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Physiomics Physiomics plc (AIM: PYC) is an Oxford-based contract research organisation and consultancy specialising in the application of mathematical and data science solutions to support the development of therapeutic drugs and personalised medicine dosing software. Physiomics has a current turnover of circa £1m p.a. It has a high-profile brand and an established customer base of clients in the UK, Europe and North America. Physiomics takes a collaborative approach to provide clients with bespoke solutions encompassing data, analytics and insight. Physiomics is structured in two service-lines; Model Informed Drug Development (MIDD) and Biometrics. The Company’s MIDD service-line provides a full range of pharmacokinetic/ pharmacodynamic contract services to companies ranging from biotechs to some of the largest pharmaceutical companies in the world, across multiple therapeutic areas. The Company uses a range of commercially available software solutions but also maintains its own proprietary Virtual Tumour™ model which simulates the effects of anti-cancer agents on pre-clinical and human tumours, helping clients to improve the success rate of drug discovery and development projects while reducing time and cost. The MIDD service-line has completed over 140 commercial projects, involving over 125 targets and drugs, and has worked with clients such as Merck KGaA, Numab Therapeutics, Cancer Research UK and Bicycle Therapeutics, to name but a few. The Company recently expanded its contract services into the field of Biometrics, which is run as a separate service-line and provides biostatistics, statistical programming and data management solutions. Even though only recently launched, this service-line is already delivering on several client contracts and has a rapidly growing pipeline of opportunities being progressed. Separately from its contract services business, Physiomics has won several Innovate UK and NIHR grants which it has used to develop a software tool to personalise the dose of chemotherapy. It has an ongoing collaboration with US company, DoseMe, and has incorporated this tool into their existing commercial platform (DoseMeRx). The dosing software tool is currently available for research use only, but as the tool is further developed, the plan is to implement paid for functionality. The CEO Role Physiomics is seeking a new leader to drive an ambitious program of expansion and strategic change within an LSE AIM-listed business. The role requires excellent influencing skills, keen commercial acumen and the ability to communicate effectively with both scientific/ clinical and commercial stakeholders. Even though prior experience is not necessary, the role will be responsible for managing all corporate activities pertaining to being a public company, work with the board of directors, Company Secretary, NOMAD and Broker to ensure compliance to AIM rules and effective governance of the business. Physiomics’ revenues are derived mostly from its core contract services business, and this will remain the first priority of the incoming CEO who will be able to support the acquisition and retention of clients, participate in key meetings and presentations, lead the internal team and have the experience and gravitas to act as a senior advisor to key client contacts. The Company currently operates virtually, although the CEO will need to be available for regular face to face team meetings in the Oxford / London area. The role will require occasional travel (in the UK and abroad) to clients, networking activities, and meetings with stakeholders. The company currently has 12 permanent employees (including Board Directors) and utilises contractors to provide additional capacity and expertise when required. The Company operates a fee for service revenue model but has developed a personalised dosing tool that could form the basis of a software-as-a-service offering. Physiomics believes this role represents a real opportunity for the right individual to make a significant impact in a small organisation. Key responsibilities of the role Operational • Set the Company’s overall strategy, balancing core consulting with other activities such as personalised medicine, • Accountable for all business development and marketing activities (BDM), supporting the Head of Business Development and heads of service-lines (MIDD and Biometrics) to develop and execute on an effective BDM strategy to identify and win new business, maximise pipeline size and quality, and further grow the Physiomics brand., • Accountable for the delivery and expansion of high-quality consultancy services, supporting heads of service-lines in effective resource management to achieve excellence in consulting and develop new service capabilities aligned with growth objectives., • Accountable for general business operations, including HR and recruitment, quality, IT, business processes and management of key internal initiatives., • As required, support key client engagements, providing strategic scientific/ clinical