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Location: Cambridge/Middlesbrough/Port Talbot Contract: Permanent Office/Hybrid: 3 days in Office Hours: Full time Job Profile: Team Manager Closing Date: 31st October 2026 Security requirements: Please note that, due to security restrictions relating to defence and nuclear sector projects, applicants must hold UK citizenship to be considered for this position. Description of role: The Non-Destructive Testing (NDT) Group is seeking to appoint a Team Manager within the “NDT Inspection Services” section to lead our Site Inspection Services. This role is critical in ensuring that all inspection activities delivered on customer sites meet the highest standards of safety, quality and compliance. As Team Manager, you will take full responsibility for managing the inspection team, providing clear direction and support to maintain operational excellence. You will oversee the day-to-day coordination of inspection schedules, ensuring resources are allocated effectively to meet project timelines and client expectations. Building strong relationships with internal and external clients will be key to maintaining seamless communication and service delivery. In addition, you will champion continuous improvement initiatives, driving efficiency and enhancing reporting processes. The position requires a leader with proven experience in inspection services and a strong understanding of regulatory compliance and quality assurance. Exceptional organisational and communication skills are essential, along with the ability to motivate and guide a team under tight deadlines and changing priorities. You will also proactively develop a pipeline of new business opportunities, engaging your team with potential customers, collaborating with colleagues across business units and working closely with the business development function. Projects must be maintained to the highest standards of safety, quality and technical excellence while meeting time, cost and delivery targets. The NIS section delivers a broad range of projects to an international customer base, often with competing demands and the requirement to co-ordinate multiple priorities in a fast paced, continually changing environment. As Team Manager, you will be responsible for the allocation of technical resource to best fit project needs, assisting in project delivery of projects and supporting day-to-day customer enquiries. To be successful you will need to: • Demonstrate experience of managing multidisciplinary teams and projects;, • Commit to providing technical excellence with effective communication and interpersonal skills,, • Possess strong knowledge of NDT and on-site application., • Show a track record in effective Project Management, including scoping of work and producing high quality technical reports;, • Capability to assist staff training and development activities within your team including motivation, succession planning and personal growth opportunities. The ideal candidate will possess a minimum of three CSWIP/PCN Level 2 and one Level 3 in at least one major NDT method (UT/PAUT/ET would be advantageous), an appropriate qualification at degree level or significant demonstrable experience in the on-site application of NDT in industry, extensive knowledge in NDT and will have gained or be working towards chartered engineer status. demonstrable experience of a leading role in NDT. For further details, please follow the Job Description link below: Travel: This position involves short-term travel within the UK and overseas, depending on project demands and client interactions. Regular travel is expected to maintain effective communication with the team. About us: TWI Ltd is a world expert in engineering, materials and joining technologies with significant property assets. We provide industry with advice and know-how in design, fabrication, failure analysis and prevention. We offer opportunities to collaborate with inspiring and expert teams and a supportive environment in which you are actively encouraged to share your ideas and continually develop your own skills and knowledge. If you are looking to join an organisation that is fuelled by innovation, teamwork, and openness, this role could be for you. Diversity statement: TWI Ltd is committed to treating all employees fairly and to being an inclusive employer. Our aim is to create a work environment where our employees can reach their full potential. We put Equality, Diversity and Inclusion at the heart of our people practices to attract, develop and retain the best talent. Inclusion: We recognise that it’s the differences of our people that gives us the competitive edge and enables us to maintain our world leading reputation. This is why we are committed to ensuring there is diversity across every level of our organisation; representative of the Members and societies we serve. We have made Inclusion our number one corporate value to demonstrate our commitment to ensure it is at the core of everything we do at TWI. Disability Confident Scheme: We are pleased to confirm that we have achieved the first stage accreditation, which means we are a ‘Disability Confident Employer’. This is a government-supported scheme that supports organisations like TWI to make the most of the talents that people with disability can bring to our workplace. The scheme helps us recruit and retain great people; draw from the widest possible pool of talent; secure high-quality employees who are skilled, loyal and hardworking; and improve employee morale and commitment by demonstrating that we treat all of our people fairly. If you require any additional support during your application, interview or any other aspect of our recruitment process please reach out to Why work for TWI? We offer a competitive salary, share-in-success bonus scheme, generous pension scheme (both employee contribution (flexible amount) and TWI contribution (up to 10% of salary), holiday (20 days + 5 Corporate days + 8 bank holiday’s), private health and dental cover, career development and training, onsite employee restaurant, onsite gym, day nursery available for companies on Granta Park (Cambridge) site (subject to availability), onsite parking and more. We know that balancing work and personal life can at times be challenging. This is why we continue to review and implement family friendly policies including hybrid working, flexible working, enhanced maternity pay and paid parental leave. Working hours: 36 hours per week (full time), 8.30am -16.30pm Monday to Thursday (finishing at 16.15pm on Friday). Part-time and hybrid working available in some roles. At TWI, we want you to know that your application is in good hands. We do not use AI tools or automated systems to review or sift through applications. Instead, every application is personally reviewed by the hiring manager. We believe in being open and transparent with our candidates, and we’re committed to giving your application the attention it deserves. #J-18808-Ljbffr

Level 3 qualification or above in early years education ?? Experience in an early years setting , with supervisory experience an advantage ideally as a Nursery Room Leader, Nursery Room Manager, or Nursery Practitioner ?? Strong leadership, organisational, and communication skills to inspire an

