Therapeutic jobs in SheffieldCreate job alerts

About Us GeneEase discovers novel gene therapies for subclinical conditions overlooked by traditional medicine - genetic disorders affecting millions (alcohol intolerance, lactose intolerance, mild autoimmunity) where existing treatments are inadequate or nonexistent. We use computational biology to identify promising therapeutic targets, design gene therapy approaches (AAV, base editing, other modalities), validate mechanisms in silico, and partner with wet labs for experimental confirmation. We file patents and license IP to gene therapy companies for clinical development. Role Overview Lead computational gene therapy development: design therapeutics that can be manufactured, delivered, and clinically translated - not just theoretically promising targets. You'll evaluate targets, design vectors with practical constraints in mind (manufacturability, delivery, immunogenicity), validate in silico, and coordinate academic partnerships for experimental validation. 80% computational work, 20% wet lab coordination. You design experiments—partners execute them. Critical: You must understand what makes gene therapies succeed or fail in practice, not just in silico. Key Responsibilities Therapeutic Design with Translational Focus (40%) • Evaluate genetic targets (genetic clarity, deliverability, market size), • Design gene therapy approaches considering practical constraints:Manufacturability: AAV titer requirements, production scalability, purification, • Deliverability: Tissue accessibility, dose requirements, injection volumes, immunogenicity, • Regulatory feasibility: IND pathway, safety assessment, clinical endpoint definition, • Select modality (AAV, base editing, other), vector/delivery system, regulatory elements, • Protein modeling: Structure prediction (AlphaFold), molecular dynamics (GROMACS), enzyme kinetics, • Safety assessment: Biodistribution (PBPK), immunogenicity, off-target prediction, • Translational risk assessment: Therapeutic window, dose-response, durability predictions, • Identify labs with relevant capabilities (animal models, assays, AAV production), • Design experimental protocols considering practical feasibility (realistic timelines, achievable titers, appropriate controls), • Draft manuscripts, patent applications, pharma partner dossiers emphasizing clinical translatability Requirements Education: PhD in Computational Biology, Bioinformatics, Bioengineering, Systems Biology, or related fields (or MS with 3-5 years experience) Wet Lab Experience: 1-3 years hands-on experience (cloning, cell culture, transfection, assays). Gene therapy experience strongly preferred (AAV/lentivirus production, transduction, functional validation, titer quantification). Gene Therapy Technical: Vector design (AAV serotypes, promoter selection, cargo optimization, CRISPR guide RNAs), tools (Benchling, SnapGene) Gene Therapy Development Mindset: • Understand what makes vectors succeed vs. fail in practice (not just in silico), • Consider manufacturability, deliverability, and immunogenicity upfront Programming: Python (BioPython, pandas, PyTorch), R (Bioconductor), SQL, Git, Linux/HPC Nice-to-Haves • Gene therapy industry experience: Worked at gene therapy biotech in vector development, process development, or CMC roles, • IND-enabling study experience: Familiarity with GLP tox, biodistribution studies, dose escalation strategy, • AAV manufacturing knowledge: Production optimization, titer improvement, purification troubleshooting, • Academic/CRO partnership management: Protocol transfer, feasibility assessment, troubleshooting, • Regulatory awareness: IND/CTA filings, FDA feedback meetings, clinical endpoint selection Essential Traits • Autonomous problem-solver with mechanistic thinking, • Bridges computational predictions with biological reality, • Builds tools, not just uses them, • Communicates complex work to non-technical stakeholders Why Join Us • Shape the foundation of a product that bridges biology and computation., • Collaborate with a global, interdisciplinary team., • Flexible, remote-first engagement., • Opportunity to see your expertise directly influence product development. How to Apply Please submit your application at: We look forward to hearing from you!

