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< Overview The Strategic Account Lead (SAL) roleleads strategic engagement and contracting with target key accounts in order to drive growth, revenue, and joint value creation for Alnylam and the customer by enabling and optimizingaccess toAlnylam products and driving innovation for patients and health care providers. Key Responsibilities The Strategic Account Lead (SAL) will provide innovative, influential account engagement to shape and deliver the strategy for Alnylam Strategic Accounts in order to achieve access, create value and deliver profitable growth for Alnylam. • Lead the development and execution of the comprehensive account strategy for target accounts to bring the best of Alnylam to the customer and to maximize profitability, revenue growth and market share for Alnylam, • Analyze and synthesize information from multiple sources to identify and prioritize business opportunities across the account by applying relevant frameworks and analytical methods, • Work with the Alnylam Leadership Team to co-develop and agree on strategies, programs objectives and KPIs for target regional accounts aligned with organizational and brand priorities and the wider business strategy, • Support the account team with the prioritization of solutions, programs and specific pull-through tactics to ensure sustainable growth and mutual value creation, • Anticipate likely market and customer developments, identify third party influence factors and shape the account strategy accordingly, • Partner with target healthcare systems and organized customers to foster innovation in care through the adoption of Alnylam's products, • Engage senior level stakeholders to influence policies, decisions and perceptions to enable patients to effectively navigate the treatment journey and ensure appropriate use of Alnylam products, • Facilitate the introduction of new products and indications with institutional stakeholders by ensuring adequate budget allocation at the strategic account level, • Leverage a range of strategies and tactics to maximize the level and quality of access for Alnylam products, • Identify programs to partner with the Organized Customer to enhance the system of care and clinical decision making, • Provide insights, education and information about scientific, clinical and technological innovation, • Facilitate strategic partnership with account stakeholders to create mutual value for Alnylam and customers and deliver strategic goals, • Identify and maintain strong relationships with senior business stakeholders (Chief, VP, Director) in target accounts to support access for Alnylam's products across the company portfolio, • Strengthen the perception of Alnylam as a strategic partner by sharing insights and information to support patient identification and improving the delivery of care by establishing treatment pathways and protocols, • Provide clear direction to other field teams to identify and prioritize stakeholders within their target accounts, • Negotiate, review and agree contracts, incorporating solutions to strengthen partnerships with strategic account stakeholders, • Collaborate with other functional and business leaders to ensure adequate Voice of the Customer to inform strategic planning across all stakeholders and channels, • Support the delivery of account goals for National accounts, working closely with the Strategic Accounts Team, • Support the execution and pull through of contracting and initiatives with national organized customers to ensure value maximization, • Measure, report and communicate value delivered for national organized customers in order to strengthen customer partnership, • Share insights gathered through customer engagement Qualifications * • Bachelor's degree, emphasis in Accounting, Marketing, Business Administration or equivalent work experience in business management, ideally complemented by an MBA, • Minimum 7 years of experience in B2B selling in a life sciences environment, • Previous account management experience with health systems and/or hospitals/ IDNs, • High level of confidence and capability to understand and communicate complex scientific concepts to a range of stakeholders, plus executive presence and communication skills to engage with a C-Suite audience, • Expertise and understanding of dynamic market access value models such as value-based propositions and budget impact and cost effectiveness models, etc, • Strong interpersonal skills including written and oral communication skills, ability to synthesize data, interpret and translate into compelling and clear commercial strategies and plans, • Demonstrated ability to successfully mobilize a cross-functional team, including interpersonal skills to foster collaboration and succeed in a highly matrixed environment by leading without direct authority, • Understanding of the IDN environment, including coverage and reimbursement, pricing and contracting, formulary management and health technology assessment, • Strong analytical skills and ability to think critically, challenge conclusions and underlying assumptions, • Ability to synthesize multi-source information (qualitative and quantitative) to develop strategic plans, • Knowledge of value based healthcare and outcome based models, • Executive presence and the ability to interact and negotiate with C-suite customers, • Highly proficient in Microsoft; Excel, Word, and PowerPoint Additional Preferred Experience * • Master's degree: Master of Business Administration (MBA) preferred, • Active membership of relevant pharmaceutical associations would be beneficial #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The successful candidate will join an experienced team of toxicologists providing discovery and development support across a strong and diverse pipeline of programs spanning multiple disease areas. In addition to leading and contributing to regulatory toxicology activities, this role will place strong emphasis on supporting research initiatives and providing scientific leadership within the broader Early Development department. Responsibilities: • Lead and oversee a team of toxicologists and technical staff, fostering scientific excellence, collaboration, and professional development., • Provide strategic leadership for nonclinical safety assessment programs supporting discovery, development, and regulatory submissions., • Collaborate effectively across disciplines, including pathology, DMPK, biology, clinical, regulatory, and pharmacology, ensuring strong cross-functional integration., • Engage effectively with regulatory authorities, supporting product defense and contributing to successful regulatory submissions and approvals., • Design and implement scientifically robust and strategically aligned nonclinical development programs to support advancement of drug candidates and regulatory filings., • Lead and manage nonclinical studies and programs across a portfolio of projects, conducted internally and through CRO partners, either directly or through direct reports., • Prepare and critically review scientific and regulatory documents to ensure high quality, clarity of presentation, and sound scientific interpretation., • Partner with cross-functional teams to design investigative toxicology studies supporting development candidates and platform technology evaluations., • Present key findings and safety strategies to program teams, R&D leadership, and regulatory authorities., • Mentor and develop toxicologists and scientists, helping build organizational expertise in pharmaceutical toxicology and nonclinical safety. Qualifications: • PhD in Toxicology, Pathology, or a related scientific discipline., • 15+ years of experience in the pharmaceutical or biotechnology industry, with demonstrated expertise and accomplishments in regulatory toxicology., • Proven leadership experience managing departments, groups, or teams within a scientific organization., • Demonstrated experience preparing and supporting global regulatory submissions and associated documentation., • Strong ability to interpret and integrate complex datasets across multiple disciplines, including pharmacology, DMPK, toxicology, and pathology, with a focus on assessing clinical relevance and impact., • Proven ability to apply creative and strategic approaches to resolving challenges in predictive toxicology., • Strong problem-solving skills, with the ability to remain highly organized and lead effectively in a fast-paced environment with evolving priorities., • Excellent interpersonal skills and a demonstrated ability to collaborate across diverse cross-functional teams., • Excellent written and verbal communication skills., • Strong interest in the therapeutic and scientific areas aligned with Alnylam's research focus. #LI-KB1 #LI-Onsite U.S. Pay Range $284,800.00 - $385,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: At Alnylam Pharmaceuticals, we are leading the RNAi Revolution, developing innovative therapies that transform the lives of patients with rare and prevalent diseases. As a Federal Account Director, you will play a key role in executing our U.S. federal market access strategy, with a primary focus on assigned Department of Veterans Affairs (VA) VISN and VA Hospital accounts, as well as supporting Department of Defense (DoD) ecosystems where applicable. This position requires expertise in the federal healthcare landscape, including VA/DoD reimbursement dynamics, formulary processes, Criteria for Use (CFU), utilization management, and stakeholder engagement, particularly for therapies requiring administration by healthcare professionals under the medical benefit. You will focus on optimizing access and appropriate utilization of Alnylam's HCP-administered products by ensuring compliant application of the VA National Formulary and CFU at your assigned accounts. In collaboration with cross-functional partners, you will educate site administrators, department chairs, and clinical influencers on the value proposition of Alnylam products for Veterans and service members. You will also support cross-functional pull-through efforts, contribute to federal access strategies, and provide insights to inform broader team initiatives. This role demands agility to navigate evolving policies, market conditions, and federal requirements while identifying opportunities to enhance product utilization. You will collaborate with internal teams, including sales, medical affairs, health economics, and strategic accounts, to align with Alnylam's commercial objectives and mission to deliver groundbreaking RNAi therapeutics to patients in federal systems. This is a field-based remote position requiring up to 50-70% travel and reports to the Senior Director, Federal Accounts. Key Responsibilities: • Execute federal access strategies within assigned VISN and VA Hospital accounts to optimize patient access and appropriate utilization of Alnylam's portfolio., • Ensure compliant application of the VA National Formulary and Criteria for Use (CFU) for Alnylam products at the site level., • Partner with the cross-functional team to ensure that critical education is delivered to key stakeholders including site administrators, department chairs, and healthcare professionals. This education includes: disease-state education, clinical information, as well as administration requirements of Alnylam's therapies., • Analyze account-specific data, trends, and utilization metrics to identify opportunities for enhanced pull-through and appropriate use., • Collaborate with field sales, Regional Business Directors, and cross-functional partners to implement pull-through tactics and support sales performance in federal accounts., • Contribute to the development and execution of account plans, sharing insights and best practices with the federal team., • Support federal market development initiatives, including engagement with organizations such as the Association of Military Surgeons of the United States (AMSUS)., • Provide federal payer and account insights to market access, HEOR, patient services, and leadership teams to inform strategies and address gaps. Accountabilities: • Build and maintain multi-level relationships within assigned federal accounts (VISNs, VA Hospitals, and related DoD entities), positioning Alnylam as a trusted partner for HCP-administered innovations benefiting Veterans and service members., • Navigate federal provider structures to engage key decision-makers, influencers, and clinical stakeholders, fostering long-term partnerships that support Alnylam's current products and pipeline., • Prioritize account activities to ensure consistent, compliant implementation of national formulary and CFU, addressing site-specific needs for medical benefit therapies., • Collaborate with internal experts (e.g., Medical Affairs, national contracting, and policy teams) to support access positioning and medical policy alignment., • Deliver tailored education on the value proposition of Alnylam products, emphasizing benefits for patient populations served in federal settings., • Review sales, utilization, and trend data to uncover pull-through opportunities, developing tactics aligned with team KPIs., • Work with field sales teams to execute pull-through plans, providing training on federal payer dynamics, formulary processes, CFU requirements, and reimbursement for HCP-administered therapies., • Maintain compliance with all legal, regulatory, and company policies in stakeholder interactions and program execution., • Contribute to team knowledge sharing by documenting best practices, participating in training, and supporting pilot programs or initiatives. Qualifications: • Bachelor's degree required (business or science preferred); advanced degree (e.g., MBA, PharmD) a plus., • Minimum 7+ years of pharmaceutical/biotech experience, with at least 3 years in account management, payer access, or related roles; direct experience in VA/DoD or federal channels preferred., • Proven track record in managing complex accounts, influencing stakeholders, and driving results in healthcare environments., • In-depth knowledge of federal healthcare systems, including VA National Formulary, Criteria for Use (CFU), VISN dynamics, aprocurement process for HCP-administered therapies, medical benefit coverage, utilization management, site-of-care strategies, and reimbursement pathways., • Strong analytical skills to interpret data, identify opportunities, and develop actionable account plans., • Consultative approach to stakeholder engagement, with expertise in value communication and educational program delivery., • Understanding of payer economics, utilization management, and evolving U.S. policies impacting federal systems., • Comprehensive knowledge of pharmaceutical operations, including prescribing, regulations, supply chain, managed care, sales, and compliance., • Excellent communication, presentation, and relationship-building skills; ability to collaborate effectively in cross-functional teams. #LI-ST1 #LI-Remote U.S. Pay Range $211,500.00 - $286,100.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: We seek aPatient Education Liaison (PEL)to supportAMVUTTRA (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA (vutrisiran).The approval expands theindicationfor AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.The PELis a criticalcomponentof the product brand commercial strategy and works in close coordination with Field Sales, Field Reimbursement, Patient Services, Advocacy, and Marketing teams to support Alnylam's patient-focused vision of harnessing a revolution in biology for human health. The Patient Education Liaison is responsible for educating patients, caregivers, families, nurses, medical assistants, office staff, professional nursing organizations, and pertinent community groups on disease state and Alnylam's RNAi treatments for all Alnylam brands. Using approved materials, the Patient Education Liaison will educate on the disease state, Alnylam treatments, and Alnylam's services, through phone-based, in-person, and virtual meetings. Central to this role is the ability to work with regional, field-based and internal colleagues to identify barriers to patient access and work to resolve them. The successful candidate must be passionate about science and deeply motivated by the quest of delivering education to patients and their families with the long-term success of the company in mind. The ideal candidate will be a self-motivated, self-starter with an innovative, entrepreneurial spirit. Key Responsibilities: * Actively collaborates with Field Sales, Patient Services, Medical Affairs, Marketing,Advocacyand other critical internal teams to increase disease-state awareness and early diagnosis * Leads regional effort to provide disease-state education, treatmenteducationand support to patients their families/caregivers, nurses, medical assistants, office staff, nursing organizations, and community groups * Maintains disease-state and productexpertisethrough continuing medical education and attendance at relevant symposia,conferencesand other educational opportunities * Provides comprehensive updates on activity toPELLeadandregional colleagues, ensuring that the regional team appropriately works as one entity to support patients in early diagnosis and access to treatment * Accountable for executing on targeted workplan * Completes required work in CRM system tofacilitatetracking of critical launch metrics * Ensures compliance with all corporate and industry policies with training provided by Alnylam Commercial, Legal, Regulatory and Compliance Officers Qualifications: * Bachelor of Science in Nursing, Registered Nurse(required) * 2+yrs. Pharmaceutical/biotech experience in a similar role * Experience supporting and providing education to patients, family members, nurses, medical assistants, office staff, nursing organizations, and community groups * Strong presentation skills * Cardiology experience preferred * Exceptional interpersonal skills, professional communications, problem-solving,compassionand the ability to navigate difficult conversations * Ability to translate scientific/medical information into patient-friendly language * Ability to work well and lead within cross-functional groups and in a matrix organization * Desire to innovate and work in a fast-paced, energetic environment * Self-starter who is highly passionate about Alnylam's core values:Commitment to People, Fiercely Innovative, Open Culture, Passion for Excellence, and Purposeful Urgency. * This position requires frequent travel within the region and at times nationally. Includesovernight travel and weekends. * Must be able to travel up to 75% * Valid Driver's License #LI-ST1 #LI-Remote U.S. Pay Range $136,000.00 - $184,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are seeking an accomplished and motivated Principal Scientist to lead innovation in advanced in vitro modeling to enable RNAi discovery and development. In this role, you will be responsible for designing, validating, and implementing physiologically relevant model systems-such as iPSC-derived models, organoids, and microphysiological systems (MPS)-to enhance biological predictivity, deepen mechanistic understanding, and increase translational confidence across multiple therapeutic areas. The ideal candidate will have a strong background in cellular and molecular biology, experience with complex in vitro model development, and a passion for leveraging advanced systems to drive impactful RNAi therapeutics. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities • Lead and mentor the Advanced In Vitro Delivery group, fostering scientific excellence and ensuring the team remains at the forefront of emerging technologies and methodologies., • Shape scientific strategy by staying current with advances in RNAi therapeutics and contributing to the strategic direction of discovery and platform development efforts., • Collaborate cross-functionally with internal teams and CRO partners to develop, validate, and implement advanced in vitro systems-including 2D, 3D, organoid, and organ-on-a-chip models-that are predictive of in vivo siRNA uptake and biological activity., • Drive experimental execution, including design, implementation, and troubleshooting of complex in vitro studies to evaluate siRNA delivery and mechanism of action., • Provide technical leadership in the development and deployment of next-generation in vitro modeling technologies across multiple tissue types., • Adapt and miniaturize advanced cell culture systems for automated, high-throughput screening applications., • Perform and oversee analytical assays, including imaging, ELISA, Western blotting, and cell-based functional assays, to assess siRNA delivery efficiency and receptor-mediated uptake., • Analyze and interpret data, integrating imaging and functional readouts, and effectively communicate results to internal stakeholders and external collaborators., • Partner with discovery teams to integrate validated in vitro models into RNAi screening and lead optimization workflows. Qualifications • Ph.D. in Cell Biology, Pharmacology, or a related discipline with 6+ years of hands-on industry experience in a biotechnology or pharmaceutical environment., • Demonstrated expertise in ex vivo cell assays, microphysiological systems (MPS), primary and iPSC-derived cell culture, and cell-based functional assays., • Strong understanding of in vitro assay development and the application of 2D and 3D culture systems to model and predict in vivo siRNA delivery, uptake, and activity., • Proven experience with 3D culture platforms, including spheroids, organoids, and co-culture models., • Exceptional organizational and analytical skills, with the ability to independently troubleshoot, optimize, and innovate experimental approaches., • Effective team collaborator and communicator, capable of presenting scientific findings clearly to diverse audiences., • Self-driven and proactive, with the ability to lead projects, manage multiple priorities, and adapt to evolving objectives in a fast-paced environment., • Strong project management and leadership skills, with a proven ability to lead teams and deliver results through cross-functional collaboration., • Experience with oligonucleotide or RNAi-based therapeutics is highly desirable., • #LI-JR1 U.S. Pay Range $147,200.00 - $220,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the ___.

