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Job Summary This position is for a Senior Medical Director within the atirmociclib program. This individual contributor will be responsible for supporting clinical trial(s) and lead sub teams in clinical development. The successful candidate should ideally have prior experience in clinical trials, supporting development programs, health authority interactions and demonstrated leadership capabilities to ensure that the clinical development program meets scientific, ethical, and regulatory standards. Job Responsibilities Clinical Development Leadership on Study Teams and Development Subteams • Conduct medical monitoring activities including eligibility assessment, data review and safety monitoring., • Lead peer-to-peer interactions with investigators, • Serve as the point of contact for clinical issues between the study team, investigators, ethics committees, steering committees, and regulatory authorities., • Lead and contribute to development and maintenance of clinical trial and regulatory documents, in collaboration with Clinical Scientist and the cross-functional team., • Provide clinical development leadership across several study teams., • Collaborate with the Global Development Team to create and refine development strategies., • Represent the company in external engagements or as committee member in joint collaborations., • Collaborate with Clinical Scientists to review and interpret clinical data, identify key findings and implications, and communicate to internal and external stakeholders., • Medical degree with 5+ years of industry experience, • Clinical oncology experience (typically 4+ years) Preferred Qualifications Board certified/eligible in oncology or equivalent preferred Breast Oncology experience (2+ years) Organizational Relationships Reports to Global Development Lead and partners closely with subject matter experts within cross-functional study team, Pfizer Oncology Division and counterparts in other divisions within Pfizer. Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. Work Location Assignment: This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Travel to scientific conferences / meetings several times per year, as needed Relocation support available Work Location Assignment: Hybrid The annual base salary for this position ranges from $242,000.00 to $403,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make ___ accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email ___. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Medical

Job Description POSITION SUMMARY: The Manager, Clinical Lab is a key leader in Natera's lab operations who oversees and directs the development, planning, implementation and maintenance of manufacturing methods, processes and operations for new or existing products and technologies. The Manager works closely with groups to ensure strict compliance with good manufacturing practices and CLIA/CAP guidelines at all times. Ensures the effective use of materials, equipment and employees in producing quality products. Monitor and control staffing / labor, capital expenditures, and manufacturing performance. Develops budget and monitors expenditures. Formulates and recommends manufacturing policies, procedures and programs. Selects, develops and evaluates line-management to ensure the efficient operation of the function. Shift timings are from 10.00 PM- 6.30 AM PRIMARY RESPONSIBILITIES: * Under the direction of Senior lab leadership, and in close collaboration with other Laboratory leadership, this individual provides operational and strategic leadership to laboratory products assigned to the individual. * Generates and routinely provides executive-level production/departmental summaries. * Monitors workflow and ensures production goals and deadlines are met (e.g. TAT, SLA) * Engages in future planning and scales employees and equipment appropriately * Gathers and monitors metrics on production deadlines, efficiency, scrap waste, and error rates Monitors the quality control/assurance programs, test results, and equipment (if applicable) * Uses metrics in decision-making and to drive changes across the team (e.g. cost reduction, quality improvement) * Manages sufficient headcount levels to meet production goals by proactively driving the interview process and managing employee PTO and overtime when necessary. * Refines current lab process through continuous improvement projects. * Oversees team-specific lab operations. * Go-to person when Senior lab leadership is not present; go-to person for knowledge of process and product. * Responsible for seamless transition of automation and test improvement/additions into a production workflow * Analyzes and troubleshoots lab processing errors; provides recommendations on how to proceed to lab director, scientists, and statisticians as necessary * Supports Supervisors in the closeout of NCRs. * Responsible for the initiation and closeout of CAPAs in a timely manner. * Ensures departmental lab compliance for regulatory bodies * Ensures tests are being completed according to approved procedures. * Maintains an organized, safe, and efficient work area for the team at all times. * Actively interacts with interdepartmental teams such as OPS, Accessioning, Engineering, Stats, R&D, and Support. * Handle employee issues: complaints, disciplinary actions, etc. Collaborates with Senior Manager and/or Human Resources to resolve issues. • Knows and is ready to explain Natera's core values. Explains (as much as possible) reasoning behind instructions/processes given/changes that are made. If necessary, explains to the team why certain ideas cannot be implemented effectively. Meets regularly with Supervisors to discuss goals and progress. * Performs routine skip-levels with individual team members. * Responsible for performance review of direct reports and overseeing performance review of the entire staff. * Plans and leads team meetings • Develops high-performing employees by providing them with learning opportunities, cross-training opportunities, and new challenges whenever possible. * Recognizes and rewards talent through merit reviews, promotions, and recognition programs * Adheres to Departmental Expectations • Manages the training program for direct reports. * Notifies management of all requirements for tools, supplies, etc. * Receives assignments in the form of objectives and determines how to use resources to meet schedules and goals. * Provides guidance to subordinates within the latitude of established company policies. Recommends changes to policies and establishes procedures that affect immediate organization(s). * Manages, perhaps through subordinate supervisors, the coordination of the activities of a section or department with responsibility for results, including costs, methods and staffing. In some instances this manager may be responsible for a functional area and not have any subordinate employees. QUALIFICATIONS: * BS/BA degree in Biological Sciences, related field, or equivalent * A minimum of 3+ years of relevant leadership experience and/or effectively managing a team preferred * A minimum of 5+ years of industry-related experience preferred * Current ASCP board certification in Medical Technology or California State CLS or CGMBS license (Clinical Genetics Molecular Biologist Scientist) is required KNOWLEDGE, SKILLS, AND ABILITIES: * Exceptional multi-tasking, organizational, and communication skills. * Excellent computer skills, including MS Excel. * Able to be detailed oriented and can organize, prioritize. * Strong problem-solving skills. * Independent self-starter comfortable working in teams at all levels * Experience in building and managing a high performing group of engaged and motivated employees * Experience with working on a Laboratory Operations floor * Knowledge and experience with Lean Six Sigma concepts and tools * Manufacturing/Engineering experience preferred The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.San Carlos, CA $123,400—$165,000 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: • BBB announcement on job scams, • FBI Cyber Crime resource page

