicated to building a team that brings a wide range of perspectives and experiences, reflective of the communities we serve---with over 70% of our staff identifying as people of color. Our organization values respect and open dialogue on important topics that shape our school culture. As an equal opportunity employer, Uncommon provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. We also ensure that individuals with disabilities receive all privileges and benefits associated with employment and are provided reasonable accommodations for the interview process and to perform core job functions. If you would like to request an accommodation, please email .

• This position is temporarily remote and will be full time on-site beginning in late Spring 2026* The office will be located in/around this area: Chelsea, Revere, Everett. About The Lisinski Law Firm Since 2020, Lisinski Law Firm has served as a dedicated humanitarian immigration practice committed to providing meaningful support to individuals and families seeking safety, stability, and a path forward. We frequently stand with clients who have been turned away elsewhere, offering both advocacy and care. Joining our Firm means becoming part of a team devoted to keeping families together and “Changing as Many Lives as Possible.” About The Role As our Intake Manager, you’ll own one of the most influential moments in the client journey: the first impression. You’ll lead a high energy bilingual team that transforms inquiries into committed clients, elevating every interaction with a true Red Carpet experience. This is your chance to build a powerhouse operation driven by data, fueled by coaching, and obsessed with delivering excellence. If you’re a strategic, people centered leader who loves improving processes, inspiring teams, and turning challenges into wins, this role puts you at the heart of the business. You’ll shape our Intake strategy, solve complex client needs, and create the kind of client experience that sets us apart and keeps them coming back. Your Key Contributions • Accountable for overseeing the Intake team and developing a business plan that covers sales, revenue, and expense controls for local office., • Accountable for overseeing the Intake team by providing training, guidance, and support to ensure high performance., • Responsible for ensuring that all departmental goals including revenue, conversion goals, and client calls are handled and supported by the team., • Oversee and ensure appropriate training and development is being provided to team members., • Facilitate team meetings and 1:1’s with team members to review questions and share any process updates., • Accountable for facilitating skip-level meetings with indirect reports to support with developing and improving processes., • Establish and track key performance indicators (KPI’s) for the Intake Team and share results with team members., • Serve as the point of escalation for highly complex, unique, or complicated client issues, ensuring a timely resolution., • Identify and lead opportunities to enhance and improve the client experience and provide feedback to improve processes and services., • Coordinates and collaborates with other departments and leaders to ensure appropriate and elevated support is being provided with an emphasis on retaining the client., • Bilingual (Spanish English) B2-C1, • Bachelor's degree in business management or political science. 4 or more years of leadership experience may substitute for a degree., • Prior leadership experience is required, • Possesses excellent bilingual (English and Spanish) interpersonal communication skills, both written and verbal, • Must have excellent negotiating skills and ability to close deals with clients, • Excellent time management skills with proven ability to meet deadlines and time manage themselves and others, including ability to prioritize tasks and to delegate when appropriate, • Impeccable organizational skills and attention to detail, • Strong analytical and problem-solving skills, • Highly proficient with Microsoft Office Suite, DropBox, and Case Management or related software How You'll Benefit • Compensation: $62,400, • 401k Match, • Medical, Dental, & Vision Insurance, • Options for Health Savings Account or Flexible Spending Account, • Dependent Care FSA, • Basic Life Insurance, • Voluntary Life & AD&D, • Disability Insurance, • Hospital Indemnity Insurance, • Employee Assistance Program, • Calm App Subscription, • Paid Time Off Our Firm At Lisinski Law Firm, the commitment we show to our clients is matched by how we support and invest in our people. LLF is a place where employees are encouraged by peers, heard by leadership, and strengthened by a genuinely collaborative team culture. Whether you join Marketing, IT, Accounting, Legal, or any other function, your work matters. Every role contributes to meaningful, lasting impact in the lives of those we serve. Our Values At Lisinski Law Firm, we are driven by a client obsessed mindset and a commitment to learning, advocacy, efficiency, and nimbleness in everything we do. We work as true team players, delivering creative problem-solving and high-quality service to support families with excellence and care. • This position is temporarily remote and will be full time on-site beginning in late Spring 2026 The office will be located in/around this area: Chelsea, Revere, Everett.

< Overview Alnylam Pharmaceuticals is looking for an Internal Audit Manager to be a key contributing member of the Internal Audit function for one of Cambridge's most innovative, publicly traded biotech companies, focused on translating the science of siRNA into human therapies. Reporting to the Senior Director, Internal Audit, the ideal candidate will have a solid background in audit, strong communications skills, the ability to work collaboratively with team members and stakeholders, and an enthusiastic drive to be a trusted advisor and enhance risk management and internal control through thoughtful and robust assurance and advisory activities. The Internal Audit Manager will be part of high-performing audit team with great opportunities for growth. This is ahybrid position and will primarily be based in Cambridge, MA. Key Responsibilities • Support the execution of and lead financial, compliance, operational, and strategic internal audits, both domestic and abroad to effectively assess Alnylam's risk management and internal control environment., • Perform and oversee audit procedures, including planning, scoping, and fieldwork execution in line with quality standards and timelines., • May assist with certain aspects of Alnylam's SOX program, coordinating with our co-source partner who is responsible for SOX controls testing., • Apply a systematic and risk-focused approach to evaluate and improve the effectiveness and efficiency of processes, internal controls, risk management and governance processes., • Leverage AI, analytics and data-driven audit techniques in the execution of audit activities, including scoping, fieldwork and report generation., • Prepare insightful written reports and work collaboratively with other expertise areas and the business to align on audit observations and management action plans., • Build strong relationships with key stakeholders across the organization while promoting ethical awareness., • Maintain the highest standards of professionalism and independence in the execution of responsibilities., • Support the operation and evolution of the Internal Audit function to keep pace with Alnylam's growth and priorities. Qualifications • Bachelor's degree in Accounting, Finance, or related field, • CPA, CIA, or equivalent professional certification is required, • A combined minimum of 5 years' relevant experience in audit and controls functions, • Experience with auditing and advising on governance, risk and controls including a strong understanding of audit principles and methodology, • Experience within the life sciences sector, or related fields preferred, • Experience with SAP ERP, audit software, Generative AI applications (e.g., Microsoft Copilot) and data visualization tools (e.g., Microsoft Power BI, Tableau, Qlik Sense) preferred, • Excellent project management skills with the ability to coordinate and manage multiple priorities, • Willing to travel up to 20%, domestic and international #LI-MH1 #LI-Hybrid U.S. Pay Range $120,700.00 - $163,300.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are seeking a strategic, forward-thinking leader to join our team in a newly created Product Planning role. This individual will play a critical role in shaping the long-term commercial vision of our pipeline assets-integrating deep market insight, competitive intelligence, clinical understanding, and patient-centric thinking to inform development strategy and maximize global impact. The ideal candidate thrives at the intersection of science and strategy, brings a strong track record of cross-functional leadership, and is energized by the opportunity to help build innovative medicines from early development through launch readiness. Key Responsibilities • Formulate early commercial strategy and approach for select pipeline programs; Develop target product profiles, serve as commercial voice for the asset in key governance forums, • Provide commercial input and strategic guidance to program teams to inform key business decisions on early-stage clinical programs., • Collaborate cross-functionally to conduct rigorous market assessments on key disease areas to inform preclinical strategic planning., • Understand and communicate requirements for reimbursement and differentiation to ensure successful global commercialization of pipeline assets., • Identify gaps in internal understanding of target diseases and create detailed plans to address gaps through KOL engagement and primary market research., • Inform the development of forecast assumptions for financial models. Qualifications • Bachelor's Degree in Life Sciences or equivalent required, MBA preferred, • Minimum 8 years of experience inclusive of market analytics, new product planning and global brand marketing, • Experience in at least one of ALNY's disease areas of focus (Metabolic/CV, Hematology, Rare Diseases) preferred, CNS experience required., • Experience working cross-functionally, including collaboration with and influencing of program development team., • Experience with external alliances preferred, • Solid understanding of pharmaceutical development path and ability to identify operational choices that could impact commercialization., • Ability to synthesize findings and clearly articulate implications from multiple sources of information, including primary and secondary market research and data, and formulate strong, supportable recommendations., • Strong analytical skills, including the ability to forecast., • Aptitude for understanding scientific concepts related to research and development., • Strong oral and written communication and presentation skills #LI-ST1 U.S. Pay Range $208,300.00 - $281,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Manager, Talent Management will play a key role in advancing Alnylam's employee listening efforts and supporting the development of our leadership assessment capabilities. This individual will lead the execution and reporting of enterprise listening initiatives and support the launch and administration of leadership assessments, helping ensure informed talent decisions. This role is ideal for someone who is passionate about translating data into meaningful insight to drive organizational change. As part of the Talent Management team, this individual will partner closely with the Director of Talent Management, People Experience team, and HR Business Partners to strengthen organizational health through high-quality surveys, assessments, and measurement practices. Key Responsibilities Employee Listening & Engagement • Lead the execution of Alnylam's enterprise engagement and listening strategy, including annual surveys, pulse surveys, and targeted listening efforts., • Support survey design, vendor partnerships, and reporting to ensure high-quality insights and analytics., • Translate quantitative and qualitative data into clear, actionable insights that shape enterprise, function, and team-level priorities. Leadership Assessment & Effectiveness • Support the rollout and integration of Alnylam's leadership competency model, including building awareness and understanding across the organization and helping embed the model into talent processes and programs., • Contribute to establishing foundational processes and best practices for leadership assessment at Alnylam., • Support the launch and administration of leadership assessment initiatives, beginning with 360-degree feedback and Hogan (or similar) assessments., • Manage assessment logistics, vendor coordination, participant communications, timelines, and data integrity to ensure a smooth and professional experience. Broader Talent Management Initiatives • Contribute to the continued evolution of core Talent Management processes such as performance management, talent reviews, and succession planning., • Support the preparation of talent insights and materials used in talent planning discussions with senior leaders., • Help evolve scalable tools, frameworks, and processes that strengthen Alnylam's talent management practices. Process & Project Management • Manage project plans, timelines, and stakeholder communications across talent management initiatives., • Partner with HRIS to ensure systems effectively support surveys, assessments, and talent processes., • Collaborate with the People Analytics team to align on reporting standards, data governance, and broader talent insights., • Maintain documentation and process standards to ensure consistency, scalability, and operational excellence. Qualifications • Advanced degree (Master's or PhD) in Industrial/Organizational Psychology, Organizational Behavior, HR, or related field., • 2-4+ years of experience in Talent Management, Organizational Development, Employee Engagement, or HR Analytics., • Demonstrated expertise in psychometrics, including assessment design, validation methods, reliability analysis, and interpretation of psychological instruments., • Hands-on experience administering and interpreting 360-degree feedback tools and personality-based assessments (e.g., Hogan or similar)., • Ability to synthesize complex assessment and survey data into clear, executive-ready insights., • Experience collaborating cross-functionally, including partnership with analytics teams., • Proficiency in Excel and familiarity with analytics/visualization tools (e.g., PowerBI, Tableau)., • Strong project management skills with the ability to manage multiple initiatives simultaneously. #LI-MH1 #LI-Hybrid U.S. Pay Range $119,000.00 - $161,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: We are seeking a Principal Scientist to join the Protein Sciences team to drive cell line and upstream process development for the production of monoclonal antibodies and antibody-oligo conjugates. The candidate will work across functions to advance molecules from discovery through to clinical readiness and will oversee all activities at selected CDMOs. The candidate will bring deep expertise in cell line development and act as the liaison between Research and CMC to ensure smooth transition from discovery to manufacturing. This position is onsite and will be located at our Kendall Square offices in Cambridge, MA. Responsibilities: • Lead the development, selection, and characterization of stable, high-titer cell lines for the production of monoclonal antibodies and antibody-oligo conjugates., • Evaluate, select, and manage CDMOs to execute regulatory-compliant cell line development activities including clonality documentation and cell bank generation., • Supervise all cell line development processes including construct design, generation of stable pools, clone screening, characterization, and cell line stability., • Analyze protocols, development reports, and other data packages generated by CDMOs., • Ensure activities completed at CDMOs align with project goals, timelines, and quality standards., • Support regulatory filings by authoring and reviewing relevant sections related to cell line development., • Work cross-functionally with internal teams including research, CMC, regulatory, and clinical to ensure seamless transfer of knowledge., • Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities. Qualifications: • Ph.D. in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences, Biology, or related field with 6-10 years of relevant experience., • Deep expertise in cell line development for production of therapeutic proteins including monoclonal antibodies, antibody-drug conjugates, or antibody-oligo conjugates., • Strong technical background in all aspects of cell line development including molecular biology, vector design, single cell cloning technologies, cell line characterization, and industry-leading antibody production platforms., • Additional expertise in antibody design and protein engineering is a plus., • Proven track record of managing CDMOs and delivering on biologics development programs., • Experience working across multiple projects simultaneously in a fast-paced, cross-functional environment., • Excellent written/oral communication, organizational, and interpersonal skills are required to work effectively across teams. #LI-KB1 #LI-Onsite U.S. Pay Range $147,200.00 - $220,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< The Sr. Scientist in Clinical Pharmacology position will support a rapidly expanding clinical portfolio of promising RNAi therapeutics. The candidate in this position should be well versed in PK and PD with strong ability to critically evaluate and interpret data, conduct noncompartmental analysis, and PKPD modeling. In this role, the candidate is expected to have a strong critical thinking ability with excellent oral and written communication skills. Summary of Key Responsibilities • Represent Clinical Pharmacology and provide PKPD support and guidance to early and clinical stage project teams., • Lead the analysis, interpretation, integration and reporting of clinical pharmacokinetic & pharmacodynamic data, • Conduct PK/PD analyses and data visualization to guide development decisions on project teams; ability to use model-based approaches to aid decision making, • Provide PKPD input for regulatory submissions such as briefing documents, IND, CTA and NDA., • Contribute to protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation, • Closely partner with Research, Bioanalytical, Clinical development, Regulatory, Project Management, biostatistics and other R&D functions., • Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 2-3 years' experience in pharmaceutical industry, or M.D or Pharm.D. with equivalent experience. Level and responsibilities will depend on the individual's experience and interpersonal skills., • Strong knowledge of clinical pharmacology principles in drug development including PKPD, modeling and simulation, ADME concepts, and clinical pharmacology., • Hand-on experience in using R and other data visualization techniques for representation of PKPD data., • Proficient in using Phoenix WinNonlin, Phoenix NLME, R, NONMEM, or other pharmacokinetic, modeling software. Training in application of pharmacometric principles or software would be a plus. $140,300.00 - $189,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Senior Director, Cardiology serves as the U.S. medical and scientific subject matter expert (SME) for ATTR amyloidosis and related cardiology disease states. This highly visible role blends scientific expertise, external leadership, and strategic influence across the cardiology landscape. Approximately 60% of the role is externally facing, engaging Tier 1 cardiologists, centers of excellence, and key professional societies to elevate scientific exchange and partnership. The remaining 40% focuses on internal collaboration-providing SME input into KOL strategy, evidence generation, medical education, and patient advocacy initiatives, as well as serving as a senior trainer and strategic advisor for field medical teams. Key Responsibilities External Leadership & Scientific Engagement ( 60%) • Serve as the lead U.S. cardiology expert within Medical Affairs, representing Alnylam across Tier 1 KOLs, amyloidosis centers, and national cardiology societies (AHA, ACC, HFSA)., • Lead executive-level scientific discussions to advance disease awareness, diagnostics, and treatment optimization., • Build and sustain deep, trust-based relationships with key external experts to inform strategy and identify collaboration opportunities., • Represent Alnylam Medical Affairs at major scientific meetings, symposia, and advisory boards., • Partner with field medical leadership to shape KOL mapping, segmentation, and engagement