Spectrum.Life is a whole-of-health digital partner that guides organisations and their people to thrive, delivering clinically backed digital health, mental health and wellbeing solutions. Our HealthTech delivers digital transformation for Insurers, Educators and Employers through Co-creation or seamlessly integrated out-of-the-box solutions, that decrease digital fragmentation and engage, empower, and transform their people’s lives. Established in 2018 by Stuart McGoldrick and Stephen Costello, Spectrum.Life provides services internationally to over 7.2m insurance members, 3,000 corporate clients, 60 universities and 650,000 university students. Spectrum.Life currently employs over 450 people. Our vision is to change and save as many lives as possible. Role Brief: The HCPC Clinical and Counselling Psychologists Digital Therapist role is ideal for HCPC Registered Clinical and Counselling Psychologists Chartered with BPS. This position is a vital part of the Spectrum mental health team, delivering evidence-based psychological talking therapies digitally (video, phone, text) You will be responsible for delivering psychological talking therapies, evidence based, high-intensity interventions while adhering to our clinical governance frameworks to ensure effective and safe care. Responsibilities: • Deliver Psychological Evidence-Based Interventions, • Provide high-intensity CBT (HI-CBT) and other structured evidence-based interventions digitally (video, phone, text-based)., • Deliver NICE-recommended therapies, including:, • Acceptance and Commitment Therapy (ACT), • Compassion-Focused Therapy (CFT), • Eye Movement Desensitisation and Reprocessing (EMDR), • Counselling for Depression (CfD), • Interpersonal Therapy (IPT), • Behavioural Activation (BA), • Mindfulness-Based Interventions, • Tailor individualised treatment plans based on client needs and NICE guidelines., • Adapt interventions for remote delivery, ensuring therapeutic effectiveness in a digital format., • Determine appropriate treatment pathways within a stepped-care model., • Utilise Spectrum.Life digital platforms to deliver structured psychological therapies., • Guide clients in engaging with self-help tools, psychoeducation, and digital therapy resources., • Maintain a therapeutic alliance and client engagement in a remote setting., • Work within clinical governance frameworks to ensure safe, ethical, and effective digital therapy., • Adhere to data protection (GDPR), confidentiality, and safeguarding policies., • Engage in regular clinical supervision, CPD, and peer consultation., • Participate in clinical audits, data analysis, and outcome evaluations to enhance service effectiveness., • Provide feedback on digital service improvements to enhance client engagement., • Support the development of mental health tools and online therapy innovations. Requirements: • Full accreditation and registration with: British Psychological Society (BPS) and Health and Care Professions Council (HCPC) (mandatory), • Doctoral Training: Completion of a Doctorate in Clinical Psychology (DClinPsy) or Doctorate in Counselling Psychology (DCPsych)., • (DCPsych) accredited by the BPS and approved by the HCPC., • Minimum of five years post doctoral qualification experience., • Proven experience delivering High-Intensity CBT in IAPT or another relevant service., • Experience providing other evidence-based psychological therapies in line with NICE guidelines (e.g., IPT, ACT, EMDR, BA, CFT, CfD)., • Experience working within an IAPT or stepped-care model., • Experience in working with adults and children 6+ therapeutically., • Experience in screening adults and children, assessing risk, and implementing safety plans., • Strong digital literacy skills and the ability to adapt interventions for online platforms., • Experience using video conferencing software for therapy delivery (e.g., Microsoft Teams, Zoom)., • Proficiency in clinical case management systems (CSM) for record-keeping and reporting., • Familiarity with Microsoft Office (Word, Excel, Teams), email, and internet-based tools., • A clean record with the associated regulatory body (HCPC for Clinical and Counselling Psychologists)., • Strong understanding of clinical governance, GDPR, and safeguarding procedures., • Excellent interpersonal and communication skills., • Ability to work independently while contributing to a multidisciplinary team., • Strong ability to plan, organise, and prioritise workload efficiently., • A commitment to continuous professional development (CPD) and clinical supervision., • Ability to work afternoons and evenings, supporting clients in different time zones if required. Desirable: Experience delivering evidence-based trauma therapies, including: • Eye Movement Desensitisation and Reprocessing (EMDR), • Trauma-Focused Cognitive Behavioural Therapy (TF-CBT), • Trauma-Informed Cognitive Behavioural Therapy (TI-CBT), • Compassion-Focused Therapy (CFT), • CBT-Adapted Rating Scale (CBTRS), • Generalised Anxiety Disorder Scale (GAD-7), • Patient Health Questionnaire (PHQ-9), • Additional relevant measures include:, • Work and Social Adjustment Scale (WSAS), • Core Outcome Measures (COMs), • Depression Anxiety Stress Scales (DASS-21), • Generalised Anxiety Disorder (GAD-7), • Hospital Anxiety and Depression Scale (HADS), • Trauma Symptom Checklist (TSC-40), • Post-Traumatic Stress Disorder Checklist (PCL-5) What are the benefits of working at SPECTRUM.LIFE? • Competitive salary (Dependent on experience)., • Full time or part time permanent contract, • remote working, • 25 days annual leave, • 24/7 EAP and a wide range of health and wellbeing supports, • The opportunity to work in a strengths based and inclusive way and contribute to a bigger shift in changing societal attitudes towards mental health and wellbeing, • Remote supervision, • Training, guidance and support to allow you to do your role to the best of your ability, • Opportunities to develop your skills and expertise through learning and training, • The chance to contribute to the development and shaping of a new and exciting service, • Extensive list of employee perks and benefits ___

