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We're looking for an experienced Hot End Engineering Manager to lead our IS maintenance operation at our Elton site. This is a key leadership role within our Hot End operation, responsible for maximising the reliability, availability and performance of our IS forming machines and associated equipment. You'll bring together strong engineering expertise, effective maintenance planning and people leadership to keep our equipment performing at its best. From driving preventative maintenance and reducing downtime to developing your team and embedding a culture of continuous improvement, you'll play a vital role in delivering safe, efficient and high-quality production. If you're passionate about engineering excellence, solving complex technical challenges and getting the best out of people, this could be the opportunity for you. • Lead and coordinate planned preventative and reactive maintenance activities across IS forming machines and ancillary equipment, maximising equipment availability and asset uptime., • Monitor equipment condition, identify recurring failures and use maintenance data to develop effective maintenance strategies., • Lead root cause investigations into significant breakdowns, implementing sustainable corrective actions to improve reliability and reduce downtime., • Ensure maintenance activities are properly planned, recorded and completed using the site's Computerised Maintenance Management System (CMMS)., • Drive effective use of maintenance systems, including work order management, preventative maintenance scheduling, equipment history and performance reporting., • Ensure the correct fitting, alignment and configuration of forming equipment to maintain operational performance and product quality., • Analyse shift reports, equipment losses and breakdown trends, taking action to address performance deviations and prevent repeat issues., • Ensure the availability of critical spare parts and effective inventory management to support maintenance requirements., • Coordinate and support Hot End job change activities, working closely with the Job Change Supervisor to ensure equipment, resources and maintenance support are ready when needed., • Work collaboratively with Production, Engineering and Quality teams to minimise equipment-related losses and optimise plant performance., • Support the investigation and resolution of machine-related glass defects, ensuring appropriate corrective actions are implemented., • Create and maintain job change documentation using CDM, supporting safe, consistent and efficient execution., • Develop and maintain technical instructions and maintenance procedures to improve consistency, safety and effectiveness., • Lead and develop a team of engineering and operational colleagues, setting clear expectations and promoting high standards of performance and accountability., • Oversee the deployment of resources across the operation, ensuring the right skills and support are available to meet business requirements., • Coach, support and develop team members, identifying training needs and building technical capability across the team., • Ensure new starters receive an effective induction and onboarding experience, with ongoing technical, operational and HSE training for all employees., • Build strong working relationships across departments, encouraging collaboration, knowledge sharing and a shared commitment to operational excellence., • Complete all required administration, maintenance reporting and performance documentation accurately and on time., • Provide visible HSE leadership, leading by example and ensuring safety remains at the heart of every activity., • Ensure all maintenance activities are appropriately risk-assessed, with suitable controls in place in line with relevant requirements, including COSHH and PUWER., • Promote the reporting of near misses, accidents and incidents, using learning to prevent recurrence., • Maintain compliance with site HSE, hygiene and operational procedures, addressing unsafe practices and escalating concerns where necessary., • Encourage open communication, consultation and a positive safety culture across the team. We're looking for a technically strong engineering leader who can combine hands-on knowledge of maintenance and reliability with the ability to motivate people and deliver sustainable improvements. • An engineering qualification or degree., • Experience in engineering, production or maintenance leadership within a manufacturing environment, ideally FMCG., • Proven people management experience, including coaching, performance management and developing effective teams in a large-scale, shift-based operation., • Strong understanding of maintenance planning, preventative maintenance programmes and reactive maintenance management., • Experience using CMMS systems to manage work orders, maintenance schedules, asset history and performance reporting., • The ability to analyse equipment failures, identify root causes and implement effective corrective actions., • Experience driving continuous improvement initiatives and improving operational performance., • Strong communication and relationship-building skills, with the confidence to work collaboratively across all levels of the business., • Good IT skills, including Microsoft Office., • Experience within glass manufacturing, particularly Hot End operations., • Knowledge of IS forming machines, forming equipment and ancillary equipment maintenance., • Experience with SAP and other maintenance management systems., • Knowledge of continuous improvement methodologies, including 5S, TPM, SMED, Six Sigma and Lean manufacturing., • Understanding of maintenance and quality tools such as TQM and SPC., • Familiarity with site manufacturing processes and the ability to translate technical knowledge into practical guidance for the team., • Leads with confidence: sets clear expectations, makes sound decisions and takes ownership of performance., • Develops people: coaches, motivates and builds the capability of others., • Thinks analytically: uses data, investigation and technical expertise to solve problems and prevent recurrence., • Drives improvement: challenges existing ways of working and looks for smarter, more effective solutions., • Works collaboratively: builds strong relationships with Production, Quality, HSE, Engineering and wider operations teams. At Encirc, we make, fill and move glass. Part of the Vidrala group, we are a market leader in glass container design, manufacturing, bottling and logistics solutions for the UK, Irish and European food and beverages industries. With over 2,000 employees, we operate from our three purpose-built sites: Derrylin, Co Fermanagh; Elton, Cheshire and Bristol. We produce around 3 billion glass bottles and other containers annually and can fill up to 500 million litres of bulk shipped beverages every year. Our collective purpose is to deliver and uphold world-leading sustainable innovation, with great people and a great workplace collaborating on a great future. Joining Encirc means you will be joining a business with a bespoke, 360-approach to the beverage supply chain, spanning filling, warehousing, and logistics. Reducing the road miles and carbon footprint of our customers' products, we are conscious disruptors prioritising sustainability and modern technology. As a forward-thinking and sustainable business, we are committed to achieving zero emissions by 2030. At Encirc, we're proud to be a forward-thinking manufacturer in a world that's increasingly socially and environmentally conscious. Our culture is built around six core values that sit at the heart of everything we do. They guide how we work, how we make decisions, and how we support one another - helping us create a workplace where everyone can thrive. These values aren't just words on a wall; they're lived, shared and championed across the business, shaping our mindset and inspiring us to keep making Encirc great for everyone. Encirc is committed to creating a diverse and inclusive environment and welcomes applications from all sections of the community. Every applicant will be evaluated according to skills regardless of age, gender, identity, ethnicity, sexual orientation, disability, or religion. We also want to ensure our recruitment process is accessible to everyone. That's why we have partnered with Recite Me to offer an accessibility toolbar on our job search page, recruitment application system and website. The toolbar includes screen reading functionality, multiple reading aids, customisable styling options and an on-demand live translation feature that boasts over 100 languages including 65 text-to-speech and styling options. • Free onsite gym for all employees, • MyBenefits Reward Platform with?100s of discounts at restaurants and retailers, • Employee Well-being benefits such as the Employee Assistance Programme, • Pension scheme where the company contributes up to a maximum of 7%, • Life cover at 3 timesyour annual salary, • Optional partner life cover, • Subsidised onsite staff restaurant, • Free parking onsite, • Salary sacrifice Electric car scheme, • Subsidisedonsiteelectric car charging, • Cycle to work scheme, • Enhance maternity and paternity leave, • Liftshare scheme, • Health cash plan, • Optional dental insurance, • Optional Private Medical Insurance, • Optional critical illness cover, • Social club #J-18808-Ljbffr