< Overview: We seek aPatient Education Liaison (PEL)to supportAMVUTTRA (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA (vutrisiran).The approval expands theindicationfor AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.The PELis a criticalcomponentof the product brand commercial strategy and works in close coordination with Field Sales, Field Reimbursement, Patient Services, Advocacy, and Marketing teams to support Alnylam's patient-focused vision of harnessing a revolution in biology for human health. The Patient Education Liaison is responsible for educating patients, caregivers, families, nurses, medical assistants, office staff, professional nursing organizations, and pertinent community groups on disease state and Alnylam's RNAi treatments for all Alnylam brands. Using approved materials, the Patient Education Liaison will educate on the disease state, Alnylam treatments, and Alnylam's services, through phone-based, in-person, and virtual meetings. Central to this role is the ability to work with regional, field-based and internal colleagues to identify barriers to patient access and work to resolve them. The successful candidate must be passionate about science and deeply motivated by the quest of delivering education to patients and their families with the long-term success of the company in mind. The ideal candidate will be a self-motivated, self-starter with an innovative, entrepreneurial spirit. Key Responsibilities: * Actively collaborates with Field Sales, Patient Services, Medical Affairs, Marketing,Advocacyand other critical internal teams to increase disease-state awareness and early diagnosis * Leads regional effort to provide disease-state education, treatmenteducationand support to patients their families/caregivers, nurses, medical assistants, office staff, nursing organizations, and community groups * Maintains disease-state and productexpertisethrough continuing medical education and attendance at relevant symposia,conferencesand other educational opportunities * Provides comprehensive updates on activity toPELLeadandregional colleagues, ensuring that the regional team appropriately works as one entity to support patients in early diagnosis and access to treatment * Accountable for executing on targeted workplan * Completes required work in CRM system tofacilitatetracking of critical launch metrics * Ensures compliance with all corporate and industry policies with training provided by Alnylam Commercial, Legal, Regulatory and Compliance Officers Qualifications: * Bachelor of Science in Nursing, Registered Nurse(required) * 2+yrs. Pharmaceutical/biotech experience in a similar role * Experience supporting and providing education to patients, family members, nurses, medical assistants, office staff, nursing organizations, and community groups * Strong presentation skills * Cardiology experience preferred * Exceptional interpersonal skills, professional communications, problem-solving,compassionand the ability to navigate difficult conversations * Ability to translate scientific/medical information into patient-friendly language * Ability to work well and lead within cross-functional groups and in a matrix organization * Desire to innovate and work in a fast-paced, energetic environment * Self-starter who is highly passionate about Alnylam's core values:Commitment to People, Fiercely Innovative, Open Culture, Passion for Excellence, and Purposeful Urgency. * This position requires frequent travel within the region and at times nationally. Includesovernight travel and weekends. * Must be able to travel up to 75% * Valid Driver's License #LI-ST1 #LI-Remote U.S. Pay Range $136,000.00 - $184,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: As the Patient Experience Lead, you will hold a pivotal position on a fast-paced, highly collaborative team driving the success of the TTR franchise. In this role, you will elevate and optimize the TTR Patient Experience across all touchpoints of the patient journey. This role will be pivotal in shaping and executing an integrated vision for patient experience, starting with ATTR-CM and ultimately expanding to other indications and franchises. Working closely with US TTR Patient Services and Marketing leadership, as well as key cross-functional partners, you will ensure alignment, transparency, and collaboration in delivering a best-in-class experience for patients and caregivers. The position reports to the Vice President, US Head of Patient Services. Key Responsibilities: • Bring the Patient Experience Vision to Life: Work to both define and translate strategic vision into actionable plans for implementation for the cross-functional project team and the broader Alnylam organization., • Build Collaboration and Transparency: Foster strong partnerships across Customer Experience & Innovation, Strategic Technologies, Marketing, Patient Services, and Business Operations, including sub-teams such as Digital Marketing and Analytics , Data and Diagnosis Strategy., • Gain Leadership Endorsements & Drive Reporting: Secure leadership buy-in, lead executive updates, and ensure timely, accurate reporting on progress and impact., • Lead Change Management: Drive organizational change to support the initiative, ensuring adoption and sustainability across teams., • Foster Team Communication and Accountability: Promote clear communication, shared accountability, and a culture of collaboration within the project team., • Manage External Project Support: Oversee and leverage an external day-to-day project manager for planning, communication, and leadership reporting. Qualifications: • Bachelor's degree in Marketing, Business, or a related discipline; an advanced degree is preferred., • 10+ years of experience in pharmaceutical or healthcare marketing, healthcare consulting, or patient experience, with a preference for expertise in project management across matrixed organizations and change management, • Strong analytical skills with the ability to interpret data and translate insights into actionable strategies., • Excellent communication and collaboration skills, with the ability to work effectively within cross-functional teams., • Demonstrated strategic and critical thinking abilities in fast-paced, dynamic environments., • Proven ability to influence without direct authority and collaborate with cross-functional teams to develop and execute strategic plans., • Strong experience in managing external agencies and vendors., • Solid project and program management experience. #LI-ST1 #LI-Remote U.S. Pay Range $184,600.00 - $249,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account.The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business.Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity.This position reports to the Regional Business Director within its respective area.Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities.Qualifications, • 4-year degree from an accredited college or university required., • B2B sales experience required., • 1-3 years+ of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Strong interpersonal skills with the ability to build relationships and rapport with internal teams and stakeholders., • Basic understanding of data analysis tools and ability to interpret simple datasets., • Willingness to learn and adapt to changing environments and new methodologies under supervision., • A growth mindset with the ability to treat challenges as learning opportunities., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds foundational relationships, seeks feedback, and adapts to new methods with guidance., • Customer Focus:Engages customers with empathy, delivers approved messaging based on customer needs, and starts building trust with stakeholders., • Execution:Completes tasks on time, tracks performance, and begins aligning business plans with team goals and emerging trends in their territory., • Critical Thinking:Learns basic data analysis, identifies opportunities, and makes small decisions with support., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. U.S. Pay Range $119,000.00 - $161,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Associate Director, Medical Publications - TTR Franchise supports the strategic development and execution of the global medical publication plan for Alnylam's transthyretin amyloidosis (TTR) franchise. Reporting to the Director, Medical publications - TTR Franchise, this role contributes to the planning, coordination, and delivery of high-impact publications supporting Alnylam's medical strategy across cardiomyopathy and neuropathy programs. As part of the Scientific Communications organization within Medical Affairs, the Associate Director partners closely with with cross-functional stakeholders including Medical Directors, Clinical Development, Biostatistics, Scientific Communications, Legal, and Commercial teams to develop a global publication strategy, and ensure timely, accurate, and compliant dissemination of clinical and scientific data though peer-reviewed publications and presentations at major scientific congresses. This is a highly collaborative and visible role requiring strong scientific expertise, operational excellence, and the ability to manage complex publication activities in a global matrixed environment. This is a hybrid position located in Cambrige, MA. Key Responsibilities • Support the development and execution of the global TTR publication strategy aligned with medical affairs objectives and franchise priorities., • Lead assigned components of the global publication plan across the lifecycle of evidence generation, including abstracts, posters, oral presentations, manuscripts, and plain language summaries., • Partner with Medical Directors, Clinical Development, and Biostatistics teams to identify publication opportunities aligned with strategic priorities., • Coordinate cross-functional publication planning activities and contribute to Publication Working Group (PWG) operations., • Collaborate with external authors, investigators, and key opinion leaders to support development and delivery of scientific publications., • Manage medical writing agencies and publication vendors to ensure high-quality and timely execution of deliverables., • Ensure all publication activities comply with GPP, GPCAP, ICMJE criteria, and internal governance requirements., • Maintain publication timelines, trackers, and documentations within publications management systems., • Represent Medical Publications in cross-functional discussions supporting evidence dissemination planning., • Support Publication Steering Committees where applicable., • Lead and mentor junior publication team members and foster a culture of scientific excellence and integrity., • Demonstrate alignment with Alnylam core values in all internal and external interactions. Qualifications • PhD (preferred) or PharmD/MD with 5+ years of experience in the pharmaceutical/biotech industry, or medical agency., • ISMPP Certified Medical Publication Professional (CMPP) certification - preferred., • Prior medical affairs, medical communications, publications, agency and/or KOL management experience - required., • Prior experience in rare disease, cardiology, neurology or RNA-based therapeutics - preferred., • Experience supporting publication strategy and execution for a complex, global program - required., • Strong working knowledge of GPP, GPCAP, ICMJE criteria, and industry best practices for publications - required., • Demonstrated ability to work effectively in a cross-functional, matrixed environment - required., • Excellent verbal and written communication skills; experience interacting with scientific experts and senior stakeholders - required., • Team management and project management experience - preferred., • Occasional travel (approximately 2-6 times per year), including weekends, to congresses or other scientific meetings required. #LI-JB1 #LI-Hybrid U.S. Pay Range $173,700.00 - $235,100.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Description You have what it takes: a competitive drive coupled with exceptional sales ability. The HIV Sales Specialist is part of a nationwide sales team and drives customer engagement by identifying needs and delivering tailored solutions that support healthcare professionals with approved resources in a given territory. This role ensures effective execution of customer strategies while demonstrating professionalism, leadership, and mastery of core Field Sales competencies to achieve business impact. You will: • Meet and/or exceed performance objectives in an assigned territory by developing, implementing, and executing an integrated territory business plan encompassing key customers, • Deliver specific presentations for the HIV product to appropriate health care professionals in both the clinic/office and hospital settings by utilizing approved messaging and resources, • Effectively utilize and manage all approved resources to optimize customer engagementEssential Requirements:, • Bachelor's Degree or 4+ years of the following equivalent experience:, • Professional sales experience, • Experience in the healthcare/scientific field (including pharmaceutical, biotech, or medical devices), • Military Experience, • 5+ years pharmaceutical sales experience with a proven track record of success, • Proven experience selling in an institutional setting and the ability to navigate throughout complex accounts, • Valid driver's license and the ability to travel as necessary, including overnights and/or weekends, • Must live within territory or within territory boundariesDesired Requirements: Why Syneos Health? Here, the work is challenging, and the pace is exhilarating. By joining one of our commercial teams, you're empowered to succeed with the support, resources, and autonomy that you need. The diversification and breadth of our new and existing partnerships create a multitude of career paths and employment opportunities. Syneos Health has launched more sales teams in the last 5 years across all major therapeutic areas than the top 25 pharma companies combined. Join our game-changing, global company dedicated to creating better, smarter, faster ways to get biopharmaceutical therapies to patients. Experience the thrill of knowing that your everyday efforts are contributing to improving patients' lives around the world. Work Here Matters Everywhere | How are you inspired to change lives? Syneos Health companies are affirmative action/equal opportunity employers (Minorities/Females/Veterans/Disabled) Syneos Health has a voluntary COVID-19 vaccination policy. We strongly encourage all employees to be fully vaccinated. Additionally, certain local governments or Syneos Health customers may have vaccine requirements that apply to some of our employees. These employees are required to submit proof of vaccination to Syneos Health and maintain compliance with these requirements. At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position will include a competitive compensation package, Health benefits to include Medical, Dental and Vision, Company match 401k, flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos Health complies with all applicable federal, state, and municipal paid sick time requirements. #North 400002488

< Overview The Manager, Manufacturing Operations is an integral part of the Norton Internal Manufacturing team. This role will initially be involved in the start-up of Norton's new commercial Drug Substance manufacturing train, including support for equipment commissioning & qualification, oligonucleotide technology transfer, successful execution of Drug Substance PPQ batches all the way through commercial production and launch. The successful candidate will build and manage multiple shifts for commercial GMP manufacturing in the new train. This position is an on site role in Norton that will report to the Associate Director of Manufacturing - Lead End User. Key Responsibilities • Plans, schedules, and manages deliverables for Train 2 operational readiness and PPQ execution, including development, ownership, and approval of manufacturing documentation (SOP's and batch records), • Supports commissioning and qualification testing of new equipment, as needed, • Assists with planning and directing an efficient layout of equipment and flow of materials, • Ensures manufacturing schedule adherence, • Provides coaching, feedback, and guidance for direct and indirect reports, • Provides guidance to direct and indirect reports regarding departmental goals. Ensures accountability for goal execution, • Champions a safety mindset and approach, • Maintains staff by participating in recruiting, selecting, and orienting new hires, including development and delivery of training content, • Identifies personal growth opportunities for reports, and provides guidance on development plans to achieve those opportunities, • Models a continuous improvement approach by identifying issues, taking ownership, and driving solutions, • Fosters an open culture by providing support and feedback during regular Gemba walks, • Drives GMP compliance and understands when to intervene and escalate more significant issues for resolution, • Partners with Quality functions (internal QA/QC,) to ensure timely review of new and executed batch production records, SOPs, deviations, investigations, CAPAs, and may own and drive change controls as needed, • Participates in regulatory agency audits / inspections and owns associated CAPA, • Communicates routine production manufacturing status to department head and assists as necessary with process data retrieval, processing, analysis, and presentation at various meeting forums, • Provides off-shift on-call support for issues that require escalation on a rotating schedule, • Collaborate with Engineering, Facilities, EHS, Supply Chain, Quality Assurance, Quality Control, Validation, and others to support above responsibilities Qualifications • B.S. in scientific or engineering field preferred, • Minimum 7+ years of relevant experience hiring and building a manufacturing team and working in GMP Manufacturing/Contract Manufacturing commercial plant in the Pharmaceutical/ biotech industry with 4+ years of supervisory experience, • In-depth understanding of commercial GMP manufacturing, continuous improvement, and cGMP regulations., • Broad knowledge of US and international regulations and standards (FDA, EMA, ICH). Exposure to government inspections (FDA, EMEA, etc.) for new facility approval or routine surveillance required., • Proven ability to work independently, leadership aptitude, and good people skills with the desire and ability to work in a fast-paced, start-up environment, • Strong collaboration and team-building, communication, and organizational skills required, • Experience working with third party contractors and vendors, • Hands-on experience with plant commissioning and startup, including troubleshooting and providing solutions to complex technical and logistical issues is required, • Excellent written and verbal communication skills, • Requires proficiency in MS Office applications. Proficiency with SAP, PI Historian, and LIMS preferred, • Prior experience with MES/eBR strongly preferred #LI-LJ1 #LI-Onsite U.S. Pay Range $117,300.00 - $158,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Strategic Account Lead (SAL) roleleads strategic engagement and contracting with target key accounts in order to drive growth, revenue, and joint value creation for Alnylam and the customer by enabling and optimizingaccess toAlnylam products and driving innovation for patients and health care providers. Key Responsibilities The Strategic Account Lead (SAL) will provide innovative, influential account engagement to shape and deliver the strategy for Alnylam Strategic Accounts in order to achieve access, create value and deliver profitable growth for Alnylam. • Lead the development and execution of the comprehensive account strategy for target accounts to bring the best of Alnylam to the customer and to maximize profitability, revenue growth and market share for Alnylam, • Analyze and synthesize information from multiple sources to identify and prioritize business opportunities across the account by applying relevant frameworks and analytical methods, • Work with the Alnylam Leadership Team to co-develop and agree on strategies, programs objectives and KPIs for target regional accounts aligned with organizational and brand priorities and the wider business strategy, • Support the account team with the prioritization of solutions, programs and specific pull-through tactics to ensure sustainable growth and mutual value creation, • Anticipate likely market and customer developments, identify third party influence factors and shape the account strategy accordingly, • Partner with target healthcare systems and organized customers to foster innovation in care through the adoption of Alnylam's products, • Engage senior level stakeholders to influence policies, decisions and perceptions to enable patients to effectively navigate the treatment journey and ensure appropriate use of Alnylam products, • Facilitate the introduction of new products and indications with institutional stakeholders by ensuring adequate budget allocation at the strategic account level, • Leverage a range of strategies and tactics to maximize the level and quality of access for Alnylam products, • Identify programs to partner with the Organized Customer to enhance the system of care and clinical decision making, • Provide insights, education and information about scientific, clinical and technological innovation, • Facilitate strategic partnership with account stakeholders to create mutual value for Alnylam and customers and deliver strategic goals, • Identify and maintain strong relationships with senior business stakeholders (Chief, VP, Director) in target accounts to support access for Alnylam's products across the company portfolio, • Strengthen the perception of Alnylam as a strategic partner by sharing insights and information to support patient identification and improving the delivery of care by establishing treatment pathways and protocols, • Provide clear direction to other field teams to identify and prioritize stakeholders within their target accounts, • Negotiate, review and agree contracts, incorporating solutions to strengthen partnerships with strategic account stakeholders, • Collaborate with other functional and business leaders to ensure adequate Voice of the Customer to inform strategic planning across all stakeholders and channels, • Support the delivery of account goals for National accounts, working closely with the Strategic Accounts Team, • Support the execution and pull through of contracting and initiatives with national organized customers to ensure value maximization, • Measure, report and communicate value delivered for national organized customers in order to strengthen customer