strategy, ensuring alignment and execution excellence., • Generate actionable scientific and clinical insights from external engagements and ensure integration into broader U.S. Medical Affairs insight and strategy processes., • Act as the cardiology SME contributing to U.S. medical strategy, evidence generation priorities, and the broader scientific platform for ATTR., • Provide SME input into cross-functional initiatives, collaborating closely with Clinical Development, HEOR, Payer Medical, and Patient Advocacy., • Support evidence generation and ISR strategies, including protocol input, data interpretation, and scientific dissemination., • Deliver advanced cardiology and amyloidosis training for field medical teams to elevate scientific capabilities and ensure consistency in engagement., • Ensure alignment of insights, field strategy, and scientific priorities across the Medical Affairs organization., • Strong and sustained relationships with national cardiology leaders and centers of excellence., • Measurable impact on disease education, diagnostic awareness, and scientific engagement., • Integration of cardiology insights into medical strategy, evidence planning, and cross-functional initiatives., • Enhanced scientific capabilities and quality of field medical interactions., • Prominent presence and influence at key cardiology congresses and professional forums., • Full adherence to medical governance and compliance standards. Qualifications • MD or DO, Board-Certified Cardiologist required (Advanced Heart Failure or Amyloidosis specialization strongly preferred)., • 8-10+ years of combined clinical and medical affairs experience, with 3 years in an industry medical or strategy role., • Deep understanding of the U.S. cardiology and rare disease landscape., • Demonstrated success in engaging Tier 1 KOLs and external thought leaders at the national level., • Strong cross-functional collaboration skills and ability to influence without authority., • Exceptional communication, executive presence, and data storytelling skills., • Ability to operate effectively in a fast-paced, high-accountability environment. #LI-JB1 #LI-Remote U.S. Pay Range $284,000.00 - $384,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Alnylam Pharmaceuticals is seeking a Associate Director, Study Start-up to join our dynamic and growing team. The Associate Director, Study Start-Up (SSU) provides tactical and operational leadership for assigned studies or programs, with accountability for delivery of end-to-end study start-up activities. This role drives start-up execution, ensures consistent application of SSU processes, and partners cross-functionally to proactively identify risks, resolve issues, and deliver predictable site activation timelines The Associate Director supports implementation of SSU strategy and process standards while identifying risks, driving issue resolution, and contributing to continuous improvement initiatives. Key Responsibilities • Lead execution of end-to-end study start-up activities for assigned studies, including site feasibility, site selection, regulatory and ethics submissions, site contracting, and site activation., • Drive early planning, risk identification, and proactive issue management to support delivery of study start-up timelines., • Serve as escalation point for study-level start-up issues, ensuring timely resolution in partnership with cross-functional stakeholders., • May provide people leadership for Study Start-Up Managers or SSU Leads, as needed., • Ensure consistent application of SSU SOPs, work instructions, job aids, tools, and templates across assigned studies., • Contribute to development, refinement, and rollout of SSU processes, tools, and training materials., • Drive standardization and best-practice adoption across studies and regions., • Monitor and report study-level SSU metrics and KPIs (e.g., site activation timelines, readiness-to-enroll)., • Use data and insights to identify risks, trends, and opportunities for improvement, escalating as appropriate., • Ensure accurate maintenance and use of country and site intelligence to support study planning and execution., • Partner with Study Start-up Leadership, Feasibility, Clinical Operations, Clinical Development, Regulatory, Legal, Finance, and CROs to ensure alignment and timely execution of start-up activities., • Provide oversight of CRO performance related to study-level start-up deliverables., • Support inspection readiness and ensure study start-up activities comply with ICH-GCP, global regulatory requirements, and internal policies and procedures., • Bachelor's degree in a healthcare, life sciences, or scientific discipline., • Minimum of 8 years of experience in global clinical trial operations and/or study start-up., • Minimum of 5 years of people leadership experience, including coaching, performance management, and development of direct reports., • Strong understanding of global study start-up processes, regulatory pathways, and site activation models., • Demonstrated ability to manage multiple priorities and deliver results in a matrixed environment., • Strong analytical, problem-solving, and communication skills., • Proven ability to partner cross-functionally and influence without authority., • Working knowledge of ICH-GCP and the global regulatory environment., • Experience leading complex, multi-regional studies., • Experience contributing to process improvement, transformation, or optimization initiatives., • Demonstrated success leading and retaining high-performing team members #LI-AL1 #LI-Remote U.S. Pay Range $165,800.00 - $224,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview TheAssociate Director, Feasibility Center of Excellence (CoE) is responsible for leading predictable and competitive delivery of indication, program, study, country, and site levels of feasibility. The Associate Director collaborates cross-functionally to improve processes, optimize protocols, improve predictive enrollment through data driving strategies for selecting sites and countries and supports feasibility adoption. This role emphasizes leadership, operational excellence, patient-centered design, and data innovation. Key Responsibilities Feasibility Leadership & Oversight • Lead the operational delivery of feasibility assessments across a portfolio of clinical trials, from early planning through site selection., • Ensure timely and high-quality feasibility deliverables that inform protocol design, geographic strategy, protocol optimization, and enrollment forecasting., • Lead as an expert and primary point of contact supporting global study leaders with protocol feasibility, complexity of scoring, site burden, and patient voice during the study planning phase., • Collaborate with the Sr. Director to set clear goals, support resource planning, team structure, and functional excellence initiatives., • Provide subject matter expertise and help establish and refine SOPs, work instructions, and best practices for the feasibility function., • Monitor key performance indicators (KPIs) for feasibility and enrollment predictability across studies., • Drive quality, consistency, and risk mitigation in feasibility deliverables across therapeutic areas and regions. Cross-Functional Collaboration • Partner closely with Clinical Operations, Clinical Science, Commercial, Study Start-Up, etc. to integrate feasibility insights into study planning., • Coordinate with external partners (CROs, data vendors, consultants) for feasibility data sourcing and modeling support., • Present feasibility findings and recommendations to cross-functional stakeholders and governance bodies., • Champion a patient and site centric mindset to ensure protocol design and patient eligibility. Data & Tool Utilization • Leverage a wide range of internal and external data sources to inform feasibility assessments, including RWD/RWE, site metrics, epidemiology, and historic trial performance., • Promote the use of digital tools, predictive analytics, and AI-driven platforms in feasibility forecasting and modeling., • Contribute to the continuous improvement of feasibility templates, dashboards, and methodologies., • Support the adoption of data-driven methodologies and technologies (data analytics, competitive intelligence, and country specific insights), • Monitor, support, and report feasibility KPIs, benchmarks, and insights for leadership. Qualifications Education • Bachelor's Degree in Life Science or related discipline (Master's degree or higher preferred) Experience • Minimum 8 years of experience in clinical research, feasibility, or clinical operations within a pharmaceutical, biotech, or CRO setting., • Minimum 1-2 years of feasibility-focused role., • Demonstrated ability to lead end-to-end feasibility assessments across multiple studies and/or indications., • Deep knowledge of clinical trial design, patient recruitment challenges, and global study execution., • Proficiency with feasibility data sources and tools, and data interpretation skills; familiarity with tools like CTMS, Citeline,IQVIA, RWD sources, and feasibility modeling platforms., • Excellent leadership, communication, and interpersonal skills., • Strategic thinker with strong project management and organizational abilities., • Demonstrated ability to influence, collaborate, and lead change across a complex matrixed environment., • Willingness to travel up to 10%, including international as required #LI-AL1 #LI-Remote U.S. Pay Range $165,800.00 - $224,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview For the Executive Director, Head of BD Transactions, we are seeking an experienced business development (BD) leader with strong business acumen with deep business development experience in the biotechnology and biopharmaceutical industry. The ideal candidate will process deep understanding of the deal making process in the industry, strong business acumen, and extensive experience with financial valuation and investment structure. Success in this role will be defined by the ability to provide transaction leadership in conducting business / commercial / financial analyses and structuring / negotiating complex deals across a diverse portfolio of transactions for all stages of technologies and therapeutical assets. The candidate is required to have strong interpersonal skills as this role will work with multiple senior internal and external stakeholders to drive and facilitate highly visible and time-sensitive BD projects. Reporting to SVP & Head of Business Development, this position ishybridand will be located inCambridge, MA. Key Responsibilities • Demonstrate leadership and business acumen while collaborating closely with cross-functional teams including R&D, Commercial, Finance, Legal, and Search & Evaluation to evaluate external innovation including leading development of business cases and term sheets, cross-functional due diligence, and contract negotiations to execute strategic transactions in support of BD opportunity review, prioritization, and decision-making., • Develop and recommend proposed deal structure and terms, utilizing an in-depth knowledge industry deal-making trends and co-lead, with the senior S&E / R&D / Commercial / Legal / Finance Leads, the delivery of business assessments and recommendations of external opportunities, including deal proposals, valuation, deal status, and key issues of the transaction to Alnylam governance bodies for endorsement., • Lead or coach team members to negotiate deals, find solutions to bridge gap(s) when needed, communicate key deal issues, risks, and updates to leadership and senior internal stakeholders, review and provide comments to term sheets and contracts drafted by the Legal team to make sure they reflect business intent., • Serve as thought partner to facilitate and support formulation of BD strategies to drive toward enterprise goals and objectives while sourcing and evaluating external innovation., • Communicate effectively both internally across a matrix organization and externally with potential partners by articulating the vision, purpose, and expectations of the BD initiatives to ensure clarity and alignment., • As part of the BD Leadership Team, manage or coach a team of BD professionals and foster a culture of excellence, innovation, and collaboration. Qualifications • MBA, JD, or other advanced business degrees with a background in science preferred. Must have an aptitude to quickly understand new science and technology., • At least 10+ years of relevant industry experience in biotechnology and pharmaceutical BD, in particular, transactions function with a significant number of closed deals, including experience in leading multiple complex and high-value transactions. Deal sheet specifics required., • Deep understanding of the drug development processes and extensive knowledge of biotechnology and pharmaceutical industries including market trends, regulatory environment, the macro deal making environment, and their business impact., • Proven ability to integrate scientific knowledge into business case to analyze and understand commercial forecasts, P&Ls, risk analyses, and other financial valuations techniques and strong term sheet / contract negotiation skills., • Demonstrated ability to simplify complex ideas / concepts, synthesize and summarize a complex set of facts and opportunities within the broader strategic context as well as proven track record to exert influence, facilitate candid dialogue find solutions and gain alignment., • Excellent communication, presentation, and problem-solving skills, with the proven ability to influence and persuade internal and external stakeholders at all levels., • Highly collaborative, team-oriented, and adaptable, with the ability to work effectively in a fast-paced and dynamic environment., • Proven ability to manage multiple projects efficiently with a high degree of independence and purposed urgency., • Strong executive presence, leadership, and people management skills, with the ability to inspire and motivate others. U.S. Pay Range $280,500.00 - $379,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Alnylam is the world's leading RNA interference (RNAi) company, dedicated to transforming the lives of patients through innovative medicines. As Alnylam continues to expand its global development and regulatory footprint, Regulatory Sciences supports increasing portfolio complexity, global regulatory engagement, and heightened expectations for data quality, compliance, and operational efficiency. The Director, Regulatory Sciences Technology will play a critical role in shaping and executing the technology strategy supporting Regulatory Affairs, Safety, and Medical Writing. This role serves as the primary technology leader and business partner for Regulatory Sciences, ensuring that systems, data, and digital capabilities enable compliant, efficient, and insightdriven regulatory operations across the product lifecycle. Success in this role requires a combination of strong Regulatory Sciences business acumen and deep technical fluency across regulated platforms, data integration, and documentcentric workflows, enabling the organization to operate at global scale while meeting evolving regulatory expectations. Key Responsibilities • Serve as the primary technology leader and business partner for Regulatory Sciences, building strong relationships with leadership across Regulatory Affairs, Safety, and Medical Writing to understand objectives, priorities, and technology needs., • Develop deep expertise in Regulatory Sciences business processes, proactively identifying opportunities where technology, data, and automation can improve compliance, efficiency, and submission quality., • Lead the delivery, support, and continuous improvement of Regulatory Sciences technology platforms (e.g., regulatory information management, safety systems, document and submission platforms), providing hands-on technical leadership and architectural guidance to ensure solutions are scalable, compliant, and audit-ready., • Drive adoption of the technology operating model within Regulatory Sciences, emphasizing centralized governance, in-house leadership, and close alignment with enterprise Technology, Data, and Quality teams., • Oversee the lifecycle of Regulatory Sciences technology solutions, including requirements gathering, vendor management, implementation, and ongoing support, with a focus on architecture integrity, data consistency, and inspection readiness., • Establish and enforce technology governance, standards, and best practices, including data privacy, security, validation, and compliance with global regulatory requirements. Regulatory Data, Content & Architecture Leadership • Provide technical leadership in the design and evolution of Regulatory Sciences data and content architectures, including structured regulatory data, submission metadata, safety case data, and document management workflows., • Partner with Data and Analytics teams to enable cross-system linkage and reporting across regulatory, safety, and clinical domains, while maintaining clear data ownership and compliance boundaries., • Enable technology capabilities that support regulatory intelligence, submission planning, inspection readiness, and lifecycle management., • Translate complex technical and compliance considerations into clear guidance for Regulatory Sciences leadership and operational teams. Cross-Functional & Lifecycle Collaboration • Collaborate closely with Clinical, Medical Affairs, Quality, and Commercial Technology teams to ensure Regulatory Sciences systems integrate effectively across the product lifecycle., • Support global regulatory operations by enabling technology solutions that scale across regions, health authorities, and submission types., • Partner with Quality, Security, and Validation teams to ensure technology solutions meet internal and external compliance expectations. Vendor, Platform & Operational Leadership • Collaborate with external vendors and internal technology teams to deliver Regulatory Sciences platform integrations and enhancements., • Support and guide Application Support teams and external partners, bringing sufficient technical depth to challenge solution designs, assess architectural and data tradeoffs, and ensure vendor-delivered capabilities meet Alnylam's compliance, scalability, and integration standards., • Proactively identify functional and technical gaps in Regulatory Sciences systems and recommend improvements., • Use root cause analysis and troubleshooting skills to resolve complex functional and technical issues., • Act as an escalation point for critical technology issues impacting Regulatory Sciences operations. Qualifications • Degree in Information Technology, Computer Science, Data Science, or related field, with experience in regulated life sciences environments., • Proven business analysis skills with strong analytical and problem-solving abilities., • Effective prioritization and project management skills., • Significant experience delivering and supporting GxP-regulated technology platforms in healthcare or biopharma., • Demonstrated ability to operate at both strategic and technical depth, including evaluating architecture options, validation approaches, and data integration strategies., • Experience supporting Regulatory Affairs, Safety, Medical Writing, or adjacent development functions preferred., • Familiarity with regulatory systems (e.g., RIM, safety databases, document/submission platforms) and enterprise data ecosystems., • Strong team player with the ability to maintain effective relationships at all levels., • Ability to anticipate, understand, and address changing regulatory and business needs., • Excellent communication skills, both oral and written., • Leadership and/or supervisory experience. #LI-LN1 U.S. Pay Range $187,400.00 - $253,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Job Type: Term (Fixed Term) Position Description RAND's ___, part of the Global and Emerging Risks (GER) Division conducts cutting-edge research on transformative, high-impact technologies-including artificial intelligence and biotechnology-to shape policies that protect global security and advance the public good. You will be responsible for managing significant research budgets and personnel, overseeing complex technical research and policy analysis projects, and leading multidisciplinary teams of policy researchers, engineers, and scientists. Your work will inform analysis delivered to senior government and industry leaders. Your team will communicate findings to both technical and non-technical audiences through quick-turnaround policy briefs and detailed technical analyses. A recent example of one of our research products is the ___ report, which explored protecting frontier AI model weights from theft and misuse. This position is structured as a two-year appointment with options to renew and explore opportunities for longer-term employment