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Title:Principal ScientistCompany:Ipsen Biopharm LtdAbout Ipsen:Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Hit Apply below to send your application for consideration Ensure that your CV is up to date, and that you have read the job specs first. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation. Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company’s success. Join us on our journey towards sustainable growth, creating real impact on patients and society!For more information, visit us at and follow our latest news on LinkedInand Instagram.Job Description:Principal Scientist • Cell Line Development & Upstream Process DevelopmentLocation: Wrexham, UK (Hybrid Working)Contract: PermanentTravel: Occasional travel (European)Shape the Future of Biologics at IpsenAt Ipsen, we're passionate about advancing innovative medicines that make a meaningful difference to patients' lives. We are seeking an experienced Principal Scientist to join our Bioprocess Sciences team and provide scientific and technical leadership across Cell Line Development (CLD) and Upstream Process Development (USP) activities.This is an exciting opportunity for a senior biologics development professional to lead critical Chemistry, Manufacturing and Controls (CMC) development programmes, working with cutting-edge technologies and collaborating with global teams across our international network.The OpportunityAs Principal Scientist, you will act as a recognised subject matter expert, leading the development and optimisation of cell line and upstream manufacturing processes for biologic products from candidate selection through to commercial manufacturing.A key focus of the role will be driving upstream process development activities using mammalian and/or microbial cell lines, supporting multiple development programmes while providing technical leadership and mentorship to junior scientists. You will play an integral role within cross-functional CMC teams, partnering with internal stakeholders and external Contract Development and Manufacturing Organisations (CDMOs) to ensure successful programme delivery.This position offers exposure to a diverse biologics pipeline and the opportunity to influence development strategy across multiple projects while collaborating with colleagues throughout Ipsen's global organisation.Key ResponsibilitiesLead Cell Line Development and Upstream Process Development strategies across biologics development programmes.Provide scientific leadership for CMC development projects from early development through commercialisation.Act as a subject matter expert for CLD and USP activities, supporting technical decision-making across programmes.Drive innovation and continuous improvement to enhance process productivity, robustness and product quality.Represent Upstream Process Development within multidisciplinary CMC teams.Collaborate with internal stakeholders and external CMOs to support development, scale-up and technology transfer activities.Contribute to regulatory submissions and technical documentation.Conduct technical assessments for new product opportunities and in-licensing activities.Mentor, coach and develop junior scientists, fostering a culture of scientific excellence.About YouWe're looking for a scientifically driven leader with strong biologics development experience and the ability to influence across complex, matrixed environments.Essential Experience & SkillsSignificant pharmaceutical or biotechnology industry experience within biologics development.Deep expertise in Cell Line Development and/or Upstream Process Development.Strong experience working with CHO cell lines and mammalian cell culture processes.Experience leading CMC development activities across the product lifecycle.Proven ability to work effectively with cross-functional stakeholders and external partners.Experience engaging with and managing activities CDMOsStrong communication, influencing and stakeholder management skills.DesirablePhD in a relevant scientific discipline (or equivalent industry experience).Experience supporting regulatory submissions and technology transfer activities.Experience progressing biologic products from early to late-stage development and commercialisation.Demonstrated mentoring, coaching or leadership experience within scientific teams.Why Join Ipsen?At Ipsen, you'll be part of a collaborative and innovative organisation where science drives meaningful patient outcomes. We offer:Flexible hybrid working.Opportunities to collaborate with international teams across the UK, Ireland and France.Exposure to a diverse and exciting biologics pipeline.A culture that values scientific excellence, innovation and continuous learning.The opportunity to mentor others while continuing to develop your own career within a global biopharmaceutical company.If you're an experienced biologics scientist looking to make a significant impact across Cell Line Development, Upstream Process Development and CMC programmes, we'd love to hear from you.Apply today and help shape the future of biologics at Ipsen.We are committed to creating a workplace where everyone feels heard, valued, and supported; where we embrace “The Real Us”. The value we place on different perspectives and experiences drives our commitment to inclusion and equal opportunities. When we include diverse ways of thinking, we make more thoughtful decisions and discover more innovative solutions. Together we strive to better understand the communities we serve. This means we also want to help you perform at your best when applying for a role with us. If you require any adjustments or support during the application process, please let the recruitment team know. xrnqpay This information will be handled with care and will not affect the outcome of your application.SummaryLocation: WrexhamType: Full time