partnership, • Share insights gathered through customer engagement Qualifications * • Bachelor's degree, emphasis in Accounting, Marketing, Business Administration or equivalent work experience in business management, ideally complemented by an MBA, • Minimum 7 years of experience in B2B selling in a life sciences environment, • Previous account management experience with health systems and/or hospitals/ IDNs, • High level of confidence and capability to understand and communicate complex scientific concepts to a range of stakeholders, plus executive presence and communication skills to engage with a C-Suite audience, • Expertise and understanding of dynamic market access value models such as value-based propositions and budget impact and cost effectiveness models, etc, • Strong interpersonal skills including written and oral communication skills, ability to synthesize data, interpret and translate into compelling and clear commercial strategies and plans, • Demonstrated ability to successfully mobilize a cross-functional team, including interpersonal skills to foster collaboration and succeed in a highly matrixed environment by leading without direct authority, • Understanding of the IDN environment, including coverage and reimbursement, pricing and contracting, formulary management and health technology assessment, • Strong analytical skills and ability to think critically, challenge conclusions and underlying assumptions, • Ability to synthesize multi-source information (qualitative and quantitative) to develop strategic plans, • Knowledge of value based healthcare and outcome based models, • Executive presence and the ability to interact and negotiate with C-suite customers, • Highly proficient in Microsoft; Excel, Word, and PowerPoint Additional Preferred Experience * • Master's degree: Master of Business Administration (MBA) preferred, • Active membership of relevant pharmaceutical associations would be beneficial #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Scientific Director, Global Medical Affairs - ATTR serves as a global scientific subject matter expert supporting the ATTR franchise, with a primary focus on scientific content generation and written scientific outputs. This role reports to the VP, Medical Affairs, TTR and works in close partnership with Global Medical Leads across ATTR assets (e.g., Vutrisiran, Nucresiran). The role will contribute deep scientific expertise to publications strategy, investigatorinitiated studies (IIS), research collaborations, posthoc analyses, Phase 4 activities, and business development due diligence, with a strong emphasis on handson writing, protocol development, and scientific review. The role supports increasing demand for highquality scientific content and evidence generation across the ATTR franchise and will function as a core internal SME supporting crossfunctional teams. Key Responsibilities Scientific Content Development & Publications • Serve as a scientific SME contributing to global publication strategy, planning, and execution., • Draft, review, and critically edit scientific manuscripts, abstracts, posters, slide decks, and congress materials., • Provide scientific leadership on data interpretation and scientific storytelling, ensuring accuracy, clarity, and alignment with the overall evidence strategy. Evidence Generation • Support development, review, and execution of the integrated evidence generation plan across the ATTR franchise., • Support IIS, Research Collaboration, Phase 4, post-marketing, post-hoc analyses, real-world evidence activities, including scientific review, study and analyses design, feasibility assessment, data interpretation, and ongoing oversight., • Lead protocol development and review across evidence generation activities, with a focus on scientific rigor and relevance. CrossFunctional Scientific Partnership • Collaborate closely with Global Medical Leads, Publications and Scientific Communications, Clinical Research, Regulatory, HEOR, and Commercial partners to ensure alignment and scientific integrity., • Support crossfunctional deep dives led by Value Evidence Strategy teams, synthesizing scientific and clinical data into clear, written outputs., • Provide scientific input into business development and licensing (BD&L) due diligence, including literature reviews, data gap assessments, and scientific risk evaluation., • Contribute to internal briefing documents, scientific summaries, and strategic analyses to inform senior leadership decisionmaking., • Serve as a trusted internal scientific reviewer for medical materials, protocols, and externalfacing scientific content., • Ensure all activities adhere to medical governance, compliance, and ethical standards. Qualifications • PharmD, PhD or MD, • 3-5+ years of relevant experience within the pharmaceutical or biotechnology industry., • Experience in cardiovascular, renal, metabolic, or ATTR disease areas strongly preferred., • Demonstrated primary authorship and substantial contribution to peerreviewed publications., • Strong experience in medical, scientific, and grant writing (e.g., research proposals, manuscripts) and reviewing or developing clinical or postmarketing study protocols., • Prior exposure to BD due diligence or structured scientific evaluations strongly preferred., • Deep interest in and aptitude for written scientific work; this role emphasizes writing over presenting., • Ability to critically analyze data and translate complex science into clear written narratives. U.S. Pay Range $238,800.00 - $323,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Sr. Manager, Clinical Operations is accountable for the end-to-end clinical trial delivery, providing operational leadership and oversight of cross-functional deliverables and leading a cross functional trial team to build and deliver the trial operational plan. This role is responsible for identifying and mitigating risks to effectively deliver assigned trials on time, within budget, and in a compliant manner. Summary of Key Responsibilities • Responsible for leading the Cross functional trial team to influence and execute delivery of the operational plan and for end-to-end trial execution., • Accountable for overall trial delivery, budget, timelines, quality, and milestones (e.g., support DBL/ CSR/ TLR planning and scope, define protocol deviations and resolution pathways)., • Oversight of all aspects of CRO/vendor identification, set up, statement of work creation, budget oversight and performance (KPI's and metrics), • Proactively ensure that trial deliverables and milestones are met according to corporate and study-level goals, • Identify risks and ensure mitigations and contingencies are being initiated and followed through, • Ensure trial Is operationalized in compliance with global health authority regulations and guidelines and internal operating procedures and processes, • ___Participate in preparation for, and conduct of, Health Authority Inspections and internal QA audits, • Ensure that the trial team operates in a constant state of inspection-readiness, collaborating with R&D Quality to ensure quality oversight, • ___Participate in process improvement activities at a trial and department level as needed, • Mentor & support onboarding of new team members, particularly those in Study Management., • Interface with internal key stakeholders including, but not limited to; Finance, Program Management, Vendor Management, Safety, Accounting, Supply, Quality Assurance, Data Management, Statistics, Clinical Research, Commercial, Regulatory, Bio Analytical, Medical Affairs; which may include acting as a liaison between groups., • Provide a variance analysis of budget to actual and notify finance of projected cost over/under expenditure., • Support and provide input into internal governance presentations & updates, • Ability to travel approximately 10% but flexibility to go over or below as per business need). Qualifications • ___BS/ BA degree is required., • Minimum 7+ years of clinical research experience gained with a CRO, Biotech or Pharmaceutical Company working on Phase 1-4 global clinical trials., • 3-5 years leading end to end global clinical trials ___with experience in conducting Phase 3 registrational trials, • ___Experience leading global trials outsourced to a CRO and ability to manage all aspects of execution of a clinical trial, • Excellent decision-making, analytical and financial management skills are essential to this position, • ___Excellent leadership skills, proven ability to foster team productivity and cohesiveness and the ability to operate and execute with limited supervision, • ___Experience in leading without authority and in multifunctional matrixed and global environments, • Experience mentoring/ coaching others, • Exceptional organizational skills and ability to deal with competing priorities, also strong reasoning and problem-solving ability., • ___Strong project planning/ management, communication (written and verbal) and presentation skills $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Manager, Clinical Operations is responsible for the execution of study-level activities including but not limited to creating and updating trial-specific documents, vendor oversight & delivery, compound training and country and regional oversight of CRO operational delivery. This includes alignment on the feasibility strategy, target setting, risk reviews, and country challenges that could impact overall study delivery. Summary of Key Responsibilities • Manage integration of project team activities, leveraging internal and external resources, expertise and knowledge, along with optimizing CRO resources, expertise and knowledge., • Provide input on trial level operational strategies for clinical trials from protocol design to the final clinical study report for specified studies, • Provide input into global subject/patient recruitment plans., • Relationship management between study sites and vendors, • Manage aspects of CRO/vendor identification and the day to day operational management activities of CROs & other vendors including set up, statement of work creation and budget oversight., • Manage strategic study operations including: study sites and tracking systems for regulatory submissions, drug supply and use, enrollment of subjects, regulatory document flow, study timelines, all budgetary and financial information, performance metrics, data flow, etc., • Create and update critical trial-specific documents (for example country specific ICF) and plans, • Support development of compound and protocol level training materials, • Review and provide input into budgets, timelines, and forecasts for assigned clinical studies, • Interface with internal key stakeholders including, but not limited to; Finance, Program Management, Vendor Management, Safety, Accounting, Clinical Supply, Quality Assurance, Data Management, Statistics, Clinical Research, Commercial, Regulatory, Bio Analytical, Medical Affairs; which may include acting as a liaison between groups., • Provide support for inspection readiness activities and on identification of risks and mitigation plans at the trial level, • Participate in process improvement activities at a trial and department level as needed, • Support onboarding of new team members, • Attend CTWG and provide input and updates on operational activities and progress, • BS/ BA Degree is required., • 5+ years of clinical research experience gained with a CRO, Biotech, or Pharmaceutical Company working on Phase 1-4 global clinical trials., • 2-3+ years leading aspects of global clinical trials, • Experience working with a CRO, • Strong regulatory knowledge, including Good Clinical Practices (GCPs), • Strong decision-making, analytical and financial management skills are essential to this position, • Proven ability to foster team productivity and cohesiveness and the ability to operate and execute with limited supervision, • Experience in leading without authority and in multifunctional matrixed and global environments, • Experience mentoring/ coaching others, • Exceptional organizational skills and ability to deal with competing priorities, also strong reasoning and problem-solving ability., • Strong project planning/ management, communication (written and verbal) and presentation skills, • Experience with protocol, ICF, CRF, CSR development and review., • Proficient with MS Office Suite (Excel, Word and PowerPoint) #LI-AL1 #LI-Remote U.S. Pay Range $126,700.00 - $171,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are seeking a strategic, forward-thinking leader to join our team in a newly created Product Planning role. This individual will play a critical role in shaping the long-term commercial vision of our pipeline assets-integrating deep market insight, competitive intelligence, clinical understanding, and patient-centric thinking to inform development strategy and maximize global impact. The ideal candidate thrives at the intersection of science and strategy, brings a strong track record of cross-functional leadership, and is energized by the opportunity to help build innovative medicines from early development through launch readiness. Key Responsibilities • Formulate early commercial strategy and approach for select pipeline programs; Develop target product profiles, serve as commercial voice for the asset in key governance forums, • Provide commercial input and strategic guidance to program teams to inform key business decisions on early-stage clinical programs., • Collaborate cross-functionally to conduct rigorous market assessments on key disease areas to inform preclinical strategic planning., • Understand and communicate requirements for reimbursement and differentiation to ensure successful global commercialization of pipeline assets., • Identify gaps in internal understanding of target diseases and create detailed plans to address gaps through KOL engagement and primary market research., • Bachelor's Degree in Life Sciences or equivalent required, MBA preferred, • Minimum 8 years of experience inclusive of market analytics, new product planning and global brand marketing, • Experience in at least one of ALNY's disease areas of focus (CNS, Hematology, Cardiovascular) preferred, Obesity experience required., • Experience working cross-functionally, including collaboration with and influencing of program development team., • Solid understanding of pharmaceutical development path and ability to identify operational choices that could impact commercialization., • Ability to synthesize findings and clearly articulate implications from multiple sources of information, including primary and secondary market research and data, and formulate strong, supportable recommendations., • Strong analytical skills, including the ability to forecast., • Aptitude for understanding scientific concepts related to research and development., • Strong oral and written communication and presentation skills #LI-ST1 U.S. Pay Range $208,300.00 - $281,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Alnylam is seeking an experienced labeling professional to join our labeling strategy team. This team is responsible for developing initial product label content and strategy through the Target Label Process (TLP). The ideal candidate will possess expertise in drafting label content and leading cross-functional teams within a larger development framework. In this role, you will work closely with labeling operations, compliance teams, and various internal stakeholders. Key Responsibilities • Represent Global Labeling on product-specific Global Regulatory Teams and other cross-functional product, development, and product safety teams as appropriate., • In collaboration with Global Regulatory Leads and Core Labeling Teams (CLTs): create, revise, and maintain Company Core Data Sheets (CCDS) for Alnylam's products., • Develop labeling strategies and Target Label Profiles., • Provide strategic guidance to Core Labeling Teams regarding new and revised labeling regulations, competitor labeling, and labeling trends., • Review and communicate impact of changes in health authority labelling legislation or guidelines on Alnylam's products[KM1.1]., • Lead with development and maintenance of regional labeling that aligns with the CCDS and meets the requirements of health authorities., • Lead with preparation of responses to labeling-related queries from health authorities., • Coordinate labeling activities (e.g., labeling supplements, new labeling development) with internal and external alliance partners as required., • Partner with Regulatory Technology and Operations and Supply Chain to ensure submission-ready labeling components comply with regulatory requirements. Assist with preparation of submissions to health authorities, as needed., • Track data sources supporting labeling claims, history of labeling negotiations and changes, and reasons for differences in local labeling., • Support the growth of the Global Labeling function and help design/build systems and processes. Qualifications • BS/BA degree (science or related discipline preferred), graduate degree desirable., • Professional experience in biopharmaceutical industry in fields of Regulatory Affairs, Pharmacovigilance, and/or Medical Writing/Communications., • Experience in Regulatory Affairs, including at least 2 years' experience in a Labeling role[KM1.1] responsible for developing and drafting prescribing information content., • Familiarity with US, EU and Global regulations, standards and guidance documents related to labeling of pharmaceutical products., • Keep up to date on emerging clinical and other data, product safety, changes in manufacturing, and completion of post-marketing commitments and requirements for Alnylam products that may trigger changes to the CCDS and regional or local labeling.[KM2.1], • Must be detail-oriented and able to multi-task and manage multiple projects. $170,900.00 - $231,300.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Revenue Accounting Manager is part of an accounting team responsible for global oversight of and accounting for collaboration revenue, royalties and milestones. This team is also responsible for commercial revenue accounting for the Americas region, including the US, Canada and Latin America. Reporting to Associate Director, Revenue Accounting, the position will require extensive and effective collaboration with multiple Finance functions and cross-functional teams. Working in a fast-growing company that now has four commercial products and two additional products managed by our partners, this position gives the individual the opportunity to help us scale our Finance team to support future products. This is a hybrid position and will primarily be based in Cambridge, MA. Responsibilities • Maintain revenue models for our active collaboration agreements., • Partner with TOQ and R&D FP&A, Alliances, and Business Development teams, to prepare deliverables for external parties, such as monthly or quarterly outlooks and activity reports., • Maintain the quarterly milestone tracker to account for inbound and outbound milestones with partners., • Prepare invoices to ensure timely billing under collaboration agreements, and coordinate with collaboration partners to establish and support their payment processes to facilitate timely cash collection, • Liaise with Accounts Payable to prepare payment requests and ensure timely payments to external partners., • Execute the monthly product revenue close for Canada and Latin America, including preparing monthly journal entries, account reconciliations, and variance analysis for revenue, gross to net (GTN), and accounts receivable, while ensuring accuracy and adherence to US GAAP. This also includes oversight of external 3PLs as applicable., • Support the Revenue Accounting Team on other areas of the close and special projects, as needed., • Support the Revenue Accounting Team to ensure complete and accurate documentation in accordance with US GAAP and to maintain an effective internal control environment, including the completion of monthly reconciliations in Blackline and SOX control documentation in AuditBoard., • Support the external reporting process, coordinating with the External Reporting Team to ensure timely delivery of key inputs., • Support the technical accounting team in the assessment of new partnerships including, preparation of technical memos and operationalizing of the accounting. Qualifications • Bachelor's degree in Accounting, Finance, or related field, • 4+ years of progressive experience in an accounting environment; public accounting experience and CPA preferred, • Pharmaceutical or biotech industry experience preferred, • Strong knowledge of accounting principles, including GAAP and Sarbanes-Oxley, • Advanced analytical, organizational, and problem-solving skills with a high level of attention to detail and data accuracy, • Proficiency in Microsoft Office, particularly Excel; experience with ERP systems (SAP preferred), • Ability to manage multiple assignments and competing priorities, • Self-motivated, proactive, and adaptable, with the ability to work both independently and collaboratively in a team environment, • Strong interpersonal, verbal, and written communication skills, with the ability to effectively interact with cross-functional teams and all levels of management #LI-MH1 #LI-Hybrid U.S. Pay Range $117,300.00 - $158,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We're transforming our data organization from a traditional portfolio and service delivery model to a technical, engineering-led approach where leaders architect solutions, write code, and drive business value through hands-on contribution. This role is at the epicenter of that transformation. As Senior Director of Enterprise Architecture, you'll own the architecture capability across the enterprise, leading a small team of elite architects while personally contributing to the most challenging technical problems. You'll be accountable for designing and implementing the data platform, integration patterns, and software engineering standards that enable AI/ML capabilities, operational excellence, and pharmaceutical innovation from drug discovery through commercial operations. You'll work in a matrix organization where you own your architecture capabilities and are directly accountable for delivering scalable, reliable, and secure systems that drive measurable business value. This means partnering deeply with R&D, Clinical Operations, Manufacturing, Commercial, and IT to translate complex enterprise requirements into modern technical architectures. Reporting to the VP, Data & AI, this is a Hybrid role based in Cambridge, MA, with a target of 2-3 days onsite. Responsibilities • Own Enterprise Architecture Strategy and Execution: Define and execute enterprise architecture strategy spanning data platforms, integration architecture, cloud infrastructure, and software