at RAND thereafter. RAND's reputation for excellence is built on our commitment to high-quality, rigorous analysis and objectivity. As a Research Lead - Securing Frontier AI, you'll maintain that excellence while engaging with some of the most pressing challenges of our time. Qualifications All research positions at RAND require excellent analytic skills; the ability to communicate clearly and effectively, both orally and in writing; the ability to work effectively as a member of a multi-disciplinary team; and a strong commitment to RAND's core values of quality and objectivity. Required: * 6+ years of technical experience in security engineering, software engineering, firmware engineering, hardware engineering, or related fields * 6+ years of technical management experience, including leading cross-functional teams, managing project budgets, and mentoring and developing team members * Demonstrated ability to successfully lead complex projects to completion * Proficiency in Python, Java, C/C++, or other popular programming languages * Ability to develop rigorous and comprehensive ___ and identify potential system vulnerabilities * Strong ability to communicate effectively in English, both verbally and in writing * Ability to reason about policy options given different technical considerations * Ability to work effectively in a collaborative, multidisciplinary environment * Fluency with MS Office suite Preferred: * Graduate of the Computer Network Operations Development Program (CNODP), Remote Interactive Operator Training (RIOT), Future Operator Readiness Growth and Enrichment (FORGE), or equivalent experience * Experience with red team operations or offensive cyber capabilities development * Understanding of ___ (APT) tactics, techniques, and procedures (TTPs) and experience with defending against them * Ability to think creatively about offensive and/or defensive techniques and strategies, beyond compliance with existing regulations * Familiarity with U.S. cybersecurity agencies, authorities, and policy development processes * Experience working in or with government on cybersecurity policy * Experience with advising non-technical stakeholders on security topics * Familiarity with the AI/ML hardware stack (e.g. GPUs, TPUs, data center design) * Familiarity with the AI/ML software stack (e.g. CUDA, PyTorch, TensorFlow, Ray) * Experience working on AI research, ML model training, or model deployment * Experience with securing AI systems Education Requirements RAND is hiring a Research Lead at either the specialist or expert level of experience. Minimum education requirements at the specialist level include: A PhD in Computer Science, Computer Engineering, Electrical Engineering, Cybersecurity, Information Security, Information Technology, Mathematics, Applied Mathematics, Physics, Applied Physics, Engineering Physics, Artificial Intelligence, Machine Learning, Engineering and Public Policy, Technology and Policy, National Security Policy, Policy Analysis, Political Science, International Relations, or similar with at least 3 years of relevant professional experience is required. OR A Master's degree in the fields listed above with at least 6 years of relevant professional experience, is required. OR A Bachelor's degree in the fields listed above with at least 8 years of relevant professional experience, is required. Master's or PhD preferred. Security Clearance Ability to obtain and maintain a U.S. government clearance is preferred but not required. Location We are hiring for this position in San Francisco, CA;Washington, DC; Santa Monica, CA; Pittsburgh, PA; and Boston, MA. We offer a hybrid work arrangement, combining work from home and on-site options. Fully remote work will also be considered. Writing or Code Sample Either a writing sample or a code sample is required for this position. This sample can use a recent, previously written paper or technical report (e.g., journal article, master's thesis or paper written for coursework, research project, technical analysis, briefings), or source code showing technical expertise in relevant domains. Term This position is a 3-year term appointment with a possibility of renewal, alongside options for longer term employment. Salary Range: $146,200 - $261,400 Visiting Technical Specialist = $$146,200 - $211,900 Visiting Technical Expert = $167,300 - $261,400 RAND considers a variety of factors when formulating an offer, including but not limited to, the specific role and associated responsibilities; a candidate's work experience, education/training, skills, expertise; and internal equity.Successful candidates will be offered employment in a specific title, as determined by the candidate's education and experience. The salary range includes base pay plus RAND's sabbatic pay (which provides additional compensation above base pay when vacation is taken). In addition, RAND provides strong benefits including health insurance coverage, life and disability insurance, savings plan, paid time-off and more. Equal Opportunity Employer

Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA (tenapanor) and XPHOZAH (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada.Position Summary:The Patient Advocacy & Government Affairs Intern will support Ardelyx's corporate presence and relationshipbuilding efforts by helping to plan and execute a policy roundtable event that brings together state policymakers and advocates in addition to assisting with advocacy campaigns with internal and external stakeholders to elevate the voice of patients with IBS-C and CKD Reporting to the Patient Advocacy and Government Affairs team in Waltham, the intern will work on communications, event logistics, and stakeholder engagement activities that are central to the company's government affairs and patient advocacy strategies. Key Responsibilities: • Draft invitations, outreach emails, and other communication materials for policymakers, staff, and advocacy organizations and internal stakeholders., • Develop talking points and key messages for internal leaders and speakers participating in the roundtable., • Assist with scheduling and attending meetings with state legislators, staff, and advocates to discuss event objectives and logistics., • Help secure and coordinate meeting space (either at Ardelyx or an external venue), including room setup needs and on-site logistics., • Draft social media messaging and internal communications to promote the event and highlight Ardelyx's engagement., • Manage event materials, including briefing documents, agendas, handouts, and any leave behind resources., • Track RSVPs, maintain attendee lists, and support day of event execution (check in, logistics, troubleshooting)., • Assist with post event follow up, including thank you communications and basic summary notes or readouts., • Meet with internal and external stakeholders, including patients, caregivers, patient organizations and community members to better understand the impact of CKD and IBS-C on quality of life, mental wellbeing, and daily management., • Draft campaign plans for IBS-C awareness project in IBS-C and assist with logistics of project, including participant tracking, email blasts, platform set up and communications., • Successful planning and execution of a roundtable that brings together policymakers and advocates and strengthens Ardelyx's visibility., • Clear, professional communication materials (invitations, talking points, social posts, and event collateral) that support Patient Advocacy & Government Affairs objectives., • Successful planning and execution of a virtual GI awareness project with internal and external stakeholders that elevates the voice of patients and highlights the dedication of Ardelyx to patients and their families., • Stronger relationships and a more robust community of advocates to support Ardelyx's long term government affairs strategy.Qualifications:, • Currently pursuing a degree in Public Policy, Political Science, Public Health, Communications, or a related field., • Strong written and verbal communication skills, with the ability to draft professional outreach and talking points., • Interest in patient advocacy, health policy, and/or government affairs., • Highly organized, detail oriented, and comfortable managing multiple tasks and deadlines., • Desire to learn, open to constructive mentoring and feedback. Good sense of humor and desire to serve others.Preferred Skills:, • Prior experience with event planning, advocacy, or community engagement is a plus., • Familiarity with state government or legislative processes is helpful but not required., • Hands on experience in patient advocacy and government affairs within a biopharmaceutical context., • Direct exposure to relationship building with policymakers and advocates, including observing and participating in meetings and events., • Practical skills in event planning, stakeholder communications, and policy focused messaging that can be applied to future roles in advocacy, policy, or public affairs.Work Environment:, • Location ideally in or close to Waltham, MA.The hourly rate for this Internship position is $25 per hour. Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers.Ardelyx is an equal opportunity employer.

Job Type: Term (Fixed Term) Overview ___ is seeking technically excellent and mission-driven AI Security / Biosecurity Engineers to work across a number of our most critical and fast-paced AI security and biosecurity workstreams. RAND CAST works on pressing national security challenges related to emerging technologies. Our areas of focus include AI security, compute, biosecurity and bioresilience, and the intersection of AI and biotechnology. Emerging technologies, especially AI and biotechnology, have many promising beneficial and defensive applications. Given their dual-use nature, they also present a number of new security challenges. RAND CAST explores ambitious technical and policy approaches to solving these complex problems. We are a team of world-class technical and policy analysts, engineers, and scientists giving decision-makers the objective insights they need to navigate global emerging threats. Position Description We are looking for individuals who are driven by a bias for action; capable of developing and securing complex systems under high-stakes and fast-paced conditions; and can act as an owner, not just a contributor, with end-to-end ownership of critical, sensitive data infrastructure in a highly autonomous environment. We have a number of ongoing technical projects across our AI security and biosecurity teams. Candidates will discuss initial projects with program leads as part of the interview process. Qualifications Required: * Professional experience in software engineering with a focus on backend engineering and/or data engineering. * Demonstrated ability to build robust and technically complex systems with a security-first mindset. * Experience operating, monitoring, and deploying systems using modern cloud infrastructure. * Preference for working in a fast-paced, autonomous environment. * Excellent communication skills, both written and verbal, tailored to technical and non-technical audiences * Fluency with MS Office suite Preferred: * Advanced knowledge of integrating Large Language Models (LLMs) into workflows. * Background in biosecurity, dual-use technology, or AI security and misuse. * Ability to scope cross-functional projects with internal customers and own their execution. * Experience with distributed data processing platforms. Education Requirements PhD in Biological Sciences, Computational Biology, Biotechnology, Bioinformatics, Computer Science, Computer Engineering, Electrical Engineering, Cybersecurity, Information Security, Information Technology, Mathematics, Applied Mathematics, Physics, Applied Physics, Engineering Physics, Artificial Intelligence, Machine Learning, Engineering and Public Policy, Technology and Policy, National Security Policy, Policy Analysis, Political Science, International Relations, or similar is required. OR Master's degree in the fields listed above with 3+ years of professional experience, is required. OR Bachelor's degree in the fields listed above with at least 5+ years of professional experience, is required. Master's or PhD preferred. Term This position is structured as a three-year appointment with options to later extend the initial appointment and explore other opportunities for growth. Security Clearance Ability to obtain and maintain a U.S. government clearance is preferred. Location We are hiring for this position in San Francisco, CA; Washington, DC; Santa Monica, CA; Pittsburgh, PA; and Boston, MA. We offer a hybrid work arrangement, combining work from home and on-site options. Fully remote work will also be considered. Salary Range: $118,500 - $261,400 Technical Resident, Associate II = $118,500 - $171,900 Technical Resident, Specialist = $146,200 - $211,900 Visiting Technical Expert = $167,300 - $261,400 RAND considers a variety of factors when formulating an offer, including but not limited to, the specific role and associated responsibilities; a candidate's work experience, education/training, skills, expertise; and internal equity.The salary range includes base pay plus RAND's sabbatic pay (which provides additional compensation above base pay when vacation is taken). This position may be eligible for additional compensation. In addition, RAND provides strong benefits including health insurance coverage, life and disability insurance, savings plan, paid time-off and more. Equal Opportunity Employer

< Overview: Alnylam is seeking a progressive, dynamic, business-focused HR Business Partner to support several Commercial leaders and their teams. Reporting to the VP HR, Commercial, this HR Business Partner will play a key role in delivering on the people and organizational strategy within the Commercial organization. This is an exciting time to join Alnylam in its mission to bring a new class of medicines to market as part of a well-respected and highly effective HR team. In this position, the HR Business Partner will: • Partner with senior leaders to drive business results and evolve the organization in a sustainable and effective way, • Shape and execute robust people and culture strategies and support our Company wide transformation, • Improve leadership and team effectiveness, • Drive organization development and design, • In partnership with Talent Acquisition, develop workforce plans to recruit top talent Responsibilities: Strategic Partner: • Lead HR strategy and execution. Ensure alignment between business imperatives and the HR strategy and objectives, • Partner with senior leaders to determine effective HR solutions to facilitate organizational growth and effectiveness Coach and Develop: • Act as strategic advisor on all aspects of people and leadership including development plans, change management, team effectiveness, employee engagement, • HR Lifecycle:, • Facilitate annual HR processes (i.e., compensation planning, performance management, talent review, workforce planning etc.), • Lead HR projects Qualifications: • Bachelor's degree required, • Minimum 10 years' experience in HR, including senior level HR Business Partner roles, required. Experience in HR Centers of Excellence (i.e., Talent Acquisition, Talent Management, Compensation, Employee Relations) preferred, • Successful track record of managing multiple projects in a fast-paced environment, • Experience working in a global and fully integrated Company, • Experience in life sciences required #LI-KB1 #LI-Hybrid U.S. Pay Range $199,800.00 - $270,300.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The Director,GlobalCustomer Engagement Platforms leads business product ownership for Alnylam's CRM and CDP ecosystems, ensuring they enable compliant, data-driven customer engagement across the U.S., with a clear eye toward scalability and applicability in international markets. This role defines how customer data, consent, segmentation, and personalization come together to support meaningful, measurable engagement across email, field-enabled, and digital channels. While the primary focus is U.S. execution, the Director is accountable for designing standards, configurations, and operating models that can be reused outside the United States without creating market-specific one-offs. The Director, Customer Engagement leads a team of customer engagement leaders and serves as the people manager. Together, this team ensures consistent execution standards across markets while allowing forappropriate regionalvariation. A critical aspect of this role is close partnership with the International Omnichannel Operations lead to ensure that customer engagement capabilities designed centrally can be executed effectively in non-U.S. markets. The Director works closely with IT technical product owners, Analytics, Content Enablement, and Omnichannel Operations to translate engagement strategy into scalable, compliant execution. Key Responsibilities: Platform Ownership & Global Governance * Serve asbusinessproduct owner for CRM and CDP platforms, setting priorities aligned with enterprise data, engagement, and compliance goals. * Define and enforce standards for audience segmentation, data hygiene, consent management, andjourneyorchestration. * Design configuration frameworks for journeys, triggers, and audience activation that support reuse across regions through configuration rather than customization. * Partner closely with the International Omnichannel Operations lead to ensure engagement standards are executable and scalable outside the U.S. Operational Enablement * Translate marketing and omnichannel needs into actionable platform requirements, workflows, and data models. * Partner with Omnichannel Operations to ensure data, audiences, and personalization logic are ready prior to campaign launch. * Maintain platform documentation, including configuration standards, naming conventions, and data flow definitions. * Ensure access controls, role permissions, and audit readiness across internal teams and agencies. Compliance & Data Stewardship * Embed privacy, consent, and preference management into all CRM and CDP workflows. * Ensure platforms meet data security, retention, and audit requirements under GDPR, HIPAA, and other applicable regulations. * Partner with Data Governance and Compliance on incident response and ongoing risk mitigation. Performance & Optimization * Define and track KPIs related to platform performance, adoption, and execution efficiency. * Establish feedback loops between Analytics, Operations, and Marketing to improve segmentation and personalization quality. * Identifyopportunities to automate workflows, improve deliverability, and increase targeting precision over time. Partnership & Change Management * Act as the primary business counterpart to IT for CRM and CDP platforms, jointly managing backlog and prioritization. * Collaborate with Content Enablement Platforms to ensure content, metadata, and assets integrate cleanly into engagement workflows. * Lead enablement and change-management efforts to drive consistent platform adoption across regions. * Oversee external vendors and service providers supporting configuration andfulfillmentwork, enforcing quality and performance standards. Expected Partnerships & Interfaces * IT / Strategic Technology:Technical product owners for CRM and CDP platforms; joint release and governance processes. * International Omnichannel Operations:Ensure customer engagement frameworks scale and execute effectively outside the U.S. * CXI Omnichannel Operations:Coordination of campaign sequencing, audience activation, and readiness. * Content Enablement Platforms:Integration of content and metadata into CRM/CDP workflows. * Analytics & Data Strategy:Audience design, measurement alignment, andoptimizationfeedback loops. * Compliance & Legal:Privacy, consent, and regulatory standards. * External Vendors & Agencies:Configurationsupport, managed services, andenablementadherence. Qualifications: • Bachelor's degree in Information Systems, Computer Science, Data Analytics, Engineering, or a related technical discipline. Advanced degree preferred. 