Order Ref: 1214 Position Title: Engineering Lead - Cocoa Bean Process Plant Duration: Contract Location: Chirk, Wales Our Client are seeking an experienced and driven Engineering Lead to oversee all engineering operations within our manufacturing process plant. This is a pivotal leadership role responsible for driving operational excellence, implementing lean manufacturing techniques, and transforming our maintenance strategy from a reactive model to a robust preventative and predictive maintenance programme. The successful candidate will lead a multidisciplinary engineering team and play a central role in improving plant reliability, efficiency, and safety. • Engineering Leadership & Team Management Lead, coach, and develop a team of engineers, technicians, and maintenance professionals across mechanical, electrical, and instrumentation disciplines. Set clear performance objectives, conduct regular reviews, and foster a culture of continuous improvement and accountability. Manage resource planning, shift coverage, and skills development to ensure optimal team capability. Act as the senior technical authority on-site, providing guidance on complex engineering challenges., • Lean Manufacturing Implementation Champion the adoption and embedding of lean manufacturing principles across all engineering and maintenance activities. Lead the implementation of lean tools and methodologies including 5S, Kaizen, Value Stream Mapping, SMED, TPM (Total Productive Maintenance), and Root Cause Analysis (RCA). Identify and eliminate waste in engineering processes, reducing downtime, material costs, and inefficiencies. Establish and track KPIs aligned with lean objectives: GE (Global Efficiency inc. OEE), MTBF (Mean Time Between Failures), and MTTR (Mean Time to Repair). Facilitate cross-functional workshops and training sessions to build lean capability across the wider plant team., • Reactive to Preventative Maintenance Transformation Develop and execute the strategic roadmap to transition the plant from reactive maintenance model to a structured preventative and predictive maintenance programme. Continue to implement a Computerised Maintenance Management System (SAP) to schedule, track, and optimise all maintenance activities. Develop condition-based monitoring techniques (e.g., vibration analysis, thermography, oil analysis) to predict equipment failures before they occur. Establish preventative maintenance schedules for all critical assets based on manufacturer recommendations, historical failure data, and risk assessments. Target a measurable reduction in unplanned downtime (e.g., 30-50% reduction within the first 18 months). Build a culture where maintenance is viewed as a value-adding function rather than a cost centre., • Plant Reliability & Continuous Improvement Own the plant's asset management strategy, ensuring long-term reliability and lifecycle cost optimisation. Lead failure investigations and root cause analyses for significant breakdowns, implementing corrective and preventive actions. Drive capital expenditure (CapEx) projects for equipment upgrades, replacements, and process improvements. Collaborate with Production, Quality, Health & Safety, and Supply Chain teams to align engineering priorities with business objectives., • Compliance, Safety & Standards Ensure all engineering activities comply with relevant health, safety, and environmental regulations and industry standards. Maintain up-to-date documentation including P&IDs, SOPs, risk assessments, and equipment records. Support internal and external audits and ensure engineering readiness at all times., • A high level of experience in an engineering or maintenance leadership role within a manufacturing or process plant environment., • Food industry experience is advantageous but not essential., • Proven track record of implementing lean manufacturing techniques (e.g., TPM, 5S, Kaizen, Value Stream Mapping)., • Demonstrated experience in transitioning maintenance strategies from reactive to preventative/predictive models., • Strong knowledge of CMMS platforms (ideally., SAP)., • Experience managing multidisciplinary engineering teams in a 24/7 operational environment., • Solid understanding of health and safety legislation and regulatory compliance in a manufacturing setting., • Degree (or equivalent) in related Engineering field., • Lean Six Sigma certification (Green Belt or Black Belt)., • Experience with predictive maintenance technologies (vibration analysis, thermography, ultrasonic testing)., • Familiarity with Industry 4.0 concepts, including IoT-enabled monitoring and data-driven decision-making. #J-18808-Ljbffr