input (depending on experience) to key projects, to ensure client satisfaction and maximise repeat business, • Ensure robust and timely management reporting and communication, including for monthly board meetings, • Liaise with NOMAD, legal advisors and the Company’s broker to ensure compliance with AIM, MAR, QCA and other applicable regulations and guidelines, • Maintain corporate policies and procedures in support of applicable corporate governance and employment regulations (e.g. share trading, GDPR, social media, anti-bribery etc), • Be responsible (together with NOMAD and broker) for the timely issuance of press releases via LSE’s Regulatory News Service where required, • Develop and communicate interim (half year) and full year annual reports to shareholders, • Set up and run the Company’s Annual General Meeting, • Set appropriate remuneration for employees, directors and officers through the Company’s board and remuneration sub-committee, including (as appropriate) bonuses and share options Candidate profile The successful candidate will be an experienced, high calibre international business executive, with an entrepreneurial spirit and evidence of driving successful growth and innovation. They are likely to have experience in delivering contract services (either as an individual or as part of a larger organisation) and a good knowledge of life sciences (for example drug development or technologies used in support of pharmaceutical R&D or clinical practice). They will be motivated to work in a small company environment where they can make a significant impact. Professional/technical experience • A proven track record of success in growing small/ medium sized service businesses or business units in life-sciences, preferably in biopharma R&D, • Extensive current client contacts across the biotech and pharmaceutical industry sector., • Prior experience of running a company or leading a team of scientific professionals within either a CRO or biopharma setting., • An understanding of the R&D process for therapeutic drug development and its challenges, • Knowledge of the international pharmaceuticals and biotechnology sector, • Strong interest in experience of working in a small company environment; willingness to roll up sleeves and get involved in a wide variety of activities, • Experience or knowledge of issues connected with running a public company helpful but not essential, • Hands-on experience in one or more of the following areas: quantitative pharmacology, clinical pharmacology, biometrics and clinical development is desirable. Qualifications • Good scientific or clinical credentials, ideally to PhD/ MD level, • Demonstrated financial acumen either through relevant experience or a qualification such as MBA Personal attributes • Self-motivated, with a readiness to take on tough challenges and see them through to conclusion, • Results focussed: Ability to set a strategic agenda and to execute to achieve long-term growth, • Good business acumen: Good understanding of the services business model and the factors to manage for successful growth, • Excellent communication skills; able to present arguments in a diplomatic, clear, concise, and logical manner, and to influence others positively, • Confidence, persona and gravitas to interface and negotiate with senior client contacts, and to confidently sell the Company’s capabilities to the outside world, • Demonstrated ability to resolve problems in a creative and positive manner and effectively maneuver through complex situations – internal and external, • A strong team leader with the flexibility to work with a wide range of skillsets and personalities consisting of the internal team, consultants, clients and third parties

Job Details: Director Market Access, Real World Evidence, HEOR and Pricing\n Full details of the job. \n Vacancy Name: Director Market Access, Real World Evidence, HEOR and Pricing \n Vacancy No: VN740 \n Employment Type: Full Time \n Location of role: Oxford, UK \n Department: Commercial \nKey Responsibilities\n The Director will be a core strategic leader and member of the global Market Access team responsible for shaping and executing the global Market Access, Health Technology Assessment (HTA), pricing, and evidence generation strategies, encompassing Real World Evidence (RWE) and Health Economics and Outcomes Research (HEOR) for KIMMTRAK (tebentafusp). The geography covers 40+ countries and includes collaborations with Immunocore’s commercial partners for Central and Eastern Europe, Canada, Australia, LATAM, Turkey and MEA. The Director will work closely with Medical Affairs and other global functions to build upon KIMMTRAK’s success by driving the long‑term Market Access strategy for RWE generation and HEOR projects, and publication with an emphasis on expansion of capabilities for the US market in oncology. The Director will be an entrepreneurial, highly curious and collaborative leader. They must be resourceful with a “sleeves rolled up” attitude and able to forge strong ties across the organization. They will combine strong