Join our Wrexham manufacturing site as an EHS Manager, leading the programmes and systems that support strong environmental, health and safety performance across the plant. Reporting to the Plant Director and leading two direct reports, you will provide expert guidance to plant teams while ensuring compliance with applicable legislation, company policies and global EHS standards. This is an opportunity to shape site-wide EHS practices, contribute to global projects and work closely with European EHS colleagues to share learning and best practice. You will also play an important role in strengthening the sites safety culture by coaching teams, managing risk and continually improving EHS management systems. This is a full-time, site-based role located in Wrexham. • Leading EHS Compliance Own EHS activities across the Wrexham site, ensuring compliance with relevant legislation, regulations, accreditation requirements and global standards., • Developing EHS Systems Initiate, implement and manage improvements to EHS management systems, coordinating internal audits that support site safety performance., • Managing Risk Lead site-wide hazard risk assessments and ensure appropriate actions are implemented to mitigate identified risks., • Coaching Plant Teams Coach, support and mentor plant teams on EHS activities, helping them implement recommendations in line with plant operations and cost improvements., • Building Strong Partnerships Act as a key contact for Global and European EHS functions and maintain effective relationships with local regulatory bodies and government standards agencies., • A degree or equivalent experience, together with an EHS professional qualification or relevant EHS experience., • A NEBOSH Diploma in Occupational Health and Safety., • The ability to develop effective working relationships across all levels of a manufacturing plant., • Flexibility to work outside core working hours when required to support a continuous-shift operation. Our comprehensive benefits offer you the support you need through your life events, big or small. Weve always been driven to unleash the full potential of our differentiated brands and our passionate people. Our iconic, world‑class brands at Kellanova include Pringles, Cheez‑It, Pop‑Tarts, MorningStar Farms, Special K, Krave, Zucaritas, Tresor, Crunchy Nut, among others. Mars, Incorporated has acquired Kellanova in a transaction that brings together iconic brands, storied legacies and outstanding capabilities with a view to shape the future of snacking. You can learn more here, and our hiring teams will be happy to discuss further questions if your application advances in the hiring process. Lets shape the future of snacking. Kellanova is an Equal Opportunity Employer that strives to provide an inclusive work environment, a seat for everyone at the table, and embraces the diverse talent of its people. All qualified applicants will receive consideration for employment without regard to race, color, ethnicity, disability, religion, national origin, gender, gender identity, gender expression, marital status, sexual orientation, age, protected veteran status #J-18808-Ljbffr

Join our Wrexham manufacturing site as an EHS Manager, leading the programmes and systems that support strong environmental, health and safety performance across the plant. Reporting to the Plant Director and leading two direct reports, you will provide expert guidance to plant teams while ensuring compliance with applicable legislation, company policies and global EHS standards. This is an opportunity to shape site-wide EHS practices, contribute to global projects and work closely with European EHS colleagues to share learning and best practice. You will also play an important role in strengthening the site’s safety culture by coaching teams, managing risk and continually improving EHS management systems. This is a full-time, site-based role located in Wrexham. • Leading EHS Compliance – Own EHS activities across the Wrexham site, ensuring compliance with relevant legislation, regulations, accreditation requirements and global standards., • Developing EHS Systems – Initiate, implement and manage improvements to EHS management systems, coordinating internal audits that support site safety performance., • Managing Risk – Lead site-wide hazard risk assessments and ensure appropriate actions are implemented to mitigate identified risks., • Coaching Plant Teams – Coach, support and mentor plant teams on EHS activities, helping them implement recommendations in line with plant operations and cost improvements., • Building Strong Partnerships – Act as a key contact for Global and European EHS functions and maintain effective relationships with local regulatory bodies and government standards agencies., • A degree or equivalent experience, together with an EHS professional qualification or relevant EHS experience., • A NEBOSH Diploma in Occupational Health and Safety., • The ability to develop effective working relationships across all levels of a manufacturing plant., • Flexibility to work outside core working hours when required to support a continuous-shift operation. We’ve always been driven to unleash the full potential of our differentiated brands and our passionate people. Our iconic, world-class brands at Kellanova include Pringles, Cheez-It, Pop-Tarts, MorningStar Farms, Special K, Krave, Zucaritas, Tresor, Crunchy Nut, among others. Mars, Incorporated has acquired Kellanova in a transaction that brings together iconic brands, storied legacies and outstanding capabilities with a view to shape the future of snacking. You can learn more here, and our hiring teams will be happy to discuss further questions if your application advances in the hiring process. Kellanova is an Equal Opportunity Employer that strives to provide an inclusive work environment, a seat for everyone at the table, and embraces the diverse talent of its people. All qualified applicants will receive consideration for employment without regard to race, color, ethnicity, disability, religion, national origin, gender, gender identity, gender expression, marital status, sexual orientation, age, protected veteran status #J-18808-Ljbffr