Job Description POSITION SUMMARY: Natera is seeking a Senior/Research Associate 2 to support and coordinate workflow activities involved in the execution of molecular and genetic-based assays within the Molecular Biology Development team. The ideal candidate is a meticulous and motivated scientist with hands-on experience in assay development, capable of thriving in a dynamic, fast-paced environment to ensure the highest-quality clinical assays are developed and launched for patient care. This position plays a key role in the research, development, and optimization of molecular workflows that contribute to Natera's cutting-edge products, including Signatera, our personalized molecular residual disease test, as well as new and emerging technologies in the in the cancer monitoring and detection space. The Senior Research Associate will work closely with scientists and engineers to execute experiments, perform analyses, and maintain efficient sample and data flow throughout development activities. PRIMARY RESPONSIBILITIES: • Independently execute in-lab efforts both manually and using automated liquid handlers to develop non-invasive nucleic acid based diagnostic tests, • Experience with automation systems, particularly liquid handling platforms, is required for this role, • Assist in the design, execution, and troubleshooting of laboratory workflows in collaboration with scientists, engineers, and cross-functional teams, • Perform basic data analysis using tools such as Excel, JMP, or similar software, • Contribute to the preparation of reports and other deliverables, • Develop and maintain standard operating procedures (SOPs); provide training on established methods as needed, • Contribute to the optimization of new methods and technologies supporting next-generation oncology monitoring assays, • Coordinate with internal teams (e.g., Laboratory Operations, Scientific Operations, CLIA) to plan and improve logistical workflow processes, • Maintain compliance with Natera's training, security, and privacy standards, including HIPAA/PHI and general policy requirements, • Adhere to environmental, health and safety (EHS) guidelines and good laboratory practices (GLP), • BS/BA in a biological science or equivalent, • Minimum of 4 years Molecular Biology laboratory experience required, • Hands-on experience with nucleic acid techniques, including DNA manipulation, PCR, qPCR, DNA quantification, and analysis using LabChip and BioAnalyzer systems, • Strong background in Next Generation Sequencing (NGS) techniques, protocols, and data analysis workflows, • Whole Blood processing (Isolation and extraction experience), • Proficient in target enrichment, circulating cell-free DNA/RNA (cfDNA/cfRNA) processing, and library preparation for sequencing applications, • Automation skill set is a must, including experience with developing or executing assays on automated liquid handling platforms, • Experience with reagent quality control (QC) and troubleshooting assay performance, • Practical knowledge of LIMS/database query tools, • Proficient in data analysis using Excel and related software, • Strong analytical, organizational, and problem-solving abilities, with exceptional attention to detail, • Must have proven interpersonal, communication, computer, and technical skills Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: • BBB announcement on job scams, • FBI Cyber Crime resource page

Job DescriptionRetro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan. We’re building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility. We are hiring a new member of the HSC Therapeutics team who will focus on process development and clinical lot production of GMP-ready iPSC through scalable manufacturing. About you: You’re eager to learn and approach work with a “can-do” attitude and a hands-on nature. You take pride in working at the highest standard, continuously optimizing research practices for both high speed and accuracy . You value being organized and detail-oriented. With a clear, transparent communication style, who can collaborate effectively with specialists of various backgrounds (cell biologist, quality control scientists, operational and logistic specialists). You are adaptable and able to iterate quickly and reprioritize based on a mission > team > self hierarchy. You’re motivated to work on the forefront of science and help us extend healthy lifespan! In this role you will: • Establish and validate processes to generate iPSCs at scale and within clinically-driven time limits., • Design and lead experiments that generate and characterize iPSCs ensuring their high quality for preclinical safety studies., • Optimize primary cell isolation from the patient's starting material., • Lead tech transfer of iPSC protocols into GMP manufacturing., • Design and execute experiments establishing scalable manufacturing processes of GMP-grade iPSCs through research automation., • Work with the Quality and Analytics team to define iPSC quality attributes., • Maintain detailed and accurate records of experimental procedures and results., • Maintain electronic records in GMP manufacturing and contribute to supporting documents, such as SOPs., • Generate and characterize iPSCs for clinical use., • Be part of a rotational weekend work schedule. You might thrive in this role if you:, • Have a Bachelor’s or Master’s degree in Biology or a relevant field and at least 6 or 4 years of relevant experience in industry, respectively, or a Ph.D. in Cell Biology, Molecular Biology, or related discipline., • Have 4+ years of hands-on experience generating, maintaining and characterizing iPSC lines., • Have experience with cell characterisation techniques (like FACS/flow cytometry, IF/microscopy, karyotyping)., • Proficient in designing and coordinating experiments across multiple parties., • Proficient in communicating results of experiments internally and externally., • Are familiar with good manufacturing practices., • Have experience optimizing protocols for gene delivery into primary cells ex vivo., • Learn quickly, establish and follow protocols precisely. It's a bonus if you:, • Have experience working in a GMP environment., • Have experience with process development and scaling iPSC production for cell therapies.