engineering standards. Architect end-to-end data solutions from ingestion through analytics and AI/ML consumption while establishing architecture standards, design patterns, and governance frameworks for a regulated pharmaceutical environment. Build and drive the technical roadmap aligned with business needs and 2030 transformation goals., • Architect and Build Production Data Platforms: Design and implement production-quality data platforms using modern DataOps and DevOps practices. Write production code (Python, SQL, Infrastructure as Code) for data pipelines, integration services, and platform automation. Design cloud infrastructure on AWS using Terraform/CloudFormation/CDK, build robust data pipelines using Airflow/dbt/Spark/Glue, and implement CI/CD pipelines with automated testing. Personally tackle complex technical challenges in data modeling, performance optimization, and system integration., • Lead and Develop World-Class Architecture Team: Build, mentor, and scale a team of 3-5 highly skilled enterprise architects and technical leads. Balance hands-on technical contribution (20-30% of time) with team leadership and strategic architecture. Provide technical mentorship on architecture patterns, data engineering practices, cloud infrastructure, and pharmaceutical domain knowledge. Foster a culture of engineering excellence and continuous improvement while leading from the front on the hardest technical problems., • Drive Strategic Business Partnership and Value Delivery: Partner with business and technology leaders across R&D, Clinical Operations, Manufacturing, Commercial, and IT totranslate complex requirements into scalable technical architectures. Identify architectural patterns that create the most value, communicate complex technical trade-offs to executive stakeholders, and drive data democratization and engineering best practices across the organization. Build credibility through demonstrated delivery of high-impact architectural solutions., • Establish Modern Data Architecture and Technology Standards: Lead evaluation and adoption of modern data technologies (Snowflake, Databricks, AWS services, modern data stack tools). Design reference architectures for common patterns including data ingestion, transformation, API integration, and event-driven systems. Implement APIs and integration patterns using REST, GraphQL, and event streaming (Kafka/Kinesis). Stay current with architecture trends and translate them into practical implementations that maximize organizational time-to-value., • Ensure Operational Excellence and Architecture Governance: Design for observability, monitoring, and operational resilience. Create architecture governance processes including design reviews, technical standards, and architecture decision records (ADRs). Manage technical debt while rapidly delivering new capabilities. Balance innovation with operational stability, security, and regulatory compliance in a GxP-regulated pharmaceutical environment., • Deliver in Matrix Organization with Collaborative Accountability: Work within the Data, AI and Enterprise Architecture team structure while maintaining accountability for architecture outcomes. Partner with AI/Analytics colleagues to ensure data platforms enable ML/AI capabilities. Collaborate with Data Platform teams on implementation of architecture standards. Coordinate with IT, Security, and Compliance on enterprise-wide initiatives while owning architecture delivery commitments. Qualifications • Bachelor's degree in Computer Science, Engineering, or related technical field; Master's degree preferred, • 10+ years of experience building enterprise data platforms and architectures, with 5+ years in leadership roles, • Expert-level experience with Snowflake (lakehouse implementation, data sharing, governance) and strong experience with Databricks (Delta Lake, Unity Catalog, workflows, ML integration), • Hands-on experience designing and implementing cloud data platforms on AWS (S3, Glue, EMR, Redshift, Kinesis, Lake Formation); AWS Solutions Architect Professional level or equivalent experience, • Highly skilled in Python and SQL with production-quality code standards; strong Infrastructure as Code expertise (Terraform, CloudFormation, or AWS CDK), • Experience implementing CI/CD pipelines (GitHub Actions, CircleCI, Jenkins, GitLab CI) and hands-on experience with containerization (Docker) and orchestration (Kubernetes, ECS), • Experience with data pipeline tools (Airflow, Prefect, dbt, or similar), API design patterns, microservices architecture, and event-driven systems, • Experience designing integration architectures for enterprise systems (SAP, Oracle, Workday, Salesforce, Veeva, or similar), • 5+ years leading architecture and engineering teams, including hands-on technical mentorship; proven ability to build and develop high-performing teams of 3-10 people, • Experience working in matrix organizations with cross-functional collaboration across AI/ML, data engineering, security, and IT infrastructure teams, • Demonstrated ability to translate complex business requirements into scalable technical solutions and communicate architecture decisions to executive audiences, • Experience operating in regulated environments (FDA, EMA, GxP requirements) Preferred: • Biotech, pharmaceutical, or life sciences industry experience, • Deep knowledge of architecture patterns in Clinical Development (EDC systems, CTMS, eTMF), Manufacturing (MES, LIMS, batch systems), Research (lab systems, genomic data platforms), or Commercial (CRM, marketing analytics, supply chain), • Understanding of pharmaceutical data types and systems including clinical trials, genomics, manufacturing, quality, and supply chain, • Expertise in modern data architecture concepts: data lakes, lakehouses, data mesh, streaming architectures, semantic layers, data virtualization, • Knowledge of data modeling approaches including dimensional modeling, Data Vault, normalized designs, and graph databases, • Experience with monitoring and observability tools (CloudWatch, Datadog, New Relic) and understanding of distributed systems and performance optimization #LI-Hybrid #LI-LN1 U.S. Pay Range $255,000.00 - $345,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Associate Director, GxP Audits and Inspection Excellence, serves as the lead for Alnylam's enterprise audit and inspection program, providing direction, governance, and oversight across all GxP domains. This role is responsible for establishing a unified, risk-based and inspection-ready framework that ensures consistent audit execution, proactive readiness, and transparent Quality oversight aligned with global regulatory expectations. The Associate Director, reporting to the Head of Audits, Inspection Excellence and QMS (AIQ), leads and directly manages the GxP Audit and Inspection Excellence team. They partner closely with R&D QA, PV QA, Quality Operations, Manufacturing and Technical Operations, Supply Chain, and Quality Technology & Analytics. This role drives standardization, improves inspection transparency, develops advanced audit capabilities, and ensures the organization is prepared for evolving global regulatory scrutiny. This is a hybrid position and will primarily be located in Cambridge, MA Key Responsibilities • Serve as the lead for GxP Audits & Inspection Excellence, providing strategic direction, governance, and oversight across all audit and inspection activities., • Lead development and execution of the enterprise risk-based audit strategy, consolidating the GxP audit universe and ensuring consistency across internal and external audits., • Oversee global inspection readiness programs, including readiness strategies, cross-functional preparation, and standardized inspection management processes., • Ensure consistent global management of regulatory inspections, including documentation readiness, backroom operations, evidence management, and communication pathways., • Govern post inspection activities, including response quality, commitment tracking, timeliness, and systemic issue identification., • Provide leadership and oversight of audit and inspection tools, systems, and dashboards, ensuring data integrity, transparency, and strategic insight., • Partner cross functionally to integrate audit and inspection findings into QMS processes, Quality Risk Management, and enterprise reporting., • Champion continuous improvement of audit and inspection procedures, templates, guidance, and training materials., • Oversee operational delivery of audits and inspections through management of the GxP Inspection Oversight & Audit Management team., • Ensure robust CAPA tracking and effectiveness evaluation following audits and inspections., • Provide senior level reporting, insights, and trend analysis to Quality leadership and governance forums., • Drive organizational alignment, competency development, and a culture of proactive inspection readiness across all GxP areas. Qualifications • Bachelor's degree in Life Sciences, Pharmacy, Engineering, or related field; advanced degree preferred., • 10 years of experience in pharmaceutical/biotechnology Quality Assurance with significant focus on GxP audits, regulatory inspections, and quality systems., • Demonstrated leadership of enterprise or multi-GxP audit programs, including risk based planning, supplier oversight, and global audit execution., • Strong understanding of global regulatory frameworks and inspection expectations (e.g., FDA, EMA, MHRA, ICH, PIC/S)., • Proven experience developing and maturing inspection readiness programs and leading cross functional teams through inspections., • Proficiency with electronic audit and inspection management systems and QMS platforms (e.g., Veeva, ReadyRoom, eQMS)., • Strong communication, facilitation, and stakeholder management skills with the ability to influence without direct authority., • Demonstrated ability to lead, mentor, and develop team members, promoting high performance and continuous improvement., • Ability to operate effectively in a dynamic, fast paced, and highly cross functional environment., • Ability to travel domestically and internationally up to approximately 20%. #LI-LJ1 #LI-Hybrid U.S. Pay Range $164,500.00 - $222,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Reporting to the Senior Director, U.S. Channel Distribution, Alnylam seeks an experienced and focused individual to manage processes and procedures, and act with a strategic mind-set in all aspects of optimizing the distribution strategies to provide optimal access for all patients. This individual is crucial in developing and executing integrated, evidence-based strategies and initiatives for assigned channel and distribution projects, ensuring consistency and compliance. This Associate Director will also lead strategic initiatives and projects, including vendor oversight, prioritization, and delivery of solutions that support business and future product launch objectives. This strategic contributor will have the opportunity to drive channel specific strategies, collaborating with internal partners and external vendors to support successful product launches and ongoing projects. The Associate Director must be effective in enhancing internal resources, including onboarding and training of new team members, and development of tools, processes, and best practices. The successful candidate must be passionate about science and deeply motivated by the quest of delivering value to patients and their families with the long-term success of the company in mind. Key Responsibilities • Ensure the effective operations of the US distribution network so that product flows from 3PL to customer, safely and reliably, • Ensure effective communication between Alnylam and external supply chain partners, • Troubleshoot issues, optimize daily operations, and support day-to-day business needs, • Develop, govern, and maintain SOPs, Working Instructions, and Channel Policies to leverage efficiencies and drive collaboration, while ensuring clarity, consistency, and compliance, • Develop and oversee new processes and workflow mappings, • Serve as the primary escalation point for field-identified channel and distribution issues, coordinating crossfunctional resolution strategies and driving timely and successful outcomes, • Support contractual and operational performance of our Specialty Distribution and Specialty Pharmacy partners, including Days on Hand targets, KPI monitoring, and continuous optimization of channel execution, • Partner closely with crossfunctional teams, including Payer, Field Reimbursement, Patient Services, Analytics, Legal, Supply Chain, Compliance, Field Sales, and Strategic Accounts, to align strategy, manage escalations, and deliver solutions, • Assess and track market and operational trends to inform proactive decision making, continuous improvement, and strategic and tactical planning, • Manage RFP process, as appropriate, • Liaise with Serialization Team to resolve DSCSA exceptions, • Lead Product Training / Global Safety Training / Disease State Training for channel partners, • Ensure compliance with all corporate policies and industry codes, in collaboration with Alnylam Legal, Regulatory and Compliance, • Enhance knowledge of current industry trends and anticipate future changes Required Qualifications • Pharmaceutical/biotech experience required, • Minimum of 10 years industry experience, including SOP development, process mapping, contract analysis, pharma trending analytics, KPI management, • Expertise in supply chain management including 3PLs, Specialty Distributors, Specialty Pharmacies and other customers, • Undergraduate degree required, • Strong leader with proven abilities to influence and create cross-functional alignment, • Demonstrated ability to assimilate and present complex information to higher level management and contribute to high-level discussions, • Ability to thrive in a fast-paced, high-profile environment, • Strong collaboration skills with the demonstrated ability to gather key stakeholder feedback and gain leadership alignment, • Ability to lead without authority, • Exceptional communication skills, both verbal and written, • Ability to produce board-ready presentation material, • Demonstrates strategic-thinking, problem-solving and decision-making skillsets, • Ability to travel up to 30% Preferred Qualifications: • Industry experience in Specialty Products, • Experience with supply chain management for rare disease medicines preferred, • Buy and Bill experience preferred Expectations • Clear Alignment with Alnylam Core Values:, • Commitment to People, • Innovation and Discovery, • Purposeful Urgency, • Open Culture, • Passion for Excellence, • The Associate Director, Channel Strategy and Operations will demonstrate effective self-starter and strategic planning skillsets, • Demonstrates ability to build relationships and influence colleagues across multiple functions and divisions Key Skills, Abilities and Competencies • Distribution Channel Dynamics:Knowledge of US pharmaceutical channel dynamics, data analytics and reimbursement environment, • Influence and Leadership:Influences without formal authority, able to integrate resources to achieve strategic objectives, and build/maintain strong relationships. Ability to establish close collaboration with strategic partners; able to inspire and align a diverse organization., • Business Acumen:Understanding of business analytics, possession of effective communication skills, and strong leadership skills, • Work Style:Works collaboratively across expertise areas and functions; seeks to advance higher goals; highly regarded across stakeholders both at senior and junior levels; inspires trust at all levels About Alnylam Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002,Alnylamhas led theRNAi Revolutionand continues to turn scientific possibility into reality. Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we have been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2022, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2023 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law. Alnylam is an E-Verify employer. #LI-KB2 #LI-Remote U.S. Pay Range $168,300.00 - $227,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for an experienced Regional Business Director (RBDs to support the promotion of AMVUTTRA (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA (vutrisiran). The approval expands the indication for AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults. The RBD will be principally responsible for leading and managing a high-performing team of Business Account Executives, focusing on disease awareness and product education among healthcare professionals managing hATTR amyloidosis patients. This is an incredible opportunity to build a team and shape a market in support of patients, caregivers, and the hATTR amyloidosis community. The RBD will provide coaching to help ensure every BAE meets or exceeds target. He/she will be critical in the assessment and improvement of field and selling processes. RBDs will also need to provide insights to inform commercial strategy, given their proximity to the market, and ultimately meet and exceed performance targets. The RBD will also need to embody Alnylam values: our commitment to people, sense of purposeful urgency, passion for excellence, innovation & discovery, and open culture as well as our unwavering commitment to integrity. Additionally, an RBD will be responsible for the creation of a customer-oriented climate that focuses on an understanding of patient and customer needs, value-added services, and seamless execution. Through the building of best-in-class teams, talent development, and regular monitoring and coaching, the RBD will foster a culture of accountability. The position reports to the Executive Sales Lead role. Key Responsibilities • Lead and manage a high-performing team of Business Account Executives, focusing on disease awareness, product education among healthcare professionals managing hATTR amyloidosis patients, • Utilize strong sales management, strategic planning skills, financial acumen, and analytical capabilities to align sales execution with overarching product strategies and market needs., • Analyze market and proactively develop a forward-thinking action plan, rather than solely reacting to past events. Capable of clearly conveying the current market situation and proposed plan of action to leadership, while also ensuring the team is aligned to future objectives and expectations., • Coach and develop team members to exceed performance targets, emphasizing compliance and effective local business management through strategic business planning and cross-functional alignment., • Leverage proximity and familiarity of their market to provide insights that help inform the commercial strategy., • Attract, manage, and retain top sales talent with a demonstrated experience in diverse specialties., • Hold the team accountable to sustaining a customer-oriented culture that prioritizes understanding and meeting patient needs, delivering seamless execution and value-added services., • Allocate and manage regional resources effectively that support targeted strategic and operational excellence., • Align people, processes, structure, information, and communication systems within a complex ecosystem - both within and across functions., • Inspire and motivate the team by clearly articulating the strategy and vision for the future. Qualifications • Bachelor's degree required: science focus strongly preferred; MBA/PhD is a plus., • 7+ years in sales, marketing, commercial operations, and/or account management experience in commercial healthcare organizations (i.e., Biotech, Med Device or Specialty Pharmaceuticals)., • 3+ years of experience in leading teams, experience building out field sales teams preferred, • Rare/orphan disease experience preferred., • Experience training and managing BAEs to effectively promote multiple specialties., • US product launch experience is helpful., • In-depth reimbursement knowledge of Buy/Bill and expertise of Part B & D, working with in-house patient support services team required., • Hospital / Institution knowledge and expertise with the P&T process., • Deep experience in Neurology and Cardiology is preferred., • Knowledge and experience with "site-of-care" development., • Experience in working in various departments, managing multiple teams (sales, marketing, market access, patient services)., • Demonstrated leadership in working in a matrix environment and influencing management decisions., • Effective planning, prioritization, management, and organizational skills., • Must be familiar with relevant legal and regulatory environments in biotech/pharmaceutical industry., • Significant domestic/regional travel is required (approximately 60 - 70%)., • Valid Driver's license required., • Demonstrated commitment to ethics and integrity. #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Strategic Account Lead (SAL) roleleads strategic engagement and contracting with target key accounts in order to drive growth, revenue, and joint value creation for Alnylam and the customer by enabling and optimizingaccess toAlnylam products and driving innovation for patients and health care providers. Key Responsibilities The Strategic Account Lead (SAL) will provide innovative, influential account engagement to shape and deliver the strategy for Alnylam Strategic Accounts in order to achieve access, create value and deliver profitable growth for Alnylam. • Lead the development and execution of the comprehensive account strategy for target accounts to bring the best of Alnylam to the customer and to maximize profitability, revenue growth and market share for Alnylam, • Analyze and synthesize information from multiple sources to identify and prioritize business opportunities across the account by applying relevant frameworks and analytical methods, • Work with the Alnylam Leadership Team to co-develop and agree on strategies, programs objectives and KPIs for target regional accounts aligned with organizational and brand priorities and the wider business strategy, • Support the account team with the prioritization of solutions, programs and specific pull-through tactics to ensure sustainable growth and mutual value creation, • Anticipate likely market and customer developments, identify third party influence factors and shape the account strategy accordingly, • Partner with target healthcare systems and organized customers to foster innovation in care through the adoption of Alnylam's products, • Engage senior level stakeholders to influence policies, decisions and perceptions to enable patients to effectively navigate the treatment journey and ensure appropriate use of Alnylam products, • Facilitate the introduction of new products and indications with institutional stakeholders by ensuring adequate budget allocation at the strategic