strategic thinking and analytical skills with the ability to translate complex evidence and market insights into clear access strategies, options and trade‑offs for senior leadership. \n The candidate will bring strong leadership and a publication record supporting commercialised and innovative product launches in oncology with an exceptional track record of promoting cross‑functional collaboration across the R&D, Commercial and Medical functions. They will act as a trusted advisor to senior leaders on Market Access, HTA and pricing issues, able to challenge assumptions and shape strategic decisions with robust payer and evidence‑based insights. The successful candidate will report to the Head of Market Access and HEOR and support the Heads of European, International and partnership Markets, and the US Commercial and Medical Affairs teams. The Director will also be accountable for preparation for the next indications of KIMMTRAK, including designing and leading HTA strategies, overseeing pricing and reimbursement for specific countries and is expected to act as the subject‑matter expert for internal planning of evidence needs of the Immunocore pipeline for HTA, pricing and reimbursement. They will provide early strategic input into target product profiles and clinical development plans to optimise the probability of favourable HTA and reimbursement outcomes. They will represent Immunocore at meetings with government authorities and coordinate with multiple internal functions, including Commercial, Medical, Clinical Development, Regulatory, Biostats and Project Management to achieve reimbursement of KIMMTRAK, globally. The individual will also liaise with Finance, Legal and Procurement to ensure compliance and invoice reconciliation for country‑level budgets. \n The role will include significant autonomy, exposure to the Immunocore executive team and an opportunity to develop skills at all levels of the Market Access, RWE and HEOR function to drive global and in‑country success of KIMMTRAK. The successful individual is expected to expand their expertise and responsibilities as Immunocore grows with the launch of new indications for KIMMTRAK and new assets. They will play a key role in informing portfolio, indication sequencing and lifecycle management decisions from a Market Access and payer value perspective and drive evidence generation after launch. \nKey Responsibilities\n\n • Define and own the global RWE and HEOR strategy and capabilities for KIMMTRAK and Immunocore’s oncology portfolio, ensuring evidence generation plans anticipate payer and HTA needs and add measurable value to the product portfolio, with a particular focus on the USA and oncology.\n, • Lead cross‑functional strategic planning and foster a culture of collaboration across Immunocore’s global functions, particularly Clinical Development, Commercial and Medical Affairs, to build upon current successes, drive further growth of KIMMTRAK and prepare for future product launches.\n, • Lead the development, optimisation and governance of global pricing and access strategies, including scenario planning, value‑based pricing approaches and risk sharing options, and drive robust business cases for approval of country pricing and maintenance of national reimbursement contracts.\n, • Oversee the strategy, maintenance and optimal use of the central global evidence repository to support pricing, HTA and reimbursement, ensuring timely access to high‑quality evidence for global and local teams.\n, • Strategically manage the Market Access budget for assigned countries as it relates to RWE, HEOR, pricing and Market Access activities, including prioritisation of investments, and oversight of country‑specific vendors and contracts.\n, • Represent Immunocore at national and regional payer, HTA and policy meetings, articulating a compelling value proposition and negotiating access and reimbursement in line with agreed strategic objectives.\n, • Support and shape the Immunocore pipeline by creating, synthesising and delivering clinical and economic value propositions aligned with the strategic needs of global RWE, HTA, pricing and reimbursement, including early input into clinical development and target product profiles.\n, • Build and drive a collaborative, engaged and high‑performance work culture; provide hands‑on learning, mentorship and strategic guidance to colleagues at global and local levels, leading by example.\n, • Conduct strategic landscape assessments (payer, competitor, policy and HTA trends) to proactively identify risks and opportunities, shaping Immunocore’s Market Access and evidence strategies at global and country levels.\n, • Act as a key strategic partner to the global Head of Market Access and regional Commercial teams, providing clear recommendations on access risk, opportunity sizing and investment prioritisation across indications and markets.\n, • Ensure that all Market Access activities comply with regulatory agencies, public policies/guidelines, and with corporate policies and procedures.