Job Description POSITION SUMMARY: Natera is a global leader in cell-free DNA testing. We measure fetal, tumor, or donor cfDNA at the molecular level to help inform personalized health care decisions with a non-invasive test. We are looking for a highly motivated Scientist with a strong focus on reagent and process optimization to join the Early Cancer Detection product development team, joining a group of scientists who are tasked with developing and advancing Natera's oncology product portfolio. The Scientist will be working with internal cross functional teams to develop IVD products. The ideal candidate is a driven professional who maintains broad knowledge of molecular biology and chemistry, and applies statistical principles to experiment design and analysis. The Scientist should have an in-depth understanding of design control methods and experience with current NGS oncology diagnostics devices. We are looking for a meticulous and proactive scientist with experience in both NGS-based assay development under design control and meant for submission to FDA and other regulatory bodies and who can work effectively in a fast-paced environment to ensure that the highest quality clinical assays are developed and launched for our patients. PRIMARY RESPONSIBILITIES: • Design, develop, and validate automated high-throughput NGS assays that will be submitted to FDA and regulatory bodies, and be run in a commercial single-site IVD CLIA laboratory, • Manage assigned technical projects and associated timelines and deliverables in NGS-based assays. Mentor junior employees, • Design and execute moderate to high complexity experiments and perform basic data analysis (e.g. JMP, Excel), • Collaborate with other assay development scientists on the specifications of assay, reagent, equipment and quality metrics for future production assays, • Work with Clinical Laboratory and Quality Assurance to ensure that developed methods meet Natera's rigorous quality standards, • Coordinate with multiple internal groups (automation engineering, laboratory operations, bioinformatics, statistics, project and product management) and serve as point person to ensure the successful identification and timely execution of projects, • Write project protocols, reports and SOPs and train lab operations operators on protocols, • Plan and execute verification activities, • BA/BS with 5+ years' experience, MS with 3+ years or PhD with 1+ years' experience in assay development and automation for the life science industry, • Demonstrated track record of development and validation of automated protocols for CLIA labs, • Strong understanding of the chemistry underlying nucleic acid extraction, PCR, NGS library preparation, and hybrid capture technologies, • Hands-on experience in reagent preparation and quality control for NGS-based assays, • Experience implementing, optimizing, and troubleshooting high-throughput automated assays utilizing liquid handler robots, • Strong individual contributor as well as dedicated team player, • Experience designing and executing studies including stability, guard banding, reproducibility and repeatability and QC method development, • Experience working in a regulated laboratory environment under CLIA/CAP, • Data analysis (JMP and Excel) required, coding skills (Python or R), and liquid handler programming experience are a plus, • Excellent communication, organizational, record-keeping, planning, attention to detail and time management skills, • Ability to manage multiple priorities in a fast-paced, dynamic environment and to collaborate cross-functionally with other groups (regulatory affairs, CLIA, LIMS, lab operations QA, automation, research) The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.San Carlos, CA $108,800—$135,950 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: • BBB announcement on job scams, • FBI Cyber Crime resource page

Job Description POSITION SUMMARY: Natera is a global leader in cell-free DNA testing. We measure fetal, tumor, or donor cfDNA at the molecular level to help inform personalized health care decisions with a non-invasive test. We are looking for a highly motivated Senior Scientist with a strong focus on reagent and process optimization to join the Early Cancer Detection product development team, joining a group of scientists who are tasked with developing and advancing Natera's oncology product portfolio. The Senior Scientist will be working with internal cross functional teams to develop IVD products. The ideal candidate is a driven professional who maintains broad knowledge of molecular biology and chemistry, and applies statistical principles to experiment design and analysis. The Scientist should have an in-depth understanding of design control methods and experience with current NGS oncology diagnostics devices. We are looking for a meticulous and proactive scientist with experience in both NGS-based assay development under design control and meant for submission to FDA and other regulatory bodies and who can work effectively in a fast-paced environment to ensure that the highest quality clinical assays are developed and launched for our patients. PRIMARY RESPONSIBILITIES: • Design, develop and validate automated high-throughput NGS assays that will be run in a commercial CLIA laboratory, • Manage assigned technical projects and associated timelines and deliverables in NGS-based assays. Mentor and manage the functional activities of junior employees, • Design and execute moderate to high complexity experiments and perform basic data analysis (e.g. JMP, R, Excel), • Collaborate with other assay development scientists on the specifications of assay, reagent, equipment and quality metrics for future production assays, • Work with Clinical Laboratory and Quality Assurance to ensure that developed methods meet Natera's rigorous quality standards, • Coordinate with multiple internal groups (automation engineering, laboratory operations, bioinformatics, statistics, project and product management) and serve as point person to ensure the successful identification and timely execution of projects, • Write project protocols, reports and SOPs and train lab operations operators on protocols, • Lead verification activities, • Identify areas for continuous improvement and actively contribute to the effort of introducing better practices to improve production workflows and shorten TAT for patient samples, • BA/BS with 8+ years experience, MS with 5+ years or PhD with 3+ years experience in assay development and automation for the life science industry., • Demonstrated track record of development and validation of automated protocols for CLIA labs, • Strong understanding of the chemistry underlying nucleic acid extraction, PCR, NGS library preparation, and hybrid capture technologies, • Hands-on experience in reagent preparation and quality control for NGS-based assays, • Experience implementing, optimizing, and troubleshooting high-throughput automated assays utilizing liquid handler robots, • Strong individual contributor as well as dedicated team player, • Experience designing and executing studies including stability, guard banding, reproducibility and repeatability and QC method development, • Data analysis (JMP) required, coding skills (Python or R), and liquid handler programming experience are a plus, • Excellent communication, organizational, record-keeping, planning, attention to detail and time management skills, • Ability to manage multiple priorities in a fast-paced, dynamic environment and to collaborate cross-functionally with other groups (regulatory affairs, CLIA, LIMS, lab operations QA, automation, research) The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.San Carlos, CA $125,300—$156,600 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: • BBB announcement on job scams, • FBI Cyber Crime resource page

