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The Clinical Unit Cambridge (CUC) is GSK’s MHRA-accredited early-phase clinical and translational medicine centre, combining Phase I clinical trial delivery, advanced translational science, biomarker discovery, single-cell and spatial omics capabilities, and technology-enabled operations to generate high-quality human data. Embedded within the Cambridge biomedical ecosystem and closely connected to academia, healthcare and industry partners, CUC accelerates FTIH and early clinical studies, de-risks decision-making, and improves the probability of technical and regulatory success across GSK’s early-stage pipeline.This role will provide clinical leadership and management of a team of clinical research physicians as Principal Investigator (PI) for early-phase and experimental medicine studies at Clinical Unit Cambridge to deliver high-quality, ethically conducted trials that drive mechanistic insight and decision-making for GSK’s portfolio. You will integrate clinical and scientific expertise, working closely within the Early Pipeline Unit and central GSK teams on early clinical development and translational medicine, and are expected to act as Principal Investigator (PI) on clinical pharmacology, experimental medicine and First-Time-In-Human (FTIH) studies.Key AccountabilitiesScientific and Clinical LeadershipWork closely with central GSK teams to provide CUC medical and scientific expertise into the design, conduct, and interpretation of early-phase and experimental medicine studies including FIH, PoM, PoC, and mechanistic studies.Act as co-Investigator or Principal Investigator on clinical pharmacology studies, experimental medicine studies and FTIH trials, in line with level of experience and MHRA accreditation requirements.Act as senior clinical/scientific authority on protocol development, risk–benefit assessment, and data interpretation for unit studies.Be accountable for authoring (where required), reviewing and approving the Informed Consent Form (ICF) and relevant Research Ethics Committee (REC) submission documentation, and responding to REC and regulatory authority questions.Lead and perform protocol-related activities including participant recruitment support, obtaining informed consent, medical screening, ongoing monitoring, post-study clinical examinations, and review/interpretation of vital signs, ECG, spirometry, Holter and laboratory test results.Perform and/or oversee study-specific diagnostic/therapeutic procedures (e.g. venepuncture, cannulation, suction blisters, punch biopsies, ECGs) and assist with their processing.Provide flexible support for clinical activities on an as-needed basis, including oversight when procedures are undertaken by nursing staff and Physician Associates.Dose and/or provide oversight of dosing of investigational medicinal products (IMPs) and non-IMPs via oral, intravenous, subcutaneous and other routes, ensuring safe and accurate administration.Provide complete medical cover (in conjunction with other unit physicians) for recruitment, study conduct and follow-up, including coordination and provision of medical cover outside normal working hours as defined by protocols and senior medical leadership, and participate in out-of-hours on-call rotas.Drive innovation in trial methodologies (e.g., adaptive designs, integrated PK/PD, digital endpoints, imaging) aligned with GSK R&D strategy.Principal Investigator ResponsibilitiesHold primary responsibility for medical safety and governance decisions on assigned studies, escalating as appropriateServe as named PI for allocated clinical studies, accountable for participant safety, data integrity, and regulatory/GCP compliance at the unit.Develop strategies to anticipate and expertly manage medical safety issues, including clinical emergencies in the unit and during study participation.Lead the management of adverse events and medical emergencies, including clinical decision-making, intervention, documentation and communication.Provide day-to-day medical oversight for study conduct: eligibility review, safety review, dose decisions, and management of adverse events.Chair/participate in safety review committees and dose-escalation meetings for early-phase studies.Ensure robust medical documentation, source data verification, and high-quality clinical reporting from the unitRepresent the CUC internally and externally as PI, including liaison with non-GSK co-development partners (e.g. NHS Trusts, university collaborators, research facilities) as required.Governance, Quality, and ComplianceEnsure standards are maintained to enable the delivery of consistent high quality and safe clinical trial conduct, at the CUC, through relevant audit and quality improvement and governance activitiesEnsures compliance with acceptable medical standards and the requirements of the protocol, standard operating procedures, ICH GCP, Research Ethics Committees (RECs), regulatory authorities and other applicable guidelines and regulations.Accountable for responding to questions from RECs, and regulatory authorities as required.Lead inspection readiness and response activities (MHRA, EMA, FDA, other authorities) for the unit.Sponsor continuous improvement initiatives in quality systems, SOPs, and risk management processes across the unit.Ensure alignment with GSK internal policies, medical governance, and R&D quality frameworks.People Leadership and DevelopmentProvide line leadership and coaching to the team of clinical research physiciansProvide senior medical input into training of clinical staff at the CUC and support delivery and maintenance of appropriate in-house clinical skills in the context of clinical trials.Aid the development of multidisciplinary staff through teaching, training and supervision, acting as a role model for good clinical and research practice.Support recruitment, retention, and development of high-calibre physician-scientist talent for the unit.Foster an inclusive, learning-oriented culture that encourages scientific curiosity, ethical conduct, and operational excellence.External Engagement and ReputationRepresent GSK and Clinical Unit Cambridge in external scientific and clinical forums (congresses, advisory boards, collaborations).Contribute to peer-reviewed publications and scientific communications from unit studies.Strengthen the unit’s reputation as a leading experimental medicine centre, attracting high-quality collaborations and participants.Basic Qualifications:Medical degree with full GMC registration and licence.UK-trained doctors must have completed early Specialty or GP training, with acute medicine experience.Non-UK-trained doctors must demonstrate clinical practice and get GMC registration.Industry or academic experience in early clinical development / experimental medicine, including acting as PI or sub-investigator on interventional trials, aligned with MHRA accreditation requirements.Experience in clinical pharmacology in early phase I/II studies, in a clinical or academic setting.Experience with biomarker strategy, PK/PD, and mechanism-of-action-driven development.Experience managing study teams focused on quality, on-time and on-budget delivery of clinical trials.Experience working with central teams on FTIH and early clinical development/translational medicine.Preferred Qualifications:A relevant post-graduate qualification in clinical pharmacology is desirable.Commitment to train toward and/or the Advanced Life Support Provider (as a minimum) qualification of the UK Resuscitation Council (UK).Strong verbal and written communication skills, ability to present and think critically along with a strong academic background.Excellent interpersonal skills and energy to operate in a complex organisation environment, positive mindset and willingness to learn and develop in the role.Ability to maintain and develop relationships and networks with different communities.Familiarity with advanced methodologies (adaptive designs, modelling/simulation, digital health tools, imaging, etc.) is an advantage.SkillsClinical Development, Drug Regulatory Affairs, Evidence Based Decision Making, Good Clinical Practice (GCP), Influencing Without Authority, Learning Agility, People Management, Project Management, Scientific Presentations, Strategic ThinkingWhy GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receiveImportant notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at SummaryLocation: UK - Cambridgeshire - AddenbrookesType: Full time