Head of Strategic Growth Location : Cambridge Contract : Permanent Office/Hybrid: A minimum of 3 days in the office Hours : Full time Job Profile : Associate Director Salary/annum : Min £87,911.18 - Max £138,145 Security requirements: This position is subject to security checks. Description of role: TWI is seeking an experienced and commercially focused leader to join our Technology leadership team as Head of Strategic Growth. This is a senior and influential opportunity to lead the identification and securing of opportunities that will deliver sustainable revenue growth for the TWI Technology Business. You will help expand the impact, capability and commercial performance of TWI Technology by developing a coordinated portfolio of services across industrial membership, technology research, new growth opportunities and strategic partnerships. Working closely with the Director of Technology, the Technology Leadership Team and colleagues across the Strategic Growth function, you will translate strategy into deliverable growth initiatives. You will also contribute to the development of TWI’s technology strategy, ensuring that growth plans respond to organisational priorities and market needs while creating lasting value for TWI members. The opportunity As Head of Strategic Growth, you will lead the development and delivery of strategic growth plans across the revenue generating services and solutions within the Technology Directorate. You will bring together technical, commercial and operational teams from across TWI to maximise the revenue and profitability of the organisation’s technology portfolio. Your leadership will help ensure that TWI Technology has the structure, focus and business winning capability needed to deliver its strategic ambitions. You will oversee growth planning across TWI Technology’s key market sectors of Aerospace and Defence, Oil and Gas, and Power. You will also review and develop TWI Technology’s core customer offerings, including Single Client Research, Joint Industry Programmes, Industrial Membership and Collaborative Research, ensuring that they continue to meet member needs and remain financially sustainable. Key responsibilities • Lead TWI Technology’s business winning capability and deliver strategic growth plans across its revenue generating services and solutions, • Translate technology strategy into focused and deliverable growth initiatives, • Drive collaboration across technical, commercial and operational teams to maximise revenue and profitability, • Oversee the development and delivery of growth plans for the Aerospace and Defence, Oil and Gas, and Power sectors, • Maintain a coordinated portfolio of business growth opportunities across sector plans and the three Technology Groups, • Continually review and develop TWI Technology’s core customer offerings, • Support the development of strategic partnerships with industry, academia and other external stakeholders, • Contribute to financial planning, sales forecasting and sales performance monitoring, • Improve the efficiency and effectiveness of business winning and strategic growth activities through ownership of relevant TWI processes and procedures, • Represent the Technology Directorate internally and externally, promoting TWI’s expertise and capabilities, • Champion innovation, continuous improvement and knowledge sharing, • Act as a role model for TWI’s values, leadership behaviours and inclusive culture About you You will be a strategic and commercially aware leader who can see the wider organisational picture while turning ambition into practical growth initiatives. Travel : This position may require regular travel both in the UK and abroad. About us: TWI Ltd is a world expert in engineering, materials and joining technologies with significant property assets. We provide industry with advice and know-how in design, fabrication, failure analysis and prevention. We offer opportunities to collaborate with inspiring and expert teams and a supportive environment in which you are actively encouraged to share your ideas and continually develop your own skills and knowledge. If you are looking to join an organisation that is fuelled by innovation, teamwork, and openness, this role could be for you. Diversity statement: TWI Ltd is committed to treating all employees fairly and to being an inclusive employer. Our aim is to create a work environment where our employees can reach their full potential. We put Equality, Diversity and Inclusion at the heart of our people practices to attract, develop and retain the best talent. Inclusion: We recognise that it’s the differences of our people that gives us the competitive edge and enables us to maintain our world leading reputation. This is why we are committed to ensuring there is diversity across every level of our organisation; representative of the Members and societies we serve. We have made Inclusion our number one corporate value to demonstrate our commitment to ensure it is at the core of everything we do at TWI. Disability Confident Scheme : We are pleased to confirm that we have achieved the first stage accreditation, which means we are a ‘Disability Confident Employer’. This is a government-supported scheme that supports organisations like TWI to make the most of the talents that people with disability can bring to our workplace. The scheme helps us recruit and retain great people; draw from the widest possible pool of talent; secure high-quality employees who are skilled, loyal and hardworking; and improve employee morale and commitment by demonstrating that we treat all of our people fairly. If you require any additional support during your application, interview or any other aspect of our recruitment process please reach out to Why work for TWI? We offer a competitive salary, share-in-success bonus scheme, generous pension scheme (both employee contribution (flexible amount) and TWI contribution (up to 10% of salary), holiday (20 days + 5 Corporate days + 8 bank holiday’s), private health and dental cover, career development and training, onsite employee restaurant, onsite gym, day nursery available for companies on Granta Park (Cambridge) site (subject to availability), onsite parking and more. We know that balancing work and personal life can at times be challenging. This is why we continue to review and implement family friendly policies including hybrid working, flexible working, enhanced maternity pay and paid parental leave. Working hours: 36 hours per week (full time), 8.30am -16.30pm Monday to Thursday (finishing at 16.15pm on Friday). Part-time and hybrid working available in some roles. Artificial Intelligence: At TWI, we want you to know that your application is in good hands. We do not use AI tools or automated systems to review or sift through applications. Instead, every application is personally reviewed by the hiring manager. We believe in being open and transparent with our candidates, and we’re committed to giving your application the attention it deserves. As one of the world’s leading independent research and technology organisations, we are committed to attracting, motivating and retaining the best talent from around the world. Our goal is to develop the next generation of experts to address future industry challenges. We are committed to creating a culture that recognises and respects the differences between people while valuing the contribution everyone makes to TWI. The diversity of our staff and students makes a positive and important contribution to our continuing success. TWI offers a comprehensive training programme, incorporating both in-house and external courses to support staff development. Our six values provide a point of reference for the way we expect our people to operate and behave. • Inclusion: Valuing the contribution from every individual, creating value for our customers, • Teamwork: Building effective working relationships, we accomplish more together, • Adaptability: Engaging positively with change to meet the needs of the business, • Taking Responsibility : Achieving our objectives and personal development, • Innovation & Expertise : Championing new ideas and sharing knowledge to solve industry problems, • Customer Focus : Building trusting relationships with our customers #J-18808-Ljbffr