Job Description SENIOR MEDICAL DIRECTOR, CLINICAL DEVELOPMENT At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from 'day one' to the future they've envisioned. POSITION SUMMARY: This is an exciting opportunity at a fast-paced, growing, mission-driven biotech company with a rapidly expanding pipeline. We are seeking an experienced, motivated, and engaging physician/physician-scientist to join us as a Senior Medical Director, Clinical Development. Reporting to our Chief Medical Officer, the successful candidate will be responsible for providing medical and scientific expertise and oversight for clinical trials. The incumbent will serve as the primary accountable person for the design, execution, monitoring, delivery, and reporting of one or more early and/or late-stage clinical studies. Additional study level activities include acting as the Medical Monitor for clinical trials, ensuring patient safety, and providing medical guidance during the design, execution, and reporting of clinical studies. In addition to study-level activities, this individual will also engage in program-level activities, including authoring/reviewing safety and efficacy summaries, clinical overviews, investigator brochures, risk management plans, periodic safety updates, and clinical sections of product labels. The Senior Medical Director, Clinical Development will also be responsible for presenting study results to internal and external committees or advisory boards, as well as preparing data for presentation at international scientific meetings and publications. This person will will collaborate with the DAY301 Product Team Lead, leveraging their knowledge, experience, and skills to advance our PTK7-directed antibody-drug conjugate, DAY301, currently in Phase 1. This individual will lead the Clinical Development Sub-Team within the Product Team, working closely with the Product Team Lead and Program Management to ensure cross-functional execution and alignment. Strong preference for candidates in the San Francisco Bay Area or Greater Boston area who can work a hybrid schedule with regular in-office days; however, remote opportunities may be considered. This position is subject to travel 25% for in person meetings and major conferences. ESSENTIAL DUTIES AND RESPONSIBILITIES: The areas of specific responsibility and attention will include, but are not limited to, the following: • Clinical Trial Strategy and Design, • In collaboration with the broader cross-functional study and project team(s), design of clinical studies to meet the stated objectives, • Drive and advance clinical and integrated development plans from FIH trial to regulatory approval for one or more indications, including life-cycle management, • Be accountable for the review and amendment of clinical trial protocols, • Review and approve informed consents, • Provide medical input into the assessment of investigational site capabilities, • Participate in the review and approval process for data capture and review, • Organize expert panels, consultants, or advisor board meetings to provide input into protocol development and data analysis., • Provide oversight and leadership to the study/program clinical development team, • Provide managerial oversight to a team consisting of Medical Directors, Clinical Scientists, and/of Fellows, • Build clinical development team according to needs of the program, • Provide Study Team with Medical Expertise, • Protocol training for investigators, • Issue resolution, • Audit responses, • Study conduct and closeout, • Inspection readiness, • Provide accountability for safety across studies, • Ensure development of and/or adherence to safety review plans, • Perform and document regular review of individual subject safety data, and review of cumulative safety data, • Working with our Drug Safety team, review individual subject data (including AEs and other safety data), SAEs, and potentially clinically important findings, as well as determine whether or not follow-up is needed, • Study Level Data Review, • Working with our clinical scientists and biometrics colleagues, perform reviews of data generated by statistical analyses, requesting additional tables or analyses as needed, • Perform reviews and procedures required for database finalization, • Lead the authoring of clinical study reports, • Lead the authoring of clinical sections of regulatory documents (e.g. IB, IND annual reports, etc.), • Answer and Resolve Medical and Safety Questions from Sites, • General protocol questions, questions on inclusion/exclusion, safety management, etc., • Ensure answers are consistent across study regions, • Interact with Regulatory Authorities and Internal Regulatory and QA Groups on a Study Level, • Support regulatory interactions, accountable for providing responses to regulatory inspection observations, internal audits, etc., • Support RA updates and submissions for IND documents (IB, DSUR, protocol, etc.), • Assist with clinical sections of regulatory filings, • Presentations and Publication of Clinical Trial Results The Senior Director, Clinical Development must be a natural leader with expertise in oncology clinical research. This individual will have proven experience in leading and collaborating with teams and individuals across various functions in a fast-paced, global environment. Experience in drug development for pediatric oncology and/or rare diseases would be preferred but not required. A solid understanding of early- and late-stage drug development and clinical research conducted under GCP/ICH is essential. More specifically, it is anticipated that the ideal candidate will possess: • MD or MD/PhD degree is required, • 7-10 years of experience in the biopharmaceutical industry with experience in oncology drug development and design/conduct of clinical trials, • Training and experience in oncology; pediatric oncology and/or neuro-oncology experience is preferred but not essential; board certified or eligible in oncology (and/or hematology), • Knowledge of ICH and Good Clinical Practice and familiarity with global and regional regulations, • Experience in the assessment of adverse events and safety of patients participating in oncology clinical trials, • Skilled in modern oncology protocol design, data interpretation, biostatistics, and medical monitoring, • Strong interpersonal skills, as well as the ability to function in a team environment, • Ability to lead by example, build interdependent partnerships, and participate in a culture of collaboration and teamwork that fosters open communication, constructive conflict resolution and organizational flexibility, • Able to prioritize and manage several projects simultaneously, • Ability to work in a fast-paced and ever-changing environment, as well as the proven track record of working effectively in diverse teams involving multi-functional disciplines, • Proven ability to develop internal relationships in a matrix environment, whether in person or remotely, as well as external relationships with Key Opinion Leaders and industry experts, • Outstanding verbal, written, and presentation skills to enable effective communication at all levels that allows for the presentation of complex and/or new ideas with clarity and simplicity, • A desire to be part of a highly innovative company aimed at transforming the lives of children and adults with serious, life-threatening diseases, their families and society INTERVIEW INTEGRITY At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone. COMPENSATION AND BENEFITS The salary range for this position is $320,000 - $350,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary. Please visit to see our competitive benefits. DISCLAIMER Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. We are unable to sponsor or take over sponsorship of any applicant work visas at this time. Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical's internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.