10+ years of experience in CRM, marketing automation, or data-driven customer engagement, including leadership roles in regulated environments. * Proven experience as a business product owner for CRM and/or CDP platforms in complex organizations. * Deep understanding of segmentation, identity resolution, consent management, and journey orchestration. * Hands-on familiarity with data flows, integrations, APIs, and analytics connectivity. * Demonstrated ability to design engagement frameworks that scale across regions while meeting local regulatory requirements. * Experience partnering with IT on SDLC, release planning, and incident management. * Experience in pharma or biotech preferred; background inconsumer packagedgoods or other scaled digital environments a plus. * Strongsystemsthinking and judgment in balancing standardization with regional execution needs. * Product-minded approach to platform ownership and delivery. * Crediblepartneracross IT, analytics, operations, and international stakeholders. * Ability to communicate complex technical concepts clearly to business audiences. #LI-Hybrid #LI-ST1 U.S. Pay Range $195,500.00 - $264,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The Director,GlobalContent Enablement Platformsis responsible forbusiness ownership of Alnylam's web content platforms and for defining the standards, governance, and operatingmodelthat enable compliant, scalable digital publishing across global markets. This roleoperateswith aglobal-firstmindset. The Director designs publishing frameworks, governance standards, and workflows that can be executed consistently across regions, including markets with differing regulatory, language, and operational requirements. A critical aspect of the role is close partnership with the International Omnichannel Operations lead to ensure these standards are practical, executable, and scalable outside the United States. The Director, Content Enablement leads a team of content enablement leads and serves as the people manager with individuals based in the US andInternationally. Together, this team ensures consistent execution standards across markets while allowing forappropriate regionalvariation. Through 2026, the focus will be on stabilizing core platforms, standardizing publishing practices, reducing web risk, andestablishingthe foundation for modular content reuse. The role partners closely withIT'stechnical product owners, Marketing Operations, and external vendors, whileretainingclear boundaries around technical ownership, whichremainswith IT. Key Responsibilities: * Platform Ownership:Serve asbusinessproduct owner for Alnylam's CMS platforms, defining priorities and standards aligned with enterprise governance and regulatory requirements. * Global Governance & Scalability:Define and enforce web governance standards covering publishing workflows, templates, metadata, tagging, and accessibility, ensuring frameworks are designed for reuse across global markets through configuration rather than customization. * International Alignment:Partner closely with the International Omnichannel Operations lead to ensure content enablement standards and workflows are executable and scalable across non-U.S. markets. * Web Operations Model:Define intake, QA, and publishing models that support predictable, compliant delivery across regions, while enabling regional execution through shared standards. * DAM Partnership:Partner with Marketing Operations, whoownthe DAM platform, to define metadata, taxonomy, and asset usage standards that enable modular content reuse and scalable publishing. * IT Collaboration:Work closely with IT technical product owners on SDLC alignment, release governance, security controls, and audit readiness, without assuming technical ownership. * Vendor & Agency Oversight:Define expectations and operating standards for managed-service partners responsible for publishing and platform support. * Enablement & Adoption:Establishglobal onboarding and enablement approaches to drive consistent adoption of publishing workflows and governance standards. * Continuous Improvement:Monitor platform performance and risk indicators,identifyingopportunities to improve stability, efficiency, and scalability over time. Expected Partnerships & Interfaces: * International Omnichannel Operations:Ensure global standards translate into executable, market-ready workflows outside the U.S. * IT / Strategic Technology:Align onplatform stability, release management, and security controls. * Marketing Operations:Align onDAM standards, metadata, and asset readiness for scalable publishing. * Brand and Regional Teams:Support application of enterprise publishing standards. * External Vendors & Agencies:Oversee performance and adherence to enterprise playbooks. Qualifications: • Bachelor's degree in Information Systems, Computer Science, Digital Media, Engineering, or a related technical or systems-oriented field. Advanced degree preferred., • 10+ years managing enterprise web platforms in regulated environments, including leadership of global web governance or digital publishing operations., • Hands-on experience with CMS platforms (AEM, Sitecore, Drupal) and familiarity with modular content and reuse frameworks., • Demonstrated ability to design publishing standards and operating models that scale across regions., • Proven partnership with IT on SDLC, risk mitigation, and audit readiness., • Working knowledge of privacy, consent, and accessibility standards (GDPR, WCAG)., • Experience collaborating with marketing operations on DAM integration and asset governance., • Experience in pharma or biotech preferred; background in consumer packaged goods or other scaled digital environments is a plus., • Strong systems thinking and judgment in balancing standardization with regional execution needs., • Ability to translate regulatory and technical constraints into practical governance models., • Credible partner across IT, operations, and international stakeholders., • Clear communicator with a pragmatic, execution-oriented leadership style. #LI-ST1 #LI-Hybrid U.S. Pay Range $195,500.00 - $264,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Join the Alnylam Commercial Data and Analytics team and help build a product-driven engine that turns data-driven insights into deployed decisions with measurable business impact. As part of Customer Experience and Innovation, you will work cross-functionally with technical and business partners to accelerate commercial outcomes by standardizing what we build, how we build it, and how we deliver it through the tools and workflows business users rely on every day. As Director, Advanced Analytics, you will lead the Customer & Account Growth Value Team, and contribute as needed to additional prioritized Value Teams across the commercial organization, including Business Performance & Drivers, Omnichannel & Media Optimization, Patient Pull-Through & Outcomes, and Evaluation & Learning. Value Teams collaborate fluidly to deliver and manage decision products that enable specific business outcomes, driving competitive foresight and actioning for the commercial organization through predictive and prescriptive analytics. In this role, you will lead advanced analytics as a portfolio of decision products and set the standard for product thinking across analytics delivery. You will combine deep business partnership with technical rigor to shape roadmaps, define success measures, and ensure analytics are adopted, measurable, and continuously improved. As a Director, you will also provide people leadership for a small team and serve as the primary point of contact for leadership alignment across the Value Team whose delivery you lead. The position will be based in Cambridge, MA. Key Responsibilities • Provide people leadership for a small team of 2 to 4, including mentoring, skill development, performance coaching, and career growth planning., • Maintain oversight responsibility Customer & Account Growth Value Team, serving as a primary point of contact for leadership alignment, prioritization, and delivery commitments across stakeholders., • Work within and across multiple Value Teams, aligning to transparent priorities and delivering reusable analytics that scale across franchises and markets., • Own analytics product strategy and roadmap for assigned decision products, identifying the highest-leverage decisions, sizing opportunity, and sequencing releases to maximize impact and adoption., • Lead complex decision-product analytics with outputs embedded into core workflows, such as launch readiness and early performance, competitive dynamics and share shifts, account opportunity prioritization, and patient journey risk forecasting., • Drive end-to-end product framing for decision-focused use cases, including user definition, problem statement, hypotheses, decision points, and success metrics that combine value and adoption., • Translate business needs into deployable analytic requirements, including thresholds, segmentation logic, trigger definitions, measurement plans, and learning loops that improve over time., • Deliver decision-ready insights with clear storytelling and stakeholder-ready visuals, including executive-level readouts that drive decisions and follow-through., • Partner with AI/ML Engineering to move prototypes into production and define expectations for monitoring, retraining, and operational performance where models are involved., • Partner with Data Stewardship to define and use single source of truth metrics, ensure traceability to governed definitions and gold-layer data products, and contribute to analytics engineering for throughput using dbt-informed specifications and documentation while avoiding logic forks., • Use AI tooling to increase efficiency and throughput, including AI-native IDEs and safe use of agentic AI analytics when appropriate; operate in agile delivery rhythms using Jira and GitHub-based version control for analytic artifacts. Qualifications • BS degree in Business, Data Science, Computer Science, Engineering, Information Systems, or related field, or equivalent experience., • Minimum 12 years in commercial advanced analytics or data science, ideally in healthcare or life sciences., • Significant domain expertise aligned to the Value Team area this role oversees, with the ability to translate business strategy into decision-product roadmaps, analytic requirements, and measurable outcomes., • Experience leading and developing teams, including mentoring, technical skill development, and supporting career growth for team members., • Strong product-thinking and cross-functional delivery skills, including discovery, prioritization, measurement discipline, and adoption-focused enablement across multiple Value Teams., • Advanced proficiency in SQL and Python or R, and strong comfort with modern analytics tooling such as Spark and dbt, including analytics engineering concepts and metric standardization., • Experience partnering with engineering teams to productionize analytics and support monitoring, evaluation, and continuous improvement., • Comfort using AI tooling to improve throughput and quality, including responsible use of agentic AI analytics and AI-native IDEs., • Strong measurement and inference skill set, including experimentation, causal inference, uplift modeling, optimization, or advanced forecasting as relevant to commercial and patient decisions., • Proven ability to communicate complex insights to diverse audiences, including senior executives, and to drive alignment and decisions in ambiguous environments., • Experience working in Jira and collaborating using git-based version control in GitHub. Value Teams • Business Performance & Drivers: delivering a single, trusted view of performance, key drivers, and competitive dynamics to unlock growth through sophisticated products and skillful leadership in business reviews., • Customer & Account Growth: optimizing commercial levers across field, strategic accounts, and digital to achieve sales ambition through proactive opportunity analytics and predictive insight, productized to drive ongoing value., • Omnichannel & Media Optimization: enabling proactive management of channel mix, messaging, sequencing, and spend through data products and a centralized user console., • Patient Pull-Through and Outcomes: identifying and preventing journey drop-offs and targeting access interventions to start and sustain therapy, enabling a differentiated patient experience that continuously improves outcomes., • Evaluation & Learning: providing objective measurement of what worked and why and feeding learnings back to enable rapid optimization of commercial strategies and investment guidance. #LI-ST1 U.S. Pay Range $195,500.00 - $264,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< The Associate Director, Case Management Vendor Oversight (CMVO), Global Safety Operations is responsible for implementing processes and procedures to support the oversight of ICSR processing activities as well as maintaining regulatory compliance. This role is responsible for the technical development of personnel and ensuring the quality of deliverables within their purview. • Act as lead for the Case Management Vendor Oversight (CMVO) CT team in an outsourced model for ICSR Management., • Management of outsourced vendors to ensure agreed upon KPIs are met., • Identification of gaps in processes, and areas in which efficiencies can be gained., • Proactively coordinate development and implementation of processes and procedures in collaboration with QSC for compliance and quality metrics., • Establish/maintain effective cross-functional team communication to advance quality activities of Alnylam., • Interface with other Alnylam stakeholders to support ongoing state of Inspection Readiness., • Oversight of Clinical Trial vendors relative to safety and regulatory compliance activities Experience: A minimum of eight years relevant experience in Patient Safety activities in pharmaceutical industry. Strong skills and experience in: • Demonstrated ability to understand, interpret, analyze, and clearly present scientific and medical data in verbal and written format (including advanced understanding and application of medical concepts and terminology)., • Solid understanding of systems and reporting tools utilized to support pharmacovigilance activities., • Demonstrated ability to be highly collaborative and effective in a team environment (including Safety, Clinical Development, Clinical Operations, Biostatistics and Regulatory), as well as with external colleagues for partnered products., • Demonstrated ability to lead and mentor personnel., • Ability to work independently, with minimal supervision., • Excellent written and verbal communication skills., • Solid experience in drug development process., • Strong expertise in postmarketing pharmacovigilance., • Solid understanding of applicable global clinical trial safety regulations and post marketing regulations and experience in participation in regulatory inspections/audits., • Clinical judgment, critical thinking, and ability to interpret case information., • Strong organizational skills., • Experience with overseeing and coordinating work with external vendors., • Ability to adapt to a rapidly changing environment., • Basic knowledge of common data processing software (e.g. EXCEL, PowerPoint) Supervision: Individual is expected to manage outsourced resources, with support from CMVO and Global Safety Operations Sr. management. #LI-AL1 U.S. Pay Range $162,100.00 - $219,300.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Alnylam Pharmaceuticals is seeking a Director, Study Start-up to join our dynamic and growing team. The Director, Study Start-Up (SSU) provides strategic, operational and people leadership across the study start-up portfolio, with accountability for performance, scalability, and continuous improvement of the SSU function. This role sets standards, drives portfolio-level decision-making, and partners at the enterprise level to enable predictable, high-quality start-up outcomes across therapeutic areas and regions. The Director, Study Start-up is passionate about driving Study Start-up to deliver results while implementing SSU strategy and process standards. Key Responsibilities • Provide oversight of end-to-end study start-up activities, including site feasibility, site selection, regulatory and ethics submissions, site contracting, and site activation., • Ensure early planning, risk identification, and timely decision-making to support predictable study start-up timelines., • Serve as the escalation point for study start-up issues, ensuring timely resolution and minimal impact to delivery., • Lead resourcing, hiring, performance management, and talent development for SSU Leads and/or Managers., • Establish clear expectations, accountability, and development plans aligned with Alnylam leadership behaviors., • Lead development, implementation, and training of SSU SOPs, work instructions, job aids, tools, and templates in partnership with the Head of Study Start-Up., • Drive standardization and consistent execution of study start-up processes across therapeutic areas and regions., • Lead continuous improvement initiatives focused on reducing cycle time, cost, and operational burden., • Monitor, analyze, and report SSU performance metrics and KPIs (e.g., site activation timelines, readiness-to-enroll)., • Leverage data-driven insights to drive accountability, forecast performance, and inform portfolio-level decision-making., • Ensure maintenance and effective use of country and site intelligence to support study start-up strategy and planning., • Partner with the Feasibility Center of Excellence, Clinical Operations, Clinical Development, Regulatory, Legal, Finance, and CROs to facilitate cross-functional alignment and execution., • Represent SSU in governance forums, providing clear, data-driven updates, risks, and recommendations., • Provide oversight and performance management of CRO partners related to study start-up deliverables., • Ensure study start-up activities comply with ICH-GCP, global regulatory requirements, and internal policies and procedures., • Support inspection readiness and quality initiatives related to study start-up activities. Qualifications & Experience • Bachelor's degree required; degree in Life Sciences, Healthcare, or a scientific discipline preferred., • Advanced degree (e.g., Master's, MBA, MPH) preferred., • 10+ years of experience in global clinical trial operations and/or study start-up, including complex, multi-regional clinical trials., • 7+ years of people leadership experience, including leading managers and/or senior-level individual contributors., • Demonstrated success providing strategic oversight of end-to-end study start-up activities, from feasibility through site activation., • Proven experience leading complex, cross-functional study start-up initiatives with strong project management discipline, including planning, sequencing, risk management, and delivery against timelines., • Experience driving early planning, risk identification, and issue resolution to deliver predictable study timelines., • Experience leading development and implementation of SOPs, work instructions, tools, and standardized processes in a regulated environment., • Strong experience overseeing CRO partners and vendors, including performance management, issue escalation, and accountability against contracted deliverables and KPIs., • Demonstrated ability to operate effectively in a matrixed, global organization with multiple stakeholders., • Deep understanding of global study start-up processes, including feasibility, site selection, regulatory and ethics submissions, site contracting, and site activation., • Advanced working knowledge of ICH-GCP and the global regulatory environment., • Strong project management skills, including development and management of integrated plans, dependency mapping, risk mitigation, and issue resolution across cross-functional teams., • Proven vendor management skills, including CRO oversight, performance monitoring, governance participation, and driving corrective actions when required., • Strong leadership and people management skills, including talent development, performance management, and succession planning., • Proven ability to influence and align cross-functional stakeholders and drive accountability without direct authority., • Strong analytical and critical-thinking skills, with the ability to interpret data, identify trends, and make sound, data-driven decisions., • Demonstrated experience using metrics and KPIs to monitor performance, forecast outcomes, and drive continuous improvement., • Excellent written and verbal communication skills, with the ability to present clear, concise, and persuasive information to senior leadership., • Strong problem-solving skills with the ability to manage complexity and competing priorities in a fast-paced environment., • Experience with clinical trial systems and tools (e.g., CTMS, eTMF, IRT, eCOA)., • High level of business acumen, including understanding of cost drivers, resource planning, and operational trade-offs #LI-AL1 #LI-Remote U.S. Pay Range $196,600.00 - $266,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Associate Director is responsible for leading a team of Global Trial Leaders and Trial Managers within the Study Management Organization. The position is responsible for staff development and study oversight, and will work closely with the Director for input on project assignments, workload distribution, resourcing, and prioritization. The Associate Director directly influences trial objectives and ensures common operational issues/challenges are identified