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Location: United Kingdom (Hybrid or On-Site) Sector: Neuroscience / Drug Discovery Type: Full-time, Permanent About the Opportunity An innovative biotechnology company developing next-generation ion channel therapeutics is expanding its biology and electrophysiology team. We are looking for a highly motivated electrophysiologist with a passion for ion channel research and drug discovery to contribute to the advancement of novel therapeutics targeting neurological and sensory disorders. The Role You will play a central role in designing and executing electrophysiological studies to support preclinical programs, contributing to the understanding of compound activity, mechanism of action, and target validation. Working closely with cross-disciplinary teams, you will help drive the progression of promising molecules from discovery towards clinical development. Key Responsibilities • Design, conduct, and analyse electrophysiology experiments on recombinant or native systems, including whole-cell patch-clamp and tissue-based recordings, • Apply advanced electrophysiological and pharmacological techniques to characterise ion channel modulators, • Utilise and develop solid-supported membrane electrophysiology (SSME) or related biophysical approaches, • Interpret data and communicate results effectively to project teams and collaborators, • Contribute to internal documentation, technical reports, and scientific presentations, • Strong hands-on experience in manual patch-clamp electrophysiology or equivalent methods, • Comprehensive understanding of ion channel biophysics, pharmacology, and structure–function relationships, • Proven ability to independently plan, execute, and analyse complex electrophysiology studies, • Familiarity with automated electrophysiology or SSME platforms (e.g., Nanion systems), • Exposure to CNS drug discovery, lysosomal biology, or other mechanistic pharmacology fields, • PhD (or equivalent experience) in Neuroscience, Pharmacology, Physiology, Biophysics, or a related field, • The opportunity to work at the forefront of ion channel drug discovery, • A collaborative, science-first culture that values creativity, rigour, and teamwork, • Competitive compensation and benefits, with opportunities for professional growth

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