Job DescriptionCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok. Job Description The AbbVie portfolio consists of several marketed products in areas including eye care, immunology, oncology, virology, and women’s health as well as a pipeline containing multiple promising new molecules being studied in hundreds of clinical trials or advancing from Discovery into Development. AbbVie is a global organization with US research sites in Boston (Cambridge and Worcester, MA), Chicago (North Chicago, IL), and the San Francisco Bay Area (South San Francisco, CA). The biotherapeutics portfolio is comprised of diverse and tailored modalities including mono- and bispecific antibodies, antibody-drug conjugates, antibody fragments, gene therapies and cell-based therapies. The Quantitative, Translational and ADME Sciences (QTAS) group is searching for a Senior Scientist to provide mechanistic and translational modeling and project support in all disease areas, informing decision-making for primarily large, but also small molecule projects from discovery through the early stages of clinical development. The candidate will establish innovative translational modeling approaches, such as mechanistic PK/PD or systems modeling, across disease and therapeutic areas, as well as provide QTAS project support enabling translation of assets from Discovery into early Development. The position requires close collaboration with Discovery and Development project teams, clinical pharmacology, and other stakeholders, to develop and execute QTAS and PK/PD strategies necessary to facilitate the advancement of our pipeline. Key Responsibilities: * Develop and implement innovative, quantitative analyses and strategies for translational modeling across Discovery and Development projects * Liaise with Discovery biology, pharmacology, toxicology, biomarker, QTAS and clinical scientists to generate data and knowledge supporting the generation and implementation of translational models * Establish and maintain effective collaborations with key peer and team stakeholders within QTAS, Discovery and Clinical to facilitate knowledge and data integration for target prioritization, biomarker selection, candidate selection, guidance in (pre)clinical study design, human dose prediction and calculation of therapeutic index * Effectively communicate on strategies related to drug metabolism and pharmacokinetics (DMPK) and translational modeling and simulation * Maintain awareness of emerging literature and science in computational approaches and applications Qualifications Basic Qualifications: * Bachelors (B.S.), Masters (M.S.), or Doctorate (Ph.D.) in in chemical, mechanical, or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field, with at 10+ years of experience and Bachelors Degree, OR 8+ years of experience and Masters Degree., or Ph.D. and no experience necessary. * Hands-on experience with relevant modeling software and programming languages including MATLAB/SimBiology, R, Python, WinNonLin/Phoenix, etc. is required * Understanding of small or large molecule drug modalities and relevant analytical methods for measuring drug and biomarker levels in preclinical and clinical study samples is highly desired * Passion for data analysis, solving technical problems and applying new technologies to further scientific goals and answer key scientific questions enabling informed decision-making * Publication record demonstrating PK/PD or systems modeling examples is highly desired * Highly-motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable of both leading and being lead * High degree of flexibility in adapting to different projects and personalities as well as excellent networking and relationship-building skills (both internal and external) required * Must have strong communication skills and the ability to effectively communicate with both internal and external stakeholders, and to audiences of diverse backgrounds * Prior experience in an experimental in vitro or in vivo biology field is desired * Interest in developing skills to support projects as a QTAS project representative in future is highly desired Preferred Qualifications: * Doctorate (Ph.D.) in chemical, mechanical, or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field, with 1-3 years of pharmaceutical industry experience Key Leadership Competencies: * Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance * Learns fast and can change course quickly when necessary * Raises the bar and is never satisfied with the status quo * Creates a learning environment, open to suggestions and experimentation for improvement * Embraces the ideas of others, nurtures innovation and manages innovation to reality Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements understate or local law: * The compensation range described below is the range of possible base pay compensation that theCompany believes in good faith it will pay for this role at the time of this posting based on the job gradefor this position. Individual compensation paid within this range will depend on many factors includinggeographic location, and we may ultimately pay more or less than the posted range. This range may bemodified in the future. * We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to eligible employees. * This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested,and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any otherform of compensation and benefits that are allocable to a particular employee remains in the Company'ssole and absolute discretion unless and until paid and may be modified at the Company’s sole andabsolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

Job Description POSITION SUMMARY The Sr Translational Medical Scientist partners with clinicians, product managers, and key opinion leaders (KOLs) in applying genomic data to advance healthcare. This position in the Oncology department primarily focuses on developing products for early cancer detection. Secondary duties include participating in ongoing translational initiatives to optimize ctDNA testing, inform clinical decisions, and improve outcomes in patients with solid and hematological malignancies. The cross functional Translational Medicine role requires extensive collaboration with internal stakeholders and external strategic research partners, pharmaceutical companies, and KOLs to integrate genomic and clinical data across multiple high-impact projects in a fast-paced environment. The Associate Director will be empowered to build and expand a team to meet evolving company needs in early cancer detection and other translational objectives. PRIMARY RESPONSIBILITIES Work with R&D, clinicians, product managers, and KOLs to identify specimen biobanks to support early cancer detection assay development Apply knowledge of genomics, molecular biology, and cancer biology to evaluate commercial and research opportunities in early cancer detection Collaborate with