within and potentially across trials and programs and are addressed through operational risk mitigation, including proposals for alternative solutions. The Associate Director is also accountable for the operational execution of all trials within a program. Summary of Key Responsibilities Accountable for the delivery of the operational strategy in alignment with the Clinical Development Plan, ensuring alignment with the business goals and trial delivery objectives (including resourcing, budget, and change control) by partnering with CTWG and CDST on timeline creation. May Chair and/or support the Trial Leader in leading the CTWGfor the successful execution of assigned trial/s. • Define (for early development), or work with the Director to align on, the Operational Strategy for each trial in the program and gain governance endorsement on proposed plans, • Lead operational scenario planning and mitigate trial level risks that may impact timelines / budget., • Ensure appropriate timely and quality oversight, and appropriately escalate issues to the Director, Quality and functional leadership., • Ability to effectively communicate the operational strategy, and defend the operational plan and costs associated to CTWG, CDST, Director, leadership and at governance meetings as appropriate., • Lead and ensure inspection readiness for the trial/s, • Build knowledgeable and skilled team with competencies and capabilities to successfully set up and deliver clinical trials, • Promote strong collaboration across cross-functional teams, • Setting goals in alignment with company, program, and departmental goals, • Ensure staff training on procedures and systems associated with their roles, • Develop a team that consistently achieves strong results through nurturing individual growth, effectively managing performance, and providing guidance, • For early development programs, AD may represent Clinical Operations at CDST, • Interface with internal key stakeholders including, but not limited to; Finance, Program Management, Vendor Management, Safety, Accounting, Supply, Quality Assurance, Data Management, Statistics, Clinical Research, Commercial, Regulatory, Bio Analytical, Medical Affairs; which may include acting as a liaison between groups., • Lead or participate in process improvement activities at a trial and department level as needed, • Participate in preparation for, and conduct of, Health Authority Inspections and internal QA audits, • Ability to travel (expected annual average of 10% but flexibility to go over or below this as required). Qualifications • BS/ BA degree is required., • Minimum 8+ years of clinical research experience gained with a CRO, Biotech or Pharmaceutical Company working on Phase 1-4 global clinical trials., • 3-5 years leading end to end global clinical trials with experience in conducting Phase 3 registrational trials, • Experience in and knowledge of the pharmaceutical development process, • Excellent decision-making, analytical and strong financial management skills are essential to this position, • Ability to manage all aspects of execution of a clinical trial, • Must possess excellent leadership skills, proven ability to foster team productivity and cohesiveness and the ability to operate and execute with limited supervision, • Experience in leading without authority and in multifunctional matrixed and global environments, • Strong project planning/ management, communication (written and verbal) and presentation skills, • Minimum 2+ years prior line management experience or 3+ years matrixed leadership experience required, • Exceptional organizational skills and ability to deal with competing priorities, also strong reasoning and problem-solving ability., • Apply project management best practices to programs. Experience in novel clinical drug development., • Proficient with MS Office Suite (Excel, Word and PowerPoint) and MS Project. #LI-AL1 U.S. Pay Range $172,600.00 - $233,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Research Department at Alnylam is seeking a highly motivated and creative scientific leader to join our Next Wave, Target Discovery and Validation team. Our mission is to discover novel genetically informed targets and experimentally validate them to build a strong foundation for future RNAi therapeutics. By working closely with the Alnylam Human Genetics team, we integrate large-scale human genetic insights with deep biological expertise to generate high-confidence therapeutic targets. This role offers a unique opportunity to help shape the strategic direction of the next generation of RNAi medicines. You will collaborate cross-functionally with colleagues in genetics, translational science, RNAi platform, delivery sciences, clinical development, and commercial functions. This position also includes responsibility for managing and mentoring scientists and associate scientists. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities • Identify areas of unmet medical need and initiate target identification workflows in collaboration with statistical geneticists and translational science teams, • Design and execute in vitro and in vivo studies to validate candidate targets and elucidate underlying molecular and physiological mechanisms of action, • Analyze, interpret, and present scientific data at internal meetings and contribute to strategic planning discussions, • Lead collaborations with external partners, CROs, and academic institutions, including project strategy, experimental design, planning, data interpretation, and decision-making, • Communicate effectively and collaborate with key stakeholders across the organization, • Manage and mentor junior scientists and associate scientist Qualifications • PhD in biology or a related biomedical field with >10 years of postdoctoral experience and a strong record of high-quality publications, • Successful candidates must demonstrate strong scientific curiosity, flexible mindset, and passion for learning and applying knowledge across diverse therapeutic areas, biological pathways, tissues/cell types, and therapeutic modalities, • Proven expertise in developing and characterizing in vitro, ex vivo, and in vivo models, with a deep understanding of disease biology, pathogenesis, and mechanisms of action, • Experience in interpreting human genetics analyses (e.g., GWAS, PheWAS, Mendelian randomization, eQTL/pQTL/sQTL) to inform therapeutic target discovery is required, • Experience designing and executing experiments to validate genetic variants and their biological consequences is a strong plus, • Thrives in a fast-paced team environment with excellent written and verbal communication skills #LI-JR1 U.S. Pay Range $147,200.00 - $220,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: Reporting to the Director, Patient Services Operations, the Associate Director, Patient Services Operations will serve as a strategic partner to Case Management and PEL teams, enabling consistent, data-driven execution across Commercial. This role will help define what success looks like for field teams by translating strategy into measurable results, key activities, and performance metrics. The Associate Director will partner closely with our technology and analytics partners to define metrics, support the development of dashboards, and synthesize insights from multiple data sources to inform decision-making. This role will also lead field-facing processes related to customer-to-account affiliations, ensuring accuracy, consistency, and scalability. Additionally, the role will contribute to targeting, field force effectiveness initiatives, and ad hoc analyses in support of evolving business needs. Key Responsibilities: Field Force Strategy / Field Force Effectiveness • Engage effectively in strategic discussions with leadership of Case Management and PELs, including TTR Sales, Rare Sales, Market Access, and Strategic Accounts., • Define what success looks like for Case Management and PEL teams including themetrics used to measure results, • Identify key activities that are expected to drive the desired results and define Key Performance Indicators, • Work with cross-functional partners to establish dashboards and generate insights from the data to help shape strategy, • Identifytrends, inefficiencies andopportunitiesfor process improvement withinpatient services systems and data, • Lead the development of presentation materials to support monthly and quarterly leadership performance reviews, • Drive consistency in field execution through clear processes, playbooks, and standard operating procedures., • Partner with Compliance and Legal to ensure field team activities adhere to company policies and industry regulations., • Support change management efforts when deploying new processes, systems, or field strategies Qualifications: • Bachelor's degree required; advanced degree preferred., • 6+ years of experience in patient services field teams and call centers within the pharmaceutical or biotechnology industry., • Proven experience partnering with field teams and presenting senior leadership., • Strong experience working with CRM platforms and commercial data environments., • Hands-on experience with data visualization tools (e.g., Tableau, Power BI, etc)., • Demonstrated expertise in field force effectiveness, alignments, HCP and patient segmentation, reporting, size and structure, and strategic analysis., • Experience across multiple commercial functions, including operations and strategy., • Strong analytical skills with experience leveraging pharmaceutical data sources to generate and iterate on insights., • Advanced proficiency in Excel and PowerPoint., • Highly organized, agile learner with the ability to think in real time and communicate effectively., • High sense of urgency balanced with attention to quality, rigor, and process., • Strong interpersonal and communication skills with the ability to influence at all levels of the organization., • Demonstrated project management skills with the ability to lead multiple initiatives and priorities concurrently., • Experience working directly with field teams; prior field experience strongly preferred., • Ability to travel for key internal and external meetings as needed (approximately 10% overnight travel). #LI-ST1 #LI-Remote U.S. Pay Range $155,600.00 - $210,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Site and Monitoring Health Lead (SMH Lead) will apply knowledge of regulations and GCPs as well as experience in monitoring to safeguard the quality of clinical trial execution at investigator sites and ensure Alnylam's oversight of CRO monitoring effectiveness. This is a site-facing position that reports to the Associate Director, Site and Monitoring Health or above. Summary of Key Responsibilities • Implement Alnylam's Site and Monitoring Health strategy in alignment with ICH GCP E6 and E8, • Employ risk-based thinking to focus on what is critical to quality, and exhibit an "inspection ready at all times" mentality, • Create Study Specific Oversight Plans (SSOP) for aligned trials in scope and/or follow SSOP when conducting oversight activities, • Implement various types of oversight encounters and activities as applicable including but not limited to: site risk analysis, site contacts, aggregate review of data, monitoring visit report review, Sponsor Oversight Visits, system/data spot checks, and periodic summaries; ensure timely documentation of these activities is completed and filed, • Build relationships with investigators and site staff in region; act as a resource for identifying potential sites for new studies, • Utilize root cause analysis to assess identified issues and provide suggested actions to Study Management / CRO to mitigate risk, • Support investigator sites less experienced in research; assist in assuring sites are engaged in the study and have what they need to recruit participants successfully, • Troubleshoot and use alternative and innovative approaches to solve problems impacting clinical site delivery and quality, • Work closely with Clinical Risk & Analytics staff to understand the risk management plan (Risk MAP) for assigned studies, ensure the SSOP is aligned with the Risk MAP, and assess sites who are outliers, • Lead oversight and trend meetings with the study team and/or CRO to discuss risks, issues, and trends identified by the SMH team for the trial, • Complete administrative tasks (e.g., timesheets, expense reports, Sponsor Oversight Visit reports, etc.) consistently on time and with good quality, • Work independently and collaboratively with cross-functional teams, • Support inspection preparation and management, • Maintain awareness of changes in industry and regulatory standards for GCP requirements, • Bachelor's Degree is required. A clinical or advanced degree (e.g. RN, MPH, MS, MA, MBA, PharmD) is preferred, • Previous direct monitoring experience gained with a CRO or pharmaceutical company working on multinational clinical studies; Lead CRA/management experience preferred, • Experience in all study phases of clinical research (Phase I-III; experience in both prevalent and rare medical conditions preferred, • Previous audit support and regulatory inspection experience preferred, • Demonstrate flexibility in schedule and willingness to travel frequently in assigned region, • Excellent interpersonal, verbal, and written communication skills, • Fluency in multiple languages and cultural awareness is a plus, • Ability to build and maintain relationships with key investigators and sites (e.g. key networks, key trial sites and investigators, key opinion leaders and their site staff, • Innovator, willing to initiate changes, introduce new ideas, and creatively problem-solve, • Experience with Microsoft based applications and ability to learn internal and external computer systems, • Good organizational skills and ability to deal with competing priorities, • Analyze complex situations and effectively communicate issues along with potential recommendations to various functional groups, • Demonstrate good judgment and decision-making experience #LI-AL1 U.S. Pay Range $123,300.00 - $166,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: Alnylam is seeking a visionary scientific leader to serve as Vice President, Target Discovery, Validation, and Human Genetics, with end-to-end accountability for identifying, validating, and advancing novel therapeutic targets into our RNAi pipeline. This role sits at the core of the Research organization and will shape the future trajectory of Alnylam's portfolio. The VP will lead both the Human Genetics and Discovery & Validation Biology teams, integrating large-scale human genetic insights with deep biological expertise to generate high-confidence targets. Leveraging access to some of the world's largest and most diverse genetic and phenotypic datasets, including UK Biobank, All of Us, FinnGen, and others, the role will define and execute a strategy to deliver a robust and sustainable flow of targets across a broad range of therapeutic areas, including cardiometabolic, neurological, rare, renal, and ocular diseases. This leader will set the vision for how human genetics and experimental biology are jointly deployed at Alnylam, ensuring the organization remains at the forefront of genetically informed drug discovery. The role requires scientific depth, strategic acumen, and organizational leadership to build, resource, and inspire high-performing teams capable of delivering more than ten compelling, pipeline-ready targets annually. In addition, the VP will serve as a key internal and external ambassador, partnering closely across research, development, commercial, and finance to inform portfolio investment decisions, while also cultivating strategic external collaborations that strengthen Alnylam's discovery engine and scientific reputation. Key Responsibilities: • Define and execute an enterprise-level strategy for target discovery and validation, integrating human genetics and experimental biology to fuel Alnylam's RNAi pipeline., • Lead and develop the Human Genetics and Discovery & Validation Biology teams, ensuring scientific excellence, clear prioritization, and sustained target delivery (>10 targets per year)., • Establish Alnylam as an industry leader in the application of large-scale human genetic data for drug target identification and prioritization., • Oversee generation of rigorous, decision-enabling data packages to support target nomination and progression through governance forums., • Partner cross-functionally with Research, Development, Commercial, and Finance to align discovery priorities with portfolio strategy and investment decisions., • Identify, evaluate, and champion opportunities to expand Alnylam's access to genetic datasets, technologies, and external collaborations., • Represent the discovery portfolio internally and externally, building credibility with senior leadership, partners, and the broader scientific community. Qualifications: • PhD in human genetics, statistical genetics, molecular biology, or a related discipline, with deep scientific credibility in genetically driven drug discovery., • 15+ years of progressive experience in biopharmaceutical research, including senior leadership roles with accountability for strategy, teams, and portfolio outcomes., • Internationally recognized expert in human genetics-enabled target discovery, with a strong record of high-impact publications, target nominations, and/or pipeline contributions., • Demonstrated ability to lead and integrate large, multidisciplinary teams spanning computational genetics, in vitro biology, and in vivo disease models., • Proven track record of shaping discovery strategy and influencing portfolio-level investment decisions at the enterprise level., • Strong business and matrix leadership skills, with experience partnering effectively across research, development, commercial, and corporate functions., • Exceptional communication and executive presence, with the ability to articulate complex scientific concepts to diverse internal and external stakeholders. U.S. Pay Range $310,000.00 - $420,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Principal Statistical Programmer The Principal Statistical Programmer will provide expert-level hands-on principal programming support and technical leadership to develop, maintain, validate and run SAS computer programs that access, visualize, analyze, and report clinical trial data, in accordance with statistical analysis plans, ICH guidelines, and applicable regulatory requirements. The ability to work independently with a strong expertise in SAS/GRAPH programming experience is required. While SAS expertise is required, experience with R programming, particularly data visualization and exploratory analysis is strongly preferred. Summary of Key Responsibilities • Write programs that produce or validate tables, listings, figures and analysis datasets, in support of clinical studies or complex integrated analyses for submission;, • Develop and follow good programming practices, including adequately documenting SAS and R code;, • Perform, plan and coordinate project work to ensure timely, quality delivery across multiple projects;, • Use, modify, and maintain existing SAS and R code;, • Write specifications to describe programming needs;, • Create and validate global macros or systems that streamline repetitive operations to increase programming efficiency;, • Keep abreast of current and new statistical programming techniques and other applicable technical advancements while assisting in their implementation;, • Provide input into, or lead general standardization efforts (e.g., CRFs, query checks, standard statistical programs, data presentations);, • Assist or lead efforts to develop programming processes consistent with industry best practices;, • Review DMP, eCRF specs, and other clinical data management documents;, • Review statistical analysis plans and other related documents;, • Partner with or oversee CROs or Programming vendors to perform any of the above tasks;, • Other duties as assigned. Qualifications • At least 8 years' industry (Pharmaceutical, Biotech, CRO) SAS programming experience or equivalent;, • Knowledge of clinical trials and experience in using SAS to report the results of clinical trials and/or integrated analysis for submission;, • Experience in constructing technical programming specifications and producing complex, validated programs;, • Strong experience in working with CDISC standards, including SDTM, and ADaM, and Define xml;, • Preferred experience in R programming;, • Excellent knowledge of applied statistical methodologies;, • Excellent knowledge of SAS Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT;, • Good communication and organizational skills required;, • Bachelor's Degree required, Master's Degree Preferred., • ___Clear alignment with Alnylam Core Values:, • Commitment to People, • Innovation and Discovery, • Sense of Urgency, • Open