We are seeking an experienced and driven Engineering Lead to oversee all engineering operations within our manufacturing process plant. This is a pivotal leadership role responsible for driving operational excellence, implementing lean manufacturing techniques, and transforming our maintenance strategy from a reactive model to a robust preventative and predictive maintenance programme. The successful candidate will lead a multidisciplinary engineering team and play a central role in improving plant reliability, efficiency, and safety. Lead, coach, and develop a team of engineers, technicians, and maintenance professionals across mechanical, electrical, and instrumentation disciplines. Set clear performance objectives, conduct regular reviews, and foster a culture of continuous improvement and accountability. Manage resource planning, shift coverage, and skills development to ensure optimal team capability. Act as the senior technical authority on site, providing guidance on complex engineering challenges. Champion the adoption and embedding of lean manufacturing principles across all engineering and maintenance activities. Lead the implementation of lean tools and methodologies including 5S, Kaizen, Value Stream Mapping, SMED, TPM (Total Productive Maintenance), and Root Cause Analysis (RCA). Identify and eliminate waste in engineering processes, reducing downtime, material costs, and inefficiencies. Establish and track KPIs aligned with lean objectives: GE (Global Efficiency inc OEE), MTBF (Mean Time Between Failures), and MTTR (Mean Time to Repair). Facilitate cross-functional workshops and training sessions to build lean capability across the wider plant team. Develop and execute the strategic roadmap to transition the plant from reactive maintenance model to a structured preventative and predictive maintenance programme. Continue to implement a Computerised Maintenance Management System (SAP) to schedule, track, and optimise all maintenance activities. Develop condition-based monitoring techniques (e.g., vibration analysis, thermography, oil analysis) to predict equipment failures before they occur. Establish preventative maintenance schedules for all critical assets based on manufacturer recommendations, historical failure data, and risk assessments. Target a measurable reduction in unplanned downtime (e.g., 30–50% reduction within the first 18 months). Build a culture where maintenance is viewed as a value-adding function rather than a cost centre. Own the plant's asset management strategy, ensuring long‑term reliability and lifecycle cost optimisation. Lead failure investigations and root cause analyses for significant breakdowns, implementing corrective and preventive actions. Drive capital expenditure (CapEx) projects for equipment upgrades, replacements, and process improvements. Collaborate with Production, Quality, Health & Safety, and Supply Chain teams to align engineering priorities with business objectives. Ensure all engineering activities comply with relevant health, safety, and environmental regulations and industry standards. Maintain up‑to‑date documentation including P&IDs, SOPs, risk assessments, and equipment records. Support internal and external audits and always ensure engineering readiness. A high level of experience in an engineering or maintenance leadership role within a manufacturing or process plant environment. Food industry experience is advantageous but not essential Proven track record of implementing lean manufacturing techniques (e.g., TPM, 5S, Kaizen, Value Stream Mapping). Demonstrated experience in transitioning maintenance strategies from reactive to preventative/predictive models. Strong knowledge of CMMS platforms (ideally., SAP). Experience managing multidisciplinary engineering teams in a 24/7 operational environment. Solid understanding of health and safety legislation and regulatory compliance in a manufacturing settings Degree (or equivalent) in related Engineering field Lean Six Sigma certification (Green Belt or Black Belt). Experience with predictive maintenance technologies (vibration analysis, thermography, ultrasonic testing). Familiarity with Industry 4.0 concepts, including IoT-enabled monitoring and data-driven decision-making. #J-18808-Ljbffr

