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Company overview Founded in 1999, Asymchem has grown into a leading global integrated Contract Development and Manufacturing Organization (CDMO), renowned for its innovative solutions and commitment to excellence. Our mission is to drive smarter, greener, and more cost-effective manufacturing to support pharmaceutical and biotech research and commercialization. Our research laboratories and small molecule API pilot plant at Discovery Park, Sandwich, UK, is our flagship site for European R&D and we are looking to recruit into key roles. This is a fantastic opportunity to join an innovative, collaborative, dynamic team of scientists and help shape our operations and the future growth of our organisation. What we offer We offer competitive compensation, flexible benefits package including health insurance, retirement plans, opportunities to buy or sell holidays, as well as a good work-life balance. Enjoy a fun and rewarding career with daily opportunities to collaborate with highly talented scientists. Additionally, there will be myriad opportunities to learn new technical and interpersonal skills, develop existing strengths, coach and mentor others, while pursuing our company's mission. Position summary Analytical Research and Development at Asymchem Ltd UK, is seeking an experienced and passionate Structure Elucidation Senior Scientist to join our dynamic, interdisciplinary research team in Sandwich, Kent. Working within our state-of-the-art laboratories, you will play a key role in identifying and characterizing small molecules and complex structures for our development projects. At Asymchem you will have the opportunity to • Work both independently and in cross-functional project teams to solve complex analytical and synthetic chemistry problems., • Work collaboratively with peers to elucidate structures of novel compounds, degradants, impurities and synthetic intermediates using advanced spectroscopic, e.g. NMR (1D, 2D, quantitative), MS (HRMS, MS/MS), and chromatographic techniques., • Independently design, conduct and interpret advanced NMR experiments (e.g., COSY, HSQC, HMBC, NOESY)., • Demonstrate your comprehensive knowledge and experience of operating, maintaining, and troubleshooting NMR instrumentation and software., • Demonstrate your experience of operating, maintaining and troubleshooting high-end mass spectrometers and software from different vendors such as Thermo and Agilent., • Interpret complex spectral data and integrate findings from multiple analytical methods. Provide expert analysis for impurity profiling and degradation product characterization., • Be highly proficient with structure elucidation software (e.g., MestReNova, ACD/Labs, Bruker TopSpin, MassHunter, FreeStyle)., • Lead authoring of detailed technical reports and a reviewer of reports and data of your peers., • Interact effectively with team members and partner groups, including verbal presentations, reasoned review of data and preparation of technical reports., • Effectively communicate progress, plans, requirements and risks to scientists, managers, stakeholders and clients informally and through written reports, emails and presentations. Qualifications, skills and experience • Bachelor’s or Master’s degree in Chemistry, Analytical Chemistry, Pharmaceutical Sciences (or a related discipline) with significant relevant industrial experience in area of structure elucidation OR a PhD in Chemistry, Analytical Chemistry, Pharmaceutical Sciences (or a related discipline) with some relevant industrial experience in the field of structure elucidation is essential., • Excellent troubleshooting skills and ability to develop and implement complex analytical solutions to solve complex chemistry problems is essential., • A strong desire to develop technical skills and a high learning agility with an ability to apply learning from prior experience to new situations and problems is essential., • The ability to communicate effectively both in verbal and written forms and to take a collaborative approach to working in a team environment is essential., • Comfortable working as part of diverse multi-disciplinary, cross-functional teams is essential., • A good knowledge of small molecule pharmaceutical development and analytical science, with the ability to apply scientific technical skills and knowledge to projects independently and proactively is highly desirable., • Knowledge in the use of diverse computational, modelling and digital tools is desirable.

Company overview Founded in 1999, Asymchem has grown into a leading global integrated Contract Development and Manufacturing Organization (CDMO), renowned for its innovative solutions and commitment to excellence. Our mission is to drive smarter, greener, and more cost-effective manufacturing to support pharmaceutical and biotech research and commercialization. We recently announced the acquisition of research laboratories and a small molecule API pilot plant at Discovery Park, Sandwich, UK, establishing our first manufacturing facility in Europe and expanding our capabilities to meet the needs of global clients. The Sandwich facility will act as the flagship site for European R&D and we are looking to recruit into key roles. This is a fantastic opportunity to join an innovative, collaborative, dynamic team of scientists and help shape our operations and the future of our organisation. What we offer We offer competitive compensation, a flexible benefits package including health insurance, retirement plans, opportunities to buy or sell holidays, as well as a good work-life balance. Enjoy a fun and rewarding career with daily opportunities to collaborate with highly talented scientists. Additionally, there will be myriad opportunities to learn new technical and interpersonal skills, develop existing strengths, coach and mentor others, while pursuing our company's mission. Position summary Working within our state-of-the-art laboratories at Sandwich, your role will be to design and develop new routes to RSMs (Regulatory Starting Materials) and APIs (Active Pharmaceuticals Ingredients) through considered experimental execution in the laboratory. Within a collaborative team environment, you will create safe, robust, scalable and efficient chemical processes to manufacture pharmaceutical API’s.You will also have the opportunity to transfer these chemical processes to scale-up facilities and ultimately manufacturing. Roles & responsibilities may include Asymchem will invest in your development so that you can: • Design and demonstrate new synthetic routes to small molecule API candidates., • Develop robust processes which ensure safe, reproducible and scalable manufacturing in large scale GMP equipment., • Employ a range of laboratory equipment from mg to multigram scale, in conjunction with a suite of analytical tools, to maximise the generation of knowledge from each experiment., • Contribute directly to technology transfer activities into the Sandwich pilot plant facility and other sites within the Asymchem network., • Collaborate with scientists within and outside functional area to achieve team goals., • Utilise a systematic, methodical approach to solve complex chemistry problems and identify the root cause of any processing issues., • Perform laboratory operations with a critical focus on safety ensuring process safety guidelines are followed when conducting scale-up experiments., • Apply a continuous improvement mindset to identify opportunities for improved work processes to deliver increased productivity, safety and quality., • Utilise the experience of the group to support continued professional development in a range of technical areas to develop a high level of expertise supplemented with transferrable soft skills. Qualification, skills and experience • A degree in chemistry with a very good knowledge of organic chemistry is essential., • Industrial experience in pharmaceutical or a related industry is desirable but not essential., • The ability to communicate effectively both in verbal and written forms is essential., • A collaborative approach to working in a team environment is essential., • Proactive planning and organizational skills and the ability of multi-tasking and prioritizing in a highly dynamic environment. Company values At Asymchem, we are deeply committed to fostering an inclusive and diverse workplace where every individual feels valued and cared for. We believe that diversity drives innovation and success, and we provide career development opportunities to support the professional growth of all employees. Join us in creating a workplace where diversity is celebrated, and inclusivity is at the heart of everything we do.

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