Culture, • Passion for Excellence Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment. #LI-AB1 #LI-Hybrid U.S. Pay Range $151,300.00 - $204,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Job DescriptionGet to Know Rivia Mind At Rivia Mind, we believe great mental health care begins with a human connection. Where We Are: We are a psychiatrist-owned mental health practice rooted in New York City, serving individuals across New York, New Jersey, Connecticut, Florida, and Massachusetts through both virtual and hybrid appointments. How We Support: With a 360°ree; view of each individual, we provide compassionate, science-based care that honors the full complexity of a person's biology, psychology, and life circumstances. We go beyond symptom management with an interdisciplinary care model grounded in collaboration, personalization, and delivered with warmth, respect, and clinical integrity. We bring a high-touch, human-centered approach to every aspect of care, from clinical treatment to operational coordination. Click Here to learn more about our services. Thrive Together: 🌟 Our shared North Star unites us to provide the best patient experience. At Rivia Mind, we cultivate a collegial culture rooted in: • A foundation of shared values and reciprocal support, • A mindset of curiosity, learning, and growth Job Summary The Nurse Practitioner provides clinical Psychotherapy and Psychopharmacology services to patients through a primarily tele-health environment. Supported by collaborating Psychiatrists, Therapists, and Operational teams who assist you with clinical excellence and administrative tasks. Our practice leverages clinical experience and a diverse knowledge base to provide quality care and reliable service. This individual will utilize their expertise in Psychotherapy modalities (i.e. CBT, MI, DBT, etc.) and Medication Management to provide access to reliable, quality care in the communities we serve. As an employee at Rivia Mind, you will collaborate within a dynamic interdisciplinary team to foster continued learning and growth. All employees at Rivia Mind benefit from working in a diverse group with internal education opportunities and frequent collaboration. • Participate in Rivia Mind supervision groups, trainings, and attend department and organization meetings, such as:, • Weekly Group Supervision, • Case and peer discussion, knowledge sharing, guidance, etc., • Frequent 1:1 Supervisor/Supervisee meetings, • Weekly Education Meeting, • Case presentations, guest speakers, training, etc., • Orientation/Onboarding Training Meetings and Reviews, • Psychiatrist-Led Office Hours (optional), • Specialty Supervision Groups (if enrolled) Responsibilities • Provide excellent quality clinical care on a consistent basis that exemplifies Rivia Mind's culture, values, and guiding principles, • Service and maintain a weekly average standard of 50 patient sessions (25 or 45-minute sessions), • Maintain a consistent weekly patient care schedule in alignment with Rivia Mind's standard productivity expectations., • Follow Care Model practices that emphasize continuity of care, high-frequency follow-up appointments, and effective calendar management., • Conduct comprehensive intake evaluations and develop curated patient-centered treatment plans, • Provide appropriate Psychotherapy practices that leverage various modalities (CBT, DBT, motivational interviewing, etc.) with proper Psychopharmacology prescribing practices, • Appropriately prescribe medication prescriptions & refills, considering the best judgment of the patient's well-being, • Provide clinical support & counseling to diverse patient populations in a telehealth environment, • Coach patients on how to manage ongoing health conditions and provide therapy to help patients make positive behavior changes, • Counsel and provide crisis intervention for patients, including assessment and treatment of emotional and behavioral problems, • Comply with clinical standards and adhere to timely and thorough session note documentation, • Promote a friendly work culture that encourages a fun, collaborative, and co-learning environment that benefits individuals' well-being, self-improvement and potential Required Education Level: Master's Degree or higher Education Details: Master's in Nursing Licensure/Certification Requirements • Must have Massachusetts (MA) State Licensure for the following:, • Valid Certified Registered Nurse Practitioner (CRNP) / Advanced Practice Registered Nurse (APRN), • Valid Registered Nurse (RN) License, • Active DEA License in good standing, • At least one(1) year of post-licensure experience with solid competence in practicing Psychotherapy (CBT, MI, DBT, etc.), • Experience working with Patients in an Outpatient setting, • Telehealth/telemedicine experience, • Proficient with utilizing diverse technology platforms and systems (Google Suite, company-wide platforms/software and EHR platforms when applicable) Benefits That Support You, Personally and Professionally At Rivia Mind, we know that providing exceptional care starts with caring for our team. That's why we offer a comprehensive, thoughtfully designed benefits package that supports your health, financial wellness, growth, and overall well-being—so you can thrive in work and life. Learn more here. • 3 weeks of front-loaded PTO + 9 paid holidays, • Annual office closure (Dec 25–Jan 1), • Annual Impact Days for volunteering or professional development, • 401(k) with employer match, • Referral bonus potential, • Annual Continuing Education (CE) Stipend + Flexible Benefit Reimbursement, • Medical, dental, and vision insurance — with EAP and additional wellness programs, • Voluntary benefits, HSA, DCA, FSA (based on plan), transit & parking options Compensation & Employment Details Pay Range: $110,000 - $150,000Our compensation package includes a base salary based on compensable factors. Additionally, clinicians are eligible for quarterly bonuses of up to $2,000 (up to $8,000 annually), awarded based on defined metrics related to clinical excellence and care model performance.Pay Type: SalaryDepartment: Nurse PractitionersSupervisor: Psychiatrists, Nurse Practitioner SupervisorsSupervisees: NoneEmployment Status: Full Time Exemption Status: Exempt W-2Work ScheduleWe collaborate with each provider to determine a mutually beneficial and sustainable schedule. Our focus is to develop a supportive schedule that meets both the needs of our patients and the providers' preferences. Your schedule will be determined with you before starting the role. • Our operating hours are M-F: 8 am to 6 pm, but we do allow a schedule to have a start as early as 7 am, and end as late as 9 pm M-F, and between 9 am - 5 pm Saturday. All Eastern Time Zone., • Include at least four(4)+ hours within your schedule, which should be after 5 pm on a weekday or have hours on the weekend., • On-call is not required, but checking and responding to time-sensitive emails on unscheduled days is required unless on PTO. Location Eligibility: At this time, we are only able to consider applicants whose primary residence is in one of the following states within the United States of America: Connecticut, Florida, Massachusetts, New Jersey, New York, North Carolina, Pennsylvania, South Carolina, Texas. Because this is not a solely on-site role, your primary residence must remain in one of these approved states. Please note that residing outside of these states—even temporarily—may result in employment eligibility issues, tax implications, or other regulatory concerns. If your location changes or you're based elsewhere, we encourage you to stay connected for future openings. Equal Opportunity Employer: Rivia Mind is an Equal Employment Opportunity Employer. It is the policy of Rivia Mind to provide equal employment opportunities without regard to race, color, ancestry, religion, sex, gender identity or expression, pregnancy, age, ethnic or national origin, immigration or citizenship status, hair, weight, height, disability, marital status, veteran status, sexual orientation, genetic information/GINA, political affiliation or activity, or any other protected characteristic under applicable law. It is also the policy of Rivia Mind that qualified individuals with disabilities receive equal opportunity regarding job application procedures, hiring, and all aspects of the employment process. Rivia Mind is committed to the full inclusion of all qualified individuals. Consistent with the Americans with Disabilities Act (ADA) and applicable state and local laws, it is the policy of Rivia Mind to provide reasonable accommodations when requested by a qualified applicant or employee with a disability, unless such accommodation would cause an undue hardship. If reasonable accommodation is needed to participate in the job application or interview process, pre-employment testing, to otherwise participate in the selection process, to perform the essential job functions, and/or to receive other benefits and privileges of employment, please contact us directly. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Rivia Mind participates in E-Verify to confirm the identity and employment eligibility of newly hired employees. Right to Work Poster, and E-Verify Poster Applicants must be authorized to work in the United States. We are unable to sponsor work visas at this time. This is in accordance with applicable federal, state, and local laws, including Title VII of the Civil Rights Act, the Americans with Disabilities Act, the Age Discrimination in Employment Act, and the Genetic Information Nondiscrimination Act. If you need assistance or accommodation due to a disability during the application process, please contact our Talent Acquisition team at .

< Overview The Director, People Experience Operations & Transformation serves as a strategic advisor and operational partner to the VP, People Experience. This leader will shape and drive the transformation of our HR service delivery model, enabling a modern, scalable, and employeecentric approach. This role is responsible for designing and optimizing business processes, advancing technology and AIenabled solutions, improving the employee experience, and ensuring effective, sustainable change management across the organization. The Director will influence crossfunctional partners, streamline complexity, and champion operational excellence while elevating how employees experience People programs and services. This is a hybrid position and will primarily be based in Cambridge, MA. Responsibilities • Lead the design and implementation of a tiered HR service delivery model and optimize HR processes for efficiency and improved employee experience., • Assess and streamline People Experience processes, creating scalable and automated workflows using continuous improvement methodologies., • Develop and execute change management strategies, partnering with Communications and coaching leaders to support adoption., • Partner with IT, HRIS, and technology teams to enhance systems, enable AIdriven automation, and ensure seamless HR service experiences., • Simplify complex HR processes into intuitive experiences and establish mechanisms to measure and improve employee experience quality., • Lead crossfunctional initiatives across People Experience, HRBPs, COEs, IT, Finance, and Communications, and manage a strategic roadmap of priorities. Qualifications • 10+ years of experience in HR operations, HR transformation, shared services, or related roles. Ideally with a background in HR transformation consulting (internal or external)., • Bachelor's degree in relevant field, or equivalent experience, required., • Experience implementing and/or operating within a tiered HR service delivery model., • Proven ability to lead largescale transformation and organizational change efforts., • Strong HR process and workflow expertise across the employee lifecycle., • Experience partnering with IT/HRIS on system implementation, optimization, or automation., • Strong consulting skills, including structured problem solving, executive presence, analytical rigor, and stakeholder influence., • Demonstrated ability to simplify complexity and design exceptional user experiences., • Familiarity with HR technology ecosystems such as Workday, ServiceNow HRSD, or SuccessFactors, preferred., • Experience utilizing and driving adoption of AI/automation tools in HR, preferred., • Experience or certification in Lean, Six Sigma, ProSci, or Design Thinking, preferred. #LI-MH1 #LI-Hybrid U.S. Pay Range $191,300.00 - $258,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for an experienced and talented Business Account Executive (BAE) to commercially represent GIVLAARIand OXLUMO in the United States and have a significant impact on the lives of AHP patients. AHP's represent a sub-group of Porphyrias, characterized by the occurrence of neuro-visceral attacks with or without cutaneous manifestations. AHP's include four disorders: acute intermittent porphyria (the most common), variegate porphyria, hereditary coproporphyria, and a genetic deficit of delta-aminolaevulinic acid dehydratase. PH1 is a rare, life-threatening disease that can cause serious damage to kidneys and progressively to other organs. PH1 is a little-known condition and patients often spend years undiagnosed and misdiagnosed. The BAE will be principally responsible for driving physician and patient identification, disease awareness, overall market development, and brand awareness within their ascribed territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. The achievement of targets will be based in Alnylam's values: our commitment to people, sense of urgency, passion for excellence, innovation & discovery, and open culture as well as our unwavering commitment to integrity. The BAE will report to the Regional Business Director (RBD) for their respective region. Key Responsibilities • Drive patient identification through appropriate HCP driven strategies including market development, increase brand awareness through building and executing a territory strategy/account plan; continuously assess opportunities within markets and accounts to launch successfully., • Effectively prioritize and manage time, activities, and resources in order to optimize access to academic and community HCPs., • Build and maintain relationships with HCPs and office staff by maximizing their time through planning, leveraging insights, and conducting post-call analysis refining tactics based on opportunities., • Proactively build effective working relationships with internal/external stakeholders; drive agreement/decisions from multiple stakeholders; demonstrated high level of emotional intelligence adapting communication based on different stakeholders., • Collaborate with stakeholders across all commercial departments including; patient services, field reimbursement, and others to ensure access at site of care and that logistics are in place to administer medications., • Collaborate with key accounts and physicians to build individual account plans to drive patient identification through market development and physician education; achieve sales goals, and maintain relationships in order to maximize sales results., • Execute speaker programs, local sponsorships, displays and exhibits, both in and out of office across multiple account types: academic institutions, physician offices, infusion centers, and alternate site locations., • Bachelor's degree required, • 5+ years of demonstrated success in biotech, specialty pharmaceuticals, or medical devices., • Experience, success and relationships in Rare Disease, Gastroenterology, Hepatology, Neurology, Hematology/Oncology, pediatric and adult Nephrology and/or Urology are preferred but not required., • Buy & Bill understanding and experience working with HUB patient services preferred but not required., • Thorough understanding of site of care identification, development and education., • Strong examples of applied entrepreneurial mindset, business analytics and data analysis required., • Experience supporting biologic therapy administered by designated HCPs preferred., • Experience driving, leading and delivering upon territory-level cross functional business planning., • Must be familiar with relevant legal and regulatory environment in biotech/pharmaceutical industry., • Strong communication and listening skills., • Effective at managing complex individualized cases in a compliant manner., • Overnight travel required including travel to Boston, congresses and large geographical territories, • Candidates must have a valid driver's license. $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are seeking an experienced professional for the role of Senior Manager, Clinical Supply Chain In this position you will play a critical role in ensuring seamless execution of clinical supply operations across multiple programs. You will hold program-level ownership and trial-level leadership for clinical supply delivery, ensuring reliable, compliant, and uninterrupted supply of clinical trial material to sites worldwide, in support of Alnylam's growing pipeline and patient needs. This role provides both leadership and hands-on execution. You will support CSC team members in operational delivery while also serving as a senior individual contributor for complex or large scale studies when needed. The Senior Manager will collaborate closely with senior CSC leaders to maintain robust, compliant and effective operational processes. You will partner crossfunctionally with Quality Assurance, Clinical Operations, Program Management, and Regulatory Affairs, and external CMOs, to drive successful trial execution in a dynamic environment. Strong, proactive communication is essential, as the role interfaces regularly with internal stakeholders and external partners. Overall, you will be responsible for supporting CSC team members, overseeing supply execution, identifying and mitigating risks, and ensuring clinical supply program objectives are met efficiently throughout the lifecycle of assigned studies and programs. This position is well-suited for professionals with experience supporting large, global clinical studies or multiple concurrent trials in a fast-paced, cross-functional setting. You will focus on overseeing programs, protocols, and CSC team members as you manage the global supply of essential clinical materials, prioritize needs, and maintain operational excellence. Your ability to communicate clearly, collaborate effectively, and navigate complex operational challenges will be key to success. This position is hybrid and will be primarily located in the Alnylam Cambridge office. Key Responsibilities • Accountable and/or responsible for clinical supply related activities for assigned program(s) and/or protocol(s) including, but not limited to execution of supply strategy, IRT setup & management, packaging, labeling, distribution, returns, destruction, and study closeout., • Drive issue resolution across vendors and internal teams, balancing speed, quality, and compliance, • Identify, assess, and manage execution-related risks at the program and trial levels, • Provide program-specific insights, emerging risks, and execution details to Clinical Supply Chain Strategic Planners to ensure effective supply plan, • Support and mentor CSC team members as needed on operational execution of clinical supply activities, • Ensure all program goals and objectives are met on time & monitored across the course of the study, from a clinical supplies perspective (e.g. FSA, FPI, enrollment progress), • Support inspection readiness for assigned program(s) and/or protocol(s) and department processes., • Ensure current systems & procedures are aligned with current regulations & industry standards., • Responsible for program budget and long range budget planning for assigned programs., • Engage with CMO, CRO, & key suppliers that support systems, production & distribution., • People Management - direct and indirect Qualifications • B.Sc. in a scientific field or Supply Chain Management. Pharmacy degrees are encouraged to apply., • 6-8 years of direct Clinical Supply Chain experience globally, • Knowledge of end to end clinical supply chain with a focus on operational execution, • Proficient knowledge of various project management and process tools MS Office (e.g. Excel, Smartsheet, PowerPoint, Visio, Project), • Experienced working with & managing third-party CMO clinical supply operations., • Strong experience of - IRT/RTSM including development of specifications, , & understanding areas of limitations, risks, or gaps to mitigate, • Excellent communication, attention to detail, collaboration, ability to manage complex challenges, and influencing skills #LI-LJ1 #LI-Hybrid U.S. Pay Range $136,900.00 - $185,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: Alnylam is seeking an Employment Counsel to provide strategic leadership for the Company's global employment law function. Reporting