account level, • Leverage a range of strategies and tactics to maximize the level and quality of access for Alnylam products, • Identify programs to partner with the Organized Customer to enhance the system of care and clinical decision making, • Provide insights, education and information about scientific, clinical and technological innovation, • Facilitate strategic partnership with account stakeholders to create mutual value for Alnylam and customers and deliver strategic goals, • Identify and maintain strong relationships with senior business stakeholders (Chief, VP, Director) in target accounts to support access for Alnylam's products across the company portfolio, • Strengthen the perception of Alnylam as a strategic partner by sharing insights and information to support patient identification and improving the delivery of care by establishing treatment pathways and protocols, • Provide clear direction to other field teams to identify and prioritize stakeholders within their target accounts, • Negotiate, review and agree contracts, incorporating solutions to strengthen partnerships with strategic account stakeholders, • Collaborate with other functional and business leaders to ensure adequate Voice of the Customer to inform strategic planning across all stakeholders and channels, • Support the delivery of account goals for National accounts, working closely with the Strategic Accounts Team, • Support the execution and pull through of contracting and initiatives with national organized customers to ensure value maximization, • Measure, report and communicate value delivered for national organized customers in order to strengthen customer partnership, • Share insights gathered through customer engagement Qualifications * • Bachelor's degree, emphasis in Accounting, Marketing, Business Administration or equivalent work experience in business management, ideally complemented by an MBA, • Minimum 7 years of experience in B2B selling in a life sciences environment, • Previous account management experience with health systems and/or hospitals/ IDNs, • High level of confidence and capability to understand and communicate complex scientific concepts to a range of stakeholders, plus executive presence and communication skills to engage with a C-Suite audience, • Expertise and understanding of dynamic market access value models such as value-based propositions and budget impact and cost effectiveness models, etc, • Strong interpersonal skills including written and oral communication skills, ability to synthesize data, interpret and translate into compelling and clear commercial strategies and plans, • Demonstrated ability to successfully mobilize a cross-functional team, including interpersonal skills to foster collaboration and succeed in a highly matrixed environment by leading without direct authority, • Understanding of the IDN environment, including coverage and reimbursement, pricing and contracting, formulary management and health technology assessment, • Strong analytical skills and ability to think critically, challenge conclusions and underlying assumptions, • Ability to synthesize multi-source information (qualitative and quantitative) to develop strategic plans, • Knowledge of value based healthcare and outcome based models, • Executive presence and the ability to interact and negotiate with C-suite customers, • Highly proficient in Microsoft; Excel, Word, and PowerPoint Additional Preferred Experience * • Master's degree: Master of Business Administration (MBA) preferred, • Active membership of relevant pharmaceutical associations would be beneficial #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Director, Head of Global Trade Compliance and Strategy is a key supply chain leader responsible for designing, implementing, and overseeing the company's global trade compliance program while shaping trade-related strategy to support growth, resilience, and innovation. This role ensures full compliance with international trade regulations while enabling efficient, ethical, and scalable global operations across R&D, manufacturing, and commercial activities. This role will set the global trade policy and strategy direction, drive proactive regulatory engagement, and partner with senior and executive leadership across Supply Chain, Commercial, Legal, Finance, Tax, Regulatory, and Quality to align trade compliance strategies with business growth. The Director will lead a team of Trade Compliance professionals who represent Alnylam with relevant regulatory authorities, ensuring the company's operations meet all applicable import, export, customs, and sanctions regulations. Key Responsibilities Global Trade Compliance Program Leadership • Own and continuously enhance Alnylam's global trade compliance framework, including import/export policies, standards, and procedures aligned with U.S. CBP, OFAC, DEA, FDA, and relevant international agencies and programs (EU, UK, JP, etc)., • Maintain the governance model for global trade compliance, including oversight of risk assessment, monitoring, and executive-level reporting., • Ensure robust internal controls for classification, valuation, licensing, and documentation are in place across R&D, clinical, and commercial supply chains., • Partner with senior leaders across Global Supply Chain, Manufacturing, Tax, and Finance to embed compliance strategy into network design, sourcing, and product launch plans., • Collaborate with Legal, Policy, and Compliance teams to influence Alnylam's positions on global trade and regulatory policy., • Analyze and implement tariff mitigation and duty optimization strategies, including First Sale for Export, duty drawback, and Foreign Trade Zones (FTZs), to enhance supply chain efficiency and reduce costs., • Monitor international regulatory and geopolitical developments; Advise senior leadership regularly, providing strategic insights, business impacts, risk assessments, and recommendations that shape enterprise-level decision-making., • Establish KPIs to measure compliance performance, identify emerging risk, and drive continuous improvement across the team., • Support due diligence, onboarding, and qualification requirements for Logistics Service Providers (LSPs) as it relates to Trade Compliance, including compliance certifications, internal controls, and screening capabilities., • Lead and develop a global team of trade compliance professionals and regional specialists., • Build organizational capability through targeted training, knowledge sharing, and cross-functional engagement., • Partner with IT and Logistics to enable process deployment for global trade compliance operations, including supporting systems (i.e. SAP)., • Lead global process harmonization, technology enablement such as global trade management systems, and benchmarking initiatives to enhance program efficiency and scalability. Qualifications • Bachelor's degree with extensive related experience required; Master's or law degree is desirable., • Minimum 10 years of experience in international trade compliance, including 5+ years leading global operations in a regulated industry (pharmaceutical, biotech, or life sciences preferred)., • Deep expertise in U.S. import/export regulations (CBP, EAR, OFAC, FDA, DEA) and global trade frameworks (EU, UK, APAC)., • Experience in customs valuation planning, especially in supply and value chains involving IP, intercompany transactions, and other complex commercial arrangements like license and royalty agreements., • Previous collaboration with Tax, Legal, and accounting, finance groups to manage customs valuation planning is a plus, as is experience managing customs valuation for non-commercial goods (ex. clinical trial materials, research samples, unsold WIP)., • Proven success engaging with regulators and government agencies to shape or influence trade compliance policy outcomes., • Demonstrated ability to brief, influence, and align senior leaders on complex regulatory and risk management topics., • Licensed Customs Broker (LCB) certification is desirable. $192,400.00 - $260,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Description Managing Director, Commercial AdvisoryYou're driven, resourceful, and above all else - remarkably smart. You thrive on solving complex problems, inspiring teams, and helping clients bring innovative therapies to patients faster. You're as comfortable crafting strategy as you are leading the charge to deliver impact - and you know that commercial success follows exceptional client partnerships.The OpportunityAs a Managing Director within our Commercial Advisory Consulting Group, you will be a key growth leader driving the next chapter of our consulting business. This role is ideal for a strategic thinker with entrepreneurial energy to expand client relationships, lead large-scale engagements, and generate $3M+ in new consulting revenue annually through high impact, trusted advisory work.You'll shape the future of how life sciences organizations launch, grow, and optimize their portfolios - blending scientific rigor with commercial insight to create measurable value for clients across the pharmaceutical and biotech ecosystem.What You'll Do • Drive Growth: Lead business development across key accounts and new prospects; consistently deliver $3M+ in new consulting revenue annually through consultative selling and relationship-based growth., • Build and Lead: Develop and mentor consulting teams while setting a high-performance culture centered on client excellence, innovation, and measurable outcomes., • Deliver Impact: Oversee the design and execution of projects that shape launch strategies, portfolio optimization, and go-to-market models - ensuring quality, timeliness, and profitability., • Collaborate and Scale: Partner with senior leadership to define market strategy, service expansion priorities, and operational best practices to support the group's continued growth., • Inspire Trust: Serve as a senior advisor to executives within top global pharmaceutical and biotech organizations, cultivating long-term, strategic partnerships that elevate the firm's brand and reach.What You Bring, • Education: MBA or graduate degree in Life Sciences, Business, or a related discipline., • Experience: 10+ years of leadership in life sciences consulting, with proven success in commercial strategy, product launch, and portfolio optimization., • Sales Leadership: Demonstrated ability to originate and close complex consulting engagements, achieving $3M+ in new annual sales and managing a large, profitable book of business., • Thought Leadership: Recognized authority in marketing strategy, product valuation, market access, and commercialization, with an established industry network and strong executive presence. At Syneos Health, we are dedicated to building a diverse, inclusive and authentic workplace. If your past experience doesn't align perfectly, we encourage you to apply anyway. At times, we will consider transferable skills from previous roles. We also encourage you to join our ___ to stay connected to additional career opportunities. Why Syneos Health? Here, you're a part of the big picture. You will collaborate with colleagues across clinical and commercial disciplines to guide premarket development through post-market commercial strategy. Every project is a chance to solve a new challenge, learn from your colleagues, and advance your career. The diversification and breadth of our new and existing partnerships create a multitude of career paths and employment opportunities. Join our game-changing, global company dedicated to creating better, smarter, faster ways to get biopharmaceutical therapies to patients. Experience the thrill of knowing that your everyday efforts are contributing to improving patients' lives around the world. Work Here Matters Everywhere | How are you inspired to change lives? Syneos Health companies are affirmative action/equal opportunity employers (Minorities/Females/Veterans/Disabled) Syneos Health has a voluntary COVID-19 vaccination policy. We strongly encourage all employees to be fully vaccinated. Additionally, certain local governments or Syneos Health customers may have vaccine requirements that apply to some of our employees. These employees are required to submit proof of vaccination to Syneos Health and maintain compliance with these requirements. At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position will include a competitive compensation package, Health benefits to include Medical, Dental and Vision, Company match 401k, flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos Health complies with all applicable federal, state, and municipal paid sick time requirements. #LI-DR1 #LI-ComOps

Description You have what it takes: a competitive drive coupled with exceptional sales ability. In this role you will meet and/or exceed sales performance objectives in an assigned territory by developing, implementing, and executing an integrated territory business plan encompassing key specialty customer targets and accounts. • Apply scientific knowledge, business acumen, and customer engagement expertise to specialty providers in support of existing biologics portfolio., • Understand the reimbursement/distribution landscape for specialty customers and identify the appropriate resources to refer customers to appropriate resources for reimbursement and pull-through., • Analyze sales data and develop territory business plans and tactics to consistently grow business., • BA/BS degree, • 5+ years pharmaceutical or medical device experience required, • 2+ years of account-based sales experience with preference in the allergy/respiratory or biologics space., • Understanding of Buy & Bill and Specialty Pharmacy distribution modalities preferred., • Planning and organization skills, analytical ability, business acumen, decision making ability, and problem-solving skills., • Ability to influence and collaborate cross-functionally in a matrixed environment. Why Syneos Health? Here, the work is challenging, and the pace is exhilarating. By joining one of our commercial teams, you're empowered to succeed with the support, resources, and autonomy that you need. The diversification and breadth of our new and existing partnerships create a multitude of career paths and employment opportunities. Syneos Health has launched more sales teams in the last 5 years across all major therapeutic areas than the top 25 pharma companies combined. Join our game-changing, global company dedicated to creating better, smarter, faster ways to get biopharmaceutical therapies to patients. Experience the thrill of knowing that your everyday efforts are contributing to improving patients' lives around the world. Work Here Matters Everywhere | How are you inspired to change lives? Syneos Health companies are affirmative action/equal opportunity employers (Minorities/Females/Veterans/Disabled) Syneos Health has a voluntary COVID-19 vaccination policy. We strongly encourage all employees to be fully vaccinated. Additionally, certain local governments or Syneos Health customers may have vaccine requirements that apply to some of our employees. These employees are required to submit proof of vaccination to Syneos Health and maintain compliance with these requirements. At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position will include a competitive compensation package, Health benefits to include Medical, Dental and Vision, Company match 401k, flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos Health complies with all applicable federal, state, and municipal paid sick time requirements. 400003075

< Overview The Senior Manager, US Commercial Training & Development - TTR Franchise reports to the Associate Director. This role involves developing and implementing capability building strategies, plans and processes that drive measurable field performance and business outcomes within the TTR franchise. The Training Manager will collaborate cross-functionally in a matrix organization with commercial leadership, field force, marketing, access, headquarters teams, medical, legal, and external vendors. This collaboration will involve facilitating group discussions to determine the training needs and deliverables for US commercial team members. Key Responsibilities • Support the design and execution of capability-building strategies that align to TTR Franchise business priorities and drive measurable field performance outcomes, • Translate business goals into targeted learning strategies and solutions that enhance field effectiveness across the customer journey, • Partner with Commercial Leadership and cross-functional stakeholders (Marketing, Market Access, Medical, Patient Services, and Operations) to identify performance gaps and define capability needs, • Act as a trusted advisor, contributing to decisions related to field execution, capability development, and training strategy, • Design and deliver high-impact learning experiences (live, virtual, and digital) that prioritize application, practice, and behavior change over knowledge transfer, • Ensure learning solutions are scalable, efficient, and minimize time out of territory while maximizing impact, • Manage the development and execution of new hire onboarding and continuous learning programs, ensuring readiness, confidence, and sustained performance in role, • Contribute to building just-in-time learning approaches that support ongoing development and field application, • Support and operationalize the Field Trainer model, enabling Field Trainers to operate as an extension of the CT&D team through strong facilitation, coaching, and in-field execution, • Provide guidance, tools, and support to ensure consistent, high-quality delivery of learning initiatives, • Leverage data, insights, and field feedback to assess capability gaps, measure training effectiveness, and recommend improvements to learning strategies, • Track and report on key performance indicators (KPIs) to demonstrate the impact of training on behavior change and business outcomes, • Design, develop, and deploy learning materials and assets, ensuring alignment with brand strategy, clinical accuracy, and compliance requirements, • Manage the CRB submission process and ensure all training materials meet legal, regulatory, and medical standards, • Apply innovative learning approaches and technologies (e.g., simulations, AI-enabled tools, digital platforms) to enhance engagement, retention, and scalability, • Manage multiple learning initiatives and projects simultaneously, ensuring strong execution, clear communication, and alignment across stakeholders, • Collaborate with cross-functional teams to support National Sales Meetings (NSM), POA meetings, and other key field engagements, ensuring learning is impactful and aligned to business priorities, • Manage vendor relationships and project deliverables, ensuring high-quality, cost-effective execution of learning solutions, • Demonstrate a strong understanding of commercial strategy, sales operations, and field tools, ensuring training solutions are practical, relevant, and aligned to how the field operates Qualifications • Bachelor's degree required, • Must have a minimum of 5 years of experience in the Pharmaceutical Industry, Commercial field sales experience preferred, • Preferred to have a minimum of 2 years training experience in a headquarters role or as a field trainer, • Proven ability to translate business strategy into capability-building plans that drive measurable outcomes, • Demonstrated experience supporting product launches, complex therapeutic areas, or specialty markets preferred, • Strong understanding of clinical data and the ability to translate scientific concepts into clear, compelling learning experiences, • Demonstrated ability to influence cross-functional stakeholders and senior leaders in a highly matrixed environment, • Strong executive presence with the ability to facilitate both strategic discussions and engaging learning experiences, • Experience using data, insights, and performance metrics to identify capability gaps and measure training effectiveness and business impact, • Strong foundation in adult learning principles, instructional design, and modern learning approaches, including digital, virtual, and just-in-time learning, • Experience leveraging innovative learning solutions (e.g., simulations, AI-enabled tools, scalable learning platforms) preferred, • Excellent project management skills with the ability to manage multiple priorities, workstreams, and deadlines in a fast-paced environment, • Strong written and verbal communication skills, including presentation and facilitation excellence, • Ability to build trusted relationships and collaborate effectively across all levels of the organization, • Proficiency in Microsoft Office (PowerPoint, Excel, Word) and virtual learning platforms (e.g., Zoom or similar), • Ability to travel up to 20% #LI-SS1 #LI-Remote U.S. Pay Range $147,100.00 - $198,900.