Performance & Dynamics Engineer 6 months £45.00 - £50.00 per hour inside IR35 Gloucester - onsite We are looking to recruit Performance & Dynamics Engineer to work on major programmes within the Systems Engineering team by building computational models and running simulations. You will be delivering performance and dynamic analysis for the mechanical, hydraulic and occasionally basic electrical systems as they relate to the operation of aircraft, landing gear, shock absorption, extension/retraction and steering. You will be able to understand and derive requirements and how these impact the validation and verification of the product utilising standardised methods and tools. Possessing good knowledge of mechanical and hydraulic system products, you will help guide product development to ensure the performance and dynamics of the integrated system meet the program requirements. Key aspects of this job include the following: • Build computational models and run simulations, • Calculate static and dynamic loads, • Conduct performance and frequency response analyses, • Conduct stability, shimmy, modal analysis and failure case analyses, • Correlate and validate computational models, • Write and validate performance and dynamics requirements, • Define and document simulation cases and pass/fail criteria, • Optimise design solutions in conjunction with other engineering disciplines, • Define test requirements and analyse and interpret test results, • Adherence to the programme schedules Requirements • Multi-body dynamic modelling and simulation, • Landing gear extension/retraction analysis, • Shock absorber performance analysis, • Recoil analysis, • Shimmy and stability analysis, • System loads generation, • Model Integration, • Working knowledge of MATLAB/Simulink, MSC ADAMS, MSC EASY5 and AMESim Desirable: • Knowledge of nose-wheel steering analysis, vibration analysis, electrical systems engineering, airworthiness requirements and aircraft systems certification, • Experience on requirements management and DOORS DBS clearance required Candidates with a Stress and/or Simulation Engineering background are welcomed to apply. JBRP1_UKTJ

