UK - Principal Scientist PKPD Non Clin
5 days ago
Slough
Principal Scientist – Non-Clinical PKPD (Contract) UK (Slough-based, VDI only – remote access provided) | 12-month contract |Full-time (37.5 hrs/week) | £35.20–£47.92/hr (PAYE/LTD/Umbrella) We are supporting a global biopharma organisation seeking an experienced Principal Scientist, Non-Clinical PKPD to join their Early Clinical Development & Translational Sciences group on a 12-month contract. This role sits within the Quantitative Clinical Pharmacology function, which integrates PK/PD, systems modelling, clinical pharmacology, and DMPK approaches across the full drug development lifecycle. The position offers an excellent opportunity for a skilled pharmacokinetics/pharmacodynamics scientist to contribute to innovative drug development projects from preclinical through regulatory submission. Key Responsibilities * Lead strategy and execution of non-clinical PKPD and GLP toxicokinetic studies. * Provide scientific input into study protocols and regulatory study designs. * Collaborate cross-functionally with Non-Clinical Safety, Bioanalysis, Clinical Pharmacology, and external CRO partners. * Ensure delivery of high-quality data packages that meet GLP and regulatory submission standards. * Analyse, interpret, and report PKPD/toxicokinetic study results; deliver reports and summaries for regulatory submissions. * Effectively communicate interim and final results to project teams and stakeholders. * Represent the function internally and externally, contributing to scientific reputation and best practices. Candidate Profile * PhD, MSc, or BSc in pharmacology, quantitative pharmacology, pharmacokinetics/pharmacodynamics, DMPK, or related field. * 5+ years’ hands-on PKPD data analysis experience within pharma or CRO environments. * Strong knowledge of pharmacology and drug mechanisms. * Proven ability to design and deliver non-clinical PKPD studies and GLP toxicokinetics reports. * Proficiency with Phoenix WinNonlin is essential; experience with modelling/simulation tools (e.g., Berkeley Madonna, R) a plus. * Track record of regulatory submissions and/or scientific publications desirable. * Strong communication skills with the ability to influence and collaborate in a matrix environment. Contract Details * Duration: 12 months (potential extension). * Hours: 37.5 per week (7.5 per day). * Location: UK-based; virtual desktop infrastructure (VDI only). Candidate provides own equipment. Future office relocation to Surrey anticipated in 2026/27. \n#J-18808-Ljbffr