Store Manager | Chester | Up to £55,000 + Bonus | Leading Retail Brand Zachary Daniels Retail Recruitment is proud to partner with a market-leading retailer in the search for an exceptional Store Manager in Chester. With a competitive salary, strong benefits and strong career progression, this is a fantastic opportunity to take your next step in retail leadership. About the Role: As Store Manager, you'll be at the heart of the store's success by driving performance, leading a high-energy team and delivering an outstanding customer experience. This is a role for a hands-on, commercially focused leader who thrives in a fast-paced retail environment. Key Responsibilities: • Deliver exceptional customer service and drive brand loyalty., • Lead, coach, and inspire a team to achieve sales and service goals., • Manage store operations efficiently, including stock, rotas and merchandising., • Maintain the highest standards of compliance, health & safety and store presentation., • Analyse sales data, monitor trends and respond quickly to market opportunities., • Consistently hit and exceed KPIs and commercial targets.What We're Looking For:, • Experience as a Store Manager, Branch Manager or General Manager., • Strong people leadership skills and a proven ability to build high-performing teams., • Excellent commercial acumen and ability to drive store profitability., • A customer-first mindset with a passion for retail and team development.What's on Offer:, • Competitive salary with regular reviews based on performance., • Long-term career progression with a well-known and respected brand., • Join a dynamic, supportive business culture that values its people.Apply Now If you're a motivated, passionate retail leader ready to make your mark in a high-profile store, we want to hear from you! Apply with your latest CV today and one of our specialist consultants will be in touch. BBBH37855 JBRP1_UKTJ