Overview Our client, a well-regarded further and higher education provider, is seeking a Counselling Supervisor (Psychodynamic) to support students enrolled on a Diploma in Psychodynamic Counselling. This part-time, fixed-term role is based within a Higher Education setting and is suited to an experienced, accredited psychodynamic practitioner with a strong commitment to ethical practice, supervision, and student development. The role focuses on supporting trainee counsellors to apply theory to practice while maintaining clear professional boundaries in line with recognised ethical frameworks. Responsibilities • Provide supervision support to students studying on a Diploma in Psychodynamic Counselling., • Work in accordance with BACP and/or UKCP ethical frameworks at all times., • Manage and facilitate a designated student supervision group as part of a wider supervisory team., • Support students to integrate psychodynamic theory into their client work., • Model psychodynamic practice consistently and professionally., • Produce objective, timely written assessments and reports., • Attend scheduled meetings and peer supervision sessions as required., • Maintain clear professional boundaries and demonstrate appropriate professional behaviours with both staff and students. Essential • Professionally qualified psychodynamic counsellor or psychotherapist., • Current accreditation with the British Association for Counselling and Psychotherapy (BACP) or equivalent professional body., • Minimum of three years’ post-qualification experience., • Current practice as a psychodynamic counsellor or psychotherapist., • Experience in psychoeducation and professional report writing., • Evidence of ongoing continuing professional development within a therapeutic context., • Discounted access to on-site gym, sports facilities, fitness classes, osteopathy, and on-site nursery., • Discounted café facilities., • Free on-site parking., • Convenient location within a short walk of a mainline train station., • Access to free online qualifications and professional development. The closing date for applications is 9 January 2026. This role involves working in a regulated education environment. The successful candidate will be required to complete pre-employment checks, including enhanced DBS clearance, employment references, and safeguarding screening. Our client is committed to equality, diversity, and inclusion and welcomes applications from candidates of all backgrounds. Reasonable adjustments will be supported throughout the recruitment process. Please note that this is a smoke-free campus.

Join MAC Clinical Research, a leading full-service global CRO, and be part of a team that’s shaping the future of clinical trials. We work across a wide range of therapeutic areas, delivering high-quality research that makes a real difference to human health. We’re looking for a Senior Biostatistician to take a leading role in our growing Biostatistics team. You’ll work alongside experts across disciplines, providing statistical leadership, guiding high-impact projects, and mentoring colleagues. If you’re passionate about clinical research, thrive in a collaborative environment, and want to make a tangible impact, we’d love to hear from you. What you’ll do: • Act as Lead Statistician across multiple studies, ensuring quality, compliance, and client satisfaction., • Oversee statistical planning, analysis, and documentation (SAPs, Tables/Figures/Listings, Randomisation Specs, Reports)., • Provide statistical input to protocols, study designs, sample size calculations, and CSRs., • Lead complex statistical analyses, including PK data analysis., • Contribute to bid defences, client meetings, and departmental process improvements., • Mentor and support the development of junior team members. What we’re looking for: • PhD or MSc in Biostatistics (or related field)., • 3+ years’ experience as a Lead Statistician in a CRO, pharma, or biotech environment., • Expert knowledge of statistical principles and regulatory requirements in clinical research., • Proficiency in SAS programming., • Strong communication skills, able to present complex concepts to non-statisticians., • PK analysis experience; RWD knowledge is a plus. Why join us: • Health insurance., • 25 days’ holiday + bank holidays, increasing with service., • Your Birthday off work, • Eye Care Vouchers, • Opportunities to present at conferences, mentor, and progress into leadership. At MAC, we value people first: you’ll be supported, listened to, and given the tools to succeed. Apply now and help us deliver research that changes lives. If you require any reasonable adjustments during the selection process, please email