molecular biologists, computational biologists, and statisticians to build research strategies that solve challenging problems Perform genomic analysis to explore biological, scientific, and clinical questions in oncology and translating results to impact patient care Lead internal efforts on oncology knowledge management and curation Collaborate with external partners, including academic KOLs, biotechnology companies, and pharmaceutical companies Communicate results and findings of analyses to academic researchers and collaborate to publish findings in high impact journals Oversee and train scientists and research associates Support regulatory affairs team by assisting with responses to regulatory agency questions (CLIA, CAP, FDA) regarding product design and validations Performs other duties as assigned This role works with PHI on a regular basis both in paper and electronic form and have an access to various technologies to access PHI (paper and electronic) in order to perform the job Employee must complete training relating to HIPAA/PHI privacy, General Policies and Procedure Compliance training and security training as soon as possible but not later than the first 30 days of hire Must maintain a current status on Natera training requirements QUALIFICATIONS Ph.D. in Molecular Biology, Genomics, Cancer Biology, Genetics, Molecular Biology, or equivalent required. Minimum of 5+ years of relevant experience. KNOWLEDGE, SKILLS, & ABILITIES Deep scientific understanding or education background in oncology Specific experience with circulating nucleic acids and early cancer detection methods such as methylation, SNV/indel panels, and fragmentation preferred. Knowledgeable and experienced in the use and optimization of novel technologies and awareness of the competitive landscape Working knowledge of basic bioinformatics and genomics sequencing analysis techniques Knowledge of data mining and statistical analysis tools such as R, SQL, or Stata is a plus. Excellent verbal and written communication skills are required Strong organizational and interpersonal skills will be needed in our cross functional team. The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.San Carlos, CA $125,000—$150,000 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: • BBB announcement on job scams, • FBI Cyber Crime resource page

Job Description POSITION SUMMARY: The Translational Medical Scientist contributes to partnerships with clinicians, product managers, and key opinion leaders (KOLs) in applying genomic data to advance healthcare. This position in the Oncology department focuses on the detection and analysis of circulating tumor DNA to inform clinical decisions and improve outcomes in patients with solid and hematological malignancies. The cross functional Translational Medicine role requires extensive collaboration with internal stakeholders and external strategic research partners, pharmaceutical companies, and KOLs to integrate genomic and clinical data across multiple high-impact projects in a fast-paced environment. PRIMARY RESPONSIBILITIES: * Work with Sr. Scientists, clinicians, product managers, and key opinion leaders to transform product requirements into technical specifications for future oncology products using circulating tumor DNA. * Collaborate with molecular biologists, computational biologists, and statisticians to build research strategies that solve challenging problems. * Collaborate with sample accessioning team, legal dept, and R&D to draft contracts and execute research projects. * Perform genomic analysis to explore biological, scientific, and clinical questions in oncology and translating results to impact patient care. * Lead internal efforts on oncology knowledge management and curation. * Collaborate with external partnerships, include academics, biotechnology companies, pharmaceutical companies. * Communicate results and findings of analyses to academic researchers and collaborate to publish findings in high impact journals. * Work with business and biological teams to understand the research landscape and technology options. * Performs other duties as assigned. * This role works with PHI on a regular basis both in paper and electronic form and have an access to various technologies to access PHI (paper and electronic) in order to perform the job. * Employee must complete training relating to HIPAA/PHI privacy, General Policies and Procedure Compliance training and security training as soon as possible but not later than the first 30 days of hire. * Must maintain a current status on Natera training requirements. QUALIFICATIONS: * Ph.D. in Molecular Biology, Genomics, Cancer Biology, Genetics, or equivalent required. * Minimum of 2 years of relevant experience. KNOWLEDGE, SKILLS, AND ABILITIES: * Solid scientific understanding or education background in oncology – including diagnostics and therapeutics. * Specific experience with ctDNA is preferred. * Knowledgeable and experience in the use and optimization of novel technologies and understand the competitive landscape. * Knowledge of cancer from both a basic biology and molecular perspective. * Working knowledge of basic bioinformatics and genomics sequencing analysis techniques. * Knowledge of data mining and statistical analysis tools such as R, SQL, or Stata is a plus. * Excellent verbal and written communication skills are required. * Strong organizational and interpersonal skills will be needed in our cross functional team. The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.Remote USA$92,200—$115,200 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: • BBB announcement on job scams, • FBI Cyber Crime resource page

Job DescriptionCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok. Job Description The Biologics CMC Development team at AbbVie has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing biologic therapies, such as monoclonal antibodies, bi-specifics and novel modalities, to human clinical studies and eventual licensure. This role will be imbedded in a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs. The Cell Culture Development Group in South San Francisco, CA is seeking a Senior Scientist I to join a talented and collaborative team to develop and implement machine learning models for predicting optimal cell culture process performance. As a senior scientist, you will be responsible for all aspects of ML model development. This position is an onsite role in a lab-based function. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with face-to-face cross-functional interactions between scientists. In this position, you will perform cell culture process modeling, cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. KEY RESPONSIBILITIES: • Develop, implement, refine, and validate machine learning (ML) models for predicting cell culture process performance, • Communicate model findings and suggest experimental strategy and/or workflow improvements to support early- and late-stage development, • Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes using ML models and wet lab experiments, • Design and execute scalable ambr250, 2L, 50L, 200L and 500L single use bioreactors processes, • Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project deliverables and timelines, • Publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia, • Display effective organization, verbal written communication skills, and adherence to good documentation practicesQualifications Basic Qualifications: • Scientific degree in computer science, statistics and applied mathematics, computational biology, bioinformatics, data science, chemical engineering, bioengineering, or a related field, with BS or equivalent education and 10+ years of experience, OR MS or equivalent education and 8+ years of experience, OR PhD and 0+ years of experience, • Must have industry or research experience in developing, implementing, and validating ML models, • Must have a strong understanding of statistical methods, ML methodologies, and ML frameworks (e.g., Sci-kit Learn, TensorFlow, PyTorch), • Must demonstrate programming competency for model implementation in Python or equivalent, • Must have experience in data visualization tools (e.g., Matplotlib, Plotly) to communicate model finding, • Strong attention to detail; active and quick learner; able to change course quickly as needed; raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others, • Experienced in authoring peer-reviewed publications, technical reports, regulatory documents, and/or presentations at conferences, • Prior experience in developing and implementing ML models for biological data is highly desirable, • Experience in implementing transfer learning is highly desirable, • Expertise in programming (e.g., Python, Javascript, C++), • Experience in CMC cell culture process development is highly desirable, • Demonstrated scientific aptitude through authorship of peer-reviewed publications, • Strong understanding of design of experiments (DOE), • Proficient in aseptic technique, • Basic understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts, • Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250, and/or 2L bioreactors, • Experienced in the tech transfer of cell culture and primary recovery processes to GMP manufacturing facilities in other locations, • Experienced in authoring and reviewing technical reports, GMP campaign summary reports, and relevant sections in regulatory filings Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: * The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. * We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. * This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

Job DescriptionGenEdit is a rapidly-growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload design, formulation, and screening and preclinical groups to develop the next generation of gene therapies. GenEdit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from a platform technology to a pipeline of therapeutic candidates. We are seeking talented and motivated individuals to join our team and are expanding across all functions within the organization. Join us in South San Francisco, CA, to be at the forefront of the future of gene therapy. Senior Consultant, CMC Development and Manufacturing GenEdit is looking for an individual who will provide technical and organizational leadership and work closely with cross-functional stakeholders to ensure CMC activities are executed seamlessly and in alignment with the integrated product development plan and program timelines. The individual will lead the management of manufacturing of established drug substances and drug products for late-phase clinical trials and the development of new products. The individual will also contribute to the overall CMC strategy, planning, and execution; provide regulatory documentation for all phases of clinical trials and commercialization; and play a role in CDMO management for other CMC areas including analytical and drug product. The senior consultant will be a contributing member of the R&D management team to plan and execute on company objectives and R&D strategy for all programs. This person must be a strong scientist with a sound track record of technical expertise and organizational leadership, early and late stage CMC.and a knowledge of the drug discovery process from exploratory research to IND submission. This person must be able to guide and drive project teams to make decisions and recommendations to the executive team, is a critical and creative problem solver, and comfortable in a dynamic, start-up environment to find solutions to scientific, technical, and resource allocation issues to move programs forward. The ideal candidate will be a team player with excellent communications skills and work collaboratively across all functions within the company and with external partners. Responsibilities·Key polymer synthesis and development and manufacturing operations to maintain and advance company pipeline.·Manage and maintain project timelines for CMC activities in support of early and late-phase clinical trials, ensuring strategy and roadmaps align with and feed into company goals and project timelines.·Manage in-house CMC personnel and external subject matter experts.·Lead CDMO and other vendor identification, assessment, qualification, and management with adequate risk assessment.·Manage tech transfer, process familiarization, and manufacturing at CDMOs to ensure timely delivery of GMP drug substance and drug product.·Contract and Quality Agreement negotiation.·Develop and carry-out a QBD approach to identify CPPs in support of CQAs for efficacy and safety of drug substance.·Author/review/approve the relevant CMC sections to enable global regulatory filings.·Generate, review, and/or approve study protocols, development reports, and manufacturing batch records.·Manage developmental stage-appropriate analytical activities. ·Communicate CMC strategy and project status to key stakeholders cross-functionally and assist in driving decision-making.·Collaborate with cross-functional teams (clinical development, clinical operations, regulatory affairs, quality, IP) to ensure CMC and program goals are met. Education and Qualifications:·PhD in polymer chemistry or polymer science and engineering with industry experience in synthesis scale-up and downstream processing, ideally in a therapeutic drug context.-10+ years in industry CMC; 3+ years of experience as CMC team leader, managing team members and projects.·Proven success in vendor management, specifically CDMOs, with track record of negotiating contracts and completion of projects on time and within budget.·Successful management of CDMO to manufacture GMP product for late-phase clinical trials is a requirement.