Job Title – Engineering Manager Location – Wrexham Type – Permanent Salary – DOE Our client are a leading food manufacturer working with the Uks leading brands. Due to growth, they are now seeking an experienced Engineering Manager to manage and develop the Engineering department. This person will be responsible for day-to-day management of the engineering function to ensure all equipment, utilities, and facilities operate safely, reliably, and efficiently. The role provides strategic and operational leadership across maintenance, asset care and compliance. • Responsible for Safety and food safety within area of control, • Responsible for the maintenance & availability of the process & packing lines., • Make incremental improvements & changes in terms of reliability, moving to a preventative model, reducing machinery downtime, maintain & improve stability., • Manage departmental budget, resource planning, contractor control, and performance management., • Managing the R&R to agreed budget, controlling engineering stocks seeking ways to balance Risk vs Cost, • Build a strong culture of safety, accountability, and proactive maintenance., • Leading, coaching and developing the maintenance team, • Professionalize the maintenance department with a strong focus on predictive and preventive maintenance., • Installation & de-installation of plant & equipment, as required, • Working with others on a range of Engineering and Operational Projects ensuring budgetary, technical compliance and target timelines are met., • Driving and reporting on key performance indicators to manage the effectiveness of the department and share to the wider team, • Ensure the department is Audit ready at all times and fully compliant with ALL legal and mandatory requirements including BRC, SMETA, L8, Pressure system regulations, Electrical fixed wiring, PAT testing and customer audits., • Drive the completion of PPM standards and planned reactive activities to an overall target of >85%, with all category A (high priority) activities >95% completion., • Drive system and process improvements in the department to support the delivery of a site OEE of greater than 80%., • Manage the annual (R&R) Repairs and renewals budget and labor budget to within agreed levels., • Manage and coach the team to ensure resources are utilized effectively, skills developed, • A minimum of 3 years’ experience in a maintenance/ engineering leadership position, ideally within Food manufacturing., • Relevant qualifications in Electrical and/or Mechanical Engineering., • An engaged, positive and strong leader with a ‘can do’ mentality, who can solve problems, • Strong knowledge of BRCGS, HACCP, HSE regulations, and food safety engineering standards., • Data driven with a continuous improvement mentality, formal knowledge and use of CI tools, • Demonstrable success improving OEE and leading maintenance teams., • Strong understanding of automated production equipment, packaging machinery, and utilities., • Excellent people leadership, communication, and problem‑solving skills., • Working knowledge of IT and Engineering CMMS systems, • IOSH/NEBOSH qualification., • Experienced in the implementation of Engineering CMMS systems (e.g., Shire, Agility, SAP PM,, • Experience of chilled and bakery processing environments., • Experience managing capex projects from design to commissioning., • Experience of audit processes with BRC and retailers, • would be an advantage, • Experienced in the implementation of Engineering CMMS systems (e.g., Shire, Agility, SAP PM,, • Experience of chilled and bakery processing environments. #J-18808-Ljbffr

Principal ScientistApply: Wrexham: Full time: Posted Today: R-22446Title:Principal ScientistCompany:Ipsen Biopharm LtdAbout Ipsen:Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation. Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company’s success. Join us on our journey towards sustainable growth, creating real impact on patients and society!For more information, visit us at https://www.ipsen.com/and follow our latest news on LinkedIn and Instagram.Job Description:Principal Scientist - Cell Line Development & Upstream Process DevelopmentLocation: Wrexham, UK (Hybrid Working) Contract: Permanent Travel: Occasional travel (European)Shape the Future of Biologics at IpsenAt Ipsen, we're passionate about advancing innovative medicines that make a meaningful difference to patients' lives. We are seeking an experienced Principal Scientist to join our Bioprocess Sciences team and provide scientific and technical leadership across Cell Line Development (CLD) and Upstream Process Development (USP) activities.This is an exciting opportunity for a senior biologics development professional to lead critical Chemistry, Manufacturing and Controls (CMC) development programmes, working with cutting-edge technologies and collaborating with global teams across our international network.The OpportunityAs Principal Scientist, you will act as a recognised subject matter expert, leading the development and optimisation of cell line and upstream manufacturing processes for biologic products from candidate selection through to commercial manufacturing.A key focus of the role will be driving upstream process development activities using mammalian and/or microbial cell lines, supporting multiple development programmes while providing technical leadership and mentorship to junior scientists. You will play an integral role within cross-functional CMC teams, partnering with internal stakeholders and external Contract Development and Manufacturing Organisations (CDMOs) to ensure successful programme delivery.This position offers exposure to a diverse biologics pipeline and the opportunity to influence development strategy across multiple projects while collaborating with colleagues throughout Ipsen's global organisation.Key Responsibilities Lead Cell Line Development and Upstream Process Development strategies across biologics development programmes. Provide scientific leadership for CMC development projects from early development through commercialisation. Act as a subject matter expert for CLD and USP activities, supporting technical decision-making across programmes. Drive innovation and continuous improvement to enhance process productivity, robustness and product quality. Represent Upstream Process Development within multidisciplinary CMC teams. Collaborate with internal stakeholders and external CMOs to support development, scale-up and technology transfer activities. Contribute to regulatory submissions and technical documentation. Conduct technical assessments for new product opportunities and in-licensing activities.* Mentor, coach and develop junior scientists, fostering a culture of scientific excellence.About YouWe're looking for a scientifically driven leader with strong biologics development experience and the ability to influence across complex, matrixed environments.Essential Experience & Skills Significant pharmaceutical or biotechnology industry experience within biologics development. Deep expertise in Cell Line Development and/or Upstream Process Development. Strong experience working with CHO cell lines and mammalian cell culture processes. Experience leading CMC development activities across the product lifecycle. Proven ability to work effectively with cross-functional stakeholders and external partners. Experience engaging with and managing activities CDMOs* Strong communication, influencing and stakeholder management skills.Desirable PhD in a relevant scientific discipline (or equivalent industry experience). Experience supporting regulatory submissions and technology transfer activities. Experience progressing biologic products from early to late-stage development and commercialisation. Demonstrated mentoring, coaching or leadership experience within scientific teams.Why Join Ipsen?At Ipsen, you'll be part of a collaborative and innovative organisation where science drives meaningful patient outcomes. We offer: Flexible hybrid working. Opportunities to collaborate with international teams across the UK, Ireland and France. Exposure to a diverse and exciting biologics pipeline. A culture that values scientific excellence, innovation and continuous learning.* The opportunity to mentor others while continuing to develop your own career within a global biopharmaceutical company.If you're an experienced biologics scientist looking to make a significant impact across Cell Line Development, Upstream Process Development and CMC programmes, we'd love to hear from you.Apply today and help shape the future of biologics at Ipsen. #J-18808-Ljbffr

Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation. Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company’s success. Join us on our journey towards sustainable growth, creating real impact on patients and society! For more information, visit us at https://www.ipsen.com/ and follow our latest news on LinkedIn and Instagram. At Ipsen, we are committed to improving the lives of patients, with a special focus on advancing neuroscience therapies. Our Wrexham site is a vital part of this mission, delivering cutting-edge solutions in a dynamic and collaborative environment. We are proud to be winner of Pharma Company of the Year 2025, Great Place to Work certified and a Shingo Bronze Medallion holder, reflecting our commitment to excellence, innovation, and continuous improvement. With a recent £24 million investment in the site and a further £86.4 million expansion underway, there has never been a more exciting time to join us. If you are passionate about making an impact and want to be part of a team that values growth, innovation, and excellence, then Ipsen could be where you thrive! We are seeking an experienced and driven OT Support Lead to oversee and develop our Operational Technology function. This is a key leadership position responsible for ensuring the reliability, security, and performance of manufacturing systems and automation technologies that support critical site operations. Working closely with Production, Engineering, Quality, and Global IT teams, you will lead a talented team of specialists while driving continuous improvement, cybersecurity, and digitalisation initiatives across the site. • Lead, coach, and develop a team of Operational Technology professionals., • Ensure the reliability, availability, and security of manufacturing and automation systems., • Drive site OT and cybersecurity strategies in line with business and regulatory requirements., • Partner with cross-functional stakeholders to deliver technology solutions that support operational excellence., • Identify and implement continuous improvement and digital transformation opportunities., • Manage OT projects and system upgrades, ensuring compliance with relevant quality and regulatory standards., • Prior experience in a similar position., • People management experience or experience from a senior position in the team., • Good communication skills., • Able to keep multiple stakeholders informed., • Regulatory knowledge e.g. GAMP5, FDA 21 CFR 11, EU ANNEX 11., • Ideally experience gained in the pharma industry. We are committed to creating a workplace where everyone feels heard, valued, and supported; where we embrace “The Real Us”. The value we place on different perspectives and experiences drives our commitment to inclusion and equal opportunities. When we include diverse ways of thinking, we make more thoughtful decisions and discover more innovative solutions. Together we strive to better understand the communities we serve. This means we also want to help you perform at your best when applying for a role with us. If you require any adjustments or support during the application process, please let the recruitment team know. This information will be handled with care and will not affect the outcome of your application. At Ipsen, each employee makes a real impact. Our teams are passionate about what they do because they care about making a difference in patients’ lives. We invest in our employees to support life-changing projects that create positive impact for patients and society. #J-18808-Ljbffr