to the SVP, General Counsel, Corporate and Governance, this role will evolve, lead and execute Alnylam's employment legal strategy in support of a growing, global, commercial-stage biotechnology organization. As a senior leader within the Legal function, the Employment Counsel will have enterprise-wide accountability for employment-related legal risk management, governance, policy development, and litigation strategy. This individual will serve as a trusted advisor to executive leadership, partnering closely with HR, Talent Acquisition, Ethics & Compliance, and business leaders across the organization to ensure alignment between Alnylam's People & Culture strategy and its legal framework. This role requires a strategic, solutions-oriented leader who can operate at both the executive and operational levels, setting direction for the employment law function while driving disciplined execution across both complex/high-impact and more routine matters. Responsibilities: • Lead and set strategy for Alnylam's global employment law function, ensuring alignment with enterprise growth objectives and evolving workforce strategy, • Establish and oversee governance frameworks for employment risk management, compliance, and policy development across jurisdictions, • Provide executive-level counsel and be a trusted partner to the CHRO, HR Leadership Team, HR Business Partners and functional heads across the organization on complex employment matters with material enterprise impact, • Contribute to Legal function strategy and serve as a senior leader within the Legal team, • Own and drive strategy for pre-litigation and litigation employment matters, including oversight of outside counsel, cost management, and resolution strategy, • Assess and proactively mitigate systemic employment risks, including regulatory exposure, pay equity, classification, investigations, reorganizations, and workforce actions, • Lead negotiations with plaintiffs' counsel and represent the Company in mediations and high-risk employment disputes, • Oversee the design, implementation, and evolution of employment-related policies and programs (e.g., performance management, workforce restructuring, accommodations, leave, compensation practices), • Ensure compliance with applicable federal, state, and international employment laws, including FLSA, wage and hour regulations, immigration, and emerging regulatory requirements, • Partner with HR and Compliance to deliver enterprise-wide training and education on employment law risk and best practices, • Serve as primary legal advisor to Employee Relations, HR Business Partners, and Talent Acquisition on employment agreements, background checks, investigations, and workforce planning initiatives, • Collaborate with Compliance and Ethics on internal investigations and governance matters, • Support enterprise-wide initiatives, including workforce expansions, organizational redesign, global growth, and public health or regulatory response matters, • Strategically manage external counsel relationships, including selection, performance oversight, and budget management, • Determine when external expertise is required versus internally managed Qualifications: • Juris Doctor (JD) with strong academic credentials; member in good standing of a U.S. Bar (Massachusetts preferred), • 12+ years of progressive experience in labor and employment law, including significant in-house experience within a complex, regulated industry (life sciences experience strongly preferred), • Demonstrated ability to lead an employment law function or significant employment practice area with enterprise impact, • Deep expertise across employment litigation, wage and hour law, investigations, workforce restructuring, compensation, immigration, and regulatory compliance, • Proven executive presence and ability to influence senior leaders on high-risk, high-visibility matters, • Strong strategic judgment with the ability to balance legal risk, business objectives, and organizational culture, • Experience operating in a global, matrixed organization, • High degree of integrity, discretion, and sound judgment #LI-Hybrid #LI-JD1 U.S. Pay Range $297,500.00 - $402,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Job Type: Term (Fixed Term) Position Description RAND's ___, part of the Global and Emerging Risks (GER) Division conducts cutting-edge research on transformative, high-impact technologies-including artificial intelligence and biotechnology-to shape policies that protect global security and advance the public good. You will be responsible for managing significant research budgets and personnel, overseeing complex technical research and policy analysis projects, and leading multidisciplinary teams of policy researchers, engineers, and scientists. Your team will build systems to evaluate how AI models perform across the full attack lifecycle, including resource development, initial access, discovery, lateral movement, and defense evasion. Your projects may include developing benchmarks for fully autonomous operations using scaffolding and tools, as well as uplift of both novice and expert humans. Such benchmarks may involve environments like CTF challenges, frameworks for assessing ability to reason over attack graphs and conduct multi-stage operations, assessment of stealth and defense evasion capabilities, and benchmarks for ability to conduct time-sensitive operations at machine speed. Many of your evaluations will be commissioned directly by relevant government agencies, and the results of your evaluations will drive responsible AI policy across the world. Your team will communicate findings through detailed technical analyses, evaluation frameworks, and quick-turnaround policy briefs. Your work will inform analysis delivered to senior government and industry leaders. This position is structured as a two-year appointment with options to renew and explore opportunities for longer-term employment at RAND thereafter. RAND's reputation for excellence is built on our commitment to high-quality, rigorous analysis and objectivity. As a Research Lead - AI Cyber Testing & Evaluation, you'll maintain that excellence while engaging with some of the most pressing challenges of our time. Qualifications All research positions at RAND require excellent analytic skills; the ability to communicate clearly and effectively, both orally and in writing; the ability to work effectively as a member of a multi-disciplinary team; and a strong commitment to RAND's core values of quality and objectivity. Required: * 6+ years of technical experience in security engineering, software engineering, firmware engineering, hardware engineering, or related fields * 6+ years of technical management experience, including leading cross-functional teams, managing project budgets, and mentoring and developing team members * Demonstrated ability to successfully lead complex projects to completion * Proficiency in Python, Java, C/C++, or other popular programming languages * Experience with red team operations or offensive cyber capabilities development * Ability to develop rigorous and comprehensive ___ and identify potential system vulnerabilities * Strong ability to communicate effectively in English, both verbally and in writing * Ability to work effectively in a collaborative, multidisciplinary environment * Fluency with MS Office suite Preferred: * Graduate of the Computer Network Operations Development Program (CNODP), Remote Interactive Operator Training (RIOT), Future Operator Readiness Growth and Enrichment (FORGE), or equivalent experience * Understanding of ___ (APT) tactics, techniques, and procedures (TTPs) and experience with defending against them * Ability to think creatively about offensive and/or defensive techniques and strategies, beyond compliance with existing regulations * Experience working on AI research, ML model training, or model deployment Education Requirements RAND is hiring a Research Lead at either the specialist or expert level of experience. Minimum education requirements at the specialist level include: A PhD in Computer Science, Computer Engineering, Electrical Engineering, Cybersecurity, Information Security, Information Technology, Mathematics, Applied Mathematics, Physics, Applied Physics, Engineering Physics, Artificial Intelligence, Machine Learning, Engineering and Public Policy, Technology and Policy, National Security Policy, Policy Analysis, Political Science, International Relations, or similar with at least 3 years of relevant professional experience is required. OR A Master's degree in the fields listed above with at least 6 years of relevant professional experience, is required. OR A Bachelor's degree in the fields listed above with at least 8 years of relevant professional experience, is required. Master's or PhD preferred. Security Clearance Ability to obtain and maintain a U.S. government clearance is preferred but not required. Location We are hiring for this position in San Francisco, CA; Washington, DC; Santa Monica, CA; Pittsburgh, PA; and Boston, MA. We offer a hybrid work arrangement, combining work from home and on-site options. Fully remote work will also be considered. Writing or Code Sample Either a writing sample or a code sample is required for this position. This sample can use a recent, previously written paper or technical report (e.g., journal article, master's thesis or paper written for coursework, research project, technical analysis, briefings), or source code showing technical expertise in relevant domains. Term This position is a 3-year term appointment with a possibility of renewal, alongside options for longer term employment. Salary Range: $146,200 - $261,400 Visiting Technical Specialist = $$146,200 - $211,900 Visiting Technical Expert = $167,300 - $261,400 RAND considers a variety of factors when formulating an offer, including but not limited to, the specific role and associated responsibilities; a candidate's work experience, education/training, skills, expertise; and internal equity.Successful candidates will be offered employment in a specific title, as determined by the candidate's education and experience. The salary range includes base pay plus RAND's sabbatic pay (which provides additional compensation above base pay when vacation is taken). In addition, RAND provides strong benefits including health insurance coverage, life and disability insurance, savings plan, paid time-off and more. Equal Opportunity Employer

< Overview Reporting to the Head of Global Investigations & Enterprise Risk Management, the Director, Ethics & Compliance, is responsible for managing all aspects of Alnylam's global investigations in all markets, including conducting and reporting on investigations into reported ethics and compliance concerns and enhancing the Company's internal investigations program and speak up culture. The role will also be responsible for assisting the Head of Global Investigations & Enterprise Risk Management with the operation and oversight of the Company's Enterprise Risk Management (ERM) program, including the identification, assessment, mitigation, and reporting of enterprise risks, and further developing the Company's enterprise risk management processes and framework. This position will require a hybrid onsite presence out of the Cambridge, MA location. Key Responsibilities • Planning and conducting investigations into reported ethics and compliance concerns, or any allegations of misconduct, as required., • Designing and implementing continuous enhancements to Alnylam's speak up program and culture and investigations processes, including drafting of policies and procedures, and development and implementation of relevant training and resources in accordance with applicable global laws and practices., • Providing training and guidance to relevant stakeholders on the reporting and investigations process and function., • Drafting concise and accurate investigation reports and presentations, and presenting key issues, findings, and outcomes related to investigations to senior management and business leaders, including at the executive level., • Identifying and presenting on investigation trends and remediation to the Chief Ethics & Compliance Officer (CECO) and other cross-functional senior leaders at various forums (e.g., regular updates to Legal, Human Resources, Internal Audit, and Compliance Committees, as necessary), including at the executive level., • Overseeing Alnylam's global database of reported ethics and compliance matters, the Alnylam Helpline, and other global reporting channels for the intake of complaints., • Managing Alnylam's case management software system, including updating matter information in the system and working with vendors on system enhancements and updates, as necessary., • Working closely and collaboratively with key internal stakeholders, including Human Resources, People Relations, and Legal on matters, including with respect to the remediation of matters and recommendations for appropriate disciplinary action., • Supporting the Company's global ERM program and related processes by conducting enterprise risk assessments and risk mitigation planning, partnering with cross-functional enterprise leaders, including Finance, Internal Audit, IT, Procurement, and Legal, among others., • Preparing enterprise risk reports and other presentations on the ERM program and annual risk assessments for key stakeholders., • Overseeing the Company's risk management software system, including by managing risk and risk assessment information in the system, and working with the vendor to make system enhancements as necessary and to align with the ERM program., • Managing ERM oversight committee meetings and coordinating with key stakeholders to continue advancing Alnylam's ERM program., • Designing and implementing enhancements to Alnylam's ERM program, including drafting of governance materials and development of related processes and systems. Qualifications • Graduate degree, or equivalent combination of education and work-related experience is required., • A law degree is strongly preferred., • 10+ years' related experience, including law firm and/or in-house experience leading and managing global ethics and compliance investigations in the pharmaceutical or life sciences industry, and experience managing enterprise risk management programs., • Experience independently managing sensitive and complex investigations globally, including matters involving fraud, corruption, interactions with HCPs, etc., • Demonstrated ability to collaborate cross-functionally with U.S. and ex-U.S. personnel., • Comprehensive knowledge of laws and regulations applicable to global pharmaceutical companies, including, U.S. healthcare fraud and abuse laws, anti-corruption laws, such as the U.S. Foreign Corrupt Practices Act and the U.K. Bribery Act (2010), U.S. fraud and abuse and false claims laws, and relevant industry codes on interactions with healthcare professionals., • Experience working with case management and enterprise risk management software systems., • Strong written and verbal communication skills, with fluency in written and spoken English required., • Possess an innovative mindset and have the ability to take a practical, solutions-oriented approach., • Ability to work collaboratively in a team environment, with a strong focus on partnerships., • Ability to manage multiple tasks simultaneously, to work independently and manage discrete areas of responsibility, and to flourish in a fast-paced environment., • Ability to thrive in a proactive ethical culture in which compliance and business objectives are mutually reinforced., • Excellent organizational and time management skills., • Strong motivation and ability to champion a comprehensive compliance program that is integrated with Alnylam's business and culture., • Strong commitment to ethics and integrity and ability to exercise sound judgment in all aspects of their work., • Travel will be required on occasion to Alnylam offices in the U.S. and overseas. U.S. Pay Range $195,500.00 - $264,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: At Alnylam Pharmaceuticals, we are leading the RNAi Revolution, developing innovative therapies that transform the lives of patients with rare and prevalent diseases. As a Federal Account Director, you will play a key role in executing our U.S. federal market access strategy, with a primary focus on assigned Department of Veterans Affairs (VA) VISN and VA Hospital accounts, as well as supporting Department of Defense (DoD) ecosystems where applicable. This position requires expertise in the federal healthcare landscape, including VA/DoD reimbursement dynamics, formulary processes, Criteria for Use (CFU), utilization management, and stakeholder engagement, particularly for therapies requiring administration by healthcare professionals under the medical benefit. You will focus on optimizing access and appropriate utilization of Alnylam's HCP-administered products by ensuring compliant application of the VA National Formulary and CFU at your assigned accounts. In collaboration with cross-functional partners, you will educate site administrators, department chairs, and clinical influencers on the value proposition of Alnylam products for Veterans and service members. You will also support cross-functional pull-through efforts, contribute to federal access strategies, and provide insights to inform broader team initiatives. This role demands agility to navigate evolving policies, market conditions, and federal requirements while identifying opportunities to enhance product utilization. You will collaborate with internal teams, including sales, medical affairs, health economics, and strategic accounts, to align with Alnylam's commercial objectives and mission to deliver groundbreaking RNAi therapeutics to patients in federal systems. This is a field-based remote position requiring up to 50-70% travel and reports to the Senior Director, Federal Accounts. Key Responsibilities: • Execute federal access strategies within assigned VISN and VA Hospital accounts to optimize patient access and appropriate utilization of Alnylam's portfolio., • Ensure compliant application of the VA National Formulary and Criteria for Use (CFU) for Alnylam products at the site level., • Partner with the cross-functional team to ensure that critical education is delivered to key stakeholders including site administrators, department chairs, and healthcare professionals. This education includes: disease-state education, clinical information, as well as administration requirements of Alnylam's therapies., • Analyze account-specific data, trends, and utilization metrics to identify opportunities for enhanced pull-through and appropriate use., • Collaborate with field sales, Regional Business Directors, and cross-functional partners to implement pull-through tactics and support sales performance in federal accounts., • Contribute to the development and execution of account plans, sharing insights and best practices with the federal team., • Support federal market development initiatives, including engagement with organizations such as the Association of Military Surgeons of the United States (AMSUS)., • Provide federal payer and account insights to market access, HEOR, patient services, and leadership teams to inform strategies and address gaps. Accountabilities: • Build and maintain multi-level relationships within assigned federal accounts (VISNs, VA Hospitals, and related DoD entities), positioning Alnylam as a trusted partner for HCP-administered innovations benefiting Veterans and service members., • Navigate federal provider structures to engage key decision-makers, influencers, and clinical stakeholders, fostering long-term partnerships that support Alnylam's current products and pipeline., • Prioritize account activities to ensure consistent, compliant implementation of national formulary and CFU, addressing site-specific needs for medical benefit therapies., • Collaborate with internal experts (e.g., Medical Affairs, national contracting, and policy teams) to support access positioning and medical policy alignment., • Deliver tailored education on the value proposition of Alnylam products, emphasizing benefits for patient populations served in federal settings., • Review sales, utilization, and trend data to uncover pull-through opportunities, developing tactics aligned with team KPIs., • Work with field sales teams to execute pull-through plans, providing training on federal payer dynamics, formulary processes, CFU requirements, and reimbursement for HCP-administered therapies., • Maintain compliance with all legal, regulatory, and company policies in stakeholder interactions and program execution., • Contribute to team knowledge sharing by documenting best practices, participating in training, and supporting pilot programs or initiatives. Qualifications: • Bachelor's degree required (business or science preferred); advanced degree (e.g., MBA, PharmD) a plus., • Minimum 7+ years of pharmaceutical/biotech experience, with at least 3 years in account management, payer access, or related roles; direct experience in VA/DoD or federal channels preferred., • Proven track record in managing complex accounts, influencing stakeholders, and driving results in healthcare environments., • In-depth knowledge of federal healthcare systems, including VA National Formulary, Criteria for Use (CFU), VISN dynamics, aprocurement process for HCP-administered therapies, medical benefit coverage, utilization management, site-of-care strategies, and reimbursement pathways., • Strong analytical skills to interpret data, identify opportunities, and develop actionable account plans., • Consultative approach to stakeholder engagement, with expertise in value communication and educational program delivery., • Understanding of payer economics, utilization management, and evolving U.S. policies impacting federal systems., • Comprehensive knowledge of pharmaceutical operations, including prescribing, regulations, supply chain, managed care, sales, and compliance., • Excellent communication, presentation, and relationship-building skills; ability to collaborate effectively in cross-functional teams. #LI-ST1 #LI-Remote U.S. Pay Range $211,500.00 - $286,100.