·Thorough understanding and working experience in drug substance development and manufacturing with respect to quality by design, GMP, quality systems, ICH guidelines, FDA, EMA, and associated regulatory requirements. Experience writing CMC section of NDA is a plus.·Experience with key analytical techniques: NMR, GPC-RI, HPLC, UV-vis, fluorescence spectroscopy, DSC, ITC, MAL-SEC, and other characterization methods.·Highly motivated scientist with particular attention to detail and the ability to independently plan, design and implement experiments·Excellent written, verbal and presentation skills·Work authorization in the US is required At GenEdit we are always looking to hire the absolute best talent and recognize that diversity in our experiences and backgrounds is what makes us stronger. We hire candidates of any race, color, ancestry, religion, sex, national origin, sexual orientation, gender identity, age, marital or family status, disability, veteran status, and any other status. These differences are what enable us to work towards the future we envision for ourselves, and the world. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Job DescriptionRetro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan. We’re building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility. We are hiring a new member of the HSC Therapeutics team who will be involved in making GMP-grade iPSCs and characterizing them. In this role, your cell culture and reprogramming skills will enable the team to move toward therapy production in a GMP setting. You will be involved in generating, maintaining, and characterizing pluripotent stem cells to later develop them into a cellular therapy product. You will help the team to transfer reprogramming protocols from the research bench into a GMP production. About you: You’re entrepreneurial and eager to spend time deeply engaged in hands-on science; building the foundation for your future career as a scientist. You approach your work with a growth-mindset, eager to use your critical thinking skills and problem solving abilities. You enjoy fast-paced, hands-on work and value being organized, planning, and paying attention to the details. You’re a highly collaborative team member with a “can-do” attitude and great communication skills.In this role you will: • Validate processes to generate iPSCs at scale and within clinically-driven time constraints., • Generate and characterize iPSCs ensuring their high quality for preclinical safety studies., • Perform primary cell isolation from patient’s starting material., • Support tech transfer of iPSC protocols into GMP manufacturing., • Contribute to establishing scalable manufacturing process of GMP-grade iPSCs., • Maintain detailed and accurate records of experimental procedures and results., • Maintain electronic records in GMP manufacturing and contribute to supporting documents, such as SOPs., • Generate and characterize iPSCs for clinical use., • Be part of a rotational weekend work schedule. You might thrive in this role if you:, • Have a B.S or an M.S. in biology or a related field and at least 2 years of hands-on experience generating, maintaining and characterizing iPSC lines., • Have experience with gene delivery into primary cells ex vivo., • Learn quickly and follow protocols precisely., • Strive to continuously optimize practices for high speed and accuracy., • Enjoy working cross-functionally with specialists with various backgrounds (cell biologist, quality control scientists, operational and logistic specialists). It’s a bonus if you:, • Are familiar with good manufacturing practices or/and have experience working in a GMP environment., • Have experience with process development and scaling iPSC production for cell therapies., • Have experience in isolating cells from human samples. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Job DescriptionSalary: $363,900 - $394,000 PURPOSE OF JOB: The Senior Medical Director reports to the VP of Clinical Development and will initially be responsible for planning and implementing the clinical strategy for RPT904, an extended half-life anti-IgE monoclonal antibody, in chronic spontaneous urticaria. This physician-scientist will serve as the subject-matter expert and medical lead in this therapeutic area to provide clinical and drug development expertise to the cross functional team. The role includes serving as the medical lead responsible for the execution and reporting of Phase II/III clinical studies, as well as supporting the regulatory and commercial/medical affairs strategies in alignment with the overall development strategy. MAJOR DUTIES AND RESPONSIBILITIES: Serve as Clinical Development Lead in Chronic Spontaneous Urticaria, eg: • Provide strategic and design input for clinical trials and clinical development plans, • Participate in/and or lead preparation, design, and/or review of clinical documents, e.g. protocols, investigators brochures, DSUR, • Contribute to clinical sections of relevant regulatory filings (IND, study reports, NDA, PIP, briefing packages, etc.), • Represent the company at scientific meetings and presentations, • Develop and maintain collaborative relationships with key opinion leaders for clinical programs, • Contribute to the medical affairs strategy through the development of the publication plan, including authoring and / or reviewing abstracts, presentations and manuscripts for medical accuracy and content, • Represent RAPT and provide medical support during investigator and consultant meetings (e.g., investigator meetings, clinical advisory boards), • Oversee internal clinical development team members and be responsible for clinical trials (e.g. Sponsor medical monitors, clinical scientists) to ensure patient safety and data integrity EDUCATION REQUIREMENTS: • M.D. or M.D./Ph.D., with board certification in Allergy and Immunology or Dermatology or related field required EXPERIENCE REQUIREMENTS: • Minimum of 8 years mid-to-late stage (Phase II/III/IV) global clinical trial experience in pharmaceutical or biotech industries preferred, or equivalent academic and clinical experience, • Clinical development or clinical practice experience in the field of Allergy/Immunology or Dermatology preferred., • Experience with successful Health Authority (eg FDA, EMA, PMDA) interactions (eg NDA, EOP2, Scientific Advice), • Minimum of 2 years experience managing a team, • Be well connected within the medical and scientific community and have a proven successful track record, • Hands-on experience with clinical trial strategy, methods and designs, • Ability to work proactively and effectively, with exceptional creative problem-solving skills, • Excellent strategic planning, organizational and communication skills, • Up to 20% travel

A leading biotechnology company in California is seeking a Senior Data Scientist to drive the development of AI and ML solutions in clinical development. You will utilize your expertise to enhance decision-making processes, optimize clinical trials, and collaborate with cross-functional teams on imp