103 Best Science Jobs in Cincinnati, Ohio (October 2025)

Ethos Holding Corp

Analytical Chemist

2 days ago

Newport

Job DescriptionDescription: JOB OVERVIEW The Analytical Chemist is responsible for the quantitation of MS data. Additionally, the Analytical Chemist will assist in the LCMS lab in daily preventative maintenance, troubleshooting, and repair of LCMS instrumentation. Ethos manages clinical samples for diagnostic drug and metabolite confirmation analysis, and this candidate will engage in professional work in conducting toxicological examinations to identify and quantify target compounds. In addition, they will participate in validation studies, proficiency testing programs, method development, and other programs at the direction of the Confirmation Supervisor. ESSENTIAL FUNCTIONS • Document completed batches and items for further review, • Collaborate and communicate with other departments to maintain the highest quality standards for testing procedures, • Initiate internal and external rerun requests, • Review calibration and quality control data for each batch of patient samples, • Perform data analysis on patient samples for multiple analytes using mass spec software programs, • Utilize established protocols to confirm retention time, precursor and product ions, and qualifier ions are within established ranges for peak qualification and note any discrepancies, • Identify patient samples requiring reinjections or re-extractions following established protocols, • Program reinjections to run on the mass spec instruments, • Document data analysis completed and items for further review, • Transmit completed data analysis to the Laboratory Information System (LIS), • Assist in proficiency testing, monitoring of daily controls, and be responsible for operating within the established quality controls parameters; including the recognition of invalid data and bringing all errors to the supervisor’s attention, • Complete updated reports as needed, • Ensure adherence to all regulatory requirements, • Prepare daily work lists for all methods and all matrices, ensuring accuracy of methods and most efficient use of instrument time, • Switch out batches of specimens on instruments to maintain workflow, as needed, • Communicate with certifying scientists regarding plate status, instrument issues, and more, • Assist in proficiency testing, monitoring of daily controls, and be responsible for operating within the established quality controls parameters; including the recognition of invalid data and bringing all errors to the supervisor’s attention, • Participate in ongoing training and continuing education courses related to LC and MS systems, • Work on selected projects as determined by the Instrument Specialist or Technical Supervisor, and meet all established deadlines and project goals, • Participate in developing new testing opportunities and method development, as needed, • Other duties as assigned Requirements: PROFESSIONAL REQUIREMENTS • Regular and prompt attendance, • An advanced understanding of drug metabolism, toxicology, forensic testing, P450 enzymes, or testing principles specifically related to urine and oral fluid metabolism, • An advanced understanding of LC-MS/MS systems and data interpretation, • High level of attention to detail, • Proficient in operating complex laboratory instrumentation and computers with scientific software, • Ability to participate in method development, validation or research with Technical Supervision preferred, • Able and willing to follow established protocols employing acceptable forensic standards of analysis and the use of judgment in searching for solutions or new applications within one’s own experience, • Must be able to work with limited supervision where the work assignments are subject to established procedures, practices, precedents, methods, techniques, standards, and/or well-defined policies, • Must be able to achieve superior results when work is reviewed in terms of quality, volume, timeliness, and adherence to established methods, standards and policies, • Participate in ongoing training and continuing education courses related to drug metabolism, toxicology, and LC-MS/MS systems, • Responsible for promoting a collaborative and entrepreneurial environment, • Must be able and willing to wear personal protective equipment (PPE) when required, • BS, MS, or Ph.D in Life Science, Pharmacology, Toxicology, Biology, Chemistry, Biochemistry, or similar analytical science field and 2-5 years of post-academic laboratory experience., • Preference for candidates with familiarity with LC-MS/MS instruments (other experience in instrumental analysis of HPLC or LC-MS/MS of drugs in biological tissues may be acceptable), • Preference for candidates with familiarity with Agilent MS and LC systems – specifically MassHunter Acquisition and Quantitation programs, • Ability to communicate effectively, orally and in writing, • Ability to coordinate laboratory functions and represent the toxicology laboratory professionally, • Excellent time management, documentation, and organizational skills, • Demonstrated troubleshooting abilities, • Must be flexible, innovative, and self-motivated, • Ability to plan and organize his/her work, • Ability to function independently and in a team environment, • Work is performed in a laboratory environment and exposes the incumbent to normal laboratory hazards and chemicals, including biohazard materials, • Work in varying degrees of temperature (heated or air conditioned), • None

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