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< CTMS Administrator Overview The CTMS Administrator is responsible for performing the day-to-day operations and support of the Alnylam Clinical Trial Management System (CTMS) for the execution of clinical trials across the development portfolio. The individual will leverage organizational, technical and interpersonal skills to meet high compliance standards and expectations for CTMS related activities. Key Responsibilities • Perform system administrative and study-related set-up activities in a timely manner, • Manage CTMS user access including user set-up and periodic review, ensuring compliance with regulatory and Alnylam system security requirements, • Provide end-user support, addressing queries and issues related to the CTMS, • Collaborate with the CTMS System Lead and stakeholders to identify potential enhancements and process improvements for CTMS, • Support any necessary governance procedural updates required to support CTMS activities, • Troubleshoot and resolve CTMS data discrepancies, maintaining data integrity, • Support CTMS related change control activities, • Support the creation and delivery of CTMS related training, • Support audits and inspections as required, • Other assignments including ad hoc and assignments in support of Clinical Operations and clinical trial execution. Skills • Detail-oriented with an ability to multi-task, be flexible, and thrive in a fast-paced team environment with changing priorities and challenging deadlines, • Strong interpersonal, verbal, and written communication skills, • Ability to work independently, anticipating project needs and highlighting potential issues, • Willingness to work effectively in a matrix environment and value the importance of teamwork, • Excellent attention to detail and time management skills, • Proficient in common office technology e.g., Microsoft tools, teleconferencing, etc. Requirements • University degree (e.g. BA, BS or equivalent) preferably in life science, science, health related, or industry related discipline is preferred or demonstrable related experience in the pharmaceutical / biotechnology industry, • Experience working for a pharmaceutical company and/or CRO in a related role, • Two or more years' experience as CTMS administrator, superuser or similar CTMS experience in support of Phase I - III execution of clinical trials, • Strong knowledge of Good Clinical Practices (GCP), regulations/guidelines and compliance requirements in relation to clinical systems U.S. Pay Range $100,000.00 - $135,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Director, Commercial Planning & Strategic Initiatives will support company vision/goals and execution in the TTR franchise. The TTR franchise includes ONPATTRO (for hATTR-PN), AMVUTTRA (for hATTR-PN & ATTR-CM), Nucresiran (a development stage program, being studied in both hATTR-PN & ATTR-CM), and other relevant franchise lifecycle programs. The Director, Commercial Planning & Strategic Initiatives is a high performing, driven, curious/learning agile, highly collaborative and humble individual, with strong planning and executive communication skills. This role will report to the SVP, TTR Franchise Global Commercialization Lead, will work closely other members of the Global TTR disease area team. This position is onsite / hybrid onsite and will be primarily located in Cambridge, MA. Key Responsibilities Commercial Planning • Work closely with various Commercial business units and and medical affairs to ensure alignment of strategies with overall TTR objectives, and to advance TTR-related strategic initiatives, • Support annual strategic planning and long range forecasting, • Integrate insights from different functional areas to author/consolidate a cohesive global strategic plan, • Address conflicts to facilitate informed decision-making through maintaining objectivity, influencing others, and leveraging data & insights, • Develop MBR/QBR content and dissemination of follow up actions Strategic Initiatives • Proactively assess data, intelligence reports and financial information to identify business trends and opportunities to identify "pivotal" GTM shifts that may be required to realize LRP strategies (i.e., those that may require new enterprise capabilities or significant shifts in resourcing), • Drives strategic initiatives by in identifying areas of opportunity to ensure delivery against financial and business goals, • Oversee ad hoc business initiatives from development through successful execution, • Drive the governance and management of key initiatives including execution and tracking of impact, • Provide support to the Global AMVUTTRA brand team and/or Global Nucresiran brand team on priority commercial initiatives where additional support required Qualifications • BA/BS degree required; business degree strongly preferred with strategy/consulting experience., • 7+ years of varied biopharmaceutical or related experience, including global/international matrix team responsibilities, with a focus on marketing, strategic planning, or product management, • Exceptional written and verbal communication skills. Ability to articulate program vision and motivate the team; communicates in an open, direct and timely manner; ensures broader organization is aligned with and aware of the program strategy, status and risks., • Collaborative and can flex when needed and pursues data-driven decisions, • Deep understanding of cardiomyopathy, transthyretin amyloidosis, specialty diseases, or similar therapeutic areas, • Demonstrated ability in strategic planning, market analysis, and translating complex data into actionable insights and strategies, • Proven experience in leading cross-functional teams and managing projects, demonstrating strong leadership and team-building skills, • Prior involvement in launching pharmaceutical products and managing their lifecycle, • Knowledge of the regulatory environment in the pharmaceutical industry, especially as it relates to marketing and commercial activities, • Skills in budgeting and financial management to oversee commercial planning activities and ensure they align with the company's financial goals, • Ability to adapt to changing market conditions, address complex challenges, and devise innovative solutions in a dynamic industry #LI-Hybrid #LI-ST1 U.S. Pay Range $208,300.00 - $281,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The Director, Process Sciences will be responsible for downstream process development, optimization, and process characterization of antibody oligonucleotide conjugates for platform delivery of oligonucleotide APIs. The candidate will work closely with cross-functional teams and contract manufacturing organizations (CDMOs) on process development, process transfer, and oversight of manufacturing processes. This position is onsite and will be located at our Kendall Square offices in Cambridge, MA. Responsibilities: • Oversee downstream process development and contract manufacturing of antibody and antibody-oligonucleotide conjugates., • Contribute to the development of long-term strategy for platform delivery programs and provide recommendations to the leadership team., • Author and review technical documentation supporting API manufacture and process characterization activities., • Accountable for the preparation of the Quality section for regulatory filings and interaction with regulatory authorities., • Contribute to strategic technical discussions and present progress at internal and external meetings., • Represent Process Development on cross-functional teams including internal cross-functional program teams and externally with contract manufacturing and/or corporate partners., • Effectively integrate Process Development activities with other CMC functions in Drug Substance Development & Manufacturing, Analytical Development, Quality Assurance, and Regulatory Affairs., • Periodic travel to manufacturing and other partner sites is required. Qualifications: • Ph.D. in chemistry, chemical engineering, or biochemical engineering with at least 10 years of process research and development experience in the manufacture of antibody and antibody-drug conjugates., • Extensive experience in downstream process development including purification and characterization of ADCs including mAbs., • Experience in process transfer and management of contract manufacturing at CDMOs., • Hands-on experience with analytical methods for process and product characterization as well as conjugation is a strong plus., • Excellent organizational and communication skills., • Demonstrated strong operational execution and problem-solving skills., • Desire to work in a fast-paced, deadline-driven environment. U.S. Pay Range $197,100.00 - $266,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Scientific Director, Global Medical Affairs - ATTR serves as a global scientific subject matter expert supporting the ATTR franchise, with a primary focus on scientific content generation and written scientific outputs. This role reports to the VP, Medical Affairs, TTR and works in close partnership with Global Medical Leads across ATTR assets (e.g., Vutrisiran, Nucresiran). The role will contribute deep scientific expertise to publications strategy, investigatorinitiated studies (IIS), research collaborations, posthoc analyses, Phase 4 activities, and business development due diligence, with a strong emphasis on handson writing, protocol development, and scientific review. The role supports increasing demand for highquality scientific content and evidence generation across the ATTR franchise and will function as a core internal SME supporting crossfunctional teams. Key Responsibilities Scientific Content Development & Publications • Serve as a scientific SME contributing to global publication strategy, planning, and execution., • Draft, review, and critically edit scientific manuscripts, abstracts, posters, slide decks, and congress materials., • Provide scientific leadership on data interpretation and scientific storytelling, ensuring accuracy, clarity, and alignment with the overall evidence strategy. Evidence Generation • Support development, review, and execution of the integrated evidence generation plan across the ATTR franchise., • Support IIS, Research Collaboration, Phase 4, post-marketing, post-hoc analyses, real-world evidence activities, including scientific review, study and analyses design, feasibility assessment, data interpretation, and ongoing oversight., • Lead protocol development and review across evidence generation activities, with a focus on scientific rigor and relevance. CrossFunctional Scientific Partnership • Collaborate closely with Global Medical Leads, Publications and Scientific Communications, Clinical Research, Regulatory, HEOR, and Commercial partners to ensure alignment and scientific integrity., • Support crossfunctional deep dives led by Value Evidence Strategy teams, synthesizing scientific and clinical data into clear, written outputs., • Provide scientific input into business development and licensing (BD&L) due diligence, including literature reviews, data gap assessments, and scientific risk evaluation., • Contribute to internal briefing documents, scientific summaries, and strategic analyses to inform senior leadership decisionmaking., • Serve as a trusted internal scientific reviewer for medical materials, protocols, and externalfacing scientific content., • Ensure all activities adhere to medical governance, compliance, and ethical standards. Qualifications • PharmD, PhD or MD, • 3-5+ years of relevant experience within the pharmaceutical or biotechnology industry., • Experience in cardiovascular, renal, metabolic, or ATTR disease areas strongly preferred., • Demonstrated primary authorship and substantial contribution to peerreviewed publications., • Strong experience in medical, scientific, and grant writing (e.g., research proposals, manuscripts) and reviewing or developing clinical or postmarketing study protocols., • Prior exposure to BD due diligence or structured scientific evaluations strongly preferred., • Deep interest in and aptitude for written scientific work; this role emphasizes writing over presenting., • Ability to critically analyze data and translate complex science into clear written narratives. U.S. Pay Range $238,800.00 - $323,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are seeking a strategic, forward-thinking leader to join our team in a newly created Product Planning role. This individual will play a critical role in shaping the long-term commercial vision of our pipeline assets-integrating deep market insight, competitive intelligence, clinical understanding, and patient-centric thinking to inform development strategy and maximize global impact. The ideal candidate thrives at the intersection of science and strategy, brings a strong track record of cross-functional leadership, and is energized by the opportunity to help build innovative medicines from early development through launch readiness. Key Responsibilities • Formulate early commercial strategy and approach for select pipeline programs; Develop target product profiles, serve as commercial voice for the asset in key governance forums, • Provide commercial input and strategic guidance to program teams to inform key business decisions on early-stage clinical programs., • Collaborate cross-functionally to conduct rigorous market assessments on key disease areas to inform preclinical strategic planning., • Understand and communicate requirements for reimbursement and differentiation to ensure successful global commercialization of pipeline assets., • Identify gaps in internal understanding of target diseases and create detailed plans to address gaps through KOL engagement and primary market research., • Bachelor's Degree in Life Sciences or equivalent required, MBA preferred, • Minimum 8 years of experience inclusive of market analytics, new product planning and global brand marketing, • Experience in at least one of ALNY's disease areas of focus (CNS, Hematology, Cardiovascular) preferred, Obesity experience required., • Experience working cross-functionally, including collaboration with and influencing of program development team., • Solid understanding of pharmaceutical development path and ability to identify operational choices that could impact commercialization., • Ability to synthesize findings and clearly articulate implications from multiple sources of information, including primary and secondary market research and data, and formulate strong, supportable recommendations., • Strong analytical skills, including the ability to forecast., • Aptitude for understanding scientific concepts related to research and development., • Strong oral and written communication and presentation skills #LI-ST1 U.S. Pay Range $208,300.00 - $281,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview At Alnylam, the Executive Director, Biostatistics is a senior scientific leader responsible for developing and driving statistical strategy across clinical development programs. This role provides strategic leadership in statistical methodology, trial design, regulatory strategy, and quantitative insights that support decisionmaking from early development through registration. The Executive Director leads a team of statisticians and works closely with crossfunctional leaders to ensure rigorous and innovative quantitative approaches to drug development. This position reports to the Head of Biostatistics within the Quantitative Science organization. This position is hybrid onsite and remote working and will be primarily located at Cambridge or Philadelphia. Key Responsibilities • Provide strategic statistical leadership across a portfolio of clinical development programs, ensuring rigorous and innovative quantitative approaches throughout all phases of drug development., • Lead the development and implementation of statistical strategies across programs, including clinical trial designs, endpoint strategies, and regulatory strategies, partnering with Clinical Development and cross-functional leaders to shape development plans., • Lead statistical strategy for global regulatory submissions, including NDA filings and major regulatory interactions, and represent Biostatistics in engagements with global regulatory authorities (e.g., FDA, EMA, PMDA) and external scientific stakeholders., • Review and ensure the quality and scientific rigor of key statistical deliverables and study documents across development programs., • Evaluate, apply, and advance innovative statistical approaches and emerging quantitative methodologies, including advanced analytics and data science tools, to enhance development and decision-making., • Lead and develop a team of statisticians, providing mentorship, scientific guidance, and review of statistical work to ensure high-quality support across development programs., • Contribute to departmental strategy and advance statistical standards, best practices, and innovation within the Biostatistics and Quantitative Science organization. Qualifications • PhD in Statistics, Biostatistics, or a related quantitative discipline with 15+ years of relevant experience in pharmaceutical or biotechnology drug development; or MS with 18+ years of relevant experience., • Demonstrated leadership of statistical strategy across multiple clinical development programs and phases of development., • Expertise in clinical trial design and statistical methodologies supporting drug development, including the application of innovative approaches such as adaptive designs, Bayesian methods, or simulation-guided decision-making., • Experience leading major global regulatory submissions (e.g., NDA/BLA) and interactions with health authorities such as FDA, EMA, and PMDA., • Experience with people management, particularly in developing high-performing teams and managing resources across programs. #LI-AB1 #LI-Hybrid U.S. Pay Range $301,800.00 - $408,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Talent Acquisition Partner: Jeannine Ripley Hiring Manager: Elena Stamenova Overview Our RNAi Lead Development team is seeking a motivated Associate Scientist II to join our interdisciplinary team, whose mission is pre-clinical evaluation of siRNA-based therapeutics and advancement of our clinical stage pipeline The successful candidate will support RNA sequencing core function and expand next generation sequencing based assay pipeline. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities • Support various transcriptomics studies via bulk, small RNA , long read , single cell , spatial and other platforms., • Execute day to day operations for RNASeq sample preparation, including: RNA isolation, library preparation, QC and sequencing., • Responsible for the operation and maintenance of NGS equipment and supplies., • Maintain samples and oversee logistics of data generation and collection., • Prepare protocol and data reports., • Troubleshoot technical problems and participate in the continuing development and optimization of existing and new protocols and technologies., • Train and assist additional personnel as needed., • Adapt to the changing platform needs, in workflow, projects and other tasks as required by the platform. Qualifications • BS in a biological science., • At least 1+ years of hands-on laboratory experience in NGS and/or molecular biology are required., • Experience with laboratory automation including liquid handling systems such as Beckman Coulter or other systems desired. U.S. Pay Range $67,600.00 - $101,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.