An exciting opportunity has arisen to join a large school with over 200 staff and 1,700 students as a Graduate Programme Teaching Assistant or a Teaching Assistant to work within our Special Educational Needs Department, supporting the effective operation of the SEND provision on a day-to-day basis in school. We are looking for support for our students with Maths and Science specialisms being desirable. Teaching Assistants play a vital role in our SEND support and provision as part of the SEND Team which is led by the SENDCO and the SEND Lead Practitioner. Teaching Assistant support students through 1:1 interventions, small group work as well as main classroom support. Those interested in a Graduate Programme position, this opportunity is specifically aimed at recent graduates who are considering a career in teaching. We are founder members of the Gloucestershire Initial Teacher Education Partnership (GITEP) who are one of the few training institutions rated by OFSTED as Outstanding. If appointed we would provide tailored support to help with your application to GITEP and as you take the next step in your career. The Graduate programme includes in-house training sessions, observational visits to other schools, coaching programme and additional CPD activities depending on your specialist areas. Although starting with us would not imply a firm commitments to train as a teacher, the appointment would be fixed contract which will give you the opportunity to decide whether you would like to make teaching your career. Early application is recommended. We reserve the right to interview and appoint prior to the closing date. Closing Date: Friday 18th September 2026 at 9am Person Specification Qualifications: Essential Graduate Programme Teaching Assistant Degree in relevant subject Excellent literacy and numeracy skills (minimum of grade C/4 at GCSE or equivalent) in both English Language andMaths Teaching Assistant Excellent literacy and numeracy skills (minimum of grade C / 4 at GCSE or equivalent) in both English Language and Maths Communication and Interaction specialism and/or subject knowledge and a desire to support within Maths or Science Desirable Subject knowledge and a desire to support within Maths or Science Experience: Essential Ability to self-evaluate learning needs and actively seek learning opportunities Ability to relate well to children and adults Work constructively as part of a team Shows a personal commitment to safeguarding and promoting the welfare and rights of young people. Excellent interpersonal skills both in working relationship with young students and in forming effective professional relationships Enthusiasm, drive and love for the job Committed to high personal standards at all times Ability to form and maintain appropriate relationships and personal boundaries with children and young people Desirable Experience of working within an educational setting Experience of work within specific areas of SEND Adaption of ICT equipment to specific student needs Understanding of child development Working knowledge of national curriculum and other relevant learning programmes Employee Benefits Lifestyle and wellbeing Family-friendly policies Attractive salary and pension Generous annual leave entitlement/term time only working options Free one-to-one wellbeing support Onsite parking facilities and cycle storage Four electric car charging points Free/discounted access to the schools onsite Gym (conditions apply) Cycle to work scheme Techscheme save money on the latest tech from Apple and Currys PC World Blue Light Card - Discount Scheme Staff social events Onsite catering (8.00am - 1.30pm daily) Statutory and other benefits The full range of statutory benefits including sick pay, maternity, parental, and adoption leave Enhanced Paternity Leave Policy We will honour your continuity of service in other state-funded schools in relation to sick pay and pension rights. Provision of all necessary IT equipment. Candidate Source Ltd is an advertising agency. Once you have submitted your application it will be passed to the third party Recruiter who is responsible for processing your application. This will include holding and sharing your personal data, our legal basis for this is legitimate interest subject to your declared interest in a job. Our privacy policy can be found on our website and we can be contacted to confirm who your application has been forwarded to. TPBN1_UKTJ

Employment Partner/Senior Associate 8+ PQE | Top Tier L500 Firm | London, City | Hybrid Working from Home 3 Days per Week | High-Quality Employment Work.Top Tier L500-ranked firm in a period of exceptional growth.With offices across the UK, including the.London Bridge office to accommodate demand.De

Degree in Chemical Engineering, Materials/Surface Science, Chemistry, Physics or a related discipline.

Energy Management Consultant | UK-remote - site visits as required | up to £60,000.Are you passionate about sustainability and energy management?.Are you a qualified ESOS Assessor and have a background conducting Energy Audits?.PT Renewables is partnered with a growing Energy Consultancy (voted one

Interim Executive Divisional Director of External Engagement & Global.This high-profile role provides strategic leadership for the University's marketing, reputation, communications, digital communication, global partnerships, student recruitment/admissions and fundraising activities.They lead a div

Our client is a PE backed Insurance provider with offices in Cheltenham.They have 500 employees and have exciting growth plans.They are looking for an Compliance Analyst to work within the Broking division reporting to the Head of Compliance.You will have 2yrs + experience in the Insurance industry

Obtain quotations from suppliers and contractors and assist with monitoring facilities-related expenditure.