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: We are seeking a strategic, forward-thinking leader to join our team in a newly created role that is accountable for conducting assessment of both internal and external asset opportunities. This individual will be accountable to integrate deep market insight, competitive intelligence, clinical understanding, and patient-centric thinking to inform development strategies and maximize global impact. This individual will also support our BD team in evaluating external opportunities as Alnylam looks to supplement internal innovation with external opportunities. This role will report to the VP of Early Commercial Strategy. The ideal candidate thrives at the intersection of science and strategy, brings a strong track record of cross-functional engagement, and is energized by the opportunity to help build innovative medicines from early development through launch readiness. The candidate is required to have strong interpersonal skills as this role will work with a variety of stakeholders across all levels of the organization. Key Responsibilities: • Market Research & Analysis:Conduct in-depth research on market trends, competitor activity, and potential new business segments to identify growth opportunities. Inform the development of forecast assumptions for financial models., • Formulate early commercial strategy and approach for select pipeline programs; Develop target product profiles, serve as commercial voice for the asset in key governance forums., • Provide commercial input and strategic guidance to program teams to inform key business decisions on early-stage clinical programs., • Collaborate cross-functionally to conduct rigorous market assessments on key disease areas to inform preclinical strategic planning., • Understand and communicate requirements for reimbursement and differentiation to ensure successful global commercialization of pipeline assets., • Identify gaps in internal understanding of target diseases and create detailed plans to address gaps through KOL engagement and primary market research. Qualifications: • Bachelor's Degree in Life Sciences or equivalent required, MBA preferred, • Minimum 8 years' experience inclusive of market analytics, new product planning and global brand marketing, • Ability to navigate across multiple disease areas. Experience in CNS, Cardiovascular, Hematology, or Metabolic therapeutic areas preferred, • Demonstrated experience collaborating cross-functionally and influencing program development teams., • Strong understanding of pharmaceutical development path and ability to identify operational choices that could impact commercialization., • Ability to synthesize insights multiple data sources (e.g. primary and secondary market research and data) and translate into strong, well-supported recommendations., • Strong analytical and forecasting capabilities., • Aptitude for understanding scientific concepts related to research and development., • Excellent communication and presentation skills, both written and oral. U.S. Pay Range $208,300.00 - $281,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Strategic Account Lead (SAL) roleleads strategic engagement and contracting with target key accounts in order to drive growth, revenue, and joint value creation for Alnylam and the customer by enabling and optimizingaccess toAlnylam products and driving innovation for patients and health care providers. Key Responsibilities The Strategic Account Lead (SAL) will provide innovative, influential account engagement to shape and deliver the strategy for Alnylam Strategic Accounts in order to achieve access, create value and deliver profitable growth for Alnylam. • Lead the development and execution of the comprehensive account strategy for target accounts to bring the best of Alnylam to the customer and to maximize profitability, revenue growth and market share for Alnylam, • Analyze and synthesize information from multiple sources to identify and prioritize business opportunities across the account by applying relevant frameworks and analytical methods, • Work with the Alnylam Leadership Team to co-develop and agree on strategies, programs objectives and KPIs for target regional accounts aligned with organizational and brand priorities and the wider business strategy, • Support the account team with the prioritization of solutions, programs and specific pull-through tactics to ensure sustainable growth and mutual value creation, • Anticipate likely market and customer developments, identify third party influence factors and shape the account strategy accordingly, • Partner with target healthcare systems and organized customers to foster innovation in care through the adoption of Alnylam's products, • Engage senior level stakeholders to influence policies, decisions and perceptions to enable patients to effectively navigate the treatment journey and ensure appropriate use of Alnylam products, • Facilitate the introduction of new products and indications with institutional stakeholders by ensuring adequate budget allocation at the strategic account level, • Leverage a range of strategies and tactics to maximize the level and quality of access for Alnylam products, • Identify programs to partner with the Organized Customer to enhance the system of care and clinical decision making, • Provide insights, education and information about scientific, clinical and technological innovation, • Facilitate strategic partnership with account stakeholders to create mutual value for Alnylam and customers and deliver strategic goals, • Identify and maintain strong relationships with senior business stakeholders (Chief, VP, Director) in target accounts to support access for Alnylam's products across the company portfolio, • Strengthen the perception of Alnylam as a strategic partner by sharing insights and information to support patient identification and improving the delivery of care by establishing treatment pathways and protocols, • Provide clear direction to other field teams to identify and prioritize stakeholders within their target accounts, • Negotiate, review and agree contracts, incorporating solutions to strengthen partnerships with strategic account stakeholders, • Collaborate with other functional and business leaders to ensure adequate Voice of the Customer to inform strategic planning across all stakeholders and channels, • Support the delivery of account goals for National accounts, working closely with the Strategic Accounts Team, • Support the execution and pull through of contracting and initiatives with national organized customers to ensure value maximization, • Measure, report and communicate value delivered for national organized customers in order to strengthen customer partnership, • Share insights gathered through customer engagement Qualifications * • Bachelor's degree, emphasis in Accounting, Marketing, Business Administration or equivalent work experience in business management, ideally complemented by an MBA, • Minimum 7 years of experience in B2B selling in a life sciences environment, • Previous account management experience with health systems and/or hospitals/ IDNs, • High level of confidence and capability to understand and communicate complex scientific concepts to a range of stakeholders, plus executive presence and communication skills to engage with a C-Suite audience, • Expertise and understanding of dynamic market access value models such as value-based propositions and budget impact and cost effectiveness models, etc, • Strong interpersonal skills including written and oral communication skills, ability to synthesize data, interpret and translate into compelling and clear commercial strategies and plans, • Demonstrated ability to successfully mobilize a cross-functional team, including interpersonal skills to foster collaboration and succeed in a highly matrixed environment by leading without direct authority, • Understanding of the IDN environment, including coverage and reimbursement, pricing and contracting, formulary management and health technology assessment, • Strong analytical skills and ability to think critically, challenge conclusions and underlying assumptions, • Ability to synthesize multi-source information (qualitative and quantitative) to develop strategic plans, • Knowledge of value based healthcare and outcome based models, • Executive presence and the ability to interact and negotiate with C-suite customers, • Highly proficient in Microsoft; Excel, Word, and PowerPoint Additional Preferred Experience * • Master's degree: Master of Business Administration (MBA) preferred, • Active membership of relevant pharmaceutical associations would be beneficial #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai's human health care (hhc) mission. We're a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer's disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you. The Medical Science Liaison (MSL or Sr. MSL) is a field-facing representative of US Medical Affairs with a primary responsibility of engaging in the exchange of scientific data and other medical and/or scientific information with KOLs/HCPs, researchers, pharmacists, and decision makers in the areas of Eisai's interest. The person in this position will demonstrate a thorough understanding of Alzheimer's disease (AD), including the needs, issues and priorities as they relate to Eisai's strategic medical plan. MSLs will be trained and certified on AD and Eisai's dementia pipeline data in order to fulfill educational gaps with KOLs/HCPs and gather medical insights to refine medical strategy and continue to close the gap on unmet educational needs for AD HCPs. MSLs also assume responsibility for special internal/external projects as they arise. The impact that a MSL will have on the organization includes the following: a) as a representative of Eisai, a MSL will communicate key information about Eisai, the company and its hhc mission; b) provide key scientific and clinical information about Eisai's products/pipeline; serve as a conduit for communication between Eisai Research and the medical community regarding ideas for future research, and c) provide corporate value through demonstrated leadership, teamwork, participation in strategic thinking, and special projects ESSENTIAL FUNCTIONS:\ Product/Therapeutic Area Support to Stakeholders • Act as the primary clinical/scientific resource to HCPs in the territory for information pertaining to disease state and Eisai's product(s) to ensure awareness and understanding., • Serve as a conduit for accurate and updated clinical, scientific and medical information between Key Opinion Leaders (KOLs)/investigators and the company's Medical Affairs and development groups., • Establish, foster, cultivate and maintain peer relationships with KOLs in AD and dementia in which Eisai has current and future interests., • Present clinical and scientific data on Eisai's products and relevant therapeutic areas, as requested., • Support assigned professional congresses in accordance with MSL plan. Be prepared to lead congress coverage efforts, including coordination of all MSL activities., • Identify and report key scientific, clinical and research insights from KOLs to Medical Affairs. Training/Education Resource • Maintain and demonstrate thorough and up-to-date knowledge of disease state, study methodology, clinical information, and product data, • Demonstrate full knowledge of and ability to execute on approved medical platforms/strategies and MSL initiatives, • Serve as technical/scientific subject matter resource to Eisai cross functional partners, • Teach, coach and mentor new or less experienced MSLs; assist with supervision/performanceevaluation; assume responsibility for special projects. Provide valuable contributions to the organization including leadership and strategic planning., • Ability to lead and motivate team members without a direct reporting relationship Research Support • Facilitate review and follow up of submitted Investigator-InitiatedStudies (IISs) and assist with Eisai sponsored trials., • The MSL may also be involved with providing recommendations for site selection and scientific expertise to Investigators involved in company sponsored studies. REQUIREMENTS: Educational Requirements: Advanced terminal D degree in medical or health sciences (e.g MD/DO, PhD, PharmD) Experience: • 2-3 years MSL experience in neurology or complex disease states; prior dementia or AD research experience strongly preferred, 3 yrs+ required for Sr MSL title, • Established relationships with KOLs in neurology, and knowledge of institutions focused on AD preferred, • 3-5 years industry/ clinical research/ related experience in a scientific or clinical setting., • Strong broad-based scientific and pharmaceutical knowledge, • Clinical trial development and drug launch experience is strongly preferred, • Knowledge of treatment guidelines, clinical research processes, FDA regulations, pharma regulations/compliantpractices, and OIG guidelines are required., • Knowledge and experience within AD and ability to communicate with confidence and accuracy across multiple dementia disease states. Other Skills and Abilities: • Interested and skilled in communicating complex data sets and the ability to be seen as a scientific peer while educating top KOLs., • Committed to the concept of team and working within the framework of the Medical Affairs, • Strong overall written and verbal communication skills. Keen understanding of your audience and ability to tailor information appropriately., • Highly skilled in the art of strategic conversation along with a demonstrated ability to assess issues, as they arise and adapt appropriately., • Demonstrated ability to anticipate, organize, plan and handle multiple priorities, while adapting to the needs of the company and KOLs., • Has an ability to work independently and not require close supervision while adhering to compliance/regulatorypolicies., • Interest in leading and participating in projects while effectively balancing field work., • Demonstrated ability to proactively identify opportunities/challenges,willingness to communicate these challenges to leadership while working together to overcome them., • Seamlessly adapts to field situations and effectively problem solves within your territory, • Experience working in matrix environment including cross-functional commercial partners, with an understanding of the pharmaceutical corporate environment and appreciation for Commercial Operations, including Marketing and Sales strategies, • Sound computer/technology skills including applications for word processing, producing slide materials, working with spreadsheets, and video conferencing, • Possesses and maintains a valid driver's license and clean driving record., • Capable of engaging in frequent business travel (approximately 60% of time), including air travel, ability to travel overnight and occasionally on weekends., • This is a field-based position. The employee is required to set up a home-based office within their defined territory. Salary range for MSL is $144,300.00 - $189,400 USD Annual Salary range for Sr. MSL is $160,100.00 - $210,100 USD Annual #LI-MI1 As a condition of employment and an essential function of this field-based position, applicants must be able to engage in person with HCPs and other third parties at their offices, institutions and other appropriate locations on a regular basis. In order to gain in-person access, applicants selected for the position may be required to complete third parties' credentialing and/or entry requirements, which often include an attestation to and/or providing proof of having received certain vaccinations. To the extent you are unable to meet certain requirements for qualifying medical (including pregnancy-related) or religious reasons, applicants must request a reasonable accommodation by contacting the Human Resources Department.Skills:Communication & Cross-functional Influence, Critical Thinking & Agility, Healthcare Environment Dynamics, KOL/ HCP Engagement, Medical Data and Insights, Mentoring, Resource Planning & Management, Territory Management (MSL) Eisai Salary Transparency Language: The annual base salary range for the MSL/Sr. MSL, Neurology - Alzheimer's Disease, New England (Eastern MA, ME, NH, RI, VT) - Field-based is from :$160,100-$210,100 Under current guidelines, this position is eligible to participate in : Eisai Inc. Annual Incentive Plan & Eisai Inc. Long Term Incentive Plan. Final pay determinations will depend on various factors including but not limited to experience level, education, knowledge, and skills. Employees are eligible to participate in Company employee benefit programs. For additional information on Company employee benefits programs, visit ___. Certain other benefits may be available for this position, please discuss any questions with your recruiter. Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, Eisai prohibits discrimination against persons because of disability, including disabled veterans. Eisai Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States. Please click on the following link for more information:

Description You have what it takes: a competitive drive coupled with exceptional sales ability. In this role, you will be an integral part of a sales team developing and managing an assigned territory. You will have the opportunity to implement clients' marketing plan by using your professional expertise, clinical training, and judgement. You will: • Utilize marketing and selling materials designed for a respective audience, • Plan and organize activities to ensure consistent coverage of the territory depending on each client's needs, • Engage in meaningful dialogue that addresses the needs of the health provider and patient, • Bachelor's degree, • Sales aptitude, • Track record of success with outside sales experience, • 2-4 years' business-to-business (B2B) sales experience, • Pharmaceutical sales experience Why Syneos Health? Here, the work is challenging, and the pace is exhilarating. By joining one of our commercial teams, you're empowered to succeed with the support, resources, and autonomy that you need. The diversification and breadth of our new and existing partnerships create a multitude of career paths and employment opportunities. Syneos Health has launched more sales teams in the last 5 years across all major therapeutic areas than the top 25 pharma companies combined. Join our game-changing, global company dedicated to creating better, smarter, faster ways to get biopharmaceutical therapies to patients. Experience the thrill of knowing that your everyday efforts are contributing to improving patients' lives around the world. Work Here Matters Everywhere | How are you inspired to change lives? Syneos Health companies are affirmative action/equal opportunity employers (Minorities/Females/Veterans/Disabled) Syneos Health has a voluntary COVID-19 vaccination policy. We strongly encourage all employees to be fully vaccinated. Additionally, certain local governments or Syneos Health customers may have vaccine requirements that apply to some of our employees. These employees are required to submit proof of vaccination to Syneos Health and maintain compliance with these requirements. As a Syneos Health freelance, temporary, or contract employee, you may be eligible to participate in the Company 401k match and benefits such as paid time off or benefits through provisions in the Affordable Care Act or State-specific requirements depending on the terms of your employment. Syneos Health complies with all applicable federal, state, and municipal paid sick time requirements for temporary/freelance/contract employees. 400002486

< Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. Achievement of targets will be grounded in Alnylam's core values-our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture-while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities • Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption., • Continuously assesses sales opportunities and challenges within territory and accounts to maintain and grow their business., • Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential., • Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach., • Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals., • Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care., • Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results., • Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers., • Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results., • Demonstrates and upholds the highest standards of integrity and compliance., • Additional responsibilities as required to support business needs and organizational priorities. Qualifications • 4-year degree from an accredited college or university required. MBA/Science Degree preferred., • 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry., • Experience in Cardiology, • A successful track record of strong sales performance., • Specialty product launch experience, • Understanding of buy and bill and specialty channel distribution is preferred., • Hospital / Institution knowledge and expertise with pharmacy formulary processes., • Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority., • Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times., • Excellent communication and listening skills., • Collaboration:Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues., • Customer Focus:Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge, • Execution:Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact., • Critical Thinking:Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence., • Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories., • Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable., • Must live within assigned territory. U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Associate Director MedEd Marketing, KOL Education will lead national strategy and execution for HCP education and peer-to-peer engagement across the TTR franchise. This individual will lead the development of scalable, innovative, and high-impact initiatives that support brand goals, close educational gaps, and elevate AMVUTTRA's presence across key stakeholder groups. This role requires a visionary, cross-functional leader who can drive strategic alignment across the organization, lead enterprise-wide initiatives, and serve as an internal champion for HCP education. Reporting to the Director of Marketing, Medical Education the Associate Director will lead the planning and execution of peer-to-peer HCP education initiatives, including speaker bureau, congress presence, and related content development. This role will collaborate cross functionally and with marketing and medical partners to ensure educational efforts are scientifically accurate, compliant, and aligned with brand strategy. This position is based in Cambridge, MA with travel up to ~20% for congresses, KOL engagements, and internal planning meetings. Key Responsibilities • Peer-to-Peer Education & Speaker Bureau: Lead end-to-end strategy and execution of speaker bureau programs, including speaker identification and selection, training, content development, and ongoing performance optimization., • Educational Content Development: Oversee creation, approval, and lifecycle management of speaker decks, educational toolkits, and HCP-facing materials to ensure scientific accuracy, consistency, and alignment with brand strategy., • Congresses & Educational Presence: Define and execute congress education strategy, including symposia, product theaters, booth content, and congress sponsorships; ensure compliant development and seamless onsite execution., • Media & Digital Education: Drive strategy and execution of HCP-focused media initiatives, including digital education platforms and video content to expand reach and engagement., • HCP Video Content (Recorded HCP Education): Lead development of recorded HCP video content, including identification of speakers, content planning, recording, and deployment for broader educational reach., • Field Team Content & Engagement: Develop and execute KOL-led education and training sessions for field teams to support internal clinical expertise and reinforce key messaging., • Cross-Functional Collaboration: Partner with Medical, Legal, Compliance, Marketing, and field teams to ensure all educational initiatives meet regulatory standards and strategic objectives., • Performance Tracking & Optimization: Establish metrics to evaluate effectiveness of educational programs; continuously refine strategy based on insights and performance data., • Vendor & Agency Management: Oversee external partners supporting content development, logistics, and execution across educational initiatives., • Bachelor's degree required; MBA or advanced degree in life