\n\nPerson Specification\nExperience & Knowledge\nEssential\n\n, • Demonstrated experience (10+ years) in designing and leading global Market Access strategies for oncology products, including launch and lifecycle management across multiple regions (e.g. US, EU5, key international markets) within a multinational company.\n, • Experience in long‑term access strategy development, including scenario planning, market shaping, and responses to evolving payer and HTA policies.\n, • Proven capability in RWE generation, HEOR and analysis of Patient‑Reported Outcomes (PROs), including publication record across multiple assets, ideally relevant to the USA.\n, • Proven leadership in designing and delivering global Integrated Evidence Plans with Commercial, Medical and Regulatory to support launch and lifecycle management, and in aligning these plans with global Market Access and HTA strategies.\n, • Experience of external stakeholder management e.g. KOLs, PAGs and data source owners especially in Oncology and the USA.\n, • Hands‑on experience of HEOR methodology and other technical approaches to generating value evidence, including localisation (e.g. national, regional, hospital) of clinical and economic evidence to persuade national and local decision‑makers to reimburse KIMMTRAK and future Immunocore products.\n, • Demonstrated success working in a cross‑functional, matrixed environment with the ability to influence without authority, own strategic projects end‑to‑end and deliver impactful solutions, including treatment pathway analyses to assess resource utilisation, clinical/economic drivers and opportunities for positive disruption.\n, • A good business acumen, including ROI‑based decision‑making.\n, • Understanding of international Payer / HTA environments at the national, regional and hospital levels.\n, • A creative, curious and entrepreneurial approach in looking for new ways to uncover opportunities that enable value to be created for patients, healthcare systems and Immunocore.\n\nDesirable\n\n, • Proven record of providing strategic counsel to regional and global Executive Management (and, where appropriate, Boards) on key Market Access policies and reimbursement practices affecting corporate objectives, quantifying risks and opportunities and making clear recommendations for launching and reimbursement of new assets and indications.\n, • Demonstrated track record in building new organisations across internal and external groups.\n, • Understanding and consideration of cultural differences for international business.\n\nSpecific Behavioural Attributes\n\n, • Strategic thinker with the ability to see the “big picture”, connect disparate data and insights, and formulate clear strategic options and recommendations; strong organisational skills with forensic attention to detail.\n, • Good, cross‑cultural / country communication skills with the ability to manage internal and external stakeholders, drive a culture of high‑performing teams, whilst having the confidence and gravitas to manage potential conflicts in prioritising external access challenges and price negotiations.\n, • Strong desire to learn with a hands‑on experiential approach and culture of curiosity.\n, • Strong influencing and negotiation skills, with the ability to challenge and align senior stakeholders around access strategies and trade‑offs.\n, • Comfortable operating with ambiguity and making sound decisions in complex, evolving payer and policy environments.\n, • Resilience and positivity with high volume of work in challenging situations.\n\nKey Behavioural Attributes\n\n, • Openness and honesty: proactive offering of information and advice on business impact and patient access.\n, • Taking responsibility: being prepared to accept full responsibility for tasks entrusted to them, seeing tasks through to completion and dealing with the consequences of failure or success.\n, • Flexibility: being flexible to new ideas and approaches; changes of plans, objectives and/or priorities. Handling disjointed tasks effectively.\n, • Team spirit: being able to work productively with others to achieve tasks. Showing consideration for the needs and feelings of others.\n\nExperience and Qualifications\n\n, • Minimum 10+ years’ experience in Market Access, HEOR, RWE, and pricing within the pharmaceutical / Biotech industry, with a proven track record in leading roles supporting multiple oncology assets.\n, • Advanced degree in Health Economics.\n

