Biomedical Data Scientist
hace 5 días
Cambridge
Job Description This Biomedical Data Scientist will help develop, deploy, maintain, and effectively use tools for the analysis of all-optical electrophysiology data. This role will have a special emphasis on development of novel optical assays of neuronal electrophysiology, which will involve image processing, signal processing, and rapid prototyping. The successful applicant will work as part of a small, close-knit team at the hub of Quiver’s scientific programs to derive actionable insights from a broad range of relevant biomedical data modalities, including the company’s proprietary all-optical electrophysiology data and other genomics/omics and imaging data sets. The candidate will also work on projects integrating complementary data streams. (e.g., transcriptomics, high-content imaging, clinical datasets, etc.) using knowledge graphs or advanced statistical, machine learning, and AI methods. The ideal candidate will be a thoughtful and creative programmer with expertise in advanced statistical approaches, machine learning and AI methodologies. The candidate should be eager to gain practical experience across all stages of the software lifecycle and motivated to learn expansively across a wide array of skills and problem domains. Quiver Bioscience is a technology-driven company established to create transformational medicines for the brain. We combine proprietary single-cell functional assays with other multi-modal measurements to discover new biology and new drug targets. We take advantage of cutting-edge AI/ML to build the world’s most information-rich maps of neuronal function to drive our drug discovery programs. This position is based in Cambridge, MA, with the expectation of on-site presence 3-4 days per week to support lab integration, team meetings, and collaborative project work. Fully remote applicants will not be considered. Responsibilities and Duties • Analyze electrophysiological (and other biological) data to serve research project goals. Make effective visualizations, draw sound inferences from complex experiments, assist biologists with experimental design and implementation, conduct reproducible analyses, and disseminate analytics findings with biologists and other stakeholders., • Contribute to all aspects of analytics software development including design, implementation, source control, performance optimization, unit testing, defect management, documentation, and ongoing maintenance and support., • Proficiently manage timelines, relationships, and work priorities to comfortably operate independently to make an impact., • Utilize excellent interpersonal skills to build consensus, share insights with relevant stakeholders, deliver interpretable data products, and serve both business and scientific goals of the company with your work. Minimum Qualifications Required • PhD degree or corresponding demonstrable professional experience in Data Science, Computer Science, Neuroscience, (Bio)Statistics, Physics, Computer vision, Electrical engineering, Mathematics, or related technical discipline (e.g., engineering, science, or biology with a strong quantitative flavor)., • Experience with image processing, video processing, signal processing, or time series analysis., • Comfort with multiple programming languages and computational APIs (the role will utilize Python, Matlab, R, git, SQL, and AWS, among others)., • Experience developing complex data pipelines or analysis tools., • Broad experience with commonly used data science and machine learning toolkits, libraries, and frameworks (sklearm, pytorch, statsmodels etc)., • Experience integrating complementary data streams. (e.g., transcriptomics, high-content imaging, clinical datasets, etc.) using knowledge graphs or advanced statistical, machine learning, and AI methods., • High level of creativity, with a passion for neuroscience or other biomedical fields., • Excellent skills in the areas of verbal/written communication, problem solving, and leadership. Additional Qualifications Desired • Knowledge and experience in biophysics, physiology, or neuroscience, especially electrophysiology, high-content imaging, or computational neuroscience., • Experience working with single-cell data of any modality., • Comfortable with linear algebra and probability theory., • Experience with statistical analysis and techniques for inference (including regression, splines/smooths, bootstrap and permutation methods, power analysis, theory of experimental design etc)., • Experience with deep-learning and neural network models, including modern convolutional models, unsupervised /self-supervised learning approaches, data augmentation, and current best-practices for training and optimization., • Experience with cheminformatics approaches (molecular fingerprints, similarity searches, etc.)Company DescriptionQuiver Bioscience was built to create transformational medicines for patients living with disorders of the brain. Utilizing our human disease models, novel AI, and the best-in-world platform, we stand as the premier partner in the journey from target discovery to the clinic.Quiver Bioscience was built to create transformational medicines for patients living with disorders of the brain. Utilizing our human disease models, novel AI, and the best-in-world platform, we stand as the premier partner in the journey from target discovery to the clinic.