Location: Cambridge, Sheffield, Middlesbrough or Port-Talbot Contract: Permanent Office/Hybrid: A minimum of 3 days in the office Hours: Full time Job Profile: Associate Director Salary/annum: Min £87,911.18 - Max £138,145 Security requirements: This position is subject to security checks. Description of role: TWI is seeking an experienced and commercially focused leader to join our Technology leadership team as Head of Strategic Growth. This is a senior and influential opportunity to lead the identification and securing of opportunities that will deliver sustainable revenue growth for the TWI Technology Business. You will help expand the impact, capability and commercial performance of TWI Technology by developing a coordinated portfolio of services across industrial membership, technology research, new growth opportunities and strategic partnerships. Working closely with the Director of Technology, the Technology Leadership Team and colleagues across the Strategic Growth function, you will translate strategy into deliverable growth initiatives. You will also contribute to the development of TWI’s technology strategy, ensuring that growth plans respond to organisational priorities and market needs while creating lasting value for TWI members. The opportunity As Head of Strategic Growth, you will lead the development and delivery of strategic growth plans across the revenue generating services and solutions within the Technology Directorate. You will bring together technical, commercial and operational teams from across TWI to maximise the revenue and profitability of the organisation’s technology portfolio. Your leadership will help ensure that TWI Technology has the structure, focus and business winning capability needed to deliver its strategic ambitions. You will oversee growth planning across TWI Technology’s key market sectors of Aerospace and Defence, Oil and Gas, and Power. You will also review and develop TWI Technology’s core customer offerings, including Single Client Research, Joint Industry Programmes, Industrial Membership and Collaborative Research, ensuring that they continue to meet member needs and remain financially sustainable. • Lead TWI Technology’s business winning capability and deliver strategic growth plans across its revenue generating services and solutions, • Translate technology strategy into focused and deliverable growth initiatives, • Drive collaboration across technical, commercial and operational teams to maximise revenue and profitability, • Oversee the development and delivery of growth plans for the Aerospace and Defence, Oil and Gas, and Power sectors, • Maintain a coordinated portfolio of business growth opportunities across sector plans and the three Technology Groups, • Continually review and develop TWI Technology’s core customer offerings, • Support the development of strategic partnerships with industry, academia and other external stakeholders, • Contribute to financial planning, sales forecasting and sales performance monitoring, • Improve the efficiency and effectiveness of business winning and strategic growth activities through ownership of relevant TWI processes and procedures, • Represent the Technology Directorate internally and externally, promoting TWI’s expertise and capabilities, • Champion innovation, continuous improvement and knowledge sharing, • Act as a role model for TWI’s values, leadership behaviours and inclusive culture About you You will be a strategic and commercially aware leader who can see the wider organisational picture while turning ambition into practical growth initiatives. For further details, please follow the Job Description link below: Travel: This position may require regular travel both in the UK and abroad. About us: TWI Ltd is a world expert in engineering, materials and joining technologies with significant property assets. We provide industry with advice and know-how in design, fabrication, failure analysis and prevention. We offer opportunities to collaborate with inspiring and expert teams and a supportive environment in which you are actively encouraged to share your ideas and continually develop your own skills and knowledge. If you are looking to join an organisation that is fuelled by innovation, teamwork, and openness, this role could be for you. Diversity statement: TWI Ltd is committed to treating all employees fairly and to being an inclusive employer. Our aim is to create a work environment where our employees can reach their full potential. We put Equality, Diversity and Inclusion at the heart of our people practices to attract, develop and retain the best talent. Inclusion: We recognise that it’s the differences of our people that gives us our competitive edge and enables us to maintain our world leading reputation. This is why we are committed to ensuring there is diversity across every level of our organisation; representative of the Members and societies we serve. We have made Inclusion our number one corporate value to demonstrate our commitment to ensure it is at the core of everything we do at TWI. Disability Confident Scheme: We are pleased to confirm that we have achieved the first stage accreditation, which means we are a ‘Disability Confident Employer’. This is a government-supported scheme that supports organisations like TWI to make the most of the talents that people with disability can bring to our workplace. The scheme helps us recruit and retain great people; draw from the widest possible pool of talent; secure high-quality employees who are skilled, loyal and hardworking; and improve employee morale and commitment by demonstrating that we treat all of our people fairly. If you require any additional support during your application, interview or any other aspect of our recruitment process please reach out to Why work for TWI? We offer a competitive salary, share-in-success bonus scheme, generous pension scheme (both employee contribution (flexible amount) and TWI contribution (up to 10% of salary), holiday (20 days + 5 Corporate days + 8 bank holiday’s), private health and dental cover, career development and training, onsite employee restaurant, onsite gym, day nursery available for companies on Granta Park (Cambridge) site (subject to availability), onsite parking and more. Working hours: 36 hours per week (full time), 8.30am -16.30pm Monday to Thursday (finishing at 16.15pm on Friday). Part-time and hybrid working available in some roles. Artificial Intelligence: At TWI, we want you to know that your application is in good hands. We do not use AI tools or automated systems to review or sift through applications. Instead, every application is personally reviewed by the hiring manager. We believe in being open and transparent with our candidates, and we’re committed to giving your application the attention it deserves. TWI Culture As one of the world’s leading independent research and technology organisations, we are committed to attracting, motivating and retaining the best talent from around the world. Our goal is to develop the next generation of experts to address future industry challenges. We are committed to creating a culture that recognises and respects the differences between people while valuing the contribution everyone makes to TWI. The diversity of our staff and students makes a positive and important contribution to our continuing success. TWI offers a comprehensive training programme, incorporating both in-house and external courses to support staff development. TWI Values: Our six values provide a point of reference for the way we expect our people to operate and behave. Inclusion: Valuing the contribution from every individual, creating value for our customers Teamwork: Building effective working relationships, we accomplish more together Adaptability: Engaging positively with change to meet the needs of the business Taking Responsibility: Achieving our objectives and personal development Innovation & Expertise: Championing new ideas and sharing knowledge to solve industry problems Customer Focus: Building trusting relationships with our customers TWI Ltd is a world expert in engineering, materials and joining technologies with significant property assets. We provide industry with advice and know-how in design, fabrication, failure analysis and prevention. We offer opportunities to collaborate with inspiring and expert teams and a supportive environment in which you are actively encouraged to share your ideas and continually develop your own skills and knowledge. If you are looking to join an organisation that is fuelled by innovation, teamwork, and openness, this role could be for you. #J-18808-Ljbffr

