Trabajos investigator en Reino Unido

🚀 Head of Clinical Operations | Gene Therapy We’re partnering with an exciting gene therapy company that has recently secured £50,000,000 in funding to accelerate its next phase of growth. With a cutting-edge AAV-based platform targeting both CNS and systemic diseases, this company is advancing potentially curative therapies across multiple indications. This is a rare opportunity to join at a pivotal moment and lead the clinical strategy from early-stage through to late-phase development. You will: • Lead and scale the Clinical Operations function globally, • Drive execution of first-in-human and later-stage gene therapy trials, • Oversee CROs, vendors, and international investigator sites, • Build and implement clinical development operational strategy, • Partner closely with Clinical, Regulatory, CMC, and Translational teams 🎯 What We’re Looking For • Significant leadership experience in Clinical Operations (biotech/pharma), • Strong background in gene therapy, rare disease, or CNS trials, • Proven delivery of early-phase and/or registrational studies, • Deep understanding of global clinical trial execution, • A hands-on leader who thrives in a high-growth, fast-paced environment 🌍 Why Join? • Recently funded with £50M—strong runway and momentum, • Innovative platform with broad therapeutic potential (brain and beyond), • Opportunity to shape and build a world-class clinical function, • Work on therapies with the potential to transform patients’ lives

About the Citrin Foundation ___ is a dynamic, forward-thinking organisation focused on pioneering innovative research and supporting patients with citrin deficiency. We fund research projects to better understand the condition and develop new therapies. We also provide support to citrin deficiency patients and their families globally. By collaborating with leading institutions, clinicians, and researchers worldwide, we drive impactful change through our research efforts, clinical programmes, patient engagement, and advocacy efforts. Find out more about us: Role Summary We are seeking a highly skilled and motivated Research Programme Manager to drive our global research portfolio that spans basic and translational research through to clinical studies and therapy development. This role is both strategic and hands-on. The postholder will connect scientific discovery to therapeutic application in partnership with a global consortium of scientific and clinical leaders. This is a fantastic opportunity for an early-career translational science professional such as a recent post-doc to move beyond singular research projects and take ownership of research operations and patient-centred solutions in the rare disease space. The Foundation operates as the hub in the entire translation pathway. You will gain a unique perspective of the entire drug development journey and serve as a vital contributor every step of the way. Come join us and make a tangible difference in the rare disease community. Key Responsibilities 1. Research and project management • Manage Foundation-funded research projects, monitoring study progress, budgets, and milestones to ensure alignment with our core objectives., • Serve as primary liaison between academic investigators, clinical collaborators and industry partners. 2. Translational strategy and operations • Identify and evaluate new research opportunities with high translational potential., • Support both Foundation initiatives and projects led by our consortium of investigators in navigating logistical, operational, and regulatory hurdles to accelerate the translation from lab to clinic. 3. Clinical and regulatory support • Support the planning and operational management of natural history studies., • Collaborate with our patient engagement team to ensure that studies are patient-focused and data-driven, informing future clinical development and study designs. 4. Stakeholder Advocacy • Foster collaboration across a multi-disciplinary network of scientists, clinicians, and patient families., • Communicate complex scientific findings in a clear, impactful way to internal and external stakeholders, our patient community, and the public. About You Essential Skills and Experience • PhD or equivalent experience in biomedical sciences or a related field., • A good understanding of basic and translational research, research operations, or clinical study designs., • Critical thinker with strong problem-solving ability., • Strong organisational skills and ability to manage multiple complex projects and competing priorities while maintaining a high level of operational detail., • Exceptional written and verbal communication skills, engaging confidently with both leading experts and lay stakeholders., • An adaptable, entrepreneurial and “can-do” mindset, working both collaboratively and independently in a lean multi-disciplinary team., • Patient-centred, empathetic, and discreet, with a deep commitment to the mission of improving outcomes in the rare disease space. Desirable • Experience in early-phase studies or investigator-led clinical trials is strongly preferred., • Experience in rare diseases or metabolic conditions., • Established track record of peer-reviewed publications or conference presentations., • Keen interest in basic and translational science for medical conditions., • Experience working in a charity, foundation, or multi-stakeholder environment.

Senior Clinical Research Associate | London, UK | 6-Month Contract (Full-time) HYBRID Key responsibilities • Support the day-to-day operational delivery of Phase I–III clinical trials across multiple complex indications, • Maintain and oversee Trial Master File (TMF) quality and completeness to ensure inspection readiness, • Assist with study start-up activities including site documentation collection, regulatory submissions and site activation support, • Coordinate trial documentation, vendor communications and study tracking to support global clinical operations teams, • Collaborate with Clinical Trial Managers, CRAs, regulatory teams and external partners to ensure timely study execution, • Track study milestones, manage essential documents and support reporting across clinical programs, • Assist with preparation and management of study materials including investigator meeting documentation and training materials, • Support audit and inspection readiness activities and ensure compliance with ICH-GCP and internal procedures Candidate requirements • Minimum 5 years’ experience as a Clinical Trial Associate or within a comparable clinical operations role, • Strong experience supporting Phase I–III clinical trials, • Experience working within biotechnology environments, ideally supporting innovative or complex therapeutic programs such as cell or gene therapy, • Exposure to multiple complex therapeutic areas and global clinical trial operations, • Strong understanding of clinical trial documentation, TMF management and regulatory processes, • Excellent organisational skills with the ability to manage multiple studies and priorities simultaneously, • Strong communication skills and ability to work effectively within cross-functional clinical teams What is offered • Opportunity to work within an innovative cell therapy biotech environment, • Exposure to cutting-edge clinical development programs, • Hybrid working model in London, • 6-month fixed term contract.

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