sciences or marketing strongly preferred., • 8+ years of experience in pharmaceutical or biotech marketing, healthcare consulting, or healthcare agencywith a focus on HCP engagement, medical education, or peer-to-peer strategy preferred., • Ability to navigate a dynamic, fast-paced environment by managing competing and complex priorities and engaging with cross-functional partners to ensure goals are met efficiently and collaboratively., • Demonstrate a meticulous attention to detail, ensuring accuracy, consistency, and quality across all deliverables, communications, and project components., • Deep understanding of compliance requirements and experience in highly regulated environments. #LI-KB2 #LI-Hybrid U.S. Pay Range $161,500.00 - $218,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< • Provide balanced risk perspectives and top-quality legal advice in a highly regulated market to the U.S. Patient Services, Market Access, and other Commercial teams based on applicable laws, regulations, and Alnylam policies and guidelines, • Analyze and provide strategic guidance on Alnylam's patient support programs, field reimbursement activities, and payer engagement; serve as legal reviewer on promotional and medical review committees for related collateral, communications, and training materials, • Identify, analyze, and mitigate legal and operational risks; engage and manage outside counsel for certain advice as agreed within U.S. Commercial Legal, • Present to relevant business partners, including senior leadership, on key legal matters, • Partner with the Ethics & Compliance team on training and other activities, • Proactively progress team initiatives and processes by helping ensure consistency of guidance, stakeholder momentum, and effective change management, • Bachelor's Degree and Juris Doctor from an accredited law school in the U.S. both required, with excellent academic credentials preferred, • 4-7 years of legal experience in the pharmaceutical / biotech industry advising on patient support programs, reimbursement matters, and/or payer communications, or from a law firm working with pharmaceutical / biotech industry clients on similar matters, • Direct experience serving on a promotional review committee is highly preferred, • Bar license in good standing; ability to register as Massachusetts in-house counsel, • Ability to work collaboratively in a team environment with a wide variety of company colleagues as well as with external parties on a broad range of matters, • Ability to make and communicate thoughtful, integrated and timely decisions, take corresponding actions, and escalate certain matters in U.S. Commercial Legal as appropriate, • Ability to manage outside counsel as agreed within U.S. Commercial Legal, • Ability to manage multiple tasks simultaneously, to work independently and manage discrete areas of responsibility, and to flourish in a fast-paced and high energy environment, • Strong organizational skills in order to maintain a high level of productivity, innovation and priority-settling in order to meet commitments on-time and handle a high volume of work, • Proven ability to work with a high level of integrity, transparency, accuracy and attention to detail #LI-AB1 #LI-Hybrid U.S. Pay Range $208,800.00 - $282,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: We are seeking an experienced Regional Business Director (RBD) to support the promotion of OXLUMO (lumasiran) for Primary Hyperoxaluria Type 1 and GIVLAARI (givosiran) for Acute Hepatic Porphyria. This is an exceptional opportunity to build a meaningful legacy of support for patients, caregivers, and the PH1 and AHP communities. The RBD will lead and develop a high-performing team of Business Account Executives (BAEs), driving disease awareness and product education among healthcare professionals. In addition to coaching and performance management, the RBD will provide market insights to inform commercial strategy, champion a customer-oriented culture, and foster a team environment grounded in accountability and excellence. The RBD will embody Alnylam's core values: commitment to people, purposeful urgency, passion for excellence, innovation and discovery, open culture, and an unwavering commitment to integrity. The position reports to the Head of Rare Sales. Key Responsibilities: • Lead, coach, and develop a high-performing BAE team focused on disease awareness and product education across PH1 and AHP patient communities., • Apply strong sales management, strategic planning, financial acumen, and analytical capabilities to align field execution with broader commercial strategy., • Proactively analyze market dynamics and develop forward-looking action plans; clearly communicate market context and proposed direction to both leadership and the field team., • Coach team members to meet and exceed performance targets, with an emphasis on compliance, business planning, and cross-functional alignment., • Leverage deep market knowledge to provide insights that shape and refine commercial strategy., • Build best-in class team culture by attracting, developing, and retaining top sales talent., • Cultivate a customer-oriented culture that prioritizes patient needs, value-added services, and seamless execution., • Allocate and manage regional resources to support strategic and operational excellence., • Align people, processes, and communication systems effectively across a complex, matrixed organization., • Inspire and motivate the team by clearly articulating strategy, vision, and future objectives. Qualifications: • Bachelor's degree required; science focus is strongly preferred. MBA or PhD is a plus., • 5+ years of experience leading commercial teams; 7+ years in sales, marketing, commercial operations, or account management within biotech, medical device, or specialty pharma., • Rare/orphan disease experience preferred., • Proven experience training and managing BAEs across multiple specialties and working cross-functionally across sales, marketing, market access, and patient services., • In-depth reimbursement knowledge of Buy/Bill and Part B & D, including experience with in-house patient support services and site-of-care development., • Strong familiarity with hospital/institutional environments and the P&T committee process., • Demonstrated ability to lead and influence a matrixed organization across multiple teams and functions., • Strong planning, prioritization, and organizational skills with the ability to manage competing priorities effectively., • Working knowledge of relevant legal and regulatory requirements within the biotech/pharmaceutical industry., • Demonstrated commitment to ethics and integrity in all aspects of work. $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: We seek aPatient Education Liaison (PEL)to supportAMVUTTRA (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA (vutrisiran).The approval expands theindicationfor AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.The PELis a criticalcomponentof the product brand commercial strategy and works in close coordination with Field Sales, Field Reimbursement, Patient Services, Advocacy, and Marketing teams to support Alnylam's patient-focused vision of harnessing a revolution in biology for human health. The Patient Education Liaison is responsible for educating patients, caregivers, families, nurses, medical assistants, office staff, professional nursing organizations, and pertinent community groups on disease state and Alnylam's RNAi treatments for all Alnylam brands. Using approved materials, the Patient Education Liaison will educate on the disease state, Alnylam treatments, and Alnylam's services, through phone-based, in-person, and virtual meetings. Central to this role is the ability to work with regional, field-based and internal colleagues to identify barriers to patient access and work to resolve them. The successful candidate must be passionate about science and deeply motivated by the quest of delivering education to patients and their families with the long-term success of the company in mind. The ideal candidate will be a self-motivated, self-starter with an innovative, entrepreneurial spirit. Key Responsibilities: * Actively collaborates with Field Sales, Patient Services, Medical Affairs, Marketing,Advocacyand other critical internal teams to increase disease-state awareness and early diagnosis * Leads regional effort to provide disease-state education, treatmenteducationand support to patients their families/caregivers, nurses, medical assistants, office staff, nursing organizations, and community groups * Maintains disease-state and productexpertisethrough continuing medical education and attendance at relevant symposia,conferencesand other educational opportunities * Provides comprehensive updates on activity toPELLeadandregional colleagues, ensuring that the regional team appropriately works as one entity to support patients in early diagnosis and access to treatment * Accountable for executing on targeted workplan * Completes required work in CRM system tofacilitatetracking of critical launch metrics * Ensures compliance with all corporate and industry policies with training provided by Alnylam Commercial, Legal, Regulatory and Compliance Officers Qualifications: * Bachelor of Science in Nursing, Registered Nurse(required) * 2+yrs. Pharmaceutical/biotech experience in a similar role * Experience supporting and providing education to patients, family members, nurses, medical assistants, office staff, nursing organizations, and community groups * Strong presentation skills * Cardiology experience preferred * Exceptional interpersonal skills, professional communications, problem-solving,compassionand the ability to navigate difficult conversations * Ability to translate scientific/medical information into patient-friendly language * Ability to work well and lead within cross-functional groups and in a matrix organization * Desire to innovate and work in a fast-paced, energetic environment * Self-starter who is highly passionate about Alnylam's core values:Commitment to People, Fiercely Innovative, Open Culture, Passion for Excellence, and Purposeful Urgency. * This position requires frequent travel within the region and at times nationally. Includesovernight travel and weekends. * Must be able to travel up to 75% * Valid Driver's License #LI-ST1 #LI-Remote U.S. Pay Range $136,000.00 - $184,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview For the Vice President, Head of BD Transactions, we are seeking a seasoned business development leader with exceptional strategic and financial acumen and a proven track record of leading complex, high-impact transactions in the biotechnology and biopharmaceutical industry. The ideal candidate brings deep expertise across the full dealmaking lifecycle, including opportunity evaluation, valuation, investment structuring, negotiation, and execution across a broad range of therapeutic areas, modalities, and stages of development. Success in this role will be defined by the ability to set transaction strategy, lead and close sophisticated deals, and serve as a trusted advisor to executive leadership and governance bodies on matters of external growth and value creation. This role requires strong executive presence and the ability to influence, align, and drive outcomes with senior internal leaders and external partners in highly visible, timesensitive situations. The Vice President will play a critical role in shaping and executing Alnylam's business development strategy and ensuring disciplined, valuedriven decisionmaking across the portfolio. Reporting to the SVP & Head of Business Development, this position is hybrid and located in Cambridge, MA. Key Responsibilities: • Provide enterprise-level transaction leadership across a diverse portfolio of business development opportunities, partnering closely with R&D, Commercial, Finance, Legal, and Search & Evaluation to assess external innovation and drive disciplined, value-creating deal decisions., • Set and lead transaction strategy, including development of business cases, valuation frameworks, and deal structures, and oversee cross-functional due diligence and negotiations to successfully execute strategic transactions., • Serve as a primary advisor to executive leadership and governance bodies, delivering clear, data-driven recommendations on external opportunities, including valuation, risk assessment, deal rationale, and key deal terms., • Lead, mentor, and coach BD Transaction team members in deal execution and negotiations, providing guidance on complex issues, bridging gaps between parties, and ensuring alignment between business intent and contractual outcomes., • Act as a thought partner to the SVP and BD Leadership Team in shaping overall BD strategy, portfolio priorities, and long-term external growth initiatives aligned with enterprise objectives., • Represent Alnylam externally at the executive level, building and maintaining strong relationships with potential partners, advisors, and industry stakeholders, and articulating Alnylam's strategic vision and partnering approach., • Build and sustain a high-performing BD organization, fostering a culture of excellence, accountability, collaboration, and innovation while developing next-generation BD leaders. Qualifications: • MBA, JD, or other advanced business degree required; scientific background or strong aptitude to rapidly understand complex science and emerging technologies strongly preferred., • 15+ years of progressive business development experience in the biotechnology and/or pharmaceutical industry, with significant leadership responsibility and a strong record of originating, leading, and closing multiple complex, high-value transactions. Detailed deal sheet required., • Deep expertise in drug development processes and a comprehensive understanding of industry dynamics, including market trends, regulatory considerations, and the macro deal-making environment., • Demonstrated ability to integrate scientific, clinical, and commercial insights into robust financial and strategic analyses, including valuations, P&Ls, risk assessments, and investment structures., • Exceptional negotiation skills with extensive experience shaping and reviewing term sheets and contracts to ensure alignment with strategic and commercial objectives., • Proven ability to synthesize complex information, frame strategic trade-offs, and influence decision-making at the executive level., • Outstanding communication and presentation skills, with the ability to clearly and persuasively engage senior internal leaders, governance bodies, and external partners., • Highly collaborative, adaptable, and effective in a fast-paced, evolving environment with competing priorities., • Strong people leadership and executive presence, with a track record of building, developing, and inspiring high-performing teams. U.S. Pay Range $318,800.00 - $431,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview The Senior Manager, Clinical Systems Quality Lead, is responsible for developing and implementing the process and framework for the assessment and management of GCP technologies across Alnylam Clinical programs, including development, validation, implementation, and oversight. The incumbent will establish and operationalize expectations for technology selection, study specific user requirements and testing approaches, documentation standards and oversight responsibilities. This role will collaborate across the Development and QA organizations to establish a risk-proportionate, quality-driven oversight to enable data integrity and regulatory compliance. The framework and processes will provide a sustainable foundation for compliance across studies, systems, devices, and vendors. This position requires close collaboration with Global Quality Assurance (GQA), Clinical Development, and IT to ensure the suitability, integrity, and compliance of both vendor-hosted and internal technologies that support trial conduct and data collection. Key Responsibilities • Collaborate across Clinical Development and GQA to develop and maintain an enterprise-wide framework for risk assessment of clinical technology solutions, including devices and computerized systems., • Collaborate with Vendor Management, Clinical Operations and QA to proactively identify systems and technologies proposed for use in clinical trials., • Drive a risk assessment process assessing factors such as GxP relevance, validation approach (internal or external) and supporting evidence, system criticality to study outcomes, and the complexity of study-specific functionality (e.g., calculations, data transfers, quality control checkpoints, and integrations)., • Create a sponsor oversight framework that defines responsibilities, expectations, and documentation standards across the system lifecycle from technology selection, vendor and study specific implementation requirements, vendor validation and sponsor supplemental validation, implementation, change control, decommissioning and archiving. 2. Oversight of Study-Level Technology • Partner with GCP QA and study teams to ensure endpoint data flows capture all Technology steps and interactions, including, data entry, validation, transfers/system interfaces, data integrations, Quality Control/Quality Gateways, notifications, transformation, and data analysis to inform technology risk assessment., • Lead or facilitate study-specific risk assessments for technology applications used in randomization, data capture, data monitoring, and analysis (e.g., EDC, eCOA, ePRO, EAS, IRT, eTMF, LIMS, safety databases)., • Align system assessment outcomes with study-specific database build requirements, specifications, validation and UAT documentation, and audit trail review expectations., • Translate risk assessment outcomes into oversight expectations, including qualification needs, testing rigor & ongoing monitoring requirements and ensuring outcomes are reflected in supplier risk assessments and study Risk Management Plans., • Conduct reviews to evaluate system functionality, technical controls, validation documentation, and data flow risks for study-specific configurations., • Identify, communicate and coordinate with Quality Technology and Analytics team for the review of external validation processes and validation packages or the need for internal validation., • Develop mitigation strategies to address identified gaps, including procedural updates, system controls, or vendor corrective and preventive actions., • Ensure traceability between study-specific data flow, vendor system controls, and sponsor oversight activities., • Support inspection readiness by ensuring clear documentation of sponsor responsibility and oversight rationale for computerized systems., • Contribute to CAPA development and effectiveness reviews where study configuration or system-related deficiencies are identified in oversight activities, audits or inspections., • Develop and deliver training materials and guidance documents for functional teams on risk assessment and associated oversight of vendor-managed systems supporting clinical trials., • Monitor evolving regulatory expectations (FDA, EMA, MHRA, PMDA) and update internal frameworks to maintain compliance., • Identify and contribute to process improvement opportunities to enhance efficiency, consistency, and traceability of system oversight. Qualifications • Bachelor's or Master's degree in life sciences, computer science, or a related discipline., • Minimum 6-8 years of experience in clinical quality, compliance, data management, or computer system validation within the pharmaceutical, biotech, or CRO industry., • Deep understanding of ICH E6(R3), EMA Guideline on Computerised Systems (2023), 21 CFR Part 11, CSV documentation standards, GAMP 5 and data integrity principles., • Experience with e-systems in clinical trials, AI technology, cloud-based platforms, and data privacy considerations under GDPR., • Experience leading risk assessments for computerized systems or vendor oversight in a GCP-regulated environment., • Demonstrated ability to interpret complex system designs, map data flows, and assess implications for data quality and regulatory compliance., • Strong collaboration and communication skills to work effectively across cross-functional and global teams. #LI-LJ1 #LI-Hybrid U.S. Pay Range $135,400.00 - $183,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The Senior Manager, Regulatory Affairs CMC Development is responsible for implementation of the global regulatory CMC strategy for developmental programs. This role will play a critical part in shaping regulatory strategies for emerging and complex modalities, with an emphasis on oligonucleotide-based therapeutics, including siRNA and novel conjugate delivery systems. The Senior Manager will bring a broad scientific foundation and the ability to translate complex CMC data into clear regulatory strategies. The Senior Manager will partner cross-functionally to define developmental pathways, anticipate regulatory risks, and enable efficient global submissions. This position reports to the Director of Regulatory Affairs CMC, or equivalent. This position is hybrid and will be primarily located in Cambridge, MA. Responsibilities: • Contributes to the development and implementation of the global regulatory CMC strategy for developmental programs., • Helps to lead the interpretation of regulatory expectations for emerging modalities, including:, • siRNA and oligonucleotide therapeutics, • Conjugated delivery systems (e.g., GalNAc and other targeting ligands including biologic modalities), • Complex drug substance and drug product configurations, • Helps to assess CMC implications of new technologies and modalities, including:, • Impact on product characterization, control strategies, and specifications, • Regulatory classification considerations (e.g., small-molecule vs biologic paradigms), • Manages regulatory compliance activities including periodic regulatory reporting, review of technical documents, and providing regulatory assessments., • Leads and manages the preparation of Module 3 (CMC) content supporting global submissions., • Contributes to regulatory intelligence and policy interpretation for novel modalities., • Actively participates in the development of regulatory CMC infrastructure and capability building. Qualifications: • Advanced degree in chemistry, biochemistry, pharmaceutical sciences, molecular biology, or related field., • Minimum 4-6 years of experience in the pharmaceutical/biotechnology/life science industry, including at least 2 years of Regulatory Affairs CMC experience. Equivelant technical experience may be substituted for direct experience in Regulatory Affairs experience., • Experience supporting oligonucleotide, antibody, peptide or other complex modalities strongly preferred., • Ability to quickly understand and evaluate