Irish Power Market (Senior) Associate Department: Advisory Employment Type: Permanent - Full Time Location: Oxford, UK \nDescription\n Based in Oxford, you will be a senior member of the GB & Ireland advisory team at Aurora, delivering cutting-edge advice to clients across the energy transition, with a focus on Ireland. You will manage junior colleagues in developing insights to help clients make better strategic and investment choices. You will support all aspects of client engagement: helping identify issues, forming hypotheses, conducting analysis, synthesising conclusions into recommendations, and presenting to key decision-makers in the industry. You will develop data-based strategic insights into the energy transition for both public and private sector clients. \n Successful candidates will work in a dynamic, stimulating, and demanding yet supportive environment. They will apply their interpersonal skills to build connected, co-operative project teams. They will be given the responsibility to chart the path of their teams through projects, and opportunities to substantially influence the thinking of organisations across the energy sector. Over time, they will be able to grow into industry experts addressing major strategic issues for the industry. \n The position suits an experienced analyst or associate from a top-tier strategic or economic consultancy, energy company, financial services company, or knowledge-focused firm or institution. The successful candidate will combine technical ability with a strong client mindset and track record of dependable performance in team-oriented environments. \nKey Responsibilities\n\n • Managing advisory projects for our Irish clients, across a diverse range of energy transition technologies, business models and strategies, including planning out the work of the team and ensuring we maintain rigorous standards of analysis and clear communication of insights\n, • Line management of junior analysts in the team to help them develop and coaching/managing analysts within a project\n, • Supporting business development work, for example by contributing delivery plans to our proposals\n\nWhat we are looking for\nRequired attributes:\n\n, • Minimum 3 years’ experience with I-SEM power market\n, • Experience at a major consultancy, energy company, financial services company, or other knowledge-focused firm or institution\n, • First-class or high second-class university degree\n, • Demonstrated success in taking responsibility for project and process management in team-oriented environments\n, • Proven ability to interpret and derive insight from complex quantitative data and information\n, • Ability to communicate clearly and co-operate effectively with both technically and non-technically minded people\n, • Self-starting, entrepreneurial mind-set, and desire to grow the business\n\nDesirable attributes:\n\n, • Previous experience working on energy-related projects or policy – particularly in the context of the I-SEM\n, • Leadership, management or mentoring experience demonstrated by previous roles of professional responsibility or extracurricular activities\n, • Demonstrated success in working together with clients\n, • Competence in advanced data analytics (e.g. Python, R, Matlab, Advanced Excel)\n, • Private Medical Insurance\n, • Dental Insurance\n, • Parental Support\n, • Salary-Exchange Pension\n, • Employee Assistance Programme (EAP)\n, • Local Oxford Discounts\n, • Cycle-to-work Scheme\n

We are partnering with a rapidly expanding, high-growth property consultancy in Oxfordshire to recruit an experienced Asset & Property Management Surveyor at Associate Partner level. This is a rare opportunity to join a dynamic firm managing high-profile assets, delivering strategic, commercially-focused property advice to a diverse portfolio of clients. The Role As an Associate Partner, you will play a pivotal leadership role within the firm, overseeing the management of prime assets while driving business growth. You will combine strategic asset management, tenant liaison, and commercial property expertise to maximise value for clients. The role offers significant autonomy, exposure to high-profile projects, and the opportunity to influence the strategic direction of a rapidly expanding consultancy. Key Responsibilities • Leading the management of high-value and high-profile property assets across commercial, mixed-use, and investment portfolios, • Delivering strategic asset management advice, including lease review, rent negotiations, and capital/project planning, • Building and maintaining strong client relationships, acting as a trusted advisor, • Managing teams of surveyors and support staff, mentoring junior colleagues and driving high performance, • Overseeing compliance, risk management, and service delivery standards, • Contributing to business development and growth initiatives, identifying new opportunities for the firm Candidate Profile • MRICS qualified with proven experience in asset and property management at senior level, • Track record of managing high-profile assets and delivering commercial outcomes, • Strong leadership skills with experience managing teams and influencing stakeholders, • Excellent client-facing, negotiation, and communication skills, • Strategic thinker with the ability to provide commercially-focused solutions, • Entrepreneurial mindset, capable of contributing to the growth and development of a high-performing consultancy Why Join? This is a rare opportunity to step into an Associate Partner role within a fast-growing, ambitious property consultancy in Oxfordshire. You will manage prestigious assets, enjoy a high degree of autonomy, and be part of a team shaping the future of a dynamic and innovative firm.

