Oxford
Get AI-powered advice on this job and more exclusive features. This range is provided by Northreach. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Direct message the job poster from Northreach We are seeking an exceptional Scientist with a passion for immuno-oncology and hands-on expertise in CAR-T and TCR cell therapy discovery and development. This is a dynamic, lab-based role based at our Oxford site, where you will lead experimental design, execute in vitro functional assays, and collaborate cross-functionally to advance innovative cell therapies toward the clinic. This position offers an exciting opportunity to contribute directly to the design and optimisation of novel CAR-T constructs within a fast-paced, collaborative biotech environment. Key Responsibilities: • Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity, including cytotoxicity, cytokine release, and target engagement., • Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering., • Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data., • Develop and validate ELISA and Western blot assays to support functional and mechanistic studies., • Generate actionable insights from experimental data to guide CAR/TCR construct selection and refinement., • Collaborate closely with bioinformatics, translational, and cell engineering teams to integrate data and align project goals., • Prepare scientific presentations, technical reports, and contribute to regulatory documentation as needed., • Stay abreast of emerging trends in CAR-T/TCR research and immuno-oncology; implement innovative approaches in R&D., • Mentor junior scientists and foster a culture of scientific rigor, curiosity, and innovation. Qualifications: • PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required for Scientist level (Master’s with significant biotech experience considered for Senior RA role)., • Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy., • Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture., • Proven ability to analyse complex datasets and extract meaningful biological insights., • Excellent scientific communication skills, both written and verbal., • Ability to work independently and collaboratively in a fast-paced, team-oriented environment., • Must be able to work on-site at our Oxford facility. Why Join Us? • Contribute to groundbreaking advances in next-generation cell therapy innovation., • Work within a mission-driven, supportive, and collaborative scientific team., • Opportunity to make a tangible impact on the future of immuno-oncology therapies. If you are passionate about driving CAR-T/TCR therapy development and thrive in a fast-moving, impactful environment, and are able to work at our Oxford site, we encourage you to apply. • Mid-Senior level, • Full-time, • Science Referrals increase your chances of interviewing at Northreach by 2x Oxfordshire, England, United Kingdom 3 weeks ago Oxfordshire, England, United Kingdom 3 weeks ago Reading, England, United Kingdom 2 weeks ago Oxford, England, United Kingdom 1 day ago Abingdon-On-Thames, England, United Kingdom 1 week ago Oxford, England, United Kingdom 3 weeks ago Oxford, England, United Kingdom 1 day ago Oxford, England, United Kingdom 6 days ago Oxfordshire, England, United Kingdom 2 weeks ago Reading, England, United Kingdom 2 weeks ago Oxford, England, United Kingdom 1 week ago Witney, England, United Kingdom 2 weeks ago Oxford, England, United Kingdom 1 week ago Oxfordshire, England, United Kingdom 5 days ago Oxford, England, United Kingdom 1 week ago Oxford, England, United Kingdom 1 week ago Oxford, England, United Kingdom 1 week ago Abingdon-On-Thames, England, United Kingdom 1 week ago Oxford, England, United Kingdom 2 weeks ago Oxford, England, United Kingdom 1 week ago Witney, England, United Kingdom 1 week ago Didcot, England, United Kingdom 3 weeks ago Oxford, England, United Kingdom 3 weeks ago Oxford, England, United Kingdom 4 days ago Oxfordshire, England, United Kingdom 2 weeks ago Reading, England, United Kingdom 4 days ago Witney, England, United Kingdom 1 month ago Oxford, England, United Kingdom 1 week ago Oxford, England, United Kingdom 3 weeks ago Witney, England, United Kingdom 1 week ago Oxford, England, United Kingdom 1 day ago Oxford, England, United Kingdom 5 days ago Oxford, England, United Kingdom 2 weeks ago Oxford, England, United Kingdom 2 weeks ago Abingdon-On-Thames, England, United Kingdom 2 weeks ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. #J-18808-Ljbffr