new technologies., • Strong communication skills with the ability to translate complex technical concepts into clear regulatory positions., • Agility - must be able to thrive in an evolving, fast-paced environment with emerging science., • Experience with BLA submissions or content generation preferred., • Broad understanding of:, • Drug substance and drug product development, • Analytical characterization and control strategies, • Regulatory framework across major regions (e.g., US, EU, Japan, China), • Strong ability to integrate scientific, technical, and regulatory considerations into clear strategies #LI-KB1 #LI-Hybrid U.S. Pay Range $144,400.00 - $195,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview We are looking for an experienced and talented Business Account Executive (BAE) to commercially represent GIVLAARIand OXLUMO in the United States and have a significant impact on the lives of AHP patients. AHP's represent a sub-group of Porphyrias, characterized by the occurrence of neuro-visceral attacks with or without cutaneous manifestations. AHP's include four disorders: acute intermittent porphyria (the most common), variegate porphyria, hereditary coproporphyria, and a genetic deficit of delta-aminolaevulinic acid dehydratase. PH1 is a rare, life-threatening disease that can cause serious damage to kidneys and progressively to other organs. PH1 is a little-known condition and patients often spend years undiagnosed and misdiagnosed. The BAE will be principally responsible for driving physician and patient identification, disease awareness, overall market development, and brand awareness within their ascribed territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders to effectively manage all aspects of the regional business. The achievement of targets will be based in Alnylam's values: our commitment to people, sense of urgency, passion for excellence, innovation & discovery, and open culture as well as our unwavering commitment to integrity. The BAE will report to the Regional Business Director (RBD) for their respective region. Key Responsibilities • Drive patient identification through appropriate HCP driven strategies including market development, increase brand awareness through building and executing a territory strategy/account plan; continuously assess opportunities within markets and accounts to launch successfully., • Effectively prioritize and manage time, activities, and resources in order to optimize access to academic and community HCPs., • Build and maintain relationships with HCPs and office staff by maximizing their time through planning, leveraging insights, and conducting post-call analysis refining tactics based on opportunities., • Proactively build effective working relationships with internal/external stakeholders; drive agreement/decisions from multiple stakeholders; demonstrated high level of emotional intelligence adapting communication based on different stakeholders., • Collaborate with stakeholders across all commercial departments including; patient services, field reimbursement, and others to ensure access at site of care and that logistics are in place to administer medications., • Collaborate with key accounts and physicians to build individual account plans to drive patient identification through market development and physician education; achieve sales goals, and maintain relationships in order to maximize sales results., • Execute speaker programs, local sponsorships, displays and exhibits, both in and out of office across multiple account types: academic institutions, physician offices, infusion centers, and alternate site locations., • Routinely report territory-level market dynamics and trends, including prescriber opinion and competitive activity to RBD as required. Qualifications • Bachelor's degree required, • 5+ years of demonstrated success in biotech, specialty pharmaceuticals, or medical devices., • Experience, success and relationships in Rare Disease, Gastroenterology, Hepatology, Neurology, Hematology/Oncology, pediatric and adult Nephrology and/or Urology are preferred but not required., • Buy & Bill understanding and experience working with HUB patient services preferred but not required., • Thorough understanding of site of care identification, development and education., • Strong examples of applied entrepreneurial mindset, business analytics and data analysis required., • Experience supporting biologic therapy administered by designated HCPs preferred., • Experience driving, leading and delivering upon territory-level cross functional business planning., • Must be familiar with relevant legal and regulatory environment in biotech/pharmaceutical industry., • Strong communication and listening skills., • Effective at managing complex individualized cases in a compliant manner., • Overnight travel required including travel to Boston, congresses and large geographical territories, • Candidates must have a valid driver's license., • Must live in the assigned territory. #LI-ST1 #LI-Remote U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: We seek aPatient Education Liaison (PEL)to supportAMVUTTRA (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA (vutrisiran).The approval expands theindicationfor AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.The PELis a criticalcomponentof the product brand commercial strategy and works in close coordination with Field Sales, Field Reimbursement, Patient Services, Advocacy, and Marketing teams to support Alnylam's patient-focused vision of harnessing a revolution in biology for human health. The Patient Education Liaison is responsible for educating patients, caregivers, families, nurses, medical assistants, office staff, professional nursing organizations, and pertinent community groups on disease state and Alnylam's RNAi treatments for all Alnylam brands. Using approved materials, the Patient Education Liaison will educate on the disease state, Alnylam treatments, and Alnylam's services, through phone-based, in-person, and virtual meetings. Central to this role is the ability to work with regional, field-based and internal colleagues to identify barriers to patient access and work to resolve them. The successful candidate must be passionate about science and deeply motivated by the quest of delivering education to patients and their families with the long-term success of the company in mind. The ideal candidate will be a self-motivated, self-starter with an innovative, entrepreneurial spirit. Key Responsibilities: * Actively collaborates with Field Sales, Patient Services, Medical Affairs, Marketing,Advocacyand other critical internal teams to increase disease-state awareness and early diagnosis * Leads regional effort to provide disease-state education, treatmenteducationand support to patients their families/caregivers, nurses, medical assistants, office staff, nursing organizations, and community groups * Maintains disease-state and productexpertisethrough continuing medical education and attendance at relevant symposia,conferencesand other educational opportunities * Provides comprehensive updates on activity toPELLeadandregional colleagues, ensuring that the regional team appropriately works as one entity to support patients in early diagnosis and access to treatment * Accountable for executing on targeted workplan * Completes required work in CRM system tofacilitatetracking of critical launch metrics * Ensures compliance with all corporate and industry policies with training provided by Alnylam Commercial, Legal, Regulatory and Compliance Officers Qualifications: * Bachelor of Science in Nursing, Registered Nurse(required) * 2+yrs. Pharmaceutical/biotech experience in a similar role * Experience supporting and providing education to patients, family members, nurses, medical assistants, office staff, nursing organizations, and community groups * Strong presentation skills * Cardiology experience preferred * Exceptional interpersonal skills, professional communications, problem-solving,compassionand the ability to navigate difficult conversations * Ability to translate scientific/medical information into patient-friendly language * Ability to work well and lead within cross-functional groups and in a matrix organization * Desire to innovate and work in a fast-paced, energetic environment • Bilingual (Spanish) Preferred Self-starter who is highly passionate about Alnylam's core values:Commitment to People, Fiercely Innovative, Open Culture, Passion for Excellence, and Purposeful Urgency. * This position requires frequent travel within the region and at times nationally. Includesovernight travel and weekends. * Must be able to travel up to 75% * Valid Driver's License #LI-ST1 #LI-Remote U.S. Pay Range $136,000.00 - $184,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: Reporting to the Director, Patient Services Operations, the Associate Director, Patient Services Operations will serve as a strategic partner to Case Management and PEL teams, enabling consistent, data-driven execution across Commercial. This role will help define what success looks like for field teams by translating strategy into measurable results, key activities, and performance metrics. The Associate Director will partner closely with our technology and analytics partners to define metrics, support the development of dashboards, and synthesize insights from multiple data sources to inform decision-making. This role will also lead field-facing processes related to customer-to-account affiliations, ensuring accuracy, consistency, and scalability. Additionally, the role will contribute to targeting, field force effectiveness initiatives, and ad hoc analyses in support of evolving business needs. Key Responsibilities: Field Force Strategy / Field Force Effectiveness • Engage effectively in strategic discussions with leadership of Case Management and PELs, including TTR Sales, Rare Sales, Market Access, and Strategic Accounts., • Define what success looks like for Case Management and PEL teams including themetrics used to measure results, • Identify key activities that are expected to drive the desired results and define Key Performance Indicators, • Work with cross-functional partners to establish dashboards and generate insights from the data to help shape strategy, • Identifytrends, inefficiencies andopportunitiesfor process improvement withinpatient services systems and data, • Lead the development of presentation materials to support monthly and quarterly leadership performance reviews, • Drive consistency in field execution through clear processes, playbooks, and standard operating procedures., • Partner with Compliance and Legal to ensure field team activities adhere to company policies and industry regulations., • Support change management efforts when deploying new processes, systems, or field strategies Qualifications: • Bachelor's degree required; advanced degree preferred., • 6+ years of experience in patient services field teams and call centers within the pharmaceutical or biotechnology industry., • Proven experience partnering with field teams and presenting senior leadership., • Strong experience working with CRM platforms and commercial data environments., • Hands-on experience with data visualization tools (e.g., Tableau, Power BI, etc)., • Demonstrated expertise in field force effectiveness, alignments, HCP and patient segmentation, reporting, size and structure, and strategic analysis., • Experience across multiple commercial functions, including operations and strategy., • Strong analytical skills with experience leveraging pharmaceutical data sources to generate and iterate on insights., • Advanced proficiency in Excel and PowerPoint., • Highly organized, agile learner with the ability to think in real time and communicate effectively., • High sense of urgency balanced with attention to quality, rigor, and process., • Strong interpersonal and communication skills with the ability to influence at all levels of the organization., • Demonstrated project management skills with the ability to lead multiple initiatives and priorities concurrently., • Experience working directly with field teams; prior field experience strongly preferred., • Ability to travel for key internal and external meetings as needed (approximately 10% overnight travel). #LI-ST1 #LI-Remote U.S. Pay Range $155,600.00 - $210,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The Principal Statistical Programmer will provide expert-level hands-on principal programming support and technical leadership to develop, maintain, validate and run SAS computer programs that access, visualize, analyze, and report clinical trial data, in accordance with statistical analysis plans, ICH guidelines, and applicable regulatory requirements. The ability to work independently with a strong expertise in SAS/GRAPH programming experience is required. While SAS expertise is required, experience with R programming, particularly data visualization and exploratory analysis is strongly preferred. Responsibilities: • Write programs that produce or validate tables, listings, figures and analysis datasets, in support of clinical studies or complex integrated analyses for submission;, • Develop and follow good programming practices, including adequately documenting SAS and R code;, • Perform, plan and coordinate project work to ensure timely, quality delivery across multiple projects;, • Use, modify, and maintain existing SAS and R code;, • Write specifications to describe programming needs;, • Create and validate global macros or systems that streamline repetitive operations to increase programming efficiency;, • Keep abreast of current and new statistical programming techniques and other applicable technical advancements while assisting in their implementation;, • Provide input into, or lead general standardization efforts (e.g., CRFs, query checks, standard statistical programs, data presentations);, • Assist or lead efforts to develop programming processes consistent with industry best practices;, • Review DMP, eCRF specs, and other clinical data management documents;, • Review statistical analysis plans and other related documents;, • Partner with or oversee CROs or Programming vendors to perform any of the above tasks;, • Other duties as assigned. Qualifications: • At least 8 years' industry (Pharmaceutical, Biotech, CRO) SAS programming experience or equivalent;, • Knowledge of clinical trials and experience in using SAS to report the results of clinical trials and/or integrated analysis for submission;, • Experience in constructing technical programming specifications and producing complex, validated programs;, • Strong experience in working with CDISC standards, including SDTM, and ADaM, and Define xml;, • Preferred experience in R programming;, • Excellent knowledge of applied statistical methodologies;, • Excellent knowledge of SAS Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT;, • Good communication and organizational skills required;, • Bachelor's Degree required, Master's Degree Preferred., • Clear alignment with Alnylam Core Values:, • Commitment to People, • Innovation and Discovery, • Sense of Urgency, • Open Culture, • Passion for Excellence #LI-AB1 #LI-Hybrid U.S. Pay Range $151,300.00 - $204,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview Alnylam Pharmaceuticals is building a data-driven digital marketing capability that integrates technology and commercial operations to deliver personalized experiences for healthcare professionals and patients across our rare disease portfolio. The Associate Director, Marketing Data and Software Engineering serves as the primary technical interface between the Data, AI & Enterprise Architecture organization and the Commercial/Marketing business function, owning the engineering backbone that powers Alnylam's digital marketing execution: data pipelines, platform integrations, CDP activation, and analytics infrastructure connecting the Alnylam Data Platform (Snowflake lakehouse) to the marketing technology ecosystem. Reporting to the Head of AI, Data & Engineering, this role partners daily with the Chief Marketing Officer's organization to translate marketing data and technology requirements into production-grade engineering solutions. The position manages a team of data engineers, software engineers, and MarTech integration specialists, and serves as the engineering co-lead across Alnylam's five-team commercial digital marketing structure. This is a hybrid role based in Cambridge, MA, with 3 days per week onsite. Responsibilities • Own the end-to-end marketing data pipeline architecture, ingesting data from all marketing platforms (Veeva, Adobe Experience Cloud, Salesforce, Google Ads, paid media) into the Snowflake data lakehouse using the Alnylam Common Integration Pattern (Snowflake Data Sharing, Fivetran, Snowpipe), • Design and maintain the composable CDP architecture with Snowflake as the system of record and Salesforce Data Cloud as the activation layer, ensuring identity resolution, consent propagation, and event schemas are standardized across all marketing touchpoints, • Architect and maintain the "data spine": the standardized integration layer connecting all marketing execution tools to the Snowflake/dbt core, eliminating ad hoc point-to-point integrations that create technical debt, • Lead the technical implementation of real-time journey orchestration infrastructure, including audience suppression logic, frequency caps, channel sequencing, and agentic decisioning capabilities using AWS Bedrock, • Serve as the primary technical interface to Commercial/Marketing business stakeholders, partnering with Business co-lead Directors across the five commercial digital marketing teams (Audience Science, Digital Experience, Content Intelligence, Omnichannel Delivery, Performance Analytics), • Lead the engineering implementation of AI-powered marketing capabilities, including Next-Best-Experience engine infrastructure, audience propensity modeling pipelines, content personalization at scale, and Generative Engine Optimization (GEO) monitoring across AI search platforms, • Manage and develop a team of data engineers, software engineers, MarTech integration engineers, and BI engineers while contributing hands-on to production code, architecture decisions, and technical design reviews Qualifications Required • Bachelor's degree in Computer Science, Data Engineering, Software Engineering, or a related technical field; Master's degree preferred, • 10+ years of progressive experience in data engineering, software engineering, or platform engineering, with at least 5 years in a leadership role managing technical teams, • 3+ years of experience building data pipelines and platform integrations for marketing, commercial analytics, or digital experience teams; pharmaceutical or life sciences industry experience strongly preferred, • Deep hands-on expertise with the modern data stack: Snowflake, dbt, Fivetran, and cloud-native orchestration tools (Astronomer/Airflow), • Production experience with CDP architectures, including Salesforce Data Cloud, Adobe Experience Platform, or equivalent composable CDP implementations, • Strong software engineering fundamentals: Python, SQL, REST/GraphQL APIs, CI/CD, and infrastructure-as-code practices, • Experience with AWS services (Bedrock, SageMaker, S3, Lambda) in a production environment, • Demonstrated ability to serve as a trusted technical partner to non-technical business stakeholders, particularly in marketing and commercial functions, • Understanding of pharmaceutical regulatory requirements including GxP, 21 CFR Part 11, HIPAA, and MLR review processes as they apply to marketing data and technology Preferred • Experience with identity resolution, consent management, and privacy-by-design architectures in a regulated industry, • Familiarity with the Veeva ecosystem (Vault PromoMats, CRM) and its data integration patterns, • Background in real-time personalization engineering, including A/B testing infrastructure (Adobe Target) and journey orchestration platforms, • Experience with multi-touch attribution modeling and marketing mix analytics data products, • AWS Solutions Architect or equivalent cloud certification, • Prior experience in rare disease, specialty pharma, or biotech commercial operations, • Track record of recruiting and developing engineering talent from non-pharma industries (financial services, technology, consumer digital), • Travel: Minimal; occasional travel to vendor conferences (Google, AWS) and team offsites #LI-Hybrid #LI-LN1 U.S. Pay Range $174,800.00 - $236,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

< Overview: The role is responsible for statistical activities in support of Medical Affairs, including post approval value evidence generation, secondary publications, post marketing study design and study protocol development, analysis and reporting of observational or clinical study data, and other post hoc and exploratory analyses as needed. Responsibilities: • Leads statistical support for post approval value evidence generation and reimbursement submissions, • Conducts post hoc analysis to support publications and presentations, • Reviews and authors abstract, manuscript, regulatory documents, • Collaborates with cross-functional team to support observational studies, • Develops statistical sections of study protocols and statistical analysis plans., • Collaborates with Data Management and Medical Research on design of eCRFs., • Provides statistical guidance on conduct of ongoing studies., • Accountable for the collaboration with Statistical Programming to implement statistical analysis of all clinical trial, registry, observational and non-interventional data supporting Medical Affairs needs, • Contributes to observational study reports and regulatory documents, e.g., DSURs, briefing documents, etc., • Contributes to scientific articles, summarizing data collected in Alnylam studies., • Participates in other activities and meetings to support Biostatistics and the Medical Affairs team as needed. Qualifications: • PhD in Biostatistics, Statistics, or equivalent with at least 6 years pharmaceutical biostatistics experience; or MS with at least 9 years' relevant experience., • Excellent written and oral communication and presentation skills., • Extensive experience and strong hand-on skills programming in SAS., • Extensive experiences working on data analysis with clinical studies database, • Experience working on post-approval observational and clinical studies., • Understanding of ICH GCP as well as general knowledge of industry practices and standards., • Experiences in R programming language and other statistical software., • Experience with CDISC, including SDTM, ADaM, CDASH. #LI-AB1 #LI-Hybrid U.S. Pay Range $185,300.00 - $250,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: ___ AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.