To work closely with the Academy Manager and Academy Head of Coaching to develop the Coaching Strategy/Programme appropriate to the Youth Development Phase players. Leading on and ensuring a developmental approach to individual player development is adopted and evident in line with the academy performance plan, whilst supporting and leading a team of age specific coaches within the phase. The development of players, coaches, and environment conducive to the development of elite footballers is an integral aspect of the Youth Development Phase Lead role. • Lead on the delivery of the Coaching Curriculum for players in the Youth Development Phase., • Oversee a team of age specific coaches and ensure the YDP programme is delivered to the relevant high standards expected., • Development of strong working relationships with Academy Manager, Head of Coaching, Head of recruitment and Head of Academy Administration., • Contribute to the multi-disciplinary reviews of all Academy Players in the YDP Phase - actively participating in the decision-making process that sees Academy players progress from the YDP into the Professional Development Phase (PDP)., • Provide individual, small group and full team coaching sessions to develop the skill level of Academy players., • In conjunction with the Designated Safeguarding Officer, ensure all policies, practices and procedures relating to the safeguarding of young people are implemented., • Ensure each Academy Player in the YDP has access to an individual coaching plan tailored to their specific needs., • Ensure each YDP Academy Player and Parent is made aware of their individual coaching plan (and any changes thereto) as soon as reasonably practicable in advance of their being coached., • Ensure all coaching is recorded on the Academy Player’s Performance Clock, • Ensure that all sessions are planned by Coaches setting out the learning objectives which the session is designed to achieve and the coaching which will be given to achieve them., • Work with relevant coaches and support staff to plan, deliver and evaluate coaching sessions and game plans, using a variety of coaching methods that meet the needs and demands of all players., • Confirm fitness programmes relative and beneficial to an elite group of athletic Academy players., • Follow the Club playing strategy when delivering coaching sessions in accordance with the club playing philosophy., • Provide a comprehensive programme of training and produce relevant Session Plans to meet the demands of the Academy., • Participate in Academy Management Team Meetings (and other meetings) when required, to update the meeting on the progress and development of players in the YDP., • Assist in the identification and recruitment of players in the YDP., • Assist in the analysis and review the YDP coaching programme on a regular basis to adapt the programme to meet specific player and squad needs., • Liaise with the Academy Head of Coaching, Head of Academy Administration regarding fixtures in the Games Programme, • Demonstrates enthusiasm and is committed to achieving agreed objectives within Academy activities., • Ability to lead staff members and change., • Effective at preparing, planning and implementing all aspects of academy administration that are aligned with whole-club objectives for coaching young talented football players., • A dynamic, hardworking individual that can relate to all staff members and participants engaged in academy and coaching activities., • Proactive decision maker with excellent verbal and written communication skills that is effective in communicating across all departments within a multi-disciplinary approach., • Takes responsibility for ensuring a high quality of work and maintaining standards in line with the responsiveness needed for delivering against the club's coaching objectives and philosophies., • Is receptive to feedback about own behaviour, strengths and areas for improvement that identifies improvement strategies relating to academy coaching activities., • Displays a high level of confidentiality and transparency and can contribute to team meetings in a professional manner., • Displays an understanding of the academy's coaching curriculum and can transfer and communicate information in an informative and constructive manner., • Committed to, and an understanding of, equality and diversity in sport, • Flexible approach to meet the nature and demands of the business, • UEFA 'A' Licence (or actively working towards this), • FA Youth Award (Assessed - YDP u12-u16 or actively working towards this), • FA EFAiF qualification in first aid., • A current FA/FAW Safeguarding Children Workshop Certificate (or willingness to complete within 1 month of appointment), • Rydyn Ni'n Gymuned Ddewr / We’re a Fearless Community., • Rydyn Ni'n Sefyll Gyda'n Gilydd / We Stand Together., • Rydyn Ni'n Deulu I'r Carn / We’re Teulu Through and Through., • Meddwl Positif, Ysbryd Positif / Positive Mind. Positive Spirit. If you are looking for an organisation committed to building a strong, inclusive, high performing workplace where every individual is valued, supported and empowered to grow with fantastic benefits which include: • Health Cash Plan, • EAP, • Enhanced holidays and long service days, • Enhanced pension, • Death in service, • Enhancedsick leave, • Health and wellbeing time off, • Volunteering day, • Salary sacrifice benefits and retail discounts #J-18808-Ljbffr