Location: Wrexham, UK (Hybrid Working) Contract: Permanent Travel: Occasional travel (European) At Ipsen, we're passionate about advancing innovative medicines that make a meaningful difference to patients' lives. We are seeking an experienced Principal Scientist to join our Bioprocess Sciences team and provide scientific and technical leadership across Cell Line Development (CLD) and Upstream Process Development (USP) activities. This is an exciting opportunity for a senior biologics development professional to lead critical Chemistry, Manufacturing and Controls (CMC) development programmes, working with cutting-edge technologies and collaborating with global teams across our international network. As Principal Scientist, you will act as a recognised subject matter expert, leading the development and optimisation of cell line and upstream manufacturing processes for biologic products from candidate selection through to commercial manufacturing. A key focus of the role will be driving upstream process development activities using mammalian and/or microbial cell lines, supporting multiple development programmes while providing technical leadership and mentorship to junior scientists. You will play an integral role within cross-functional CMC teams, partnering with internal stakeholders and external Contract Development and Manufacturing Organisations (CDMOs) to ensure successful programme delivery. This position offers exposure to a diverse biologics pipeline and the opportunity to influence development strategy across multiple projects while collaborating with colleagues throughout Ipsen's global organisation. • Lead Cell Line Development and Upstream Process Development strategies across biologics development programmes., • Provide scientific leadership for CMC development projects from early development through commercialisation., • Act as a subject matter expert for CLD and USP activities, supporting technical decision-making across programmes., • Drive innovation and continuous improvement to enhance process productivity, robustness and product quality., • Represent Upstream Process Development within multidisciplinary CMC teams., • Collaborate with internal stakeholders and external CMOs to support development, scale-up and technology transfer activities., • Contribute to regulatory submissions and technical documentation., • Conduct technical assessments for new product opportunities and in-licensing activities., • Mentor, coach and develop junior scientists, fostering a culture of scientific excellence. We're looking for a scientifically driven leader with strong biologics development experience and the ability to influence across complex, matrixed environments. • Significant pharmaceutical or biotechnology industry experience within biologics development., • Deep expertise in Cell Line Development and/or Upstream Process Development., • Strong experience working with CHO cell lines and mammalian cell culture processes., • Experience leading CMC development activities across the product lifecycle., • Proven ability to work effectively with cross-functional stakeholders and external partners., • Experience engaging with and managing activities CDMOs, • Strong communication, influencing and stakeholder management skills., • PhD in a relevant scientific discipline (or equivalent industry experience)., • Experience supporting regulatory submissions and technology transfer activities., • Experience progressing biologic products from early to late-stage development and commercialisation., • Demonstrated mentoring, coaching or leadership experience within scientific teams., • Flexible hybrid working., • Opportunities to collaborate with international teams across the UK, Ireland and France., • Exposure to a diverse and exciting biologics pipeline., • A culture that values scientific excellence, innovation and continuous learning., • The opportunity to mentor others while continuing to develop your own career within a global biopharmaceutical company. If you're an experienced biologics scientist looking to make a significant impact across Cell Line Development, Upstream Process Development and CMC programmes, we'd love to hear from you. #J-18808-Ljbffr

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Job Description JOIN DHL E-COMMERCE AS A VAN DRIVER THIS AUTUMN.Our busiest period is approaching and we’re looking for motivated multi-drop drivers to join us for our peak period! .Nis the perfect time to get on the road.Enjoy consistent work, competitive pay and the opportunity to earn more dur

Amazon Flex Delivery Driver - Earn £14 to £18* per hour.Deliver packages on your schedule and get paid weekly.Flexible hours and get access to a wide range of deals & discounts.Deliver with us this winter as a seasonal delivery partner.To continue delivering smiles to all our customers, we’re op

You'll contribute to the development of retail sector propositions, thought leadership, customer success stories, and wider business development best practices.

JOIN DHL E-COMMERCE AS A VAN DRIVER THIS AUTUMN.Our busiest period is approaching and we’re looking for motivated multi-drop drivers to join us for our peak period!.Nis the perfect time to get on the road.Enjoy consistent work, competitive pay and the opportunity to earn more during our busiest pe

Own Every Moment at NetApp At NetApp, your ideas power innovation.We lead in intelligent data infrastructure—delivering unified storage, integrated data services, and solutions that help organizations unlock the full potential of their data, from AI to multicloud.Ready to innovate and contribute t

Strong stakeholder management and cross-functional leadership skills.

Join the UK's Favourite Parcel Delivery Company!.Read on to fully understand what this job requires in terms of skills and experience If you are a good match, make an application.Christmas Incentive 2026 - Earn an EXTRA 50p for every stop***.To qualify and be paid before Christmas Eve, simply:.Deliv

Join the UK's Favourite Parcel Delivery Company!*Christmas Incentive 2026 - Earn an EXTRA 50p for every stop*.Increase your chances of reaching the interview stage by reading the complete job description and applying promptly.To qualify and be paid before Christmas Eve, simply:.Deliver parcels o