Help bring science to life and join a leading pharmaceutical company to play a key role in delivering impactful research that drives healthcare innovation! Proclinical is recruiting for a Director of Global Evidence Generation to oversee the design and implementation of strategic evidence generation initiatives for key assets in Immunology and Respiratory. In this role, you will collaborate with cross-functional teams to align on priorities, coordinate tactics, and ensure impactful delivery of evidence generation activities. This is an exciting opportunity to contribute to innovative therapies in a dynamic and collaborative environment. Responsibilities: • Oversee the creation and implementation of the Integrated Strategic Evidence Generation plan in alignment with asset strategies., • Provide strategic oversight on evidence generation needs, priorities, and tactics., • Lead cross-functional collaboration to deliver cohesive evidence generation activities., • Ensure timely execution of studies that support strategic goals and maximize impact., • Manage budgets and track performance using key metrics and KPIs., • Identify and establish external partnerships to enhance evidence generation efforts., • Contribute to life-cycle management strategies for assigned assets. Key Skills and Requirements: • Advanced degree in a medical or scientific field., • Expertise in Immunology or Respiratory therapeutic areas is preferred., • Working history in developing and executing global evidence generation strategies., • Strong skills in data interpretation, communication, and building strategic partnerships., • Familiarity with Real-World Evidence (RWE) and/or Health Economics and Outcomes Research (HEOR) is highly desirable. If you are having difficulty in applying or if you have any questions, please contact Tom Pinnock at . If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page. Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy. By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - .

QATAR. CLINICAL PSYCHOLOGIST VACANCY(relocation required) IMS Recruitment is a leading recruiter of medical staff for top Middle East hospitals. IMS is now seeking a CLINICAL PSYCHOLOGIST. With staff comprising of leading medical practitioners from around the globe, our prestigious client operates a multidisciplinary premium mental therapy clinic in Doha, Qatar. Our client provides high quality medically driven and evidence-based services adults and juveniles. This role is designed for a clinician with deep expertise in treating adolescents and adults, particularly those presenting with complex emotional, trauma-related, and relational challenges. Key Responsibilities • Specialist Intervention: Deliver evidence-based psychological services for adolescents and adults (e.g., mood disorders, personality vulnerabilities, complex trauma, and emotional dysregulation), • Therapeutic Modalities: Utilize advanced interventions including CBT, Trauma-Informed Care, mindfulness-based approaches and couples/family therapy;, • Assessment: Conduct and interpret comprehensive psychological assessments (e.g., WAIS, MMPI-3, WIAT) to inform diagnosis and treatment planning;, • Clinical Leadership: Provide clinical supervision, mentoring, and professional guidance to junior psychologists and multidisciplinary team members. Requirements: • A minimum of 7-10 years’ experience in clinical psychology, • Masters and/or PhD in Clinical Psychology essential, • Formal training in CBT is required., • Advanced certification in Trauma modalities (e.g., EMDR) or Couples Therapy is highly desirable, • Strong experience with children, adolescents, adults, couples, and families, • International or Western training/exposure, • Experience in reputable private-sector settings, • Eligible to be licensed by the Licensing authority in the State of Qatar, • License from the country of origin as a Clinical Psychologist, • Attractive Tax-Free Incomes, • Relocation assistance, • Other benefits such as tickets, health insurance, company car If the vacancy is of interest, please apply by sending your detailed CV to: and we will be happy to assist. Your contact: Camelia Nitu IMS RECRUITMENT