Vital Group is one of the fastest growing providers of critical power support solutions and EV charging infrastructure in the UK.Our vision is to become the most trusted turnkey solutions partner within our respective markets, and we will do this by re-setting customer service benchmarks and transfo

Avalon is seeking a strategic and experienced Social Housing Asset Manager for a 3-month contract with a strong chance of extension.Based out of Leicester, this key role pays between £50,000 – £55,000 per annum equivalent, taking strategic responsibility for the performance, investment, and long

MLA is working with a leading international financial institution seeking an experienced Trade Finance & Working Capital Finance Lawyer to join its legal team on an initial 12-month contract.The role will involve advising on a broad range of trade and working capital financing matters, supporting bu

Leading Firm & Award Winning Practice.Are you an established Energy Lawyer seeking a new challenge as part of a thriving team?.Would you relish the opportunity to play a role in executing a strategic growth plan to develop an already successful energy practice?.This is an excellent opportunity for a

Client Services Manager – Private Jet Charter (Remote, UK-based).We’re looking for an experienced travel professional who understands the pace, precision and service standards of private aviation.This Client Services Manager role is fully work-from-home, UK-based, and ideal for someone with prov

Our client is an award-winning tech company building for long-term growth rather than short-term hype.Their culture runs on collaboration, curiosity and genuine care for people’s wellbeing.We back our people to solve real problems with practical, data-led products.We’re looking for a Product Man

Transmission & Distribution | North East.I’m working with an established electrical engineering business that is growing its project team and looking to bring in experienced Project Managers with a strong.They’re particularly interested in people who have worked on.HV/EHV electrical infrastructu

Lead Full Stack Software Engineer – Frontend / Cloud / AI-Focused (Remote).We’re working with a fast-growing, product-led technology company building an AI-driven telephony platform for voice transcription.They are looking for a Lead Full Stack Software Engineer to help design and build scalable

Residential Conveyancer (Remote / Hybrid) – Holiday Cover Team.Unqualified) / £45k–£73k (Qualified).Ever been the one left behind while everyone else sunbathes?.Now you can be the one making holidays.This firm takes cover seriously.When their fee earners go away, they want them to fully switch

Deputy Group Manager - Order to Cash Operations.Technology Consulting, Business Process Outsourcing (BPO), and Digital Transformation industry.Deputy Group Manager - Order to Cash Operations.This is an exciting opportunity for a seasoned Order to Cash professional with expertise in.Credit Management

Job Title: Content Project Manager – ELL.Content Strategy & Production (English Language Learning).We’re looking for a Content Project Manager to support English Language Learning (ELL) projects in 2026.This role owns end-to-end project delivery, working closely with Client, internal teams and e

NET MAUI, GitHub Copilot, Docker, Kubernetes, Microservices architecture, Angular 21, Vue.TypeScript, Programmer, Full Stack Engineer, Architect,.We have several fantastic new roles for.NET Developer to join an ambitious Fintech start-up.This is your chance to work with the sharpest minds in private

Help Shape the Future of Legal Content!.Are you passionate about legal publishing, quality excellence, and the transformative potential of AI?.LexisNexis Legal & Professional, which serves customers in more than 150 countries with 11,800 employees worldwide, is part of RELX (www.Our company has been

AI Solutions Architect (Practice Building and Adoption) - Up to £95k - Remote.A leading consiultancy requires an AI Solutions Architect with strong experience of builidng AI practices and owbning enetrprise adoption).A key focus of the role will be to build an AI proctiicve for the organisation wit

Flash Social is a brand new talent management agency operating under the already established Team 2 Management group, giving ambitious people the opportunity to build and grow their own roster of creators.This is a commission-only freelance opportunity, which provides you with the freedom to choose

Blue Diamond Recruitment are working on a new opportunity that has arisen due to organic growth for a Senior / Principal Planner to join a well established and growing planning consultancy.Working as part of a tight knit and experienced team, you will deliver a diverse portfolio of projects across t

Partner / Director – Employment.Nottingham or Leicester | Hybrid Working.We are working with a highly regarded and growing law firm that is looking to appoint a.Partner or Director-level Employment lawyer.This is an excellent opportunity for an established Employment specialist with a strong clien

FTC with some scope of extension or going perm.Hybrid role - some home working with regional travel across the North of England.Here at ISS as a leading Facilities Management (FM) provider, we are looking to recruit an established HSEQ professional to join our HSEQ team where you will take ownership

Level 2 or Level 3 Diploma in Welding, Fabrication, or a related discipline.