Be part of something altogether life-changing! Working at Cytiva in the Life Sciences industry means being at the forefront of providing new solutions to transform human health. Our incredible customers undertake life-saving activities ranging from fundamental biological research to developing innovative vaccines, new medicines, and cell and gene therapies. At Cytiva you will be able to continuously improve yourself and us – working on challenges that truly matter with people that care for each other, our customers, and their patients. With associates across 40 countries, Cytiva is a place where every day is a learning opportunity – so you can grow your career and expand your skills in the long term. Cytiva is one of 10 Life Sciences companies of Danaher. Together, we accelerate the discovery, development and delivery of solutions that safeguard and improve human health. • Lead the implementation, development and continuous improvement of Process Safety Management across a high-volume, high-hazard membrane manufacturing facility at Newquay., • Provide expert process safety input into projects, engineering changes, design reviews and operational improvements, ensuring safe, practical and compliant solutions., • Facilitate key process safety studies, including HAZID, HAZOP, LOPA, ALARP and DSEAR assessments, making sure actions are clearly owned and effectively closed., • Manage process safety compliance requirements, including DSEAR/ATEX, COMAH, PSSR and the maintenance of process safety critical equipment., • Own and support key process safety improvement and CAPEX projects, while coaching teams and helping build strong PSM capability across the site., • Support the implementation and ongoing improvement of Process Safety Management across other Cytiva sites, with Newquay remaining your primary manufacturing site where most of your time will be spent., • You are an experienced process safety professional with strong technical knowledge of high-hazard manufacturing environments, ideally within chemical, process, pharmaceutical, medical device or regulated manufacturing., • You bring practical experience in Process Safety Management, including HAZID, HAZOP, LOPA, ALARP, DSEAR/ATEX, COMAH and PSSR requirements., • You are confident working with engineering, operations, maintenance, EHS and project teams, with the ability to influence others and turn technical risk assessments into practical site improvements., • You are proactive, hands-on and comfortable taking ownership of key process safety activities, improvement plans and CAPEX projects from concept through to delivery., • You communicate clearly and confidently, with the ability to coach, mentor and build process safety capability across teams, stakeholders and other Cytiva sites., • You hold a degree-level qualification in science, engineering, chemical engineering, process engineering or a related discipline, with chartership, working towards chartership., • It would be a plus if you bring previous people management or facilities management experience, particularly where this has involved supporting site infrastructure, utilities, maintenance teams or operational services within a manufacturing environment. Join our winning team today. Together, we’ll accelerate the real-life impact of tomorrow’s science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life. For more information, visit www.danaher.com . #J-18808-Ljbffr

Kronospan is the world's leading manufacturer of wood-based panel products. Since 1897 we have invested in innovation to deliver on our promise of ‘Wood Perfected’, and today we employ around 15,000 people across more than 40 manufacturing sites worldwide. Our panels, decorative surfaces and engineered wood products are used every day in furniture, flooring, interiors and construction projects around the world. As the world leader in the production of wood-based panel products, we are seeking a conscientious and analytical leader to take ownership of our Resin and Formalin departments — driving efficiency, quality and safety, and building the site’s capability across the chemical function. • Hold overall responsibility for Formalin, Resin production and site quality, • Own EHS performance across the department, • Lead the department in achieving its production and quality targets, • Maximise process availability through structured maintenance programmes, agreed with the maintenance function, • Ensure efficient utilisation of the process through close coordination with the Planning department, • Manage and develop your teams through competency development and effective performance management, • Build team capability through structured training, coaching and motivation, • Manage staffing to ensure resources meet production requirements, • Control departmental costs, including energy consumption and maintenance budgets, • Act as the key point of contact for regulators and other stakeholders What we're looking for: • Degree in Chemistry, Chemical Engineering or similar, • Proven experience of chemical production and processes, • Operational experience working under COMAH regulations, with a sound understanding of process safety principles, • Proven ability to lead, direct and hold teams to account, with strong, confident leadership, • Strong analytical and problem-solving skills, with the ability to investigate and resolve issues quickly and efficiently, • Ability to perform consistently and make sound decisions under pressure What we offer: • Competitive remuneration package including work-based pension, • Full time contract, Monday-Friday 42.5 hrs/week, • Exciting and challenging work at the heart of a world-leading manufacturing site, • Continued training, professional development and opportunities for career progression, • The opportunity to work with and contribute to an international network of plant managers and technologists, sharing best practice and improvement initiatives Ref: LI-AM2 #J-18808-Ljbffr