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development. The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radioconjugates (BRCs) and imaging agents; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle®technology to develop therapies to treat diseases in a range of therapeutic areas. Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit bicycletherapeutics.com Culture is key and all Bicycle employees actively embrace and role model our company values: • We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients., • We are Dedicated to our Mission. You can’t change the world if you don’t have determination., • We are One Team. We only succeed when we work together. THE ROLE (The Mission) Your mission is to serve as the operational backbone of R&D Quality—administering, optimizing, and maintaining our electronic Quality Management System (eQMS) to ensure seamless GxP document control, comprehensive training compliance, robust CAPA management, and continuous inspection readiness across our clinical development programs. • The Quality Management System (QMS) manager is responsible for the day-to-day operational administration, maintenance, and compliance oversight of the electronic Quality Management System (eQMS) for R&D. The successful candidate will play a critical role in supporting the R&D Quality Assurance and Development Functional Area teams., • This role will oversee GCP/GLP/GPV document control, manage GCP/GLP/GPV study training matrices, facilitate deviation/CAPA tracking, follow up on CAPAs through to completion, collect CAPA evidence of completion, and administer quality records to ensure continuous inspection readiness. YOUR RESPONSIBILITIES 1. eQMS Administration & GxP Document Lifecycle Control • System Administration & Ownership: Act as the primary administrator, subject matter expert, and "go-to" operational contact for Bicycle’s validated electronic QMS (e.g., Veeva, TrackWise, Dot Compliance)., • Controlled Document Lifecycle Management: Manage the end-to-end lifecycle—including drafting, review workflows, electronic signatures, approval, distribution, periodic review, and obsolescence—of GxP Standard Operating Procedures (SOPs), quality policies, work instructions, and clinical study templates in close partnership with functional authors., • Document Integrity & Compliance: Maintain strict formatting, version control, and template adherence in compliance with internal style guides, regulatory documentation standards, and 21 CFR Part 11 requirements., • Secure Archiving & Records Management: Coordinate the compliant, secure archiving and indexing of master controlled documents, superseded revisions, and historical quality records., • Data Extraction & Process Reporting: Generate, extract, and analyze controlled document metrics to identify review bottlenecks, upcoming review milestones, and procedural gaps across R&D. 1. Training Management & Compliance Oversight • Curriculum & Matrix Administration: Configure, deploy, and maintain study-specific and role-based GxP training curricula and matrices within the eQMS across clinical, non-clinical, and pharmacovigilance teams., • Onboarding & Offboarding Workflows: Partner cross-functionally with Functional Area Leads, HR, and IT to ensure timely assignment, modification, and deactivation of training profiles for new hires, role transitions, and external contractors., • Compliance Tracking & Escalation: Actively track training completion rates across global teams, follow up directly with users, provide automated compliance dashboards to line managers, and proactively flag overdue assignments to functional leadership., • Personnel Qualification Records: Oversee the collection, review workflows, routine updates, and compliant archival of essential qualification documents, including CVs, Job Descriptions (JDs), and GxP training certificates. 1. Deviation, CAPA, and Quality Event Support • Quality Event Logging & Workflow Support: Log, monitor, and facilitate the timely progress of clinical deviations, Quality Issues (QIs), and potential Serious Breaches through their defined eQMS workflows., • CAPA Progression & Evidence Gathering: Track implementation milestones for Corrective and Preventive Actions (CAPAs), driving accountability with action owners and collecting verifiable evidence of completion prior to closure., • Quality Trend & KPI Analysis: Extract, analyze, and compile quality performance data to populate periodic QA metrics and executive dashboards, helping uncover systemic process trends, repeat issues, or targeted training needs. 1. Audit & Inspection Readiness • Audit Workflow Logistics: Support the administrative workflows for vendor assessments, internal audits, and clinical investigator site audits, tracking audit reports, observations, and audit responses through to closure., • Inspection Room Operations: Provide pivotal administrative coordination and back-room support during sponsor regulatory authority inspections (e.g., FDA, MHRA, EMA) and partner audits., • Rapid Record Retrieval: Rapidly locate, verify, and deliver essential clinical trial records, training histories, CVs, and system qualification logs requested by regulatory inspectors or auditors. WHO ARE YOU: SKILLS & COMPETENCIES Knowledge • Core Expertise: Applies solid technical understanding of validated eQMS platforms (e.g., Veeva Vault, TrackWise, MasterControl), electronic document management principles, and GxP regulatory requirements (ICH GCP E6, GLP, GPV, and 21 CFR Part 11) to administer day-to-day R&D quality systems independently., • Data / Insight: Accurately extracts, aggregates, and interprets eQMS metrics—such as SOP review cycles, training compliance rates, and CAPA