Senior Principal Scientist / Director – Computational Chemistry (IDD)
7 hours ago
Hoddesdon
Overview In this senior role you lead the Computational Sciences strategy within Pharmarons Integrated Drug Discovery (IDD) programs, shaping design and optimization of multi-modality ligands. You guide cross-functional teams, drive AI-enabled CADD approaches, and help build scalable computational capabilities while nurturing client partnerships. Your work accelerates discovery from hit finding to IND, contributing to innovative medicines on a global stage. Pay / Benefitscompetitive salarypermanent contractremote work options in the UKopportunities for international collaborationleading-edge computational science environmentprofessional development and visibility ResponsibilitiesDefine and lead computational design strategy across discovery projects from hit expansion to lead optimizationEvaluate and prioritize molecules for synthesis using a full suite of computational toolsProvide scientific leadership to multidisciplinary project teams from hit-finding to candidate selectionAdvance modern CADD approaches (AI/ML, SBDD, cheminformatics) across small molecules and other modalitiesBuild and enhance computational infrastructure, tools and capabilitiesCollaborate with global Computational Chemistry teams and cross-functional stakeholdersCultivate client relationships to support business growth and long-term collaborationContribute to departmental strategy, capability development and business proposalsRepresent Pharmaron externally to boost reputation in Computational Sciences and drug discovery communities Key requirementsPhD in Computational Chemistry, Theoretical Chemistry, Molecular Modelling or related discipline10+ years’ experience in computational drug discoveryProven track record delivering impact across drug discovery pipelinesExpertise in CADD (SBDD, AI/ML, cheminformatics)Experience across modalities (small molecules, peptides, biologics, emerging platforms)Strong publication and/or patent recordDemonstrated experience leading multidisciplinary teams and external collaborationsExcellent communication skillsExcellent communication and stakeholder influencing skillsStrategic thinker capable of translating vision into executionInspirational leader and team developerDeep knowledge of computational chemistry in drug discoveryUnderstanding of medicinal chemistry, biology and DMPK integrationProficiency in CADD approaches including SBDD, AI/ML, and cheminformatics