We are seeking a proactive and experienced Facilities Manager to oversee and manage all building-related activities in our clients UK offices. The successful candidate will ensure our facilities are safe, functional, and efficient, while delivering a high standard of service to internal stakeholders. In addition will manage local FM team members at respective locations. JOB DESCRIPTION / PURPOSE: The Facility Manager is responsible for all FM operations, planned maintenance and reactive works at client Corporate Facilities throughout the UK, primarily outside of London eg (Oxford, Leeds, Cardiff, Nottingham, Southampton, East Grinstead, Exeter areas). The FM is responsible for the delivery of all services towards our client according to the Global Master Services Agreement (MSA), Service Level Agreements (SLA’s) and Key Performance Indicators (KPI’s). Responsible for hard and soft services and act as the key interface between the different business functions, departments and supply chain partners, providing guidance and support to ensure supply chain vendors carry out their obligations and responsibilities in a manner consistent with high-quality operational performance, financial control ensuring outstanding customer service to building occupiers at all times. ESSENTIAL DUTIES: • Manage the day-to-day operations of the site in accordance with contractual, client, and company objectives., • Ensure compliance with local health & safety legislation, environmental regulations, and internal company/client policies., • Act as the primary point of contact for subcontractors and suppliers during on-site work execution., • Assist in the development and tracking of 3rd party vendor agreements to ensure compliance with scope and language., • Supervise and coordinate supply chain vendors and specialist contractors, ensuring quality and compliance with SLAs., • Maintain accurate and up-to-date records of operations, compliance, and maintenance using employers or client’s systems not limited to space planning, environmental, etc., • Lead and execute planned preventative maintenance (PPM) programs and manage reactive maintenance requests and FM-related projects. Update records in CMMS system., • Conduct risk assessments and implement appropriate control measures according to the company’s operational “Ways of Working.”, • Drive continuous improvement initiatives to optimize both operational efficiency and financial performance., • Oversee site budget and cost control, liaising regularly with finance teams and preparing financial reports as needed., • Responsibility for the preparation of operating and capital budgets including quarterly reforecasts., • Review vendor invoices for accuracy and ensure alignment with purchase orders and budget commitments., may upload into accounting system., • Own and manage the Service Activation process, from initiation through to invoicing., • Actively participate in safety operations and inspections, ensuring well-being of staff, visitors, and contractors., • Support the Senior Facilities Manager in strategic planning, budgeting, and implementation of cost-saving initiatives., • Ensure effective complaint handling and timely resolution of service issues., • Maintain and update all management systems and compliance documentation., • Represent the facilities function in internal and external meetings, audits, and events as required., • Responsible for statutory compliance at the location scheduling, tracking and ensuring all compliance is completed., • Liaison with landlord to ensure lease language and, landlords’ scope is being properly delivered, not limited to review of any landlord issued work order invoicing., • Conduct meetings with client’s site lead or head of house to review support and facility needs to ensure client’s needs are properly supported. EDUCATION • BA Degree in a related field EXPERIENCE: • Solid experience in a FM role ideally within an international corporate environment SKILLS • Fluent English, • Strong Knowledge of local regulations, • Experience in FM software such as Tririga a plus, • Excellent interpersonal skills and vendor management skills, • Strong financial and budgeting skills, • Proactive, detail oriented and safety conscious WHAT WE OFFER: • Fast paced working environment, • Entrepreneurial and supportive team, • Competitive salary, • Discretionary Bonus

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