resolution timelines—identifying meaningful patterns and presenting actionable findings to R&D teams., • Influence & Collaboration: Communicates clearly and persuasively across global study teams, functional area leads, and external vendors/CROs, adapting style to explain compliance workflows, resolve user issues, and promote quality best practices. Job Complexity • Task / Project Delivery: Independently prioritizes and executes a diverse portfolio of operational tasks—including simultaneous document releases, study training rollouts, and CAPA tracking—managing competing timelines across fast-moving clinical trials., • Problem-Solving: Addresses operational and system-related bottlenecks, such as workflow stoppages, formatting discrepancies, or lagging compliance, applying standard quality procedures and exercise of sound judgment to resolve issues efficiently., • Strategic Impact: Directly underpins inspection readiness and data integrity across clinical development by maintaining accurate training records, transparent CAPA trails, and audit-ready document archives that protect trial credibility., • Autonomy: Operates under general supervision with clearly defined quality objectives, executing day-to-day eQMS user management and document control tasks with high initiative and minimal oversight., • Decision-Making: Makes sound operational decisions regarding document formatting compliance, workflow progressions, and training profile assignments within established quality parameters, knowing when to resolve matters directly and when to escalation compliance risks., • Leadership / Mentorship: Provides friendly, accessible technical support and system training to eQMS end‑users, mentoring less experienced colleagues on GxP documentation practices and continuous inspection readiness. Values & Behaviours One Team • Collaboration: Works seamlessly across clinical operations, regulatory affairs, biometrics, safety, and external CRO partners to streamline document workflows and maintain compliant training records., • Inclusive Leadership: Actively listens to user feedback and system challenges, ensuring cross-functional partners feel supported and empowered to navigate quality processes., • Mentorship / Support: Serves as a patient, encouraging guide for colleagues navigating eQMS workflows, simplifying system complexity to build collective quality capability. Adventurous • Innovation: Explores and champions modern digital features, automation opportunities, and efficient workflow configurations within the eQMS to enhance user experience and eliminate administrative friction., • Risk-Taking: Proactively experiments with improved tracking tools, reporting dashboards, and communication formats to elevate compliance transparency across global teams., • Change Leadership: Serves as an enthusiastic champion of system upgrades and procedural changes, helping team members embrace updated processes with confidence and clarity Dedicated to our Mission • Accountability: Demonstrates meticulous, obsessive attention to detail in document version control, record archiving, and CAPA verification, taking personal pride in audit-ready quality systems., • Resilience: Maintains calm focus, precision, and organization when managing shifting clinical study priorities, tight document approval deadlines, or high-pressure inspection environments., • Inspiration: Reinforces the vital connection between thorough GxP documentation, reliable trial data, and our shared commitment to delivering transformative therapies to patients., • Demonstrated practical expertise in electronic Quality Management System (eQMS) administration and GxP document control within a pharmaceutical sponsor, biotech, or clinical CRO environment., • Solid hands‑on experience configuring and administering modern validated electronic systems (e.g., Veeva Vault QualityDocs/Training, TrackWise, MasterControl, or Dot Compliance)., • Strong working knowledge of Good Clinical Practice (ICH GCP E6), 21 CFR Part 11 (Electronic Records and Signatures), and foundational GxP documentation regulations., • Proven track record coordinating and maintaining study training matrices, role-based curricula, and qualification records (CVs, job descriptions) to ensure audit readiness., • Experience tracking and supporting the resolution of deviations, Quality Issues, and CAPA lifecycles, including verifiable evidence gathering and compliance metric reporting., • Demonstrated capability providing operational and administrative support during regulatory agency inspections (e.g., FDA, MHRA, EMA) or internal/vendor audits., • Exceptional attention to detail, strong organizational skills, and proficiency in MS Office tools (advanced Word document formatting, Excel data management, SharePoint) and electronic signature platforms (DocuSign Part 11)., • Pension (10% employer contribution), • Private Medical Insurance (PMI) (including optical and dental cover), • Health Cash Plan, • Group Life Assurance (4x basic salary), • Group Income Protection, • Employee Assistance Program (EAP), • Cycle to Work scheme, • Access to subsidised gym membership, • Time off (28 days annual leave in addition to bank holidays & the option to buy up to 5 additional days annually), • Competitive reward including annual company bonus, • Enhanced parental leave policies, • Flexible working environment, • State‑of‑the‑art campus environment with on campus restaurant and Montessori nursery, • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status. By clicking the link above or any third-party link within this posting, you are leaving this site and going to a third-party website where the third-party website's terms and privacy policy apply #J-18808-Ljbffr

Job Description Your mission is to serve as the operational backbone of R&D Quality—administering, optimizing, and maintaining our electronic Quality Management System (eQMS) to ensure seamless GxP document control, comprehensive training compliance, robust CAPA management, and continuous inspection readiness across our clinical development programs. • The Quality Management System (QMS) manager is responsible for the day-to-day operational administration, maintenance, and compliance oversight of the electronic Quality Management System (eQMS) for R&D. The successful candidate will play a critical role in supporting the R&D Quality Assurance and Development Functional Area teams., • This role will oversee GCP/GLP/GPV document control, manage GCP/GLP/GPV study training matrices, facilitate deviation/CAPA tracking, follow up on CAPAs through to completion, collect CAPA evidence of completion, and administer quality records to ensure continuous inspection readiness., • System Administration & Ownership: Act as the primary administrator, subject matter expert, and "go-to" operational contact for Bicycle’s validated electronic QMS (e.g., Veeva, TrackWise, Dot Compliance)., • Controlled Document Lifecycle Management: Manage the end-to-end lifecycle—including drafting, review workflows, electronic signatures, approval, distribution, periodic review, and obsolescence—of GxP Standard Operating Procedures (SOPs), quality policies, work instructions, and clinical study templates in close partnership with functional authors., • Document Integrity & Compliance: Maintain strict formatting, version control, and template adherence in compliance with internal style guides, regulatory documentation standards, and 21 CFR Part 11 requirements., • Secure Archiving & Records Management: Coordinate the compliant, secure archiving and indexing of master controlled documents, superseded revisions, and historical quality records., • Data Extraction & Process Reporting: Generate, extract, and analyze controlled document metrics to identify review bottlenecks, upcoming review milestones, and procedural gaps across R&D., • Curriculum & Matrix Administration: Configure, deploy, and maintain study-specific and role-based GxP training curricula and matrices within the eQMS across clinical, non-clinical, and pharmacovigilance teams., • Onboarding & Offboarding Workflows: Partner cross-functionally with Functional Area Leads, HR, and IT to ensure timely assignment, modification, and deactivation of training profiles for new hires, role transitions, and external contractors., • Compliance Tracking & Escalation: Actively track training completion rates across global teams, follow up directly with users, provide automated compliance dashboards to line managers, and proactively flag overdue assignments to functional leadership., • Personnel Qualification Records: Oversee the collection, review workflows, routine updates, and compliant archival of essential qualification documents, including CVs, Job Descriptions (JDs), and GxP training certificates., • Quality Event Logging & Workflow Support: Log, monitor, and facilitate the timely progress of clinical deviations, Quality Issues (QIs), and potential Serious Breaches through their defined eQMS workflows., • CAPA Progression & Evidence Gathering: Track implementation milestones for Corrective and Preventive Actions (CAPAs), driving accountability with action owners and collecting verifiable evidence of completion prior to closure., • Quality Trend & KPI Analysis: Extract, analyze, and compile quality performance data to populate periodic QA metrics and executive dashboards, helping uncover systemic process trends, repeat issues, or targeted training needs., • Audit Workflow Logistics: Support the administrative workflows for vendor assessments, internal audits, and clinical investigator site audits, tracking audit reports, observations, and audit responses through to closure., • Inspection Room Operations: Provide pivotal administrative coordination and back-room support during sponsor regulatory authority inspections (e.g., FDA, MHRA, EMA) and partner audits., • Rapid Record Retrieval: Rapidly locate, verify, and deliver essential clinical trial records, training histories, CVs, and system qualification logs requested by regulatory inspectors or auditors., • Core Expertise: Applies solid technical understanding of validated eQMS platforms (e.g., Veeva Vault, TrackWise, MasterControl), electronic document management principles, and GxP regulatory requirements (ICH GCP E6, GLP, GPV, and 21 CFR Part 11) to administer day-to-day R&D quality systems independently., • Data / Insight: Accurately extracts, aggregates, and interprets eQMS metrics—such as SOP review cycles, training compliance rates, and CAPA resolution timelines—identifying meaningful patterns and presenting actionable findings to R&D teams., • Influence & Collaboration: Communicates clearly and persuasively across global study teams, functional area leads, and external vendors/CROs, adapting style to explain compliance workflows, resolve user issues, and promote quality best practices., • Task / Project Delivery: Independently prioritizes and executes a diverse portfolio of operational tasks—including simultaneous document releases, study training rollouts, and CAPA tracking—managing competing timelines across fast-moving clinical trials., • Problem-Solving: Addresses operational and system-related bottlenecks, such as workflow stoppages, formatting discrepancies, or lagging compliance, applying standard quality procedures and exercise of sound judgment to resolve issues efficiently., • Strategic Impact: Directly underpins inspection readiness and data integrity across clinical development by maintaining accurate training records, transparent CAPA trails, and audit-ready document archives that protect trial credibility., • Autonomy: Operates under general supervision with clearly defined quality objectives, executing day-to-day eQMS user management and document control tasks with high initiative and minimal oversight., • Decision-Making: Makes sound operational decisions regarding document formatting compliance, workflow progressions, and training profile assignments within established quality parameters, knowing when to resolve matters directly and when to elevate compliance risks., • Leadership / Mentorship: Provides friendly, accessible technical support and system training to eQMS end-users, mentoring less experienced colleagues on GxP documentation practices and continuous inspection readiness., • Collaboration: Works seamlessly across clinical operations, regulatory affairs, biometrics, safety, and external CRO partners to streamline document workflows and maintain compliant training records., • Inclusive Leadership: Actively listens to user feedback and system challenges, ensuring cross-functional partners feel supported and empowered to navigate quality processes., • Mentorship / Support: Serves as a patient, encouraging guide for colleagues navigating eQMS workflows, simplifying system complexity to build collective quality capability., • Innovation: Explores and champions modern digital features, automation opportunities, and efficient workflow configurations within the eQMS to enhance user experience and eliminate administrative friction., • Risk-Taking: Proactively experiments with improved tracking tools, reporting dashboards, and communication formats to elevate compliance transparency across global teams., • Change Leadership: Serves as an enthusiastic champion of system upgrades and procedural changes, helping team members embrace updated processes with confidence and clarity, • Accountability: Demonstrates meticulous, obsessive attention to detail in document version control, record archiving, and CAPA verification, taking personal pride in audit-ready quality systems., • Resilience: Maintains calm focus, precision, and organization when managing shifting clinical study priorities, tight document approval deadlines, or high-pressure inspection environments., • Inspiration: Reinforces the vital connection between thorough GxP documentation, reliable trial data, and our shared commitment to delivering transformative therapies to patients., • Demonstrated practical expertise in electronic Quality Management System (eQMS) administration and GxP document control within a pharmaceutical sponsor, biotech, or clinical CRO environment., • Solid hands-on experience configuring and administering modern validated electronic systems (e.g., Veeva Vault QualityDocs/Training, TrackWise, MasterControl, or Dot Compliance)., • Strong working knowledge of Good Clinical Practice (ICH GCP E6), 21 CFR Part 11 (Electronic Records and Signatures), and foundational GxP documentation regulations., • Proven track record coordinating and maintaining study training matrices, role-based curricula, and qualification records (CVs, job descriptions) to ensure audit readiness., • Experience tracking and supporting the resolution of deviations, Quality Issues, and CAPA lifecycles, including verifiable evidence gathering and compliance metric reporting., • Demonstrated capability providing operational and administrative support during regulatory agency inspections (e.g., FDA, MHRA, EMA) or internal/vendor audits., • Exceptional attention to detail, strong organizational skills, and proficiency in MS Office tools (advanced Word document formatting, Excel data management, SharePoint) and electronic signature platforms (DocuSign Part 11)., • Pension (10% employer contribution), • Private Medical Insurance (PMI) (including optical and dental cover), • Health Cash Plan, • Group Life Assurance (4x basic salary), • Group Income Protection, • Employee Assistance Program (EAP), • Cycle to Work scheme, • Access to subsidised gym membership, • Time off (28 days annual leave in addition to bank holidays & the option to buy up to 5 additional days annually), • Competitive reward including annual company bonus, • Employee recognition schemes, • Enhanced parental leave policies, • Flexible working environment, • State-of-the-art campus environment with on campus restaurant and Montessori nursery, • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status. #J-18808-Ljbffr