• Job Title: Senior CRA / Senior CRA II, • Location: Remote in UK, • Salary: £53,000 - £59,000 (DOE), • Additional Benefits: Car allowance (or company car) and bonus, • Sign-on Bonus: Potential sign-on bonus for qualified candidates, • Company: Global CRO RBW Consulting is thrilled to present an exciting opportunity on behalf of one of our esteemed clients. As one of the few rapidly growing Contract Research Organizations (CROs) for UK studies, our client is expanding their site management team with multiple hires this year. They are involved in a diverse range of studies, including cutting-edge research in advanced therapies such as CAR-T. Join a highly experienced team dedicated to excellence in clinical research. In this role, you will benefit from a supportive management team committed to your professional growth. They provide clear guidance on the skills needed for advancement and offer fluid career development opportunities across various departments. This company prioritizes quality over metrics and is currently generating significant excitement within their UK team. Key accountabilities • Autonomy of investigator sites with full responsibility for the successful management of sites through study life cycle (start-up to close-out);, • Conduct feasibility, pre-study, initiation, monitoring, and closeout visits for research sites, mainly phase 1 to 3 and within all available therapeutic areas;, • Prepare accordingly and attend investigator meetings, coordinating timely delivery and subsequent proper storage and accountability of clinical supplies and following-up of drug safety issues;, • Perform source document verification and case report form review;, • Perform regulatory document review;, • Conduct study drug inventory;, • Perform adverse event and serious adverse event reporting and follow-up; and, • Assess patient recruitment and retention. Qualifications • Bachelor of Science in health-related field (or equivalent), • Proven CRA experience; 3 years minimum Why Join? • Supportive Environment: Build strong relationships with a transparent management team focused on your development., • Innovative Approach: Work with a company that embraces a 360 monitoring approach and leverages AI to enhance efficiency and save time., • Results-Driven KPIs: Our client's key performance indicators are centered around tangible study outcomes, such as patient recruitment, visit reports, and resolving site issues., • Administrative Support: Dedicated admin staff to help with site management tasks, helping to maintain a balanced workload., • Training: Extensive training and buddy system in place., • Career Growth: promotion opportunities up to 4 times a year., • Therapy Areas: Access to mixed therapy areas, including advanced therapies like CAR-T. To apply Please click ‘apply’ or contact Joe Pearce for any further information About RBW Consulting RBW Consulting is a life sciences talent & strategic consultancy with purpose, delivered through what we call Human Intelligence. We help life sciences businesses change the world by giving them the people, insight & networks to innovate and scale. We are proud of our role in helping companies deliver better health and wellbeing outcomes for patients We give back by playing an active role in funding initiatives that change lives We’ve created a culture rooted in support, transparency and mutual commitment. We lead with our values from the inside; empowering and investing in our people is more important than short-term commercial gain. We are an equal opportunities Recruitment Business and Agency RBW Consulting is an equal opportunity workplace. We prioritize talent (both current and potential) over resumes, challenge the status quo, and value people as our most important asset. We do not discriminate on the basis of race, ethnicity, colour, sex, gender identity or expression, sexual orientation, religion, age, marital status, visible or invisible disability, medical condition, national origin, veteran status, or any other protected status. We strive to be a diverse workforce that is representative at all levels and are committed to building a team that represents a variety of backgrounds, perspectives, and skills.