Monday–Friday) | Part-time considered | £35k-£40k Salary range.VQ Solutions is looking for a passionate.Marketing Apprenticeship Coach.You'll deliver engaging online training, coach and assess learners, build strong employer relationships, and help apprentices achieve successful outcomes.You'll

SYR are proud to represent a long term client of ours who are one of the key players in the shipbuilding industry, in the UK.They are looking for a highly skilled & experienced.This is an extremely exciting opportunity for a bright and enthusiastic individual to join our thriving and fast-growing sh

This is an excellent opportunity for an experienced Scientist or Engineer with a strong background in underwater acoustics, sonar, signal processing or related research areas.

Category Manager – Food - Household Brand - £70,000 + Comprehensive Package - Remote (with travel).A unique opportunity has arisen to join one of the UK’s largest and most recognisable household brands as a.Due to consistent growth and investment in their procurement function, this leading orga

Competitive Executive-Level Salary + Bonus + Benefits.A unique opportunity has arisen for a quasi-MD to take ownership of a rapidly growing asset refurbishment and redevelopment business within a leading UK developer and investment partner operating at significant scale across the living sector, wit

A degree in Environmental Science, Civil Engineering, Hydrology, Geography or a related discipline.

Product Development Controller role within a category leading healthy food brand.Our client is a global branded food manufacturer with instantly recognisable leading brands.A business with strong brand heritage producing sustainably sourced natural and healthy food.This business critical role will o

Three days a week, contract basis · Remote, UK or Europe.We're a twenty-three person independent agency, founded in 2015.Brand identity, design and development for established businesses, luxury brands and ambitious B2B clients.Mostly UK, with people in Portugal, Spain, Italy and Cyprus.We've built

Senior Collections Lead - Contract - Midlands.A leading organisation within the UK energy sector is seeking an experienced Senior Collections Lead to oversee the day-to-day collections activity for a small team within its.Industrial & Commercial (I&C) Energy Supply.This is a hands-on operational rol

Operations Manager (Electrical).Looking for an exciting opportunity to lead and build an M & E business unit?.RGB Recruitment Ltd are pleased to be working exclusively with a well established regional M & E contracting company who have earned a great reputation and work on varied schemes across the

NPD Manager | Beauty, Cosmetics & Wellness | Northwest.I’m currently recruiting for an exciting NPD Manager opportunity with a growing beauty, cosmetics and wellness company based in the Northwest of England.We’re looking for an experienced NPD professional with ideally.The ideal background woul

International travel required .The Partner, EU Region is a senior leadership role responsible for establishing, growing, and leading the company’s healthcare IT consulting business across the European Union.This is a remote role with international travel required.Reporting to the Chief Delivery O

The Family Lawyer will manage a caseload involving divorce, separation, financial remedies, cohabitation issues, child arrangements, and related family law disputes.

Graduate Sustainability Analyst.This is a rare chance to start your career at the heart of the net-zero transition, working alongside experienced consultants on projects that genuinely move the needle for clients across multiple sectors.You'll be advising organisations on how to measure, reduce and

I am recruiting for a great locum role in Hertfordshire.My client is recruiting for a Property litigation solicitor to join their team.Hybrid working (Amount of days in office depends on experience).Looking to consider all candidates, NQ or 10+ years of experience.The role will include unique and co

Tuscany to London, by the team behind Petersham Nurseries.Our vision is to showcase Italy’s finest wines, with a particular focus on Tuscany as well as other celebrated regions, alongside a seasonal menu inspired by traditional Tuscan ingredients and flavours.We also offer a carefully crafted aper

Global Business Development Director (Hunter) | Global Operational Excellence Consultancy.UK or USA (Remote/Hybrid) | International Travel.Blue Arrow is proud to have been retained by a globally recognised Operational Excellence consultancy with an established presence across the UK, Europe and USA.

Crone Corkill are currently recruiting on behalf a boutique niche law firm specialising in Employment Law.Associate Employment Solicitor, who will report directly to the firm’s Managing Partner.A minimum of 4 years PQE experience required.The role is 100% flexible home or office based.Full time wo

Lead and deliver end-to-end IFS Manufacturing solution implementations, including requirements gathering, configuration, testing, and deployment.Strong functional expertise in IFS Manufacturing modules such as Production, Shop Floor Reporting, MRP, Inventory, Supply Chain, and Planning.Work closely

Interim Early Careers Programme Manager.Remote (with occasional travel to Birmingham) | Immediate Start | Contract until January 2027 with potential extension.We're partnering with a leading organisation to recruit an.Interim Early Careers Programme Manager.This is an exciting opportunity for an exp