Location: Cambridge Contract: Permanent Office/Hybrid: On-Site Hours: Full time Job Profile: Engineer or Senior Engineer (Dependent on experience) Are you passionate about advanced manufacturing, materials engineering and innovative joining technologies? TWI is seeking an Engineer or Senior Engineer to join our Friction Welding & Processing team. This is an exciting opportunity to work on a diverse portfolio of industrial research, development and consultancy projects supporting customers across aerospace, defence, energy, manufacturing and transportation sectors. Working alongside internationally recognised experts, you will contribute to the development of cutting‑edge welding and processing technologies while helping clients solve complex engineering challenges. • Delivering industrial research, development and consultancy projects., • Designing and executing experimental programmes relating to friction welding and solid state joining technologies., • Analysing technical data and producing high quality reports and recommendations., • Supporting client enquiries and developing innovative engineering solutions., • Contributing to commercially funded and collaborative research programmes., • Building strong relationships with industrial clients and research partners., • Supporting proposal development and new business opportunities., • You will have a degree, MSc or PhD in Materials Engineering, Welding Engineering, Metallurgy, Mechanical Engineering or a related discipline and experience working within engineering, manufacturing, research or technology environments., • Experience in friction welding, friction stir welding, solid state joining technologies or related manufacturing processes would be highly advantageous., • Strong technical and analytical skills., • Excellent written and verbal communication abilities., • The ability to work collaboratively with colleagues and clients., • A passion for innovation and engineering excellence. For further details, please follow the Job Description link below: Travel: This position may require regular travel in the UK. TWI Ltd is a world expert in engineering, materials and joining technologies with significant property assets. We provide industry with advice and know-how in design, fabrication, failure analysis and prevention. We offer opportunities to collaborate with inspiring and expert teams and a supportive environment in which you are actively encouraged to share your ideas and continually develop your own skills and knowledge. TWI Ltd is committed to treating all employees fairly and to being an inclusive employer. Our aim is to create a work environment where our employees can reach their full potential. We put Equality, Diversity and Inclusion at the heart of our people practices to attract, develop and retain the best talent. Inclusion: We recognise that it’s the differences of our people that gives us our competitive edge and enables us to maintain our world leading reputation. This is why we are committed to ensuring there is diversity across every level of our organisation; representative of the Members and societies we serve. We have made Inclusion our number one corporate value to demonstrate our commitment to ensure it is at the core of everything we do at TWI. Disability Confident Scheme: We are pleased to confirm that we have achieved the first stage accreditation, which means we are a ‘Disability Confident Employer’. This is a government‑supported scheme that supports organisations like TWI to make the most of the talents that people with disability can bring to our workplace. The scheme helps us recruit and retain great people; draw from the widest possible pool of talent; secure high‑quality employees who are skilled, loyal and hardworking; and improve employee morale and commitment by demonstrating that we treat all of our people fairly. If you require any additional support during your application, interview or any other aspect of our recruitment process please reach out to • We offer a competitive salary, share‑in‑success bonus scheme, generous pension scheme (both employee contribution (flexible amount) and TWI contribution (up to 10% of salary), holiday (20 days + 5 Corporate days + 8 bank holiday’s), private health and dental cover, career development and training, onsite employee restaurant, onsite gym, day nursery available for companies on Granta Park (Cambridge) site (subject to availability), onsite parking and more., • We know that balancing work and personal life can at times be challenging. This is why we continue to review and implement family friendly policies including hybrid working, flexible working, enhanced maternity pay and paid parental leave. 36 hours per week (full time), 8.30am -16.30pm Monday to Thursday (finishing at 16.15pm on Friday). Part‑time and hybrid working available in some roles. At TWI, we want you to know that your application is in good hands. We do not use AI tools or automated systems to review or sift through applications. Instead, every application is personally reviewed by the hiring manager. We believe in being open and transparent with our candidates, and we’re committed to giving your application the attention it deserves. As one of the world’s leading independent research and technology organisations, we are committed to attracting, motivating and retaining the best talent from around the world. Our goal is to develop the next generation of experts to address future industry challenges. We are committed to creating a culture that recognises and respects the differences between people while valuing the contribution everyone makes to TWI. The diversity of our staff and students makes a positive and important contribution to our continuing success. • Inclusion: Valuing the contribution from every individual, creating value for our customers, • Teamwork: Building effective working relationships, we accomplish more together, • Adaptability: Engaging positively with change to meet the needs of the business, • Taking Responsibility: Achieving our objectives and personal development, • Innovation & Expertise: Championing new ideas and sharing knowledge to solve industry problems, • Customer Focus: Building trusting relationships with our customers TWI Ltd is a world expert in engineering, materials and joining technologies with significant property assets. We provide industry with advice and know-how in design, fabrication, failure analysis and prevention. We offer opportunities to collaborate with inspiring and expert teams and a supportive environment in which you are actively encouraged to share your ideas and continually develop your own skills and knowledge. If you are looking to join an organisation that is fuelled by innovation, teamwork, and openness, this role could be for you. #J-18808-Ljbffr

This is an excellent opportunity for an existing Nursery Manager or an experienced Deputy Nursery Manager ready to take the next step into their first management role. You'll ideally have: Experience as a Nursery Manager or significant experience as a Deputy Nursery Manager ready to progress into

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The role of the Nursery Manager will include: Ensure that children are kept safe, and that staff understand, and when necessary, follow safeguarding procedures Promote and facilitate partnerships with parents/carers and other family members To manage and be responsible for the day to day running of

Time Recruitment Solutions Ltd is recruiting a Site Manager for a live nursery refurbishment in Glasgow.

Busy Bees Leicester Oadby is seeking a Deputy ready to progress to a full Nursery Manager role.

Experience as a Nursery Manager or Assistant Nursery Manager. This is an exciting opportunity for an experienced Deputy Nursery Manager who is ready to progress into a full Nursery Manager role. Step into full Nursery Manager responsibility for a well-supported setting.

Seeking a passionate Room Leader/Early Years Room Leader for a nursery in Bourne End, responsible for creating engaging learning environments and supporting child development.

Nursery Manager Job Description:. We are looking for a L3 Qualified Childcare Nursery Manager to join our Amazing Team. If you are an inspiring Early Years Professional, come and join us, We have an experienced team ready to support you in your new Nursery Manager role.

Are you an experienced Nursery Manager or Senior Nursery Supervisor ready to take the next step in your career?. We are looking for a friendly, approachable and confident Nursery Manager to join a fun and rewarding nursery in Corby.

We are seeking to appoint a Deputy Nursery Manager. This pivotal role helps sets the culture, ethos and high expectations for a brand-new setting and supports leading the team with the Nursery Manager to deliver outstanding education and care. Kingsley Explorers Nursery- Leamington Spa.

Nursery Room Leader position focused on creating engaging learning experiences, supporting child development, and leading a team.

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As a Nursery Manager, you'll have the opportunity to lead you. Join Our Team at Busy Bees Horsham– Leading Nursery Group in the UK!.

Michelle Denny Recruitment is working with Loddon Nursery School, rated Outstanding by Ofsted, to find a Deputy Manager / Early Years Lead to work alongside the owner-manager. Deputy Nursery Manager / Early Years Lead. Loddon Nursery School | Loddon, South Norfolk £37,000 - £39,000 per annum (for

At Footsteps Nursery Stafford,\ N we’re looking for a caring,enthusiastic Nursery Third in Charge\ N to join our supportive, friendly team. As a Nursery Third\ N in Charge, you’ll help children learn, play, and grow in a safe,\ N engaging environment. Support the\ N nursery leadership team bylea

Seeking a qualified Nursery Manager for a permanent, full-time role in Winchester. Responsibilities include leading a team, ensuring child safeguarding, and managing nursery operations to deliver childcare excellence.

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We are excited to be recruiting for a highly experienced, passionate Nursery Manager for our Fairfield's Private Day Nursery at Fairfield Hospital in Bury. Creche-n-Co Ltd is seeking a Nursery Manager to join our team.

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Nursery Room Leader, Nursery Room Manager, or Nursery Practitioner. We're Opening a Brand-New Busy Bees Nursery in Shoeburyness! Be Part of Something Amazing!.

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Previous experience as a Nursery Manager or Deputy Manager. Conduct nursery tours, promoting Kindred as the nursery of choice within your local area. Lead, inspire and develop your leadership team, including the Deputy Manager, Third in Charge and Room Leaders.

If you would like an informal discussion about the post, please contact Christopher Pashley, Cleaning & Janitorial Service Manager, on Christopher. It is also a requirement that the referees are your previous/current managers and are not the details of work colleagues operating at the same level as

Salary £25,661 - £25,924 (pro-rata for part time and sessional).Hours: 16 per week, 38 weeks sessional.Our cook 1's/catering assistants play a vital role in delivering high quality catering services within schools.Working as part of a team, to deliver a range of meals, basic food preparation and g

The salary advertised is full time (35 hours per week, 52 weeks per year).Part-time hours / sessional posts will be pro-rated accordingly.This is a 40-week sessional post i.Monday - Thursday, 15:00-18:00.To assist in the provision of a high quality cleaning service within Council buildings.Please do

Join our award-winning school cleaning team.We’re proud of our award-winning service, recognised with:.ASSIST-FM Contribution to Cleaning Award - 2022.APSE Building Cleaning Innovation Award - 2023.Building Cleaning Most Improved Performance Networks Award – 2024.ASSIST – FM Contribution to Cl

ACTUAL CLOSING DATE: Applications must be received by 16th of November 2026 at 11.Please ensure that you read the full advert text and do not submit a CV, as these will be disregarded as they do not form part of SLC application process.If you require to submit additional information to support your

It is also a requirement that the referees are your previous/current managers and are not the details of work colleagues operating at the same level as you or personal referees. If you would like an informal discussion about the post, please contact Christopher Pashley, Cleaning & Janitorial Service

If you have previous experience working with children, ideally as an Early Years Educator, Nursery Practitioner, Nursery Assistant or Nursery Nurse and you're ready to make a meaningful impact in early childhood education we encourage you to apply! TPBN1_UKTJ. About our Nursery Our beautiful Newcas