How would you like to get paid for five days, but only work four? At Outcomes First Group, we believe in better work/life balance and were putting wellbeing first. Thats why were proud to be part of a 4-Day Working Week (4DWW) trial, where you can work one day less each week (or equivalent hours), while still receiving your full-time pay. Many of our schools have already introduced the 4DWW and others are preparing to roll it out as soon as they reach full staffing. So, whether its already in place or just around the corner, nows the perfect time to join #teamOFG. Job Title: SENCo Location: Bradford Beacon School, Rooley Lane, Bradford, BD5 8LJ Salary: Up to 45,000.00 per annum ( not pro rata ) Hours: 40 hours per week | Monday to Friday Contract: Permanent | Term Time Only Start: January 2026 UK Applicants only this role does not offer sponsorship Bradford Beacon School, part of Options Autism, is a brand-new specialist setting opening its doors to pupils with autism, complex communication needs, and associated learning or emotional challenges. We are building something exceptional a nurturing, forward-thinking school where every child is supported to shine. This is your chance to be part of that journey from the very beginning. About the Role As our SENCo, youll take a central leadership role in ensuring that every pupil receives the personalised support they deserve to thrive academically, socially, and emotionally. Working alongside the Headteacher and our dedicated on-site therapy team, youll shape the vision and strategy for SEND provision across the school, ensuring inclusive practices are embedded in every classroom and every interaction. This is an exciting opportunity to make a profound impact influencing whole-school development and helping every learner reach their potential. Key Responsibilities • Lead and implement the schools SEND policy and inclusive practices., • Support and guide staff through the graduated approach and targeted interventions., • Work closely with teachers, families, therapists, and external professionals to ensure the best outcomes for every pupil., • Monitor, evaluate, and continually improve the quality and impact of SEND provision. What Were Looking For Youre an inspiring, knowledgeable SEN professional with a passion for transforming lives through inclusive education. You thrive on collaboration, innovation, and seeing pupils with additional needs flourish. Youll Bring: • Qualified Teacher Status (QTS) or recognised equivalent., • Proven experience supporting pupils with SEND, particularly autism and complex needs., • Strong leadership and interpersonal skills, with the ability to motivate and guide others., • A strategic, solution-focused mindset and commitment to best practice. About us Our new Options Autism school Bradford Beacon School opened in September 2025 and caters for up to 37 pupils aged 4 to 11 years with a variety of complex needs, including ASC. Bradford Beacon School provides a nurturing, inclusive environment where every child is supported to achieve their full potential through personalised, high-quality education and therapeutic support. For over 19 years Options Autism have provided care and education to pupils, young people and adults with autism, complex needs and learning difficulties. We are a leading provider of education for neurodivergent young people and young adults. As part of Outcomes First Group, we are leading our sector in setting and delivering new approaches that provide measurable outcomes for those in our care. We are really proud to say that in 2024, Outcomes First Group were officially certified as a Great Place to Work for the fifth year running. Why join Options Autism? We place the outcomes of the pupils and vulnerable young adults in our services at the heart of everything we do, so youll wake every day in the knowledge that your role will have a significant positive impact on the lives of others. We are committed to the safeguarding and promoting the welfare of pupils and young people. All applicants will be subject to social media checks and successful applicants to a fully enhanced DBS. Benefits Your health and wellbeing are important to us, so youll get an exceptional reward package including: • Life Assurance, • Pension scheme with options to increase your contributions, • A wide range of health, wellbeing, and insurance benefits, • 100s of discount options valid in the UK and abroad, • Cycle to Work Schemes, • Electric Car Purchase Scheme, • Critical illness cover *Youll work 80% of your contractual hours for 100% of your pay, giving you more time to do the things that make you happy. 4DWW is subject to successful completion of probation and is not a contractual benefit Outcomes First Group is committed to carrying out a fair, thorough and efficient recruitment process in line with Keeping Children Safe in Education. Whilst we aim to keep applicants informed throughout, Outcomes First Group does not accept liability for any loss of earnings or other associated costs incurred by applicants as a result of delays or changes in the compliance process. All stages of the compliance process are subject to necessary safeguarding checks and compliance with statutory requirements, which may affect timescales. #1

UK's largest leading communities of children's service providers.For over 30 years, our group has included independent fostering and adoption agencies, leaving care services, therapeutic residential homes, specialist ed.

Senior Residential Support Worker Up to £34,145 per year Location: Chipping (North of Preston) Salary: Up to £34,145 per annum (Base £30,545 incl. £40 per sleep-in + up to £3,600 performance bonus) Contract: Permanent, Full TimeShift Pattern: 2 days on, 4 days off (paid sleep-ins at £50) Were partnering with a well-established provider of therapeutic childrens services to recruit an experienced and m...

Our 2 bedded home offers a comfortable, homely setting for up to two young people who need therapeutic placements. With over 35 years of residential childcare experience, the Esland group